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Editing gene: ALDH1L1 (CAeditome ID:10840)

Gene summary for ALDH1L1

Gene summary

Gene information	Gene symbol	ALDH1L1
	Gene ID	10840
	Gene name	aldehyde dehydrogenase 1 family member L1
	Synonyms	10-FTHFDH\|10-fTHF\|FDH\|FTHFD
	Cytomap	3q21.3
	Type of gene	protein-coding
	Description	cytosolic 10-formyltetrahydrofolate dehydrogenase10-formyltetrahydrofolate dehydrogenaseMER57B-ALDH1L1
	Modification date	20210518
	UniProtAcc	O75891
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
ALDH1L1	GO:0005829	Cytosolic 10-formyltetrahydrofolate dehydrogenase	0000052

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RNA A-to-I events for ALDH1L1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000144908.12

RNA A-to-I editing events in Cancer.

CAediting_306179(126115569, -), CAediting_306180(126115585, -), CAediting_306181(126115597, -), CAediting_306182(126115643, -), CAediting_306183(126115644, -), CAediting_306184(126115671, -), CAediting_306185(126115712, -), CAediting_306186(126115713, -), CAediting_306187(126115739, -), CAediting_306188(126115751, -), CAediting_306189(126115757, -), CAediting_306190(126115788, -), CAediting_306191(126115793, -), CAediting_306192(126115794, -), CAediting_306193(126115812, -), CAediting_306194(126115847, -), CAediting_306195(126115848, -), CAediting_306196(126115946, -), CAediting_306197(126115951, -), CAediting_306198(126115969, -), CAediting_306199(126115970, -), CAediting_306200(126115978, -), CAediting_306201(126115979, -), CAediting_306202(126115996, -), CAediting_306203(126116005, -), CAediting_306204(126116019, -), CAediting_306205(126116021, -), CAediting_306206(126116033, -), CAediting_306207(126116077, -), CAediting_306208(126116085, -), CAediting_306209(126116086, -), CAediting_306210(126116119, -), CAediting_306211(126116162, -), CAediting_306212(126116305, -), CAediting_306213(126116324, -), CAediting_306214(126116343, -), CAediting_306215(126116362, -), CAediting_306216(126116366, -), CAediting_306217(126116372, -), CAediting_306218(126116382, -), CAediting_306219(126117089, -), CAediting_306220(126117121, -), CAediting_306221(126117123, -), CAediting_306222(126117133, -), CAediting_306223(126117150, -), CAediting_306224(126117194, -), CAediting_306225(126117219, -), CAediting_306226(126117225, -), CAediting_306227(126117227, -), CAediting_306228(126117395, -), CAediting_306229(126117429, -), CAediting_306230(126117434, -), CAediting_306231(126117437, -), CAediting_306232(126117438, -), CAediting_306233(126117452, -), CAediting_306234(126117461, -), CAediting_306235(126117463, -), CAediting_306236(126117487, -), CAediting_306237(126117489, -), CAediting_306238(126117491, -), CAediting_306239(126117512, -), CAediting_306240(126117524, -), CAediting_306241(126117528, -), CAediting_306242(126117532, -), CAediting_306243(126117544, -), CAediting_306244(126117547, -), CAediting_306245(126117548, -), CAediting_306246(126117569, -), CAediting_306247(126117590, -), CAediting_306248(126117595, -), CAediting_306249(126117600, -), CAediting_306250(126117605, -), CAediting_306251(126117630, -), CAediting_306252(126117646, -),

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RNA editing positional annotations for ALDH1L1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_306179	chr3_126115569_-	intronic
CAediting_306180	chr3_126115585_-	intronic
CAediting_306181	chr3_126115597_-	intronic
CAediting_306182	chr3_126115643_-	intronic
CAediting_306183	chr3_126115644_-	intronic
CAediting_306184	chr3_126115671_-	intronic
CAediting_306185	chr3_126115712_-	intronic
CAediting_306186	chr3_126115713_-	intronic
CAediting_306187	chr3_126115739_-	intronic
CAediting_306188	chr3_126115751_-	intronic
CAediting_306189	chr3_126115757_-	intronic
CAediting_306190	chr3_126115788_-	intronic
CAediting_306191	chr3_126115793_-	intronic
CAediting_306192	chr3_126115794_-	intronic
CAediting_306193	chr3_126115812_-	intronic
CAediting_306194	chr3_126115847_-	intronic
CAediting_306195	chr3_126115848_-	intronic
CAediting_306196	chr3_126115946_-	intronic
CAediting_306197	chr3_126115951_-	intronic
CAediting_306198	chr3_126115969_-	intronic
CAediting_306199	chr3_126115970_-	intronic
CAediting_306200	chr3_126115978_-	intronic
CAediting_306201	chr3_126115979_-	intronic
CAediting_306202	chr3_126115996_-	intronic
CAediting_306203	chr3_126116005_-	intronic
CAediting_306204	chr3_126116019_-	intronic
CAediting_306205	chr3_126116021_-	intronic
CAediting_306206	chr3_126116033_-	intronic
CAediting_306207	chr3_126116077_-	intronic
CAediting_306208	chr3_126116085_-	intronic
CAediting_306209	chr3_126116086_-	intronic
CAediting_306210	chr3_126116119_-	intronic
CAediting_306211	chr3_126116162_-	intronic
CAediting_306212	chr3_126116305_-	intronic
CAediting_306213	chr3_126116324_-	intronic
CAediting_306214	chr3_126116343_-	intronic
CAediting_306215	chr3_126116362_-	intronic
CAediting_306216	chr3_126116366_-	intronic
CAediting_306217	chr3_126116372_-	intronic
CAediting_306218	chr3_126116382_-	intronic
CAediting_306219	chr3_126117089_-	intronic
CAediting_306220	chr3_126117121_-	intronic
CAediting_306221	chr3_126117123_-	intronic
CAediting_306222	chr3_126117133_-	intronic
CAediting_306223	chr3_126117150_-	intronic
CAediting_306224	chr3_126117194_-	intronic
CAediting_306225	chr3_126117219_-	intronic
CAediting_306226	chr3_126117225_-	intronic
CAediting_306227	chr3_126117227_-	intronic
CAediting_306228	chr3_126117395_-	intronic
CAediting_306229	chr3_126117429_-	intronic
CAediting_306230	chr3_126117434_-	intronic
CAediting_306231	chr3_126117437_-	intronic
CAediting_306232	chr3_126117438_-	intronic
CAediting_306233	chr3_126117452_-	intronic
CAediting_306234	chr3_126117461_-	intronic
CAediting_306235	chr3_126117463_-	intronic
CAediting_306236	chr3_126117487_-	intronic
CAediting_306237	chr3_126117489_-	intronic
CAediting_306238	chr3_126117491_-	intronic
CAediting_306239	chr3_126117512_-	intronic
CAediting_306240	chr3_126117524_-	intronic
CAediting_306241	chr3_126117528_-	intronic
CAediting_306242	chr3_126117532_-	intronic
CAediting_306243	chr3_126117544_-	intronic
CAediting_306244	chr3_126117547_-	intronic
CAediting_306245	chr3_126117548_-	intronic
CAediting_306246	chr3_126117569_-	intronic
CAediting_306247	chr3_126117590_-	intronic
CAediting_306248	chr3_126117595_-	intronic
CAediting_306249	chr3_126117600_-	intronic
CAediting_306250	chr3_126117605_-	intronic
CAediting_306251	chr3_126117630_-	intronic
CAediting_306252	chr3_126117646_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_306179	chr3_126115569_-	SINE	Alu	AluSq2
CAediting_306180	chr3_126115585_-	SINE	Alu	AluSq2
CAediting_306181	chr3_126115597_-	SINE	Alu	AluSq2
CAediting_306182	chr3_126115643_-	SINE	Alu	AluSq2
CAediting_306183	chr3_126115644_-	SINE	Alu	AluSq2
CAediting_306184	chr3_126115671_-	SINE	Alu	AluSq2
CAediting_306185	chr3_126115712_-	SINE	Alu	AluSq2
CAediting_306186	chr3_126115713_-	SINE	Alu	AluSq2
CAediting_306187	chr3_126115739_-	SINE	Alu	AluSq2
CAediting_306188	chr3_126115751_-	SINE	Alu	AluSq2
CAediting_306189	chr3_126115757_-	SINE	Alu	AluSq2
CAediting_306190	chr3_126115788_-	SINE	Alu	AluSq2
CAediting_306191	chr3_126115793_-	SINE	Alu	AluSq2
CAediting_306192	chr3_126115794_-	SINE	Alu	AluSq2
CAediting_306193	chr3_126115812_-	SINE	Alu	AluSq2
CAediting_306194	chr3_126115847_-	SINE	Alu	AluSq2
CAediting_306195	chr3_126115848_-	SINE	Alu	AluSq2
CAediting_306196	chr3_126115946_-	SINE	Alu	AluSz
CAediting_306197	chr3_126115951_-	SINE	Alu	AluSz
CAediting_306198	chr3_126115969_-	SINE	Alu	AluSz
CAediting_306199	chr3_126115970_-	SINE	Alu	AluSz
CAediting_306200	chr3_126115978_-	SINE	Alu	AluSz
CAediting_306201	chr3_126115979_-	SINE	Alu	AluSz
CAediting_306202	chr3_126115996_-	SINE	Alu	AluSz
CAediting_306203	chr3_126116005_-	SINE	Alu	AluSz
CAediting_306204	chr3_126116019_-	SINE	Alu	AluSz
CAediting_306205	chr3_126116021_-	SINE	Alu	AluSz
CAediting_306206	chr3_126116033_-	SINE	Alu	AluSz
CAediting_306207	chr3_126116077_-	SINE	Alu	AluSz
CAediting_306208	chr3_126116085_-	SINE	Alu	AluSz
CAediting_306209	chr3_126116086_-	SINE	Alu	AluSz
CAediting_306210	chr3_126116119_-	SINE	Alu	AluSz
CAediting_306211	chr3_126116162_-	SINE	Alu	AluSz
CAediting_306212	chr3_126116305_-	SINE	Alu	AluSc8
CAediting_306213	chr3_126116324_-	SINE	Alu	AluSc8
CAediting_306214	chr3_126116343_-	SINE	Alu	AluSc8
CAediting_306215	chr3_126116362_-	SINE	Alu	AluSc8
CAediting_306216	chr3_126116366_-	SINE	Alu	AluSc8
CAediting_306217	chr3_126116372_-	SINE	Alu	AluSc8
CAediting_306218	chr3_126116382_-	SINE	Alu	AluSc8
CAediting_306219	chr3_126117089_-	SINE	Alu	AluJb
CAediting_306220	chr3_126117121_-	SINE	Alu	AluJb
CAediting_306221	chr3_126117123_-	SINE	Alu	AluJb
CAediting_306222	chr3_126117133_-	SINE	Alu	AluJb
CAediting_306223	chr3_126117150_-	SINE	Alu	AluJb
CAediting_306224	chr3_126117194_-	SINE	Alu	AluJb
CAediting_306225	chr3_126117219_-	SINE	Alu	AluJb
CAediting_306226	chr3_126117225_-	SINE	Alu	AluJb
CAediting_306227	chr3_126117227_-	SINE	Alu	AluJb
CAediting_306228	chr3_126117395_-	SINE	Alu	AluJo
CAediting_306229	chr3_126117429_-	SINE	Alu	AluJo
CAediting_306230	chr3_126117434_-	SINE	Alu	AluJo
CAediting_306231	chr3_126117437_-	SINE	Alu	AluJo
CAediting_306232	chr3_126117438_-	SINE	Alu	AluJo
CAediting_306233	chr3_126117452_-	SINE	Alu	AluJo
CAediting_306234	chr3_126117461_-	SINE	Alu	AluJo
CAediting_306235	chr3_126117463_-	SINE	Alu	AluJo
CAediting_306236	chr3_126117487_-	SINE	Alu	AluJo
CAediting_306237	chr3_126117489_-	SINE	Alu	AluJo
CAediting_306238	chr3_126117491_-	SINE	Alu	AluJo
CAediting_306239	chr3_126117512_-	SINE	Alu	AluJo
CAediting_306240	chr3_126117524_-	SINE	Alu	AluJo
CAediting_306241	chr3_126117528_-	SINE	Alu	AluJo
CAediting_306242	chr3_126117532_-	SINE	Alu	AluJo
CAediting_306243	chr3_126117544_-	SINE	Alu	AluJo
CAediting_306244	chr3_126117547_-	SINE	Alu	AluJo
CAediting_306245	chr3_126117548_-	SINE	Alu	AluJo
CAediting_306246	chr3_126117569_-	SINE	Alu	AluJo
CAediting_306247	chr3_126117590_-	SINE	Alu	AluJo
CAediting_306248	chr3_126117595_-	SINE	Alu	AluJo
CAediting_306249	chr3_126117600_-	SINE	Alu	AluJo
CAediting_306250	chr3_126117605_-	SINE	Alu	AluJo
CAediting_306251	chr3_126117630_-	SINE	Alu	AluJo
CAediting_306252	chr3_126117646_-	SINE	Alu	AluJo

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RNA A-to-I editing events in the alternative splicing sites for ALDH1L1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000144908.12.ALDH1L1.

Correlation between RNA A-to-I editing and PSI for ENSG00000144908.12.ALDH1L1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ALDH1L1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ALDH1L1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ALDH1L1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000144908.12	ENST00000473607	hsa-miR-200b-3p	126137819	126137825	7mer-m8	126137818	126137840	149	-16.96
CAediting_1306323	chr19_13836462_-	ENSG00000144908.12	ENST00000473607	hsa-miR-27a-3p	126157390	126157396	7mer-m8	126157389	126157409	147	-23.17
CAediting_1368054	chr19_46709310_-	ENSG00000144908.12	ENST00000473607	hsa-miR-320e	126136836	126136842	7mer-m8	126136835	126136851	142	-15.19

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ALDH1L1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for ALDH1L1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for ALDH1L1

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
KIRC	pathologic_stage	CAediting_306182	chr3_126115643_-	0.00581213746973514	0.352011909874501

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Relation with survival for ALDH1L1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for ALDH1L1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ALDH1L1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
ALDH1L1	C0003129	Anoxemia	1	CTD_human
ALDH1L1	C0003130	Anoxia	1	CTD_human
ALDH1L1	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
ALDH1L1	C0028754	Obesity	1	CTD_human
ALDH1L1	C0242184	Hypoxia	1	CTD_human
ALDH1L1	C0700292	Hypoxemia	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene