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Editing gene: ESM1 (CAeditome ID:11082)

Gene summary for ESM1

Gene summary

Gene information	Gene symbol	ESM1
	Gene ID	11082
	Gene name	endothelial cell specific molecule 1
	Synonyms	endocan
	Cytomap	5q11.2
	Type of gene	protein-coding
	Description	endothelial cell-specific molecule 1ESM-1
	Modification date	20210531
	UniProtAcc	Q9NQ30
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
ESM1	GO:0008284	Endothelial cell-specific molecule 1	11590178
ESM1	GO:1902204	Endothelial cell-specific molecule 1	11590178

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RNA A-to-I events for ESM1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000164283.11

RNA A-to-I editing events in Cancer.

CAediting_407378(54983120, -), CAediting_407379(54983221, -), CAediting_407380(54983226, -), CAediting_407381(54983227, -), CAediting_407382(54983241, -), CAediting_407383(54983242, -), CAediting_407384(54983642, -), CAediting_407385(54983643, -), CAediting_407386(54983649, -), CAediting_407387(54983690, -), CAediting_407388(54983700, -), CAediting_407389(54983727, -), CAediting_407390(54983730, -), CAediting_407391(54983735, -), CAediting_407392(54983762, -), CAediting_407393(54983763, -), CAediting_407394(54983769, -), CAediting_407395(54983770, -), CAediting_407396(54983771, -), CAediting_407397(54983786, -), CAediting_407398(54983791, -), CAediting_407399(54983792, -),

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RNA editing positional annotations for ESM1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_407378	chr5_54983120_-	ncRNA_intronic
CAediting_407379	chr5_54983221_-	ncRNA_intronic
CAediting_407380	chr5_54983226_-	ncRNA_intronic
CAediting_407381	chr5_54983227_-	ncRNA_intronic
CAediting_407382	chr5_54983241_-	ncRNA_intronic
CAediting_407383	chr5_54983242_-	ncRNA_intronic
CAediting_407384	chr5_54983642_-	ncRNA_intronic
CAediting_407385	chr5_54983643_-	ncRNA_intronic
CAediting_407386	chr5_54983649_-	ncRNA_intronic
CAediting_407387	chr5_54983690_-	ncRNA_intronic
CAediting_407388	chr5_54983700_-	ncRNA_intronic
CAediting_407389	chr5_54983727_-	ncRNA_intronic
CAediting_407390	chr5_54983730_-	ncRNA_intronic
CAediting_407391	chr5_54983735_-	ncRNA_intronic
CAediting_407392	chr5_54983762_-	ncRNA_intronic
CAediting_407393	chr5_54983763_-	ncRNA_intronic
CAediting_407394	chr5_54983769_-	ncRNA_intronic
CAediting_407395	chr5_54983770_-	ncRNA_intronic
CAediting_407396	chr5_54983771_-	ncRNA_intronic
CAediting_407397	chr5_54983786_-	ncRNA_intronic
CAediting_407398	chr5_54983791_-	ncRNA_intronic
CAediting_407399	chr5_54983792_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_407397	chr5_54983786_-	Simple_repeat	Simple_repeat	(ATGTAC)n
CAediting_407398	chr5_54983791_-	Simple_repeat	Simple_repeat	(ATGTAC)n
CAediting_407399	chr5_54983792_-	Simple_repeat	Simple_repeat	(ATGTAC)n

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RNA A-to-I editing events in the alternative splicing sites for ESM1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000164283.11.ESM1.

Correlation between RNA A-to-I editing and PSI for ENSG00000164283.11.ESM1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ESM1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ESM1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ESM1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1399425	chr20_1392958_-	ENSG00000164283.11	ENST00000381403	hsa-miR-6869-5p	54978503	54978509	7mer-m8	54978502	54978523	145	-18.36
CAediting_580943	chr7_100356700_+	ENSG00000164283.11	ENST00000381403	hsa-miR-6840-3p	54978693	54978699	7mer-m8	54978692	54978716	148	-23.75

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ESM1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for ESM1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for ESM1

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
KIRC	pathologic_stage	CAediting_407385	chr5_54983643_-	0.0274223673511503	0.146078165872483

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Relation with survival for ESM1

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
KIRC	CAediting_407383	chr5_54983242_-	0.0379601819430173	0.00378832	447.541

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RelatedDrugs for ESM1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ESM1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
ESM1	C0023903	Liver neoplasms	1	CTD_human
ESM1	C0345904	Malignant neoplasm of liver	1	CTD_human
ESM1	C2239176	Liver carcinoma	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene