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Editing gene: MAP4K1 (CAeditome ID:11184)

Gene summary for MAP4K1

Gene summary

Gene information	Gene symbol	MAP4K1
	Gene ID	11184
	Gene name	mitogen-activated protein kinase kinase kinase kinase 1
	Synonyms	HPK1
	Cytomap	19q13.2
	Type of gene	protein-coding
	Description	mitogen-activated protein kinase kinase kinase kinase 1MAPK/ERK kinase kinase kinase 1MEK kinase kinase 1MEKKK 1hematopoietic progenitor kinase 1
	Modification date	20210518
	UniProtAcc	Q92918
	Context	- 31591939(DLX6-AS1 promotes cell proliferation, migration and EMT of gastric cancer through FUS-regulated MAP4K1)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MAP4K1	GO:0004674	Mitogen-activated protein kinase kinase kinase kinase 1	8824585
MAP4K1	GO:0005524	Mitogen-activated protein kinase kinase kinase kinase 1	8824585
MAP4K1	GO:0008349	Mitogen-activated protein kinase kinase kinase kinase 1	11053428
MAP4K1	GO:0006468	Mitogen-activated protein kinase kinase kinase kinase 1	8824585
MAP4K1	GO:0007257	Mitogen-activated protein kinase kinase kinase kinase 1	8824585
MAP4K1	GO:0018105	Mitogen-activated protein kinase kinase kinase kinase 1	11053428
MAP4K1	GO:0018105	Mitogen-activated protein kinase kinase kinase kinase 1	24362026
MAP4K1	GO:0046777	Mitogen-activated protein kinase kinase kinase kinase 1	24362026
MAP4K1	GO:0046777	Mitogen-activated protein kinase kinase kinase kinase 1	8824585
MAP4K1	GO:1904628	Mitogen-activated protein kinase kinase kinase kinase 1	8824585

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RNA A-to-I events for MAP4K1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000104814.11

RNA A-to-I editing events in Cancer.

CAediting_1346915(38588676, -), CAediting_1346916(38589181, -), CAediting_1346917(38589194, -), CAediting_1346918(38589203, -), CAediting_1346919(38589220, -), CAediting_1346920(38589221, -), CAediting_1346921(38589246, -), CAediting_1346922(38589265, -), CAediting_1346923(38589289, -), CAediting_1346924(38589295, -), CAediting_1346925(38589755, -), CAediting_1346926(38589812, -), CAediting_1346927(38589842, -), CAediting_1346928(38589873, -), CAediting_1346929(38589881, -), CAediting_1346930(38589898, -), CAediting_1346931(38589908, -), CAediting_1346932(38589930, -), CAediting_1346933(38589935, -), CAediting_1346934(38589944, -), CAediting_1346935(38589973, -), CAediting_1346936(38589980, -), CAediting_1346937(38589988, -), CAediting_1346938(38590576, -), CAediting_1346939(38590678, -), CAediting_1346940(38590679, -), CAediting_1346941(38590712, -), CAediting_1346942(38590724, -), CAediting_1346943(38591138, -), CAediting_1346944(38591143, -), CAediting_1346945(38591808, -), CAediting_1346946(38592021, -), CAediting_1346947(38592026, -), CAediting_1346948(38592027, -), CAediting_1346949(38592028, -), CAediting_1346950(38592054, -), CAediting_1346951(38592144, -), CAediting_1346952(38592150, -), CAediting_1346953(38592158, -), CAediting_1346954(38592192, -), CAediting_1346955(38592267, -), CAediting_1346956(38592330, -), CAediting_1346957(38592383, -), CAediting_1346958(38592387, -), CAediting_1346959(38592453, -), CAediting_1346960(38592467, -), CAediting_1346961(38592475, -), CAediting_1346962(38592492, -), CAediting_1346963(38592493, -), CAediting_1346964(38593498, -), CAediting_1346965(38593878, -), CAediting_1346966(38593879, -), CAediting_1346967(38593880, -), CAediting_1346968(38594865, -), CAediting_1346969(38595177, -), CAediting_1346970(38595220, -), CAediting_1346971(38601863, -), CAediting_1346972(38601866, -), CAediting_1346973(38601875, -), CAediting_1346974(38602050, -), CAediting_1346975(38602113, -), CAediting_1346976(38603840, -), CAediting_1346977(38604445, -), CAediting_1346978(38604465, -), CAediting_1346979(38605056, -), CAediting_1346980(38608405, -), CAediting_1346981(38610241, -), CAediting_1346982(38610303, -), CAediting_1346983(38610304, -), CAediting_1346984(38610308, -), CAediting_1346985(38610454, -), CAediting_1346986(38614655, -), CAediting_1346987(38614676, -), CAediting_1346988(38614678, -), CAediting_1346989(38614695, -), CAediting_1346990(38614699, -), CAediting_1346991(38614703, -), CAediting_1346992(38614704, -), CAediting_1346993(38614755, -), CAediting_1346994(38614758, -), CAediting_1346995(38614773, -), CAediting_1346996(38614774, -), CAediting_1346997(38614800, -), CAediting_1346998(38614822, -), CAediting_1346999(38614838, -), CAediting_1347000(38615769, -), CAediting_1347001(38615786, -), CAediting_1347002(38615790, -), CAediting_1347003(38615795, -), CAediting_1347004(38615796, -), CAediting_1347005(38615822, -), CAediting_1347006(38615832, -), CAediting_1347007(38615834, -), CAediting_1347008(38615836, -), CAediting_1347009(38615837, -), CAediting_1347010(38615838, -), CAediting_1347011(38615877, -), CAediting_1347012(38615886, -), CAediting_1347013(38616015, -), CAediting_1347014(38616036, -), CAediting_1347015(38616067, -), CAediting_1347016(38616069, -),

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RNA editing positional annotations for MAP4K1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1346915	chr19_38588676_-	ncRNA_intronic
CAediting_1346916	chr19_38589181_-	exonic
CAediting_1346917	chr19_38589194_-	exonic
CAediting_1346918	chr19_38589203_-	exonic
CAediting_1346919	chr19_38589220_-	exonic
CAediting_1346920	chr19_38589221_-	exonic
CAediting_1346921	chr19_38589246_-	exonic
CAediting_1346922	chr19_38589265_-	exonic
CAediting_1346923	chr19_38589289_-	ncRNA_intronic
CAediting_1346924	chr19_38589295_-	ncRNA_intronic
CAediting_1346925	chr19_38589755_-	ncRNA_intronic
CAediting_1346926	chr19_38589812_-	ncRNA_intronic
CAediting_1346927	chr19_38589842_-	ncRNA_intronic
CAediting_1346928	chr19_38589873_-	ncRNA_intronic
CAediting_1346929	chr19_38589881_-	ncRNA_intronic
CAediting_1346930	chr19_38589898_-	ncRNA_intronic
CAediting_1346931	chr19_38589908_-	ncRNA_intronic
CAediting_1346932	chr19_38589930_-	ncRNA_intronic
CAediting_1346933	chr19_38589935_-	ncRNA_intronic
CAediting_1346934	chr19_38589944_-	ncRNA_intronic
CAediting_1346935	chr19_38589973_-	ncRNA_intronic
CAediting_1346936	chr19_38589980_-	ncRNA_intronic
CAediting_1346937	chr19_38589988_-	ncRNA_intronic
CAediting_1346938	chr19_38590576_-	ncRNA_intronic
CAediting_1346939	chr19_38590678_-	ncRNA_intronic
CAediting_1346940	chr19_38590679_-	ncRNA_intronic
CAediting_1346941	chr19_38590712_-	ncRNA_intronic
CAediting_1346942	chr19_38590724_-	ncRNA_intronic
CAediting_1346943	chr19_38591138_-	ncRNA_intronic
CAediting_1346944	chr19_38591143_-	ncRNA_intronic
CAediting_1346945	chr19_38591808_-	ncRNA_intronic
CAediting_1346946	chr19_38592021_-	ncRNA_intronic
CAediting_1346947	chr19_38592026_-	ncRNA_intronic
CAediting_1346948	chr19_38592027_-	ncRNA_intronic
CAediting_1346949	chr19_38592028_-	ncRNA_intronic
CAediting_1346950	chr19_38592054_-	ncRNA_intronic
CAediting_1346951	chr19_38592144_-	ncRNA_intronic
CAediting_1346952	chr19_38592150_-	ncRNA_intronic
CAediting_1346953	chr19_38592158_-	ncRNA_intronic
CAediting_1346954	chr19_38592192_-	ncRNA_intronic
CAediting_1346955	chr19_38592267_-	ncRNA_intronic
CAediting_1346956	chr19_38592330_-	ncRNA_intronic
CAediting_1346957	chr19_38592383_-	ncRNA_intronic
CAediting_1346958	chr19_38592387_-	ncRNA_intronic
CAediting_1346959	chr19_38592453_-	ncRNA_exonic
CAediting_1346960	chr19_38592467_-	ncRNA_exonic
CAediting_1346961	chr19_38592475_-	ncRNA_exonic
CAediting_1346962	chr19_38592492_-	ncRNA_exonic
CAediting_1346963	chr19_38592493_-	ncRNA_exonic
CAediting_1346964	chr19_38593498_-	ncRNA_intronic
CAediting_1346965	chr19_38593878_-	ncRNA_intronic
CAediting_1346966	chr19_38593879_-	ncRNA_intronic
CAediting_1346967	chr19_38593880_-	ncRNA_intronic
CAediting_1346968	chr19_38594865_-	ncRNA_intronic
CAediting_1346969	chr19_38595177_-	ncRNA_intronic
CAediting_1346970	chr19_38595220_-	ncRNA_intronic
CAediting_1346971	chr19_38601863_-	intronic
CAediting_1346972	chr19_38601866_-	intronic
CAediting_1346973	chr19_38601875_-	intronic
CAediting_1346974	chr19_38602050_-	intronic
CAediting_1346975	chr19_38602113_-	intronic
CAediting_1346976	chr19_38603840_-	intronic
CAediting_1346977	chr19_38604445_-	intronic
CAediting_1346978	chr19_38604465_-	intronic
CAediting_1346979	chr19_38605056_-	intronic
CAediting_1346980	chr19_38608405_-	ncRNA_intronic
CAediting_1346981	chr19_38610241_-	ncRNA_intronic
CAediting_1346982	chr19_38610303_-	ncRNA_intronic
CAediting_1346983	chr19_38610304_-	ncRNA_intronic
CAediting_1346984	chr19_38610308_-	ncRNA_intronic
CAediting_1346985	chr19_38610454_-	ncRNA_intronic
CAediting_1346986	chr19_38614655_-	ncRNA_exonic
CAediting_1346987	chr19_38614676_-	ncRNA_exonic
CAediting_1346988	chr19_38614678_-	ncRNA_exonic
CAediting_1346989	chr19_38614695_-	ncRNA_exonic
CAediting_1346990	chr19_38614699_-	ncRNA_exonic
CAediting_1346991	chr19_38614703_-	ncRNA_exonic
CAediting_1346992	chr19_38614704_-	ncRNA_exonic
CAediting_1346993	chr19_38614755_-	ncRNA_exonic
CAediting_1346994	chr19_38614758_-	ncRNA_exonic
CAediting_1346995	chr19_38614773_-	ncRNA_exonic
CAediting_1346996	chr19_38614774_-	ncRNA_exonic
CAediting_1346997	chr19_38614800_-	ncRNA_exonic
CAediting_1346998	chr19_38614822_-	ncRNA_exonic
CAediting_1346999	chr19_38614838_-	ncRNA_exonic
CAediting_1347000	chr19_38615769_-	ncRNA_intronic
CAediting_1347001	chr19_38615786_-	ncRNA_intronic
CAediting_1347002	chr19_38615790_-	ncRNA_intronic
CAediting_1347003	chr19_38615795_-	ncRNA_intronic
CAediting_1347004	chr19_38615796_-	ncRNA_intronic
CAediting_1347005	chr19_38615822_-	ncRNA_intronic
CAediting_1347006	chr19_38615832_-	ncRNA_intronic
CAediting_1347007	chr19_38615834_-	ncRNA_intronic
CAediting_1347008	chr19_38615836_-	ncRNA_intronic
CAediting_1347009	chr19_38615837_-	ncRNA_intronic
CAediting_1347010	chr19_38615838_-	ncRNA_intronic
CAediting_1347011	chr19_38615877_-	ncRNA_intronic
CAediting_1347012	chr19_38615886_-	ncRNA_intronic
CAediting_1347013	chr19_38616015_-	ncRNA_intronic
CAediting_1347014	chr19_38616036_-	ncRNA_intronic
CAediting_1347015	chr19_38616067_-	ncRNA_intronic
CAediting_1347016	chr19_38616069_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1346915	chr19_38588676_-	SINE	Alu	AluY
CAediting_1346916	chr19_38589181_-	SINE	Alu	AluSx
CAediting_1346917	chr19_38589194_-	SINE	Alu	AluSx
CAediting_1346918	chr19_38589203_-	SINE	Alu	AluSx
CAediting_1346919	chr19_38589220_-	SINE	Alu	AluSx
CAediting_1346920	chr19_38589221_-	SINE	Alu	AluSx
CAediting_1346921	chr19_38589246_-	SINE	Alu	AluSx
CAediting_1346922	chr19_38589265_-	SINE	Alu	AluSx
CAediting_1346923	chr19_38589289_-	SINE	Alu	AluSx
CAediting_1346924	chr19_38589295_-	SINE	Alu	AluSx
CAediting_1346925	chr19_38589755_-	SINE	Alu	AluJb
CAediting_1346926	chr19_38589812_-	SINE	Alu	AluJb
CAediting_1346927	chr19_38589842_-	SINE	Alu	AluJb
CAediting_1346928	chr19_38589873_-	SINE	Alu	AluJb
CAediting_1346929	chr19_38589881_-	SINE	Alu	AluJb
CAediting_1346930	chr19_38589898_-	SINE	Alu	AluJb
CAediting_1346931	chr19_38589908_-	SINE	Alu	AluJb
CAediting_1346932	chr19_38589930_-	SINE	Alu	AluJb
CAediting_1346933	chr19_38589935_-	SINE	Alu	AluJb
CAediting_1346934	chr19_38589944_-	SINE	Alu	AluJb
CAediting_1346935	chr19_38589973_-	SINE	Alu	AluJb
CAediting_1346936	chr19_38589980_-	SINE	Alu	AluJb
CAediting_1346937	chr19_38589988_-	SINE	Alu	AluJb
CAediting_1346938	chr19_38590576_-	SINE	Alu	AluSx
CAediting_1346939	chr19_38590678_-	SINE	Alu	AluSx
CAediting_1346940	chr19_38590679_-	SINE	Alu	AluSx
CAediting_1346941	chr19_38590712_-	SINE	Alu	AluSx
CAediting_1346942	chr19_38590724_-	SINE	Alu	AluSx
CAediting_1346943	chr19_38591138_-	SINE	Alu	AluSp
CAediting_1346944	chr19_38591143_-	SINE	Alu	AluSp
CAediting_1346945	chr19_38591808_-	SINE	Alu	AluSx
CAediting_1346946	chr19_38592021_-	SINE	Alu	AluJr
CAediting_1346947	chr19_38592026_-	SINE	Alu	AluJr
CAediting_1346948	chr19_38592027_-	SINE	Alu	AluJr
CAediting_1346949	chr19_38592028_-	SINE	Alu	AluJr
CAediting_1346950	chr19_38592054_-	SINE	Alu	AluJr
CAediting_1346951	chr19_38592144_-	SINE	Alu	AluJr
CAediting_1346952	chr19_38592150_-	SINE	Alu	AluJr
CAediting_1346953	chr19_38592158_-	SINE	Alu	AluJr
CAediting_1346954	chr19_38592192_-	SINE	Alu	AluJr
CAediting_1346955	chr19_38592267_-	SINE	Alu	AluJr
CAediting_1346956	chr19_38592330_-	SINE	Alu	AluSx
CAediting_1346957	chr19_38592383_-	SINE	Alu	AluSx
CAediting_1346958	chr19_38592387_-	SINE	Alu	AluSx
CAediting_1346959	chr19_38592453_-	SINE	Alu	AluSx
CAediting_1346960	chr19_38592467_-	SINE	Alu	AluSx
CAediting_1346961	chr19_38592475_-	SINE	Alu	AluSx
CAediting_1346962	chr19_38592492_-	SINE	Alu	AluSx
CAediting_1346963	chr19_38592493_-	SINE	Alu	AluSx
CAediting_1346964	chr19_38593498_-	SINE	Alu	AluSx
CAediting_1346965	chr19_38593878_-	SINE	Alu	AluSz6
CAediting_1346966	chr19_38593879_-	SINE	Alu	AluSz6
CAediting_1346967	chr19_38593880_-	SINE	Alu	AluSz6
CAediting_1346968	chr19_38594865_-	SINE	Alu	AluSx
CAediting_1346969	chr19_38595177_-	SINE	Alu	AluSq
CAediting_1346970	chr19_38595220_-	SINE	Alu	AluSq
CAediting_1346971	chr19_38601863_-	SINE	Alu	AluSz6
CAediting_1346972	chr19_38601866_-	SINE	Alu	AluSz6
CAediting_1346973	chr19_38601875_-	SINE	Alu	AluSz6
CAediting_1346974	chr19_38602050_-	SINE	Alu	AluSz6
CAediting_1346975	chr19_38602113_-	SINE	Alu	AluSx
CAediting_1346976	chr19_38603840_-	SINE	Alu	AluSx1
CAediting_1346977	chr19_38604445_-	SINE	Alu	AluJr
CAediting_1346978	chr19_38604465_-	SINE	Alu	AluJr
CAediting_1346979	chr19_38605056_-	SINE	Alu	AluSx
CAediting_1346980	chr19_38608405_-	SINE	Alu	AluJr
CAediting_1346981	chr19_38610241_-	SINE	Alu	AluSz6
CAediting_1346982	chr19_38610303_-	SINE	Alu	AluSz6
CAediting_1346983	chr19_38610304_-	SINE	Alu	AluSz6
CAediting_1346984	chr19_38610308_-	SINE	Alu	AluSz6
CAediting_1346985	chr19_38610454_-	SINE	Alu	AluSz
CAediting_1346986	chr19_38614655_-	SINE	Alu	AluSz
CAediting_1346987	chr19_38614676_-	SINE	Alu	AluSz
CAediting_1346988	chr19_38614678_-	SINE	Alu	AluSz
CAediting_1346989	chr19_38614695_-	SINE	Alu	AluSz
CAediting_1346990	chr19_38614699_-	SINE	Alu	AluSz
CAediting_1346991	chr19_38614703_-	SINE	Alu	AluSz
CAediting_1346992	chr19_38614704_-	SINE	Alu	AluSz
CAediting_1346993	chr19_38614755_-	SINE	Alu	AluSz
CAediting_1346994	chr19_38614758_-	SINE	Alu	AluSz
CAediting_1346995	chr19_38614773_-	SINE	Alu	AluSz
CAediting_1346996	chr19_38614774_-	SINE	Alu	AluSz
CAediting_1346997	chr19_38614800_-	SINE	Alu	AluSz
CAediting_1346998	chr19_38614822_-	SINE	Alu	AluSz
CAediting_1346999	chr19_38614838_-	SINE	Alu	AluSz
CAediting_1347000	chr19_38615769_-	SINE	Alu	AluSx1
CAediting_1347001	chr19_38615786_-	SINE	Alu	AluSx1
CAediting_1347002	chr19_38615790_-	SINE	Alu	AluSx1
CAediting_1347003	chr19_38615795_-	SINE	Alu	AluSx1
CAediting_1347004	chr19_38615796_-	SINE	Alu	AluSx1
CAediting_1347005	chr19_38615822_-	SINE	Alu	AluSx1
CAediting_1347006	chr19_38615832_-	SINE	Alu	AluSx1
CAediting_1347007	chr19_38615834_-	SINE	Alu	AluSx1
CAediting_1347008	chr19_38615836_-	SINE	Alu	AluSx1
CAediting_1347009	chr19_38615837_-	SINE	Alu	AluSx1
CAediting_1347010	chr19_38615838_-	SINE	Alu	AluSx1
CAediting_1347011	chr19_38615877_-	SINE	Alu	AluSx1
CAediting_1347012	chr19_38615886_-	SINE	Alu	AluSx1
CAediting_1347013	chr19_38616015_-	SINE	Alu	AluJb
CAediting_1347014	chr19_38616036_-	SINE	Alu	AluJb
CAediting_1347015	chr19_38616067_-	SINE	Alu	AluJb
CAediting_1347016	chr19_38616069_-	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for MAP4K1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_1346923	chr19_38589289_-	38589273:38589295	3SS	0+14i	AGTCTCACTCTGTCCCCCAGGCT	7.07	AGTCTCGCTCTGTCCCCCAGGCT	7.81
MEX_1	CAediting_1346923	chr19_38589289_-	38589273:38589295	3SS	0+14i	AGTCTCACTCTGTCCCCCAGGCT	7.07	AGTCTCGCTCTGTCCCCCAGGCT	7.81
ES	CAediting_1346924	chr19_38589295_-	38589273:38589295	3SS	0+20i	AGTCTCACTCTGTCCCCCAGGCT	7.07	GGTCTCACTCTGTCCCCCAGGCT	7.29
ES	CAediting_1346924	chr19_38589295_-	38589293:38589315	3SS	1+0i	TTGTTGTTGTTTTGAGTCAGAGT	1.21	TTGTTGTTGTTTTGAGTCAGGGT	2.38
MEX_1	CAediting_1346924	chr19_38589295_-	38589273:38589295	3SS	0+20i	AGTCTCACTCTGTCCCCCAGGCT	7.07	GGTCTCACTCTGTCCCCCAGGCT	7.29
MEX_1	CAediting_1346924	chr19_38589295_-	38589293:38589315	3SS	1+0i	TTGTTGTTGTTTTGAGTCAGAGT	1.21	TTGTTGTTGTTTTGAGTCAGGGT	2.38

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000104814.11.MAP4K1.

Correlation between RNA A-to-I editing and PSI for ENSG00000104814.11.MAP4K1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MAP4K1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for MAP4K1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for MAP4K1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_580943	chr7_100356700_+	ENSG00000104814.11	ENST00000585583	hsa-miR-6840-3p	38609950	38609957	8mer-1a	38609950	38609971	148	-24.78
CAediting_1368054	chr19_46709310_-	ENSG00000104814.11	ENST00000585583	hsa-miR-320e	38609625	38609631	7mer-m8	38609624	38609641	144	-21.16
CAediting_86358	chr1_109598906_+	ENSG00000104814.11	ENST00000585583	hsa-miR-197-5p	38609637	38609644	8mer-1a	38609637	38609663	147	-22.72
CAediting_1054808	chr15_66496985_-	ENSG00000104814.11	ENST00000585583	hsa-miR-4512	38605634	38605639	6mer	38605633	38605653	142	-28.24
CAediting_580943	chr7_100356700_+	ENSG00000104814.11	ENST00000585583	hsa-miR-6840-3p	38605461	38605468	8mer-1a	38605461	38605482	143	-23.52
CAediting_1229413	chr17_67471544_+	ENSG00000104814.11	ENST00000585583	hsa-miR-548aa	38597370	38597376	7mer-m8	38597369	38597392	148	-11.3
CAediting_1368054	chr19_46709310_-	ENSG00000104814.11	ENST00000585583	hsa-miR-320e	38597476	38597482	7mer-m8	38597475	38597492	140	-14.57
CAediting_468389	chr6_31355314_-	ENSG00000104814.11	ENST00000585583	hsa-miR-6891-5p	38606187	38606193	7mer-m8	38606186	38606204	142	-17.53

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_580943	chr7_100356700_+	ENSG00000104814.11	ENST00000585583	hsa-miR-6840-3p	38605611	38605617	7mer-m8	38605610	38605631	145	-27.76
CAediting_580943	chr7_100356700_+	ENSG00000104814.11	ENST00000585583	hsa-miR-6840-3p	38605694	38605701	8mer-1a	38605694	38605716	155	-26.9

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for MAP4K1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for MAP4K1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for MAP4K1

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for MAP4K1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for MAP4K1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
MAP4K1	Q92918	DB12010	Fostamatinib	Mitogen-activated protein kinase kinase kinase kinase 1	SmallMoleculeDrug	approved\|investigational

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RelatedDiseases for MAP4K1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene