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Editing gene: CHEK2 (CAeditome ID:11200)

Gene summary for CHEK2

Gene summary

Gene information	Gene symbol	CHEK2
	Gene ID	11200
	Gene name	checkpoint kinase 2
	Synonyms	CDS1\|CHK2\|HuCds1\|LFS2\|PP1425\|RAD53\|hCds1
	Cytomap	22q12.1
	Type of gene	protein-coding
	Description	serine/threonine-protein kinase Chk2CHK2 checkpoint homologcds1 homologcheckpoint-like protein CHK2
	Modification date	20210524
	UniProtAcc	O96017
	Context	- 34113003(Clinical utility of testing for PALB2 and CHEK2 c.1100delC in breast and ovarian cancer)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CHEK2	GO:0006974	Serine/threonine-protein kinase Chk2	24550317
CHEK2	GO:0042770	Serine/threonine-protein kinase Chk2	14744935
CHEK2	GO:0000781	Serine/threonine-protein kinase Chk2	15149599
CHEK2	GO:0004674	Serine/threonine-protein kinase Chk2	12717439
CHEK2	GO:0004674	Serine/threonine-protein kinase Chk2	16794575
CHEK2	GO:0042803	Serine/threonine-protein kinase Chk2	16794575
CHEK2	GO:0006355	Serine/threonine-protein kinase Chk2	12717439
CHEK2	GO:0006468	Serine/threonine-protein kinase Chk2	12717439
CHEK2	GO:0008630	Serine/threonine-protein kinase Chk2	12402044
CHEK2	GO:0045893	Serine/threonine-protein kinase Chk2	17101782
CHEK2	GO:0046777	Serine/threonine-protein kinase Chk2	16794575
CHEK2	GO:0046777	Serine/threonine-protein kinase Chk2	18644861
CHEK2	GO:0050821	Serine/threonine-protein kinase Chk2	12717439
CHEK2	GO:0005654	Serine/threonine-protein kinase Chk2	0000052
CHEK2	GO:0005794	Serine/threonine-protein kinase Chk2	0000052
CHEK2	GO:0016605	Serine/threonine-protein kinase Chk2	12402044

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RNA A-to-I events for CHEK2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000183765.19

RNA A-to-I editing events in Cancer.

CAediting_1469949(28696482, -), CAediting_1469950(28696487, -), CAediting_1469951(28696511, -), CAediting_1469952(28696512, -), CAediting_1469953(28696631, -), CAediting_1469954(28697635, -), CAediting_1469955(28697637, -), CAediting_1469956(28697638, -), CAediting_1469957(28697646, -), CAediting_1469958(28697667, -), CAediting_1469959(28697672, -), CAediting_1469960(28697685, -), CAediting_1469961(28697691, -), CAediting_1469962(28697698, -), CAediting_1469963(28697702, -), CAediting_1469964(28697729, -), CAediting_1469965(28697739, -), CAediting_1469966(28697751, -), CAediting_1469967(28697752, -), CAediting_1469968(28697753, -), CAediting_1469969(28697758, -), CAediting_1469970(28697789, -), CAediting_1469971(28697803, -), CAediting_1469972(28697818, -), CAediting_1469973(28697826, -), CAediting_1469974(28697843, -), CAediting_1469975(28697848, -), CAediting_1469976(28697849, -), CAediting_1469977(28697871, -), CAediting_1469978(28698140, -), CAediting_1469979(28698275, -), CAediting_1469980(28698297, -), CAediting_1469981(28698314, -), CAediting_1469982(28698315, -), CAediting_1469983(28698335, -), CAediting_1469984(28698348, -), CAediting_1469985(28698351, -), CAediting_1469986(28698393, -), CAediting_1469987(28699120, -), CAediting_1469988(28699165, -), CAediting_1469989(28699202, -), CAediting_1469990(28699222, -), CAediting_1469991(28699253, -), CAediting_1469992(28699254, -), CAediting_1469993(28699292, -), CAediting_1469994(28699298, -), CAediting_1469995(28699428, -), CAediting_1469996(28699442, -), CAediting_1469997(28699476, -), CAediting_1469998(28699486, -), CAediting_1469999(28699493, -), CAediting_1470000(28699503, -), CAediting_1470001(28699529, -), CAediting_1470002(28699532, -), CAediting_1470003(28699547, -), CAediting_1470004(28699558, -), CAediting_1470005(28699560, -), CAediting_1470006(28699564, -), CAediting_1470007(28699568, -), CAediting_1470008(28699572, -), CAediting_1470009(28699583, -), CAediting_1470010(28699591, -), CAediting_1470011(28699634, -), CAediting_1470012(28699637, -), CAediting_1470013(28704457, -), CAediting_1470014(28704461, -), CAediting_1470015(28704465, -), CAediting_1470016(28704471, -), CAediting_1470017(28704536, -), CAediting_1470018(28704537, -), CAediting_1470019(28704552, -), CAediting_1470020(28704560, -), CAediting_1470021(28705886, -), CAediting_1470022(28706536, -), CAediting_1470023(28706541, -), CAediting_1470024(28707975, -), CAediting_1470025(28708258, -), CAediting_1470026(28708306, -), CAediting_1470027(28708311, -), CAediting_1470028(28708314, -), CAediting_1470029(28708336, -), CAediting_1470030(28715516, -), CAediting_1470031(28715616, -), CAediting_1470032(28715692, -), CAediting_1470033(28715709, -), CAediting_1470034(28715958, -), CAediting_1470035(28716004, -), CAediting_1470036(28716123, -), CAediting_1470037(28716124, -), CAediting_1470038(28716128, -), CAediting_1470039(28716145, -), CAediting_1470040(28716164, -), CAediting_1470041(28716334, -), CAediting_1470042(28716400, -), CAediting_1470043(28716401, -), CAediting_1470044(28716469, -), CAediting_1470045(28716476, -), CAediting_1470046(28717189, -), CAediting_1470047(28717266, -), CAediting_1470048(28718018, -), CAediting_1470049(28720215, -), CAediting_1470050(28720228, -), CAediting_1470051(28720229, -), CAediting_1470052(28720286, -), CAediting_1470053(28720287, -), CAediting_1470054(28721359, -), CAediting_1470055(28721363, -), CAediting_1470056(28721379, -), CAediting_1470057(28721411, -), CAediting_1470058(28721435, -), CAediting_1470059(28721910, -), CAediting_1470060(28722795, -), CAediting_1470061(28722827, -), CAediting_1470062(28724308, -), CAediting_1470063(28724704, -), CAediting_1470064(28730459, -), CAediting_1470065(28730460, -), CAediting_1470066(28730481, -), CAediting_1470067(28730528, -), CAediting_1470068(28731484, -), CAediting_1470069(28732079, -), CAediting_1470070(28732080, -), CAediting_1470071(28735151, -), CAediting_1470072(28735225, -), CAediting_1470073(28735289, -), CAediting_1470074(28735294, -), CAediting_1470075(28735324, -), CAediting_1470076(28735690, -), CAediting_1470077(28735719, -), CAediting_1470078(28735742, -), CAediting_1470079(28735760, -), CAediting_1470080(28735763, -), CAediting_1470081(28735770, -), CAediting_1470082(28735796, -), CAediting_1470083(28735799, -), CAediting_1470084(28735830, -), CAediting_1470085(28736683, -), CAediting_1470086(28736695, -), CAediting_1470087(28736722, -), CAediting_1470088(28736826, -), CAediting_1470089(28736848, -), CAediting_1470090(28736881, -), CAediting_1470091(28736891, -), CAediting_1470092(28736893, -), CAediting_1470093(28737535, -), CAediting_1470094(28737536, -), CAediting_1470095(28737537, -), CAediting_1470096(28737538, -), CAediting_1470097(28737542, -), CAediting_1470098(28737562, -), CAediting_1470099(28737566, -), CAediting_1470100(28737575, -), CAediting_1470101(28737581, -), CAediting_1470102(28737584, -), CAediting_1470103(28737592, -), CAediting_1470104(28737601, -), CAediting_1470105(28737602, -), CAediting_1470106(28737607, -), CAediting_1470107(28737608, -), CAediting_1470108(28737634, -), CAediting_1470109(28737638, -), CAediting_1470110(28737643, -), CAediting_1470111(28737666, -), CAediting_1470112(28737667, -), CAediting_1470113(28737687, -), CAediting_1470114(28737698, -), CAediting_1470115(28737706, -), CAediting_1470116(28737711, -), CAediting_1470117(28737750, -), CAediting_1470118(28737751, -), CAediting_1470119(28737759, -), CAediting_1470120(28737931, -), CAediting_1470121(28737939, -), CAediting_1470122(28737943, -), CAediting_1470123(28737961, -), CAediting_1470124(28737985, -), CAediting_1470125(28738014, -), CAediting_1470126(28738023, -), CAediting_1470127(28738026, -), CAediting_1470128(28738040, -), CAediting_1470129(28738083, -), CAediting_1470130(28738085, -), CAediting_1470131(28738095, -), CAediting_1470132(28738098, -), CAediting_1470133(28738112, -), CAediting_1470134(28738124, -), CAediting_1470135(28738138, -), CAediting_1470136(28738139, -), CAediting_1470137(28738145, -), CAediting_1470138(28738199, -), CAediting_1470139(28739086, -), CAediting_1470140(28739148, -), CAediting_1470141(28739158, -), CAediting_1470142(28739683, -), CAediting_1470143(28740079, -),

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RNA editing positional annotations for CHEK2 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_1470065	chr22_28730460_-	nonsynonymous SNV	ENST00000382580.5	c.A408G	p.I136M	D	.	N
CAediting_1470065	chr22_28730460_-	nonsynonymous SNV	ENST00000439200.4	c.A408G	p.I136M	D	.	N
CAediting_1470065	chr22_28730460_-	nonsynonymous SNV	ENST00000454252.1	c.A42G	p.I14M	D	.	N
CAediting_1470067	chr22_28730528_-	nonsynonymous SNV	ENST00000382580.5	c.A340G	p.T114A	D	B	N
CAediting_1470067	chr22_28730528_-	nonsynonymous SNV	ENST00000439200.4	c.A340G	p.T114A	D	B	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1469949	chr22_28696482_-	intronic
CAediting_1469950	chr22_28696487_-	intronic
CAediting_1469951	chr22_28696511_-	intronic
CAediting_1469952	chr22_28696512_-	intronic
CAediting_1469953	chr22_28696631_-	intronic
CAediting_1469954	chr22_28697635_-	ncRNA_intronic
CAediting_1469955	chr22_28697637_-	ncRNA_intronic
CAediting_1469956	chr22_28697638_-	ncRNA_intronic
CAediting_1469957	chr22_28697646_-	ncRNA_intronic
CAediting_1469958	chr22_28697667_-	ncRNA_intronic
CAediting_1469959	chr22_28697672_-	ncRNA_intronic
CAediting_1469960	chr22_28697685_-	ncRNA_intronic
CAediting_1469961	chr22_28697691_-	ncRNA_intronic
CAediting_1469962	chr22_28697698_-	ncRNA_intronic
CAediting_1469963	chr22_28697702_-	ncRNA_intronic
CAediting_1469964	chr22_28697729_-	ncRNA_intronic
CAediting_1469965	chr22_28697739_-	ncRNA_intronic
CAediting_1469966	chr22_28697751_-	ncRNA_intronic
CAediting_1469967	chr22_28697752_-	ncRNA_intronic
CAediting_1469968	chr22_28697753_-	ncRNA_intronic
CAediting_1469969	chr22_28697758_-	ncRNA_intronic
CAediting_1469970	chr22_28697789_-	ncRNA_intronic
CAediting_1469971	chr22_28697803_-	ncRNA_intronic
CAediting_1469972	chr22_28697818_-	ncRNA_intronic
CAediting_1469973	chr22_28697826_-	ncRNA_intronic
CAediting_1469974	chr22_28697843_-	ncRNA_intronic
CAediting_1469975	chr22_28697848_-	ncRNA_intronic
CAediting_1469976	chr22_28697849_-	ncRNA_intronic
CAediting_1469977	chr22_28697871_-	ncRNA_intronic
CAediting_1469978	chr22_28698140_-	ncRNA_intronic
CAediting_1469979	chr22_28698275_-	ncRNA_intronic
CAediting_1469980	chr22_28698297_-	ncRNA_intronic
CAediting_1469981	chr22_28698314_-	ncRNA_intronic
CAediting_1469982	chr22_28698315_-	ncRNA_intronic
CAediting_1469983	chr22_28698335_-	ncRNA_intronic
CAediting_1469984	chr22_28698348_-	ncRNA_intronic
CAediting_1469985	chr22_28698351_-	ncRNA_intronic
CAediting_1469986	chr22_28698393_-	ncRNA_intronic
CAediting_1469987	chr22_28699120_-	ncRNA_intronic
CAediting_1469988	chr22_28699165_-	ncRNA_intronic
CAediting_1469989	chr22_28699202_-	ncRNA_intronic
CAediting_1469990	chr22_28699222_-	ncRNA_intronic
CAediting_1469991	chr22_28699253_-	ncRNA_intronic
CAediting_1469992	chr22_28699254_-	ncRNA_intronic
CAediting_1469993	chr22_28699292_-	ncRNA_intronic
CAediting_1469994	chr22_28699298_-	ncRNA_intronic
CAediting_1469995	chr22_28699428_-	ncRNA_intronic
CAediting_1469996	chr22_28699442_-	ncRNA_intronic
CAediting_1469997	chr22_28699476_-	ncRNA_intronic
CAediting_1469998	chr22_28699486_-	ncRNA_intronic
CAediting_1469999	chr22_28699493_-	ncRNA_intronic
CAediting_1470000	chr22_28699503_-	ncRNA_intronic
CAediting_1470001	chr22_28699529_-	ncRNA_intronic
CAediting_1470002	chr22_28699532_-	ncRNA_intronic
CAediting_1470003	chr22_28699547_-	ncRNA_intronic
CAediting_1470004	chr22_28699558_-	ncRNA_intronic
CAediting_1470005	chr22_28699560_-	ncRNA_intronic
CAediting_1470006	chr22_28699564_-	ncRNA_intronic
CAediting_1470007	chr22_28699568_-	ncRNA_intronic
CAediting_1470008	chr22_28699572_-	ncRNA_intronic
CAediting_1470009	chr22_28699583_-	ncRNA_intronic
CAediting_1470010	chr22_28699591_-	ncRNA_intronic
CAediting_1470011	chr22_28699634_-	ncRNA_intronic
CAediting_1470012	chr22_28699637_-	ncRNA_intronic
CAediting_1470013	chr22_28704457_-	ncRNA_intronic
CAediting_1470014	chr22_28704461_-	ncRNA_intronic
CAediting_1470015	chr22_28704465_-	ncRNA_intronic
CAediting_1470016	chr22_28704471_-	ncRNA_intronic
CAediting_1470017	chr22_28704536_-	ncRNA_intronic
CAediting_1470018	chr22_28704537_-	ncRNA_intronic
CAediting_1470019	chr22_28704552_-	ncRNA_intronic
CAediting_1470020	chr22_28704560_-	ncRNA_intronic
CAediting_1470021	chr22_28705886_-	ncRNA_intronic
CAediting_1470022	chr22_28706536_-	ncRNA_intronic
CAediting_1470023	chr22_28706541_-	ncRNA_intronic
CAediting_1470024	chr22_28707975_-	ncRNA_intronic
CAediting_1470025	chr22_28708258_-	ncRNA_intronic
CAediting_1470026	chr22_28708306_-	ncRNA_intronic
CAediting_1470027	chr22_28708311_-	ncRNA_intronic
CAediting_1470028	chr22_28708314_-	ncRNA_intronic
CAediting_1470029	chr22_28708336_-	ncRNA_intronic
CAediting_1470030	chr22_28715516_-	intronic
CAediting_1470031	chr22_28715616_-	intronic
CAediting_1470032	chr22_28715692_-	intronic
CAediting_1470033	chr22_28715709_-	intronic
CAediting_1470034	chr22_28715958_-	intronic
CAediting_1470035	chr22_28716004_-	intronic
CAediting_1470036	chr22_28716123_-	intronic
CAediting_1470037	chr22_28716124_-	intronic
CAediting_1470038	chr22_28716128_-	intronic
CAediting_1470039	chr22_28716145_-	intronic
CAediting_1470040	chr22_28716164_-	intronic
CAediting_1470041	chr22_28716334_-	intronic
CAediting_1470042	chr22_28716400_-	intronic
CAediting_1470043	chr22_28716401_-	intronic
CAediting_1470044	chr22_28716469_-	intronic
CAediting_1470045	chr22_28716476_-	intronic
CAediting_1470046	chr22_28717189_-	intronic
CAediting_1470047	chr22_28717266_-	intronic
CAediting_1470048	chr22_28718018_-	intronic
CAediting_1470049	chr22_28720215_-	intronic
CAediting_1470050	chr22_28720228_-	intronic
CAediting_1470051	chr22_28720229_-	intronic
CAediting_1470052	chr22_28720286_-	intronic
CAediting_1470053	chr22_28720287_-	intronic
CAediting_1470054	chr22_28721359_-	intronic
CAediting_1470055	chr22_28721363_-	intronic
CAediting_1470056	chr22_28721379_-	intronic
CAediting_1470057	chr22_28721411_-	intronic
CAediting_1470058	chr22_28721435_-	intronic
CAediting_1470059	chr22_28721910_-	intronic
CAediting_1470060	chr22_28722795_-	intronic
CAediting_1470061	chr22_28722827_-	intronic
CAediting_1470062	chr22_28724308_-	intronic
CAediting_1470063	chr22_28724704_-	UTR3
CAediting_1470064	chr22_28730459_-	exonic
CAediting_1470065	chr22_28730460_-	exonic
CAediting_1470066	chr22_28730481_-	exonic
CAediting_1470067	chr22_28730528_-	exonic
CAediting_1470068	chr22_28731484_-	intronic
CAediting_1470069	chr22_28732079_-	intronic
CAediting_1470070	chr22_28732080_-	intronic
CAediting_1470071	chr22_28735151_-	intronic
CAediting_1470072	chr22_28735225_-	intronic
CAediting_1470073	chr22_28735289_-	intronic
CAediting_1470074	chr22_28735294_-	intronic
CAediting_1470075	chr22_28735324_-	intronic
CAediting_1470076	chr22_28735690_-	intronic
CAediting_1470077	chr22_28735719_-	intronic
CAediting_1470078	chr22_28735742_-	intronic
CAediting_1470079	chr22_28735760_-	intronic
CAediting_1470080	chr22_28735763_-	intronic
CAediting_1470081	chr22_28735770_-	intronic
CAediting_1470082	chr22_28735796_-	intronic
CAediting_1470083	chr22_28735799_-	intronic
CAediting_1470084	chr22_28735830_-	intronic
CAediting_1470085	chr22_28736683_-	intronic
CAediting_1470086	chr22_28736695_-	intronic
CAediting_1470087	chr22_28736722_-	intronic
CAediting_1470088	chr22_28736826_-	intronic
CAediting_1470089	chr22_28736848_-	intronic
CAediting_1470090	chr22_28736881_-	intronic
CAediting_1470091	chr22_28736891_-	intronic
CAediting_1470092	chr22_28736893_-	intronic
CAediting_1470093	chr22_28737535_-	intronic
CAediting_1470094	chr22_28737536_-	intronic
CAediting_1470095	chr22_28737537_-	intronic
CAediting_1470096	chr22_28737538_-	intronic
CAediting_1470097	chr22_28737542_-	intronic
CAediting_1470098	chr22_28737562_-	intronic
CAediting_1470099	chr22_28737566_-	intronic
CAediting_1470100	chr22_28737575_-	intronic
CAediting_1470101	chr22_28737581_-	intronic
CAediting_1470102	chr22_28737584_-	intronic
CAediting_1470103	chr22_28737592_-	intronic
CAediting_1470104	chr22_28737601_-	intronic
CAediting_1470105	chr22_28737602_-	intronic
CAediting_1470106	chr22_28737607_-	intronic
CAediting_1470107	chr22_28737608_-	intronic
CAediting_1470108	chr22_28737634_-	intronic
CAediting_1470109	chr22_28737638_-	intronic
CAediting_1470110	chr22_28737643_-	intronic
CAediting_1470111	chr22_28737666_-	intronic
CAediting_1470112	chr22_28737667_-	intronic
CAediting_1470113	chr22_28737687_-	intronic
CAediting_1470114	chr22_28737698_-	intronic
CAediting_1470115	chr22_28737706_-	intronic
CAediting_1470116	chr22_28737711_-	intronic
CAediting_1470117	chr22_28737750_-	intronic
CAediting_1470118	chr22_28737751_-	intronic
CAediting_1470119	chr22_28737759_-	intronic
CAediting_1470120	chr22_28737931_-	UTR5
CAediting_1470121	chr22_28737939_-	UTR5
CAediting_1470122	chr22_28737943_-	UTR5
CAediting_1470123	chr22_28737961_-	UTR5
CAediting_1470124	chr22_28737985_-	UTR5
CAediting_1470125	chr22_28738014_-	UTR5
CAediting_1470126	chr22_28738023_-	UTR5
CAediting_1470127	chr22_28738026_-	UTR5
CAediting_1470128	chr22_28738040_-	splicing
CAediting_1470129	chr22_28738083_-	intronic
CAediting_1470130	chr22_28738085_-	intronic
CAediting_1470131	chr22_28738095_-	intronic
CAediting_1470132	chr22_28738098_-	intronic
CAediting_1470133	chr22_28738112_-	intronic
CAediting_1470134	chr22_28738124_-	intronic
CAediting_1470135	chr22_28738138_-	intronic
CAediting_1470136	chr22_28738139_-	intronic
CAediting_1470137	chr22_28738145_-	intronic
CAediting_1470138	chr22_28738199_-	intronic
CAediting_1470139	chr22_28739086_-	intronic
CAediting_1470140	chr22_28739148_-	intronic
CAediting_1470141	chr22_28739158_-	intronic
CAediting_1470142	chr22_28739683_-	intronic
CAediting_1470143	chr22_28740079_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1469949	chr22_28696482_-	SINE	Alu	AluSx1
CAediting_1469950	chr22_28696487_-	SINE	Alu	AluSx1
CAediting_1469951	chr22_28696511_-	SINE	Alu	AluSx1
CAediting_1469952	chr22_28696512_-	SINE	Alu	AluSx1
CAediting_1469953	chr22_28696631_-	SINE	Alu	AluSx1
CAediting_1469954	chr22_28697635_-	SINE	Alu	AluJo
CAediting_1469955	chr22_28697637_-	SINE	Alu	AluJo
CAediting_1469956	chr22_28697638_-	SINE	Alu	AluJo
CAediting_1469957	chr22_28697646_-	SINE	Alu	AluJo
CAediting_1469958	chr22_28697667_-	SINE	Alu	AluJo
CAediting_1469959	chr22_28697672_-	SINE	Alu	AluJo
CAediting_1469960	chr22_28697685_-	SINE	Alu	AluJo
CAediting_1469961	chr22_28697691_-	SINE	Alu	AluJo
CAediting_1469962	chr22_28697698_-	SINE	Alu	AluJo
CAediting_1469963	chr22_28697702_-	SINE	Alu	AluJo
CAediting_1469964	chr22_28697729_-	SINE	Alu	AluJo
CAediting_1469965	chr22_28697739_-	SINE	Alu	AluJo
CAediting_1469966	chr22_28697751_-	SINE	Alu	AluJo
CAediting_1469967	chr22_28697752_-	SINE	Alu	AluJo
CAediting_1469968	chr22_28697753_-	SINE	Alu	AluJo
CAediting_1469969	chr22_28697758_-	SINE	Alu	AluJo
CAediting_1469970	chr22_28697789_-	SINE	Alu	AluJo
CAediting_1469971	chr22_28697803_-	SINE	Alu	AluJo
CAediting_1469972	chr22_28697818_-	SINE	Alu	AluJo
CAediting_1469973	chr22_28697826_-	SINE	Alu	AluJo
CAediting_1469974	chr22_28697843_-	SINE	Alu	AluJo
CAediting_1469975	chr22_28697848_-	SINE	Alu	AluJo
CAediting_1469976	chr22_28697849_-	SINE	Alu	AluJo
CAediting_1469977	chr22_28697871_-	SINE	Alu	AluJo
CAediting_1469978	chr22_28698140_-	SINE	Alu	AluSx1
CAediting_1469979	chr22_28698275_-	SINE	Alu	AluSx1
CAediting_1469980	chr22_28698297_-	SINE	Alu	AluSx1
CAediting_1469981	chr22_28698314_-	SINE	Alu	AluSx1
CAediting_1469982	chr22_28698315_-	SINE	Alu	AluSx1
CAediting_1469983	chr22_28698335_-	SINE	Alu	AluSx1
CAediting_1469984	chr22_28698348_-	SINE	Alu	AluSx1
CAediting_1469985	chr22_28698351_-	SINE	Alu	AluSx1
CAediting_1469986	chr22_28698393_-	SINE	Alu	AluSx1
CAediting_1469987	chr22_28699120_-	SINE	Alu	AluJb
CAediting_1469988	chr22_28699165_-	SINE	Alu	AluJb
CAediting_1469989	chr22_28699202_-	SINE	Alu	AluJb
CAediting_1469990	chr22_28699222_-	SINE	Alu	AluJb
CAediting_1469991	chr22_28699253_-	SINE	Alu	AluJb
CAediting_1469992	chr22_28699254_-	SINE	Alu	AluJb
CAediting_1469993	chr22_28699292_-	SINE	Alu	AluJb
CAediting_1469994	chr22_28699298_-	SINE	Alu	AluJb
CAediting_1469995	chr22_28699428_-	SINE	Alu	AluSc
CAediting_1469996	chr22_28699442_-	SINE	Alu	AluSc
CAediting_1469997	chr22_28699476_-	SINE	Alu	AluSc
CAediting_1469998	chr22_28699486_-	SINE	Alu	AluSc
CAediting_1469999	chr22_28699493_-	SINE	Alu	AluSc
CAediting_1470000	chr22_28699503_-	SINE	Alu	AluSc
CAediting_1470001	chr22_28699529_-	SINE	Alu	AluSc
CAediting_1470002	chr22_28699532_-	SINE	Alu	AluSc
CAediting_1470003	chr22_28699547_-	SINE	Alu	AluSc
CAediting_1470004	chr22_28699558_-	SINE	Alu	AluSc
CAediting_1470005	chr22_28699560_-	SINE	Alu	AluSc
CAediting_1470006	chr22_28699564_-	SINE	Alu	AluSc
CAediting_1470007	chr22_28699568_-	SINE	Alu	AluSc
CAediting_1470008	chr22_28699572_-	SINE	Alu	AluSc
CAediting_1470009	chr22_28699583_-	SINE	Alu	AluSc
CAediting_1470010	chr22_28699591_-	SINE	Alu	AluSc
CAediting_1470011	chr22_28699634_-	SINE	Alu	AluSc
CAediting_1470012	chr22_28699637_-	SINE	Alu	AluSc
CAediting_1470013	chr22_28704457_-	SINE	Alu	AluSz
CAediting_1470014	chr22_28704461_-	SINE	Alu	AluSz
CAediting_1470015	chr22_28704465_-	SINE	Alu	AluSz
CAediting_1470016	chr22_28704471_-	SINE	Alu	AluSz
CAediting_1470017	chr22_28704536_-	SINE	Alu	AluSz
CAediting_1470018	chr22_28704537_-	SINE	Alu	AluSz
CAediting_1470019	chr22_28704552_-	SINE	Alu	AluSz
CAediting_1470020	chr22_28704560_-	SINE	Alu	AluSz
CAediting_1470021	chr22_28705886_-	SINE	Alu	AluSq2
CAediting_1470022	chr22_28706536_-	SINE	Alu	AluJb
CAediting_1470023	chr22_28706541_-	SINE	Alu	AluJb
CAediting_1470024	chr22_28707975_-	SINE	Alu	AluY
CAediting_1470025	chr22_28708258_-	SINE	Alu	AluJo
CAediting_1470026	chr22_28708306_-	SINE	Alu	AluJo
CAediting_1470027	chr22_28708311_-	SINE	Alu	AluJo
CAediting_1470028	chr22_28708314_-	SINE	Alu	AluJo
CAediting_1470029	chr22_28708336_-	SINE	Alu	AluJo
CAediting_1470030	chr22_28715516_-	SINE	Alu	AluSz
CAediting_1470031	chr22_28715616_-	SINE	Alu	AluSz
CAediting_1470032	chr22_28715692_-	SINE	Alu	AluSz
CAediting_1470033	chr22_28715709_-	SINE	Alu	AluSz
CAediting_1470034	chr22_28715958_-	SINE	Alu	AluJb
CAediting_1470035	chr22_28716004_-	SINE	Alu	AluJb
CAediting_1470036	chr22_28716123_-	SINE	Alu	AluJb
CAediting_1470037	chr22_28716124_-	SINE	Alu	AluJb
CAediting_1470038	chr22_28716128_-	SINE	Alu	AluJb
CAediting_1470039	chr22_28716145_-	SINE	Alu	AluJb
CAediting_1470040	chr22_28716164_-	SINE	Alu	AluJb
CAediting_1470041	chr22_28716334_-	SINE	Alu	AluSx
CAediting_1470042	chr22_28716400_-	SINE	Alu	AluSx
CAediting_1470043	chr22_28716401_-	SINE	Alu	AluSx
CAediting_1470044	chr22_28716469_-	SINE	Alu	AluSx
CAediting_1470045	chr22_28716476_-	SINE	Alu	AluSx
CAediting_1470046	chr22_28717189_-	SINE	Alu	AluSc8
CAediting_1470047	chr22_28717266_-	SINE	Alu	AluSc8
CAediting_1470048	chr22_28718018_-	SINE	Alu	AluSx3
CAediting_1470049	chr22_28720215_-	SINE	Alu	AluSq
CAediting_1470050	chr22_28720228_-	SINE	Alu	AluSq
CAediting_1470051	chr22_28720229_-	SINE	Alu	AluSq
CAediting_1470052	chr22_28720286_-	SINE	Alu	AluSq
CAediting_1470053	chr22_28720287_-	SINE	Alu	AluSq
CAediting_1470054	chr22_28721359_-	SINE	Alu	AluSq10
CAediting_1470055	chr22_28721363_-	SINE	Alu	AluSq10
CAediting_1470056	chr22_28721379_-	SINE	Alu	AluSq10
CAediting_1470057	chr22_28721411_-	SINE	Alu	AluSq10
CAediting_1470058	chr22_28721435_-	SINE	Alu	AluSq10
CAediting_1470059	chr22_28721910_-	SINE	Alu	AluJb
CAediting_1470060	chr22_28722795_-	SINE	Alu	FAM
CAediting_1470061	chr22_28722827_-	SINE	Alu	FAM
CAediting_1470062	chr22_28724308_-	SINE	Alu	AluSx1
CAediting_1470063	chr22_28724704_-	SINE	Alu	AluSp
CAediting_1470064	chr22_28730459_-	SINE	Alu	AluJr
CAediting_1470065	chr22_28730460_-	SINE	Alu	AluJr
CAediting_1470066	chr22_28730481_-	SINE	Alu	AluJr
CAediting_1470067	chr22_28730528_-	SINE	Alu	AluJr
CAediting_1470068	chr22_28731484_-	SINE	Alu	AluSx1
CAediting_1470069	chr22_28732079_-	SINE	Alu	AluSx1
CAediting_1470070	chr22_28732080_-	SINE	Alu	AluSx1
CAediting_1470071	chr22_28735151_-	SINE	Alu	AluSx3
CAediting_1470072	chr22_28735225_-	SINE	Alu	AluSx3
CAediting_1470073	chr22_28735289_-	SINE	Alu	AluSx3
CAediting_1470074	chr22_28735294_-	SINE	Alu	AluSx3
CAediting_1470075	chr22_28735324_-	SINE	Alu	AluSx3
CAediting_1470076	chr22_28735690_-	SINE	Alu	AluSq2
CAediting_1470077	chr22_28735719_-	SINE	Alu	AluSq2
CAediting_1470078	chr22_28735742_-	SINE	Alu	AluSq2
CAediting_1470079	chr22_28735760_-	SINE	Alu	AluSq2
CAediting_1470080	chr22_28735763_-	SINE	Alu	AluSq2
CAediting_1470081	chr22_28735770_-	SINE	Alu	AluSq2
CAediting_1470082	chr22_28735796_-	SINE	Alu	AluSq2
CAediting_1470083	chr22_28735799_-	SINE	Alu	AluSq2
CAediting_1470084	chr22_28735830_-	SINE	Alu	AluSq2
CAediting_1470085	chr22_28736683_-	SINE	Alu	AluJr
CAediting_1470086	chr22_28736695_-	SINE	Alu	AluJr
CAediting_1470087	chr22_28736722_-	SINE	Alu	AluJr
CAediting_1470088	chr22_28736826_-	SINE	Alu	AluJr
CAediting_1470089	chr22_28736848_-	SINE	Alu	AluJr
CAediting_1470090	chr22_28736881_-	SINE	Alu	AluJr
CAediting_1470091	chr22_28736891_-	SINE	Alu	AluJr
CAediting_1470092	chr22_28736893_-	SINE	Alu	AluJr
CAediting_1470093	chr22_28737535_-	SINE	Alu	AluSx
CAediting_1470094	chr22_28737536_-	SINE	Alu	AluSx
CAediting_1470095	chr22_28737537_-	SINE	Alu	AluSx
CAediting_1470096	chr22_28737538_-	SINE	Alu	AluSx
CAediting_1470097	chr22_28737542_-	SINE	Alu	AluSx
CAediting_1470098	chr22_28737562_-	SINE	Alu	AluSx
CAediting_1470099	chr22_28737566_-	SINE	Alu	AluSx
CAediting_1470100	chr22_28737575_-	SINE	Alu	AluSx
CAediting_1470101	chr22_28737581_-	SINE	Alu	AluSx
CAediting_1470102	chr22_28737584_-	SINE	Alu	AluSx
CAediting_1470103	chr22_28737592_-	SINE	Alu	AluSx
CAediting_1470104	chr22_28737601_-	SINE	Alu	AluSx
CAediting_1470105	chr22_28737602_-	SINE	Alu	AluSx
CAediting_1470106	chr22_28737607_-	SINE	Alu	AluSx
CAediting_1470107	chr22_28737608_-	SINE	Alu	AluSx
CAediting_1470108	chr22_28737634_-	SINE	Alu	AluSx
CAediting_1470109	chr22_28737638_-	SINE	Alu	AluSx
CAediting_1470110	chr22_28737643_-	SINE	Alu	AluSx
CAediting_1470111	chr22_28737666_-	SINE	Alu	AluSx
CAediting_1470112	chr22_28737667_-	SINE	Alu	AluSx
CAediting_1470113	chr22_28737687_-	SINE	Alu	AluSx
CAediting_1470114	chr22_28737698_-	SINE	Alu	AluSx
CAediting_1470115	chr22_28737706_-	SINE	Alu	AluSx
CAediting_1470116	chr22_28737711_-	SINE	Alu	AluSx
CAediting_1470117	chr22_28737750_-	SINE	Alu	AluSx
CAediting_1470118	chr22_28737751_-	SINE	Alu	AluSx
CAediting_1470119	chr22_28737759_-	SINE	Alu	AluSx
CAediting_1470120	chr22_28737931_-	SINE	Alu	AluJb
CAediting_1470121	chr22_28737939_-	SINE	Alu	AluJb
CAediting_1470122	chr22_28737943_-	SINE	Alu	AluJb
CAediting_1470123	chr22_28737961_-	SINE	Alu	AluJb
CAediting_1470124	chr22_28737985_-	SINE	Alu	AluJb
CAediting_1470125	chr22_28738014_-	SINE	Alu	AluJb
CAediting_1470126	chr22_28738023_-	SINE	Alu	AluJb
CAediting_1470127	chr22_28738026_-	SINE	Alu	AluJb
CAediting_1470128	chr22_28738040_-	SINE	Alu	AluJb
CAediting_1470129	chr22_28738083_-	SINE	Alu	AluJb
CAediting_1470130	chr22_28738085_-	SINE	Alu	AluJb
CAediting_1470131	chr22_28738095_-	SINE	Alu	AluJb
CAediting_1470132	chr22_28738098_-	SINE	Alu	AluJb
CAediting_1470133	chr22_28738112_-	SINE	Alu	AluJb
CAediting_1470134	chr22_28738124_-	SINE	Alu	AluJb
CAediting_1470135	chr22_28738138_-	SINE	Alu	AluJb
CAediting_1470136	chr22_28738139_-	SINE	Alu	AluJb
CAediting_1470137	chr22_28738145_-	SINE	Alu	AluJb
CAediting_1470138	chr22_28738199_-	SINE	Alu	AluJb
CAediting_1470139	chr22_28739086_-	SINE	Alu	AluSz6
CAediting_1470140	chr22_28739148_-	SINE	Alu	AluSz6
CAediting_1470141	chr22_28739158_-	SINE	Alu	AluSz6
CAediting_1470142	chr22_28739683_-	SINE	Alu	AluSx1
CAediting_1470143	chr22_28740079_-	SINE	Alu	AluSc5

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RNA A-to-I editing events in the alternative splicing sites for CHEK2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_1470128	chr22_28738040_-	28738036:28738058	3SS	0+2i	ATTTTTTGTATTTTCTGTAGATA	8.98	ATTTTTTGTATTTTCTGTGGATA	1.02

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000183765.19.CHEK2.

Correlation between RNA A-to-I editing and PSI for ENSG00000183765.19.CHEK2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CHEK2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CHEK2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CHEK2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1470063	chr22_28724704_-	ENSG00000183765.19	ENST00000433028	hsa-miR-8052	28724699	28724705	7mer-1a	28724699	28724717	143.00	-23.66

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1470063	chr22_28724704_-	ENSG00000183765.19	ENST00000433028	hsa-miR-10399-5p	28724703	28724709	7mer-m8	28724702	28724723	148	-10.96
CAediting_1470063	chr22_28724704_-	ENSG00000183765.19	ENST00000433028	hsa-miR-5089-5p	28724699	28724705	7mer-m8	28724698	28724718	152	-18.63
CAediting_1470063	chr22_28724704_-	ENSG00000183765.19	ENST00000433028	hsa-miR-6504-3p	28724703	28724709	7mer-m8	28724702	28724726	148	-14.06

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_980496	chr14_31014685_-	ENSG00000183765.19	ENST00000433028	hsa-miR-624-3p	28724753	28724759	7mer-m8	28724752	28724772	148	-13.23
CAediting_228905	chr2_188297554_+	ENSG00000183765.19	ENST00000416671	hsa-miR-561-3p	28719401	28719407	7mer-m8	28719400	28719419	148	-9.71
CAediting_1306323	chr19_13836462_-	ENSG00000183765.19	ENST00000416671	hsa-miR-27a-3p	28696956	28696962	7mer-m8	28696955	28696974	157	-22.14
CAediting_1306323	chr19_13836462_-	ENSG00000183765.19	ENST00000417588	hsa-miR-27a-3p	28696956	28696962	7mer-m8	28696955	28696974	157	-22.14
CAediting_1306323	chr19_13836462_-	ENSG00000183765.19	ENST00000433728	hsa-miR-27a-3p	28696956	28696962	7mer-m8	28696955	28696974	157	-22.14
CAediting_228905	chr2_188297554_+	ENSG00000183765.19	ENST00000448511	hsa-miR-561-3p	28719401	28719407	7mer-m8	28719400	28719419	148	-9.71
CAediting_1306323	chr19_13836462_-	ENSG00000183765.19	ENST00000448511	hsa-miR-27a-3p	28696956	28696962	7mer-m8	28696955	28696974	157	-22.14
CAediting_228905	chr2_188297554_+	ENSG00000183765.19	ENST00000433028	hsa-miR-561-3p	28724589	28724595	7mer-m8	28724588	28724607	147	-15.96
CAediting_228905	chr2_188297554_+	ENSG00000183765.19	ENST00000433028	hsa-miR-561-3p	28719401	28719407	7mer-m8	28719400	28719419	148	-9.71
CAediting_1306323	chr19_13836462_-	ENSG00000183765.19	ENST00000433028	hsa-miR-27a-3p	28696956	28696962	7mer-m8	28696955	28696974	157	-22.14
CAediting_77128	chr1_85133844_+	ENSG00000183765.19	ENST00000454252	hsa-miR-4423-3p	28727988	28727994	7mer-m8	28727987	28728007	142	-13.81
CAediting_228905	chr2_188297554_+	ENSG00000183765.19	ENST00000454252	hsa-miR-561-3p	28725104	28725110	7mer-m8	28725103	28725124	150	-12.58

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CHEK2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for CHEK2

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for CHEK2

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
STAD	pathologic_stage	CAediting_1469962	chr22_28697698_-	0.0234080569259211	-0.259832360829681

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Relation with survival for CHEK2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CHEK2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
CHEK2	O96017	DB12010	Fostamatinib	Serine/threonine-protein kinase Chk2	SmallMoleculeDrug	approved\|investigational

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RelatedDiseases for CHEK2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CHEK2	C0009405	Hereditary Nonpolyposis Colorectal Neoplasms	12	CLINGEN
CHEK2	C1112155	Hereditary non-polyposis colorectal cancer syndrome	12	CLINGEN
CHEK2	C1333990	Hereditary Nonpolyposis Colorectal Cancer	12	CLINGEN
CHEK2	C1333991	Hereditary Non-Polyposis Colon Cancer Type 2	12	CLINGEN
CHEK2	C2936783	Colorectal cancer, hereditary nonpolyposis, type 1	12	CLINGEN
CHEK2	C0346153	Breast Cancer, Familial	9	CLINGEN
CHEK2	C0006142	Malignant neoplasm of breast	7	CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
CHEK2	C0678222	Breast Carcinoma	4	CGI;CTD_human
CHEK2	C1257931	Mammary Neoplasms, Human	4	CTD_human
CHEK2	C1458155	Mammary Neoplasms	4	CTD_human
CHEK2	C4704874	Mammary Carcinoma, Human	4	CTD_human
CHEK2	C0085390	Li-Fraumeni Syndrome	3	CTD_human;ORPHANET
CHEK2	C1836482	Li-Fraumeni Syndrome 2	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
CHEK2	C0009402	Colorectal Carcinoma	1	CTD_human;GENOMICS_ENGLAND
CHEK2	C0009404	Colorectal Neoplasms	1	CTD_human
CHEK2	C0024121	Lung Neoplasms	1	CTD_human
CHEK2	C0024302	Reticulosarcoma	1	CTD_human
CHEK2	C0024304	Lymphoma, Mixed-Cell	1	CTD_human
CHEK2	C0024305	Lymphoma, Non-Hodgkin	1	CTD_human
CHEK2	C0024306	Lymphoma, Undifferentiated	1	CTD_human
CHEK2	C0024623	Malignant neoplasm of stomach	1	CTD_human
CHEK2	C0027819	Neuroblastoma	1	CTD_human
CHEK2	C0029463	Osteosarcoma	1	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
CHEK2	C0033578	Prostatic Neoplasms	1	CTD_human
CHEK2	C0038356	Stomach Neoplasms	1	CTD_human
CHEK2	C0079740	High Grade Lymphoma (neoplasm)	1	CTD_human
CHEK2	C0079741	Lymphoma, Intermediate-Grade	1	CTD_human
CHEK2	C0079747	Low Grade Lymphoma (neoplasm)	1	CTD_human
CHEK2	C0079757	Diffuse Mixed-Cell Lymphoma	1	CTD_human
CHEK2	C0079770	Lymphoma, Small Noncleaved-Cell	1	CTD_human
CHEK2	C0206720	Squamous Cell Neoplasms	1	CTD_human
CHEK2	C0235874	Disease Exacerbation	1	CTD_human
CHEK2	C0238033	Carcinoma of Male Breast	1	CTD_human
CHEK2	C0242379	Malignant neoplasm of lung	1	CTD_human
CHEK2	C0242788	Breast Neoplasms, Male	1	CTD_human
CHEK2	C0376358	Malignant neoplasm of prostate	1	CTD_human;GENOMICS_ENGLAND;UNIPROT
CHEK2	C0677776	Hereditary Breast and Ovarian Cancer Syndrome	1	ORPHANET
CHEK2	C0751688	Malignant Squamous Cell Neoplasm	1	CTD_human
CHEK2	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
CHEK2	C2931456	Prostate cancer, familial	1	CTD_human;ORPHANET
CHEK2	C3714542	Lymphoma, Diffuse	1	CTD_human
CHEK2	C4721532	Lymphoma, Non-Hodgkin, Familial	1	CTD_human
CHEK2	C4722327	PROSTATE CANCER, HEREDITARY, 1	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene