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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: NEU3 (CAeditome ID:10825)

Gene summary for NEU3

check button Gene summary
Gene informationGene symbol

NEU3

Gene ID

10825

Gene nameneuraminidase 3
SynonymsSIAL3
Cytomap

11q13.4

Type of geneprotein-coding
Descriptionsialidase-3N-acetyl-alpha-neuraminidase 3ganglioside sialidaseganglioside sialidasedismembrane sialidasesialidase 3 (membrane sialidase)
Modification date20210518
UniProtAcc

Q9UQ49

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
NEU3

GO:0005975

Sialidase-3

12730204

NEU3

GO:0004308

Sialidase-3

10861246

NEU3

GO:0016997

Sialidase-3

12730204

NEU3

GO:0052794

Sialidase-3

11298736

NEU3

GO:0052794

Sialidase-3

15847605

NEU3

GO:0052794

Sialidase-3

17334392

NEU3

GO:0052796

Sialidase-3

15847605

NEU3

GO:0006689

Sialidase-3

10861246

NEU3

GO:0006689

Sialidase-3

11298736

NEU3

GO:0006689

Sialidase-3

15847605

NEU3

GO:0006689

Sialidase-3

17334392

NEU3

GO:0009313

Sialidase-3

10861246

NEU3

GO:1900186

Sialidase-3

26251452

NEU3

GO:0005765

Sialidase-3

26251452

NEU3

GO:0005886

Sialidase-3

12730204

NEU3

GO:0005886

Sialidase-3

26251452

NEU3

GO:0031901

Sialidase-3

26251452

NEU3

GO:0055038

Sialidase-3

26251452


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RNA A-to-I events for NEU3

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000162139.8

check button RNA A-to-I editing events in Cancer.
CAediting_840873(74997590, +), CAediting_840874(74997591, +), CAediting_840875(74997596, +), CAediting_840876(74997657, +), CAediting_840877(74997658, +), CAediting_840878(74997742, +), CAediting_840879(74997743, +), CAediting_840880(74997783, +), CAediting_840881(74997846, +), CAediting_840882(74999052, +), CAediting_840883(74999250, +), CAediting_840884(75001416, +), CAediting_840885(75001466, +), CAediting_840886(75002076, +), CAediting_840887(75002077, +), CAediting_840888(75002079, +), CAediting_840889(75002115, +), CAediting_840890(75002154, +), CAediting_840891(75002155, +), CAediting_840892(75002243, +), CAediting_840893(75004340, +), CAediting_840894(75004365, +), CAediting_840895(75008616, +), CAediting_840896(75008634, +), CAediting_840897(75008672, +), CAediting_840898(75008680, +), CAediting_840899(75008684, +), CAediting_840900(75008736, +), CAediting_840901(75008753, +), CAediting_840902(75008816, +), CAediting_840903(75008828, +), CAediting_840904(75010023, +), CAediting_840905(75014744, +),

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RNA editing positional annotations for NEU3 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_840894chr11_75004365_+nonsynonymous SNVENST00000531619.1c.A367Gp.K123ED.N

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_840873chr11_74997590_+intronic
CAediting_840874chr11_74997591_+intronic
CAediting_840875chr11_74997596_+intronic
CAediting_840876chr11_74997657_+intronic
CAediting_840877chr11_74997658_+intronic
CAediting_840878chr11_74997742_+intronic
CAediting_840879chr11_74997743_+intronic
CAediting_840880chr11_74997783_+intronic
CAediting_840881chr11_74997846_+intronic
CAediting_840882chr11_74999052_+intronic
CAediting_840883chr11_74999250_+intronic
CAediting_840884chr11_75001416_+intronic
CAediting_840885chr11_75001466_+intronic
CAediting_840886chr11_75002076_+intronic
CAediting_840887chr11_75002077_+intronic
CAediting_840888chr11_75002079_+intronic
CAediting_840889chr11_75002115_+intronic
CAediting_840890chr11_75002154_+intronic
CAediting_840891chr11_75002155_+intronic
CAediting_840892chr11_75002243_+intronic
CAediting_840893chr11_75004340_+exonic
CAediting_840894chr11_75004365_+exonic
CAediting_840895chr11_75008616_+UTR3
CAediting_840896chr11_75008634_+UTR3
CAediting_840897chr11_75008672_+UTR3
CAediting_840898chr11_75008680_+UTR3
CAediting_840899chr11_75008684_+UTR3
CAediting_840900chr11_75008736_+UTR3
CAediting_840901chr11_75008753_+UTR3
CAediting_840902chr11_75008816_+UTR3
CAediting_840903chr11_75008828_+UTR3
CAediting_840904chr11_75010023_+UTR3
CAediting_840905chr11_75014744_+intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_840873chr11_74997590_+SINEAluAluSx3
CAediting_840874chr11_74997591_+SINEAluAluSx3
CAediting_840875chr11_74997596_+SINEAluAluSx3
CAediting_840876chr11_74997657_+SINEAluAluSx3
CAediting_840877chr11_74997658_+SINEAluAluSx3
CAediting_840878chr11_74997742_+SINEAluAluSx3
CAediting_840879chr11_74997743_+SINEAluAluSx3
CAediting_840880chr11_74997783_+SINEAluAluSx3
CAediting_840881chr11_74997846_+SINEAluAluSx3
CAediting_840882chr11_74999052_+SINEAluFLAM_A
CAediting_840883chr11_74999250_+SINEAluFAM
CAediting_840884chr11_75001416_+SINEAluAluSz
CAediting_840885chr11_75001466_+SINEAluAluSz
CAediting_840886chr11_75002076_+SINEAluAluJr4
CAediting_840887chr11_75002077_+SINEAluAluJr4
CAediting_840888chr11_75002079_+SINEAluAluJr4
CAediting_840889chr11_75002115_+SINEAluAluJr4
CAediting_840890chr11_75002154_+SINEAluAluJr4
CAediting_840891chr11_75002155_+SINEAluAluJr4
CAediting_840892chr11_75002243_+SINEAluAluJr4
CAediting_840893chr11_75004340_+SINEAluFLAM_C
CAediting_840894chr11_75004365_+SINEAluFLAM_C
CAediting_840895chr11_75008616_+SINEAluAluSx3
CAediting_840896chr11_75008634_+SINEAluAluSx3
CAediting_840897chr11_75008672_+SINEAluAluSx3
CAediting_840898chr11_75008680_+SINEAluAluSx3
CAediting_840899chr11_75008684_+SINEAluAluSx3
CAediting_840900chr11_75008736_+SINEAluAluSx3
CAediting_840901chr11_75008753_+SINEAluAluSx3
CAediting_840902chr11_75008816_+SINEAluAluSx3
CAediting_840903chr11_75008828_+SINEAluAluSx3
CAediting_840905chr11_75014744_+SINEAluAluJb

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RNA A-to-I editing events in the alternative splicing sites for NEU3

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000162139.8.NEU3.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000162139.8.NEU3.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NEU3

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for NEU3

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for NEU3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_840898chr11_75008680_+ENSG00000162139.8ENST00000294064hsa-miR-6771-5p75008674750086807mer-m87500866275008681160.00-34.33
CAediting_840899chr11_75008684_+ENSG00000162139.8ENST00000294064hsa-miR-3614-5p75008677750086837mer-m87500866175008684152.00-25.27
CAediting_840899chr11_75008684_+ENSG00000162139.8ENST00000294064hsa-miR-4691-3p75008681750086877mer-m87500866175008688150.00-26.36
CAediting_840902chr11_75008816_+ENSG00000162139.8ENST00000294064hsa-miR-3189-3p75008810750088167mer-m87500879875008817145.00-25.82
CAediting_840902chr11_75008816_+ENSG00000162139.8ENST00000294064hsa-miR-6813-3p75008811750088177mer-m87500879875008818140.00-12.15
CAediting_840903chr11_75008828_+ENSG00000162139.8ENST00000294064hsa-miR-20a-3p75008824750088307mer-m87500881075008831170.00-20.77

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_840903chr11_75008828_+ENSG00000162139.8ENST00000294064hsa-miR-10395-3p75008823750088297mer-m87500880775008830150-11.28
CAediting_840898chr11_75008680_+ENSG00000162139.8ENST00000294064hsa-miR-1212675008676750086838mer-1a7500866075008683147-13.23
CAediting_840895chr11_75008616_+ENSG00000162139.8ENST00000294064hsa-miR-1227-3p75008610750086178mer-1a7500859875008617152-18.2
CAediting_840896chr11_75008634_+ENSG00000162139.8ENST00000294064hsa-miR-17-3p75008628750086347mer-m87500861375008635153-19.01
CAediting_840898chr11_75008680_+ENSG00000162139.8ENST00000294064hsa-miR-30b-3p75008673750086808mer-1a7500865975008680151-15.38
CAediting_840898chr11_75008680_+ENSG00000162139.8ENST00000294064hsa-miR-3689a-3p75008673750086808mer-1a7500866075008680147-18.72
CAediting_840898chr11_75008680_+ENSG00000162139.8ENST00000294064hsa-miR-3689b-3p75008673750086808mer-1a7500866075008680147-17.55
CAediting_840898chr11_75008680_+ENSG00000162139.8ENST00000294064hsa-miR-3689c75008673750086808mer-1a7500866075008680147-17.55
CAediting_840896chr11_75008634_+ENSG00000162139.8ENST00000294064hsa-miR-441875008629750086357mer-m87500861775008636149-14.74
CAediting_840897chr11_75008672_+ENSG00000162139.8ENST00000294064hsa-miR-447875008669750086757mer-m87500866175008676149-25.05
CAediting_840897chr11_75008672_+ENSG00000162139.8ENST00000294064hsa-miR-4649-3p75008666750086727mer-m87500865375008673140-14.11
CAediting_840903chr11_75008828_+ENSG00000162139.8ENST00000294064hsa-miR-4742-3p75008824750088307mer-m87500880575008831155-20.04
CAediting_840896chr11_75008634_+ENSG00000162139.8ENST00000294064hsa-miR-509-3-5p75008629750086357mer-m87500861375008636141-15.45
CAediting_840896chr11_75008634_+ENSG00000162139.8ENST00000294064hsa-miR-509-5p75008629750086357mer-m87500861675008636151-13.05
CAediting_840896chr11_75008634_+ENSG00000162139.8ENST00000294064hsa-miR-509-5p75008629750086357mer-m87500861675008636151-13.05
CAediting_840899chr11_75008684_+ENSG00000162139.8ENST00000294064hsa-miR-569075008681750086877mer-m87500866875008688145-16.74
CAediting_840898chr11_75008680_+ENSG00000162139.8ENST00000294064hsa-miR-6779-5p75008673750086808mer-1a7500866275008680148-22.58
CAediting_840898chr11_75008680_+ENSG00000162139.8ENST00000294064hsa-miR-6780a-5p75008673750086808mer-1a7500865775008680152-25.37
CAediting_840897chr11_75008672_+ENSG00000162139.8ENST00000294064hsa-miR-7160-5p75008667750086737mer-m87500865475008674147-20.02
CAediting_840901chr11_75008753_+ENSG00000162139.8ENST00000294064hsa-miR-7855-5p75008750750087556mer7500873675008756140-24.29
CAediting_840896chr11_75008634_+ENSG00000162139.8ENST00000294064hsa-miR-873-3p75008632750086387mer-m87500861675008639153-25.14
CAediting_840898chr11_75008680_+ENSG00000162139.8ENST00000294064hsa-miR-887-5p75008674750086807mer-m87500866275008681143-19.73

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_748296chr10_51299626_+ENSG00000162139.8ENST00000294064hsa-miR-605-3p75008971750089777mer-m87500895675008978160-18.49
CAediting_748296chr10_51299626_+ENSG00000162139.8ENST00000294064hsa-miR-605-3p75009634750096418mer-1a7500961775009641142-18.04
CAediting_748296chr10_51299626_+ENSG00000162139.8ENST00000294064hsa-miR-605-3p75007334750073418mer-1a7500731475007341145-15.78
CAediting_688081chr9_63819627_+ENSG00000162139.8ENST00000294064hsa-miR-4477b75010727750107337mer-m87501071375010734150-14.69
CAediting_980496chr14_31014685_-ENSG00000162139.8ENST00000532963hsa-miR-624-3p75005914750059207mer-m87500590075005921142-22.6
CAediting_1229415chr17_67471547_+ENSG00000162139.8ENST00000529024hsa-miR-548aa75018869750188757mer-m87501885075018876154-11.22
CAediting_1229415chr17_67471547_+ENSG00000162139.8ENST00000294064hsa-miR-548aa75008040750080467mer-m87500802375008047152-17.77
CAediting_1229415chr17_67471547_+ENSG00000162139.8ENST00000294064hsa-miR-548aa75010598750106047mer-m87501057775010605147-15.6
CAediting_1229415chr17_67471547_+ENSG00000162139.8ENST00000294064hsa-miR-548aa75010809750108157mer-m87501079375010816144-9.13
CAediting_1399425chr20_1392958_-ENSG00000162139.8ENST00000294064hsa-miR-6869-5p75009443750094497mer-1a7500942975009449146-24.72
CAediting_228905chr2_188297554_+ENSG00000162139.8ENST00000294064hsa-miR-561-3p75009030750090367mer-m87500901775009037152-10.06
CAediting_396018chr5_1062918_-ENSG00000162139.8ENST00000294064hsa-miR-463575007337750073437mer-m87500732475007344154-16.79
CAediting_524911chr7_5495852_-ENSG00000162139.8ENST00000532963hsa-miR-589-3p75006326750063327mer-m87500631375006333151-24.32
CAediting_1229413chr17_67471544_+ENSG00000162139.8ENST00000534628hsa-miR-548aa74995024749950318mer-1a7499500674995031154-14.15
CAediting_468389chr6_31355314_-ENSG00000162139.8ENST00000531509hsa-miR-6891-5p75006613750066197mer-m87500660175006620156-22.06
CAediting_468389chr6_31355314_-ENSG00000162139.8ENST00000294064hsa-miR-6891-5p75006613750066197mer-m87500660175006620156-22.06
CAediting_468389chr6_31355314_-ENSG00000162139.8ENST00000294064hsa-miR-6891-5p75008974750089807mer-m87500896375008981153-23.15
CAediting_468389chr6_31355314_-ENSG00000162139.8ENST00000294064hsa-miR-6891-5p75009975750099817mer-m87500996475009982149-24.24
CAediting_468389chr6_31355314_-ENSG00000162139.8ENST00000532963hsa-miR-6891-5p75006613750066197mer-m87500660175006620156-22.06

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1306324chr19_13836464_-ENSG00000162139.8ENST00000294064hsa-miR-27a-3p75009251750092577mer-1a7500923775009257145-22.78
CAediting_1306323chr19_13836462_-ENSG00000162139.8ENST00000294064hsa-miR-27a-3p75009251750092577mer-1a7500923775009257145-22.78
CAediting_1306324chr19_13836464_-ENSG00000162139.8ENST00000294064hsa-miR-27a-3p75009555750095617mer-1a7500954175009561141-20.16
CAediting_1306323chr19_13836462_-ENSG00000162139.8ENST00000294064hsa-miR-27a-3p75009555750095617mer-1a7500954175009561141-20.16
CAediting_396018chr5_1062918_-ENSG00000162139.8ENST00000294064hsa-miR-463575010535750105417mer-m87501051875010542150-18.83
CAediting_1229413chr17_67471544_+ENSG00000162139.8ENST00000294064hsa-miR-548aa75007698750077047mer-m87500768175007705140-7.03
CAediting_1229415chr17_67471547_+ENSG00000162139.8ENST00000294064hsa-miR-548aa75007698750077047mer-m87500768175007705140-7.03
CAediting_524911chr7_5495852_-ENSG00000162139.8ENST00000294064hsa-miR-589-3p75010523750105297mer-m87501050775010530142-10.82
CAediting_524911chr7_5495852_-ENSG00000162139.8ENST00000294064hsa-miR-589-3p75010793750108008mer-1a7501077775010800151-18.92
CAediting_1351755chr19_40282625_-ENSG00000162139.8ENST00000294064hsa-miR-64175010804750108096mer7501078975010810145-19.82
CAediting_1399425chr20_1392958_-ENSG00000162139.8ENST00000294064hsa-miR-6869-5p75008875750088828mer-1a7500886175008882145-14.32

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for NEU3

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for NEU3

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for NEU3

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for NEU3

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for NEU3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NEU3

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource