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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: TRIM9 (CAeditome ID:114088)

Gene summary for TRIM9

check button Gene summary
Gene informationGene symbol

TRIM9

Gene ID

114088

Gene nametripartite motif containing 9
SynonymsRNF91|SPRING
Cytomap

14q22.1

Type of geneprotein-coding
DescriptionE3 ubiquitin-protein ligase TRIM9RING finger protein 91RING-type E3 ubiquitin transferase TRIM9SNAP-25-interacting RING finger proteinhomolog of rat RING finger Springtripartite motif-containing protein 9
Modification date20210529
UniProtAcc

Q9C026

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
TRIM9

GO:0061630

E3 ubiquitin-protein ligase TRIM9

20085810

TRIM9

GO:0043161

E3 ubiquitin-protein ligase TRIM9

20085810

TRIM9

GO:0005737

E3 ubiquitin-protein ligase TRIM9

11331580

TRIM9

GO:0005737

E3 ubiquitin-protein ligase TRIM9

20085810

TRIM9

GO:0030425

E3 ubiquitin-protein ligase TRIM9

20085810


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RNA A-to-I events for TRIM9

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000100505.12

check button RNA A-to-I editing events in Cancer.
CAediting_991445(50987965, -), CAediting_991446(50987968, -), CAediting_991447(50988004, -), CAediting_991448(50988020, -), CAediting_991449(50988088, -), CAediting_991450(50990051, -), CAediting_991451(50990071, -), CAediting_991452(50990110, -), CAediting_991453(50990115, -), CAediting_991454(50990142, -), CAediting_991455(50990146, -), CAediting_991456(50990150, -), CAediting_991457(50990156, -), CAediting_991458(50990172, -), CAediting_991459(50990198, -), CAediting_991460(50990221, -), CAediting_991461(50990231, -), CAediting_991462(50990250, -), CAediting_991463(50990289, -), CAediting_991464(50992360, -), CAediting_991465(50992361, -), CAediting_991466(50992373, -), CAediting_991467(50992374, -), CAediting_991468(50992375, -), CAediting_991469(50992395, -), CAediting_991470(50992406, -), CAediting_991471(50992451, -), CAediting_991472(50992460, -), CAediting_991473(50992464, -), CAediting_991474(50992486, -), CAediting_991475(50992491, -), CAediting_991476(50992510, -), CAediting_991477(50992516, -), CAediting_991478(50992529, -), CAediting_991479(50992558, -), CAediting_991480(50992564, -), CAediting_991481(50992566, -), CAediting_991482(50993429, -), CAediting_991483(50993465, -), CAediting_991484(50993550, -), CAediting_991485(50993571, -), CAediting_991486(50993581, -), CAediting_991487(50993595, -), CAediting_991488(50993600, -), CAediting_991489(50993693, -), CAediting_991490(50994188, -), CAediting_991491(50994201, -), CAediting_991492(50994202, -), CAediting_991493(50994203, -), CAediting_991494(50994240, -), CAediting_991495(50994258, -), CAediting_991496(50994285, -), CAediting_991497(50994291, -), CAediting_991498(50994307, -), CAediting_991499(50994321, -), CAediting_991500(50994324, -), CAediting_991501(50994325, -), CAediting_991502(50994360, -), CAediting_991503(50994363, -), CAediting_991504(50994395, -), CAediting_991505(50994480, -), CAediting_991506(50994520, -), CAediting_991507(50994529, -), CAediting_991508(50994540, -), CAediting_991509(50994550, -), CAediting_991510(50994567, -), CAediting_991511(50995053, -), CAediting_991512(50995055, -), CAediting_991513(50995069, -), CAediting_991514(50995079, -), CAediting_991515(50995095, -), CAediting_991516(50995108, -), CAediting_991517(50995124, -), CAediting_991518(50995125, -), CAediting_991519(50995138, -), CAediting_991520(50995147, -), CAediting_991521(51016064, -), CAediting_991522(51016095, -), CAediting_991523(51016097, -), CAediting_991524(51016666, -), CAediting_991525(51054609, -),

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RNA editing positional annotations for TRIM9 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_991445chr14_50987965_-ncRNA_intronic
CAediting_991446chr14_50987968_-ncRNA_intronic
CAediting_991447chr14_50988004_-ncRNA_intronic
CAediting_991448chr14_50988020_-ncRNA_intronic
CAediting_991449chr14_50988088_-ncRNA_intronic
CAediting_991450chr14_50990051_-intronic
CAediting_991451chr14_50990071_-intronic
CAediting_991452chr14_50990110_-intronic
CAediting_991453chr14_50990115_-intronic
CAediting_991454chr14_50990142_-intronic
CAediting_991455chr14_50990146_-intronic
CAediting_991456chr14_50990150_-intronic
CAediting_991457chr14_50990156_-intronic
CAediting_991458chr14_50990172_-intronic
CAediting_991459chr14_50990198_-intronic
CAediting_991460chr14_50990221_-intronic
CAediting_991461chr14_50990231_-intronic
CAediting_991462chr14_50990250_-intronic
CAediting_991463chr14_50990289_-intronic
CAediting_991464chr14_50992360_-intronic
CAediting_991465chr14_50992361_-intronic
CAediting_991466chr14_50992373_-intronic
CAediting_991467chr14_50992374_-intronic
CAediting_991468chr14_50992375_-intronic
CAediting_991469chr14_50992395_-intronic
CAediting_991470chr14_50992406_-intronic
CAediting_991471chr14_50992451_-intronic
CAediting_991472chr14_50992460_-intronic
CAediting_991473chr14_50992464_-intronic
CAediting_991474chr14_50992486_-intronic
CAediting_991475chr14_50992491_-intronic
CAediting_991476chr14_50992510_-intronic
CAediting_991477chr14_50992516_-intronic
CAediting_991478chr14_50992529_-intronic
CAediting_991479chr14_50992558_-intronic
CAediting_991480chr14_50992564_-intronic
CAediting_991481chr14_50992566_-intronic
CAediting_991482chr14_50993429_-intronic
CAediting_991483chr14_50993465_-intronic
CAediting_991484chr14_50993550_-intronic
CAediting_991485chr14_50993571_-intronic
CAediting_991486chr14_50993581_-intronic
CAediting_991487chr14_50993595_-intronic
CAediting_991488chr14_50993600_-intronic
CAediting_991489chr14_50993693_-intronic
CAediting_991490chr14_50994188_-intronic
CAediting_991491chr14_50994201_-intronic
CAediting_991492chr14_50994202_-intronic
CAediting_991493chr14_50994203_-intronic
CAediting_991494chr14_50994240_-intronic
CAediting_991495chr14_50994258_-intronic
CAediting_991496chr14_50994285_-intronic
CAediting_991497chr14_50994291_-intronic
CAediting_991498chr14_50994307_-intronic
CAediting_991499chr14_50994321_-intronic
CAediting_991500chr14_50994324_-intronic
CAediting_991501chr14_50994325_-intronic
CAediting_991502chr14_50994360_-intronic
CAediting_991503chr14_50994363_-intronic
CAediting_991504chr14_50994395_-intronic
CAediting_991505chr14_50994480_-intronic
CAediting_991506chr14_50994520_-intronic
CAediting_991507chr14_50994529_-intronic
CAediting_991508chr14_50994540_-intronic
CAediting_991509chr14_50994550_-intronic
CAediting_991510chr14_50994567_-intronic
CAediting_991511chr14_50995053_-intronic
CAediting_991512chr14_50995055_-intronic
CAediting_991513chr14_50995069_-intronic
CAediting_991514chr14_50995079_-intronic
CAediting_991515chr14_50995095_-intronic
CAediting_991516chr14_50995108_-intronic
CAediting_991517chr14_50995124_-intronic
CAediting_991518chr14_50995125_-intronic
CAediting_991519chr14_50995138_-intronic
CAediting_991520chr14_50995147_-intronic
CAediting_991521chr14_51016064_-intronic
CAediting_991522chr14_51016095_-intronic
CAediting_991523chr14_51016097_-intronic
CAediting_991524chr14_51016666_-intronic
CAediting_991525chr14_51054609_-intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_991445chr14_50987965_-SINEAluAluSz6
CAediting_991446chr14_50987968_-SINEAluAluSz6
CAediting_991447chr14_50988004_-SINEAluAluSz6
CAediting_991448chr14_50988020_-SINEAluAluSz6
CAediting_991449chr14_50988088_-SINEAluAluSz6
CAediting_991450chr14_50990051_-SINEAluAluJr
CAediting_991451chr14_50990071_-SINEAluAluJr
CAediting_991452chr14_50990110_-SINEAluAluJr
CAediting_991453chr14_50990115_-SINEAluAluJr
CAediting_991454chr14_50990142_-SINEAluAluJr
CAediting_991455chr14_50990146_-SINEAluAluJr
CAediting_991456chr14_50990150_-SINEAluAluJr
CAediting_991457chr14_50990156_-SINEAluAluJr
CAediting_991458chr14_50990172_-SINEAluAluJr
CAediting_991459chr14_50990198_-SINEAluAluJr
CAediting_991460chr14_50990221_-SINEAluAluJr
CAediting_991461chr14_50990231_-SINEAluAluJr
CAediting_991462chr14_50990250_-SINEAluAluJr
CAediting_991463chr14_50990289_-SINEAluAluJr
CAediting_991464chr14_50992360_-SINEAluAluJr4
CAediting_991465chr14_50992361_-SINEAluAluJr4
CAediting_991466chr14_50992373_-SINEAluAluJr4
CAediting_991467chr14_50992374_-SINEAluAluJr4
CAediting_991468chr14_50992375_-SINEAluAluJr4
CAediting_991469chr14_50992395_-SINEAluAluJr4
CAediting_991470chr14_50992406_-SINEAluAluJr4
CAediting_991471chr14_50992451_-SINEAluAluJr4
CAediting_991472chr14_50992460_-SINEAluAluJr4
CAediting_991473chr14_50992464_-SINEAluAluJr4
CAediting_991474chr14_50992486_-SINEAluAluJr4
CAediting_991475chr14_50992491_-SINEAluAluJr4
CAediting_991476chr14_50992510_-SINEAluAluJr4
CAediting_991477chr14_50992516_-SINEAluAluJr4
CAediting_991478chr14_50992529_-SINEAluAluJr4
CAediting_991479chr14_50992558_-SINEAluAluJr4
CAediting_991480chr14_50992564_-SINEAluAluJr4
CAediting_991481chr14_50992566_-SINEAluAluJr4
CAediting_991482chr14_50993429_-SINEAluAluSp
CAediting_991483chr14_50993465_-SINEAluAluSp
CAediting_991484chr14_50993550_-SINEAluAluSp
CAediting_991485chr14_50993571_-SINEAluAluSp
CAediting_991486chr14_50993581_-SINEAluAluSp
CAediting_991487chr14_50993595_-SINEAluAluSp
CAediting_991488chr14_50993600_-SINEAluAluSp
CAediting_991490chr14_50994188_-SINEAluAluJr
CAediting_991491chr14_50994201_-SINEAluAluJr
CAediting_991492chr14_50994202_-SINEAluAluJr
CAediting_991493chr14_50994203_-SINEAluAluJr
CAediting_991494chr14_50994240_-SINEAluAluJr
CAediting_991495chr14_50994258_-SINEAluAluJr
CAediting_991496chr14_50994285_-SINEAluAluJr
CAediting_991497chr14_50994291_-SINEAluAluJr
CAediting_991498chr14_50994307_-SINEAluAluJr
CAediting_991499chr14_50994321_-SINEAluAluJr
CAediting_991500chr14_50994324_-SINEAluAluJr
CAediting_991501chr14_50994325_-SINEAluAluJr
CAediting_991502chr14_50994360_-SINEAluAluJr
CAediting_991503chr14_50994363_-SINEAluAluJr
CAediting_991504chr14_50994395_-SINEAluAluJr
CAediting_991511chr14_50995053_-SINEAluFLAM_A
CAediting_991512chr14_50995055_-SINEAluFLAM_A
CAediting_991513chr14_50995069_-SINEAluFLAM_A
CAediting_991514chr14_50995079_-SINEAluFLAM_A
CAediting_991515chr14_50995095_-SINEAluFLAM_A
CAediting_991516chr14_50995108_-SINEAluFLAM_A
CAediting_991517chr14_50995124_-SINEAluFLAM_A
CAediting_991518chr14_50995125_-SINEAluFLAM_A
CAediting_991519chr14_50995138_-SINEAluFLAM_A
CAediting_991520chr14_50995147_-SINEAluFLAM_A
CAediting_991521chr14_51016064_-DNATcMar-TiggerMER2
CAediting_991522chr14_51016095_-DNATcMar-TiggerMER2
CAediting_991523chr14_51016097_-DNATcMar-TiggerMER2
CAediting_991524chr14_51016666_-DNATcMar-TiggerMER2
CAediting_991525chr14_51054609_-SINEAluAluSc

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RNA A-to-I editing events in the alternative splicing sites for TRIM9

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000100505.12.TRIM9.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000100505.12.TRIM9.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TRIM9

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TRIM9

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for TRIM9

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000100505.12ENST00000298355hsa-miR-200b-3p50976174509761807mer-m85097617350976194142-8.19
CAediting_393chr1_1167164_+ENSG00000100505.12ENST00000298355hsa-miR-200b-3p50976049509760557mer-m85097604850976066145-12.98
CAediting_1306324chr19_13836464_-ENSG00000100505.12ENST00000360392hsa-miR-27a-3p50996318509963247mer-m85099631750996335146-17.93
CAediting_442554chr5_154685830_+ENSG00000100505.12ENST00000298355hsa-miR-130350975457509754637mer-m85097545650975477147-12.22
CAediting_1054808chr15_66496985_-ENSG00000100505.12ENST00000360392hsa-miR-451250996899509969057mer-m85099689850996919143-17.01
CAediting_1351755chr19_40282625_-ENSG00000100505.12ENST00000360392hsa-miR-64150996415509964217mer-m85099641450996437151-18.69
CAediting_524911chr7_5495852_-ENSG00000100505.12ENST00000360392hsa-miR-589-3p50997930509979367mer-m85099792950997952148-13.34
CAediting_1524209chrX_134546392_-ENSG00000100505.12ENST00000298355hsa-miR-503-5p50976215509762217mer-1a5097621550976237144-22.27

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_442554chr5_154685830_+ENSG00000100505.12ENST00000298355hsa-miR-130350976599509766057mer-m85097659850976619145-13.67
CAediting_1351755chr19_40282625_-ENSG00000100505.12ENST00000298355hsa-miR-64150975524509755296mer5097552350975551140-21.37
CAediting_393chr1_1167164_+ENSG00000100505.12ENST00000360392hsa-miR-200b-3p50996131509961377mer-m85099613050996152151-15.56
CAediting_1054808chr15_66496985_-ENSG00000100505.12ENST00000360392hsa-miR-451250996629509966357mer-m85099662850996648153-17.49
CAediting_524911chr7_5495852_-ENSG00000100505.12ENST00000360392hsa-miR-589-3p50997631509976388mer-1a5099763150997652152-17.65

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TRIM9

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for TRIM9

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
LGGCAediting_991451chr14_50990071_-..0.01203153971745740.3305350025239..
LGGCAediting_991468chr14_50992375_-..3.48712339485564e-110.714080557282387..

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Relation with cancer stages for TRIM9

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for TRIM9

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for TRIM9

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIM9

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource