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Editing gene: HCP5 (CAeditome ID:10866)

Gene summary for HCP5

Gene summary

Gene information	Gene symbol	HCP5
	Gene ID	10866
	Gene name	HLA complex P5
	Synonyms	6S2650E\|D6S2650E\|P5-1
	Cytomap	6p21.33
	Type of gene	ncRNA
	Description	HLA class I histocompatibility antigen protein P5HLA complex P5 (non-protein coding)HLA complex protein P5MHC class I region ORF
	Modification date	20210518
	UniProtAcc	.
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for HCP5

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000206337.9

RNA A-to-I editing events in Cancer.

CAediting_468391(31407257, +), CAediting_468392(31407285, +), CAediting_468393(31407288, +), CAediting_468394(31407419, +), CAediting_468395(31408757, +), CAediting_468396(31408772, +), CAediting_468397(31408804, +), CAediting_468398(31408805, +), CAediting_468399(31408808, +), CAediting_468400(31408858, +), CAediting_468401(31408884, +), CAediting_468402(31408911, +), CAediting_468403(31408917, +), CAediting_468404(31408934, +), CAediting_468405(31408946, +), CAediting_468406(31408960, +), CAediting_468407(31408975, +), CAediting_468408(31408984, +), CAediting_468409(31408988, +), CAediting_468410(31415381, +), CAediting_468411(31415395, +), CAediting_468412(31415404, +), CAediting_468413(31415409, +), CAediting_468414(31415448, +), CAediting_468415(31415458, +), CAediting_468416(31415471, +), CAediting_468417(31415498, +), CAediting_468418(31415501, +), CAediting_468419(31415511, +), CAediting_468420(31415537, +), CAediting_468421(31415547, +), CAediting_468422(31415551, +), CAediting_468423(31415563, +), CAediting_468424(31415567, +), CAediting_468425(31415577, +), CAediting_468426(31415578, +), CAediting_468427(31415602, +), CAediting_468428(31415607, +), CAediting_468429(31415678, +), CAediting_468430(31415686, +), CAediting_468431(31415694, +), CAediting_468432(31415698, +), CAediting_468433(31415724, +), CAediting_468434(31415734, +), CAediting_468435(31415755, +), CAediting_468436(31415772, +), CAediting_468437(31415781, +), CAediting_468438(31415784, +), CAediting_468439(31415794, +), CAediting_468440(31415796, +), CAediting_468441(31415807, +), CAediting_468442(31415812, +), CAediting_468443(31415821, +), CAediting_468444(31415829, +), CAediting_468445(31415838, +), CAediting_468446(31415840, +), CAediting_468447(31415844, +), CAediting_468448(31415847, +), CAediting_468449(31415855, +), CAediting_468450(31415875, +), CAediting_468451(31415907, +), CAediting_468452(31415916, +), CAediting_468453(31415917, +), CAediting_468454(31415932, +), CAediting_468455(31415935, +), CAediting_468456(31415947, +), CAediting_468457(31418071, +), CAediting_468458(31418081, +), CAediting_468459(31418819, +), CAediting_468460(31418863, +), CAediting_468461(31469108, +), CAediting_468462(31469112, +), CAediting_468463(31469135, +), CAediting_468464(31469188, +), CAediting_468465(31475645, +), CAediting_468466(31475744, +), CAediting_468467(31475783, +), CAediting_468468(31475784, +), CAediting_468469(31475799, +), CAediting_468470(31475800, +), CAediting_468471(31475818, +), CAediting_468472(31475822, +),

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RNA editing positional annotations for HCP5 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_468391	chr6_31407257_+	ncRNA_intronic
CAediting_468392	chr6_31407285_+	ncRNA_intronic
CAediting_468393	chr6_31407288_+	ncRNA_intronic
CAediting_468394	chr6_31407419_+	ncRNA_intronic
CAediting_468395	chr6_31408757_+	ncRNA_intronic
CAediting_468396	chr6_31408772_+	ncRNA_intronic
CAediting_468397	chr6_31408804_+	ncRNA_intronic
CAediting_468398	chr6_31408805_+	ncRNA_intronic
CAediting_468399	chr6_31408808_+	ncRNA_intronic
CAediting_468400	chr6_31408858_+	ncRNA_intronic
CAediting_468401	chr6_31408884_+	ncRNA_intronic
CAediting_468402	chr6_31408911_+	ncRNA_intronic
CAediting_468403	chr6_31408917_+	ncRNA_intronic
CAediting_468404	chr6_31408934_+	ncRNA_intronic
CAediting_468405	chr6_31408946_+	ncRNA_intronic
CAediting_468406	chr6_31408960_+	ncRNA_intronic
CAediting_468407	chr6_31408975_+	ncRNA_intronic
CAediting_468408	chr6_31408984_+	ncRNA_intronic
CAediting_468409	chr6_31408988_+	ncRNA_intronic
CAediting_468410	chr6_31415381_+	ncRNA_intronic
CAediting_468411	chr6_31415395_+	ncRNA_intronic
CAediting_468412	chr6_31415404_+	ncRNA_intronic
CAediting_468413	chr6_31415409_+	ncRNA_intronic
CAediting_468414	chr6_31415448_+	ncRNA_intronic
CAediting_468415	chr6_31415458_+	ncRNA_intronic
CAediting_468416	chr6_31415471_+	ncRNA_intronic
CAediting_468417	chr6_31415498_+	ncRNA_intronic
CAediting_468418	chr6_31415501_+	ncRNA_intronic
CAediting_468419	chr6_31415511_+	ncRNA_intronic
CAediting_468420	chr6_31415537_+	ncRNA_intronic
CAediting_468421	chr6_31415547_+	ncRNA_intronic
CAediting_468422	chr6_31415551_+	ncRNA_intronic
CAediting_468423	chr6_31415563_+	ncRNA_intronic
CAediting_468424	chr6_31415567_+	ncRNA_intronic
CAediting_468425	chr6_31415577_+	ncRNA_intronic
CAediting_468426	chr6_31415578_+	ncRNA_intronic
CAediting_468427	chr6_31415602_+	ncRNA_intronic
CAediting_468428	chr6_31415607_+	ncRNA_intronic
CAediting_468429	chr6_31415678_+	ncRNA_intronic
CAediting_468430	chr6_31415686_+	ncRNA_intronic
CAediting_468431	chr6_31415694_+	ncRNA_intronic
CAediting_468432	chr6_31415698_+	ncRNA_intronic
CAediting_468433	chr6_31415724_+	ncRNA_intronic
CAediting_468434	chr6_31415734_+	ncRNA_intronic
CAediting_468435	chr6_31415755_+	ncRNA_intronic
CAediting_468436	chr6_31415772_+	ncRNA_intronic
CAediting_468437	chr6_31415781_+	ncRNA_intronic
CAediting_468438	chr6_31415784_+	ncRNA_intronic
CAediting_468439	chr6_31415794_+	ncRNA_intronic
CAediting_468440	chr6_31415796_+	ncRNA_intronic
CAediting_468441	chr6_31415807_+	ncRNA_intronic
CAediting_468442	chr6_31415812_+	ncRNA_intronic
CAediting_468443	chr6_31415821_+	ncRNA_intronic
CAediting_468444	chr6_31415829_+	ncRNA_intronic
CAediting_468445	chr6_31415838_+	ncRNA_intronic
CAediting_468446	chr6_31415840_+	ncRNA_intronic
CAediting_468447	chr6_31415844_+	ncRNA_intronic
CAediting_468448	chr6_31415847_+	ncRNA_intronic
CAediting_468449	chr6_31415855_+	ncRNA_intronic
CAediting_468450	chr6_31415875_+	ncRNA_intronic
CAediting_468451	chr6_31415907_+	ncRNA_intronic
CAediting_468452	chr6_31415916_+	ncRNA_intronic
CAediting_468453	chr6_31415917_+	ncRNA_intronic
CAediting_468454	chr6_31415932_+	ncRNA_intronic
CAediting_468455	chr6_31415935_+	ncRNA_intronic
CAediting_468456	chr6_31415947_+	ncRNA_intronic
CAediting_468457	chr6_31418071_+	ncRNA_intronic
CAediting_468458	chr6_31418081_+	ncRNA_intronic
CAediting_468459	chr6_31418819_+	ncRNA_intronic
CAediting_468460	chr6_31418863_+	ncRNA_intronic
CAediting_468461	chr6_31469108_+	ncRNA_intronic
CAediting_468462	chr6_31469112_+	ncRNA_intronic
CAediting_468463	chr6_31469135_+	ncRNA_intronic
CAediting_468464	chr6_31469188_+	ncRNA_intronic
CAediting_468465	chr6_31475645_+	ncRNA_intronic
CAediting_468466	chr6_31475744_+	ncRNA_intronic
CAediting_468467	chr6_31475783_+	ncRNA_intronic
CAediting_468468	chr6_31475784_+	ncRNA_intronic
CAediting_468469	chr6_31475799_+	ncRNA_intronic
CAediting_468470	chr6_31475800_+	ncRNA_intronic
CAediting_468471	chr6_31475818_+	ncRNA_intronic
CAediting_468472	chr6_31475822_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_468391	chr6_31407257_+	SINE	Alu	AluSp
CAediting_468392	chr6_31407285_+	SINE	Alu	AluSp
CAediting_468393	chr6_31407288_+	SINE	Alu	AluSp
CAediting_468394	chr6_31407419_+	SINE	Alu	AluSp
CAediting_468395	chr6_31408757_+	SINE	Alu	AluSq
CAediting_468396	chr6_31408772_+	SINE	Alu	AluSq
CAediting_468397	chr6_31408804_+	SINE	Alu	AluSq
CAediting_468398	chr6_31408805_+	SINE	Alu	AluSq
CAediting_468399	chr6_31408808_+	SINE	Alu	AluSq
CAediting_468400	chr6_31408858_+	SINE	Alu	AluSq
CAediting_468401	chr6_31408884_+	SINE	Alu	AluSq
CAediting_468402	chr6_31408911_+	SINE	Alu	AluSq
CAediting_468403	chr6_31408917_+	SINE	Alu	AluSq
CAediting_468404	chr6_31408934_+	SINE	Alu	AluSq
CAediting_468405	chr6_31408946_+	SINE	Alu	AluSq
CAediting_468406	chr6_31408960_+	SINE	Alu	AluSq
CAediting_468407	chr6_31408975_+	SINE	Alu	AluSq
CAediting_468408	chr6_31408984_+	SINE	Alu	AluSq
CAediting_468409	chr6_31408988_+	SINE	Alu	AluSq
CAediting_468410	chr6_31415381_+	SINE	Alu	AluSc
CAediting_468411	chr6_31415395_+	SINE	Alu	AluSc
CAediting_468412	chr6_31415404_+	SINE	Alu	AluSc
CAediting_468413	chr6_31415409_+	SINE	Alu	AluSc
CAediting_468414	chr6_31415448_+	SINE	Alu	AluSc
CAediting_468415	chr6_31415458_+	SINE	Alu	AluSc
CAediting_468416	chr6_31415471_+	SINE	Alu	AluSc
CAediting_468417	chr6_31415498_+	SINE	Alu	AluSc
CAediting_468418	chr6_31415501_+	SINE	Alu	AluSc
CAediting_468419	chr6_31415511_+	SINE	Alu	AluSc
CAediting_468420	chr6_31415537_+	SINE	Alu	AluSc
CAediting_468421	chr6_31415547_+	SINE	Alu	AluSc
CAediting_468422	chr6_31415551_+	SINE	Alu	AluSc
CAediting_468423	chr6_31415563_+	SINE	Alu	AluSc
CAediting_468424	chr6_31415567_+	SINE	Alu	AluSc
CAediting_468425	chr6_31415577_+	SINE	Alu	AluSc
CAediting_468426	chr6_31415578_+	SINE	Alu	AluSc
CAediting_468427	chr6_31415602_+	SINE	Alu	AluSc
CAediting_468428	chr6_31415607_+	SINE	Alu	AluSc
CAediting_468429	chr6_31415678_+	SINE	Alu	AluSz6
CAediting_468430	chr6_31415686_+	SINE	Alu	AluSz6
CAediting_468431	chr6_31415694_+	SINE	Alu	AluSz6
CAediting_468432	chr6_31415698_+	SINE	Alu	AluSz6
CAediting_468433	chr6_31415724_+	SINE	Alu	AluSz6
CAediting_468434	chr6_31415734_+	SINE	Alu	AluSz6
CAediting_468435	chr6_31415755_+	SINE	Alu	AluSz6
CAediting_468436	chr6_31415772_+	SINE	Alu	AluSz6
CAediting_468437	chr6_31415781_+	SINE	Alu	AluSz6
CAediting_468438	chr6_31415784_+	SINE	Alu	AluSz6
CAediting_468439	chr6_31415794_+	SINE	Alu	AluSz6
CAediting_468440	chr6_31415796_+	SINE	Alu	AluSz6
CAediting_468441	chr6_31415807_+	SINE	Alu	AluSz6
CAediting_468442	chr6_31415812_+	SINE	Alu	AluSz6
CAediting_468443	chr6_31415821_+	SINE	Alu	AluSz6
CAediting_468444	chr6_31415829_+	SINE	Alu	AluSz6
CAediting_468445	chr6_31415838_+	SINE	Alu	AluSz6
CAediting_468446	chr6_31415840_+	SINE	Alu	AluSz6
CAediting_468447	chr6_31415844_+	SINE	Alu	AluSz6
CAediting_468448	chr6_31415847_+	SINE	Alu	AluSz6
CAediting_468449	chr6_31415855_+	SINE	Alu	AluSz6
CAediting_468450	chr6_31415875_+	SINE	Alu	AluSz6
CAediting_468451	chr6_31415907_+	SINE	Alu	AluSz6
CAediting_468452	chr6_31415916_+	SINE	Alu	AluSz6
CAediting_468453	chr6_31415917_+	SINE	Alu	AluSz6
CAediting_468454	chr6_31415932_+	SINE	Alu	AluSz6
CAediting_468455	chr6_31415935_+	SINE	Alu	AluSz6
CAediting_468456	chr6_31415947_+	SINE	Alu	AluSz6
CAediting_468457	chr6_31418071_+	SINE	Alu	AluSp
CAediting_468458	chr6_31418081_+	SINE	Alu	AluSp
CAediting_468459	chr6_31418819_+	SINE	Alu	FLAM_C
CAediting_468460	chr6_31418863_+	SINE	Alu	FLAM_C
CAediting_468461	chr6_31469108_+	SINE	Alu	AluSx
CAediting_468462	chr6_31469112_+	SINE	Alu	AluSx
CAediting_468463	chr6_31469135_+	SINE	Alu	AluSx
CAediting_468464	chr6_31469188_+	SINE	Alu	AluSx
CAediting_468465	chr6_31475645_+	LTR	ERVL-MaLR	THE1A
CAediting_468466	chr6_31475744_+	LTR	ERVL-MaLR	THE1A
CAediting_468467	chr6_31475783_+	LTR	ERVL-MaLR	THE1A
CAediting_468468	chr6_31475784_+	LTR	ERVL-MaLR	THE1A
CAediting_468469	chr6_31475799_+	LTR	ERVL-MaLR	THE1A
CAediting_468470	chr6_31475800_+	LTR	ERVL-MaLR	THE1A
CAediting_468471	chr6_31475818_+	LTR	ERVL-MaLR	THE1A
CAediting_468472	chr6_31475822_+	LTR	ERVL-MaLR	THE1A

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RNA A-to-I editing events in the alternative splicing sites for HCP5

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000206337.9.HCP5.

Correlation between RNA A-to-I editing and PSI for ENSG00000206337.9.HCP5.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for HCP5

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

BRCA.CAediting_468444.ENSG00000206337.HCP5.png
Soverview

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Protein coding region RNA A-to-I editings for HCP5

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for HCP5

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_117844	chr1_162342605_+	ENSG00000206337.9	ENST00000460889.4	hsa-miR-556-3p	31463428	31463434	7mer-m8	31463414	31463435	147	-9.76
CAediting_468389	chr6_31355314_-	ENSG00000206337.9	ENST00000460889.4	hsa-miR-6891-5p	31463230	31463236	7mer-m8	31463219	31463237	145	-23.85

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for HCP5

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for HCP5

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
STAD	CAediting_468433	chr6_31415724_+	0.0192598412328714	0.231437030371863	.	.	.	.
BRCA	CAediting_468444	chr6_31415829_+	3.56616290294563e-05	0.472897882335488	.	.	.	.
THCA	CAediting_468444	chr6_31415829_+	0.00961420109804093	0.305348626361468	.	.	.	.

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Relation with cancer stages for HCP5

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
STAD	pathologic_stage	CAediting_468438	chr6_31415784_+	0.0440726078854478	0.238025054723842

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Relation with survival for HCP5

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for HCP5

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for HCP5

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene