![]() |
||||||
|
![]() | |
![]() | |
![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
![]() | |
![]() | |
![]() | The effects of the RNA editing to the stability of the RNA structures |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Editing gene: AKR1C4 (CAeditome ID:1109) |
Gene summary for AKR1C4 |
![]() |
Gene information | Gene symbol | AKR1C4 | Gene ID | 1109 |
Gene name | aldo-keto reductase family 1 member C4 | |
Synonyms | 3-alpha-HSD|C11|CDR|CHDR|DD-4|DD4|HAKRA | |
Cytomap | 10p15.1 | |
Type of gene | protein-coding | |
Description | aldo-keto reductase family 1 member C43-alpha-HSD13alpha-hydroxysteroid 3-dehydrogenasechlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4dihydrodiol dehydrogenase isozyme DD4type I 3-alpha-hydroxysteroid | |
Modification date | 20210518 | |
UniProtAcc | P17516 | |
Context |
![]() |
Gene | GO ID | GO term | PubMed ID |
AKR1C4 | GO:0001758 | Aldo-keto reductase family 1 member C4 | 21851338 |
AKR1C4 | GO:0016655 | Aldo-keto reductase family 1 member C4 | 20837989 |
AKR1C4 | GO:0047023 | Aldo-keto reductase family 1 member C4 | 21851338 |
AKR1C4 | GO:0047743 | Aldo-keto reductase family 1 member C4 | 2427522 |
AKR1C4 | GO:0071395 | Aldo-keto reductase family 1 member C4 | 19487289 |
Top |
RNA A-to-I events for AKR1C4 |
![]() |
![]() |
![]() |
![]() |
CAediting_725915(5213045, +), CAediting_725916(5213054, +), CAediting_725917(5213060, +), CAediting_725918(5215129, +), CAediting_725919(5215208, +), CAediting_725920(5215237, +), CAediting_725921(5215262, +), CAediting_725922(5216278, +), CAediting_725923(5216280, +), CAediting_725924(5216325, +), CAediting_725925(5216349, +), CAediting_725926(5216383, +), CAediting_725927(5216447, +), CAediting_725928(5216452, +), |
Top |
RNA editing positional annotations for AKR1C4 using Annovar |
![]() |
CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
![]() |
CAeditome ID | Position | Variant type |
CAediting_725915 | chr10_5213045_+ | exonic |
CAediting_725916 | chr10_5213054_+ | exonic |
CAediting_725917 | chr10_5213060_+ | exonic |
CAediting_725918 | chr10_5215129_+ | intronic |
CAediting_725919 | chr10_5215208_+ | intronic |
CAediting_725920 | chr10_5215237_+ | intronic |
CAediting_725921 | chr10_5215262_+ | intronic |
CAediting_725922 | chr10_5216278_+ | intronic |
CAediting_725923 | chr10_5216280_+ | intronic |
CAediting_725924 | chr10_5216325_+ | intronic |
CAediting_725925 | chr10_5216349_+ | intronic |
CAediting_725926 | chr10_5216383_+ | intronic |
CAediting_725927 | chr10_5216447_+ | intronic |
CAediting_725928 | chr10_5216452_+ | intronic |
![]() |
CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_725920 | chr10_5215237_+ | LTR | ERVL-MaLR | MSTB |
CAediting_725921 | chr10_5215262_+ | LTR | ERVL-MaLR | MSTB |
CAediting_725922 | chr10_5216278_+ | LTR | ERVL-MaLR | MSTB |
CAediting_725923 | chr10_5216280_+ | LTR | ERVL-MaLR | MSTB |
CAediting_725924 | chr10_5216325_+ | LTR | ERVL-MaLR | MSTB |
CAediting_725925 | chr10_5216349_+ | LTR | ERVL-MaLR | MSTB |
Top |
RNA A-to-I editing events in the alternative splicing sites for AKR1C4 |
![]() |
AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
![]() |
![]() |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for AKR1C4 |
![]() * The grey color means N/A. |
![]() |
![]() * Click on the image to enlarge it in a new window. |
Top |
Protein coding region RNA A-to-I editings for AKR1C4 |
![]() * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for AKR1C4 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_1351755 | chr19_40282625_- | ENSG00000198610.9 | ENST00000380448 | hsa-miR-641 | 5218820 | 5218826 | 7mer-m8 | 5218805 | 5218827 | 152 | -20.53 |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
Top |
The effects of the RNA editing to the stability of the RNA structures for AKR1C4 |
![]() * Click on the image to enlarge it in a new window. |
ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
![]() |
CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for AKR1C4 |
![]() |
Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
Top |
Relation with cancer stages for AKR1C4 |
![]() |
Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
Top |
Relation with survival for AKR1C4 |
![]() |
Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
Top |
RelatedDrugs for AKR1C4 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
AKR1C4 | P17516 | DB00157 | NADH | Aldo-keto reductase family 1 member C4 | SmallMoleculeDrug | approved|nutraceutical |
Top |
RelatedDiseases for AKR1C4 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
AKR1C4 | C0005586 | Bipolar Disorder | 2 | CTD_human;PSYGENET |
AKR1C4 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
AKR1C4 | C0005587 | Depression, Bipolar | 1 | CTD_human |
AKR1C4 | C0024713 | Manic Disorder | 1 | CTD_human |
AKR1C4 | C0338831 | Manic | 1 | CTD_human |
AKR1C4 | C1456784 | Paranoia | 1 | CTD_human |
AKR1C4 | C1839840 | MALE PSEUDOHERMAPHRODITISM: DEFICIENCY OF TESTICULAR 17,20-DESMOLASE | 1 | CTD_human;ORPHANET |