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Editing gene: CCT8 (CAeditome ID:10694)

Gene summary for CCT8

Gene summary

Gene information	Gene symbol	CCT8
	Gene ID	10694
	Gene name	chaperonin containing TCP1 subunit 8
	Synonyms	C21orf112\|Cctq\|D21S246\|PRED71
	Cytomap	21q21.3
	Type of gene	protein-coding
	Description	T-complex protein 1 subunit thetaCCT-thetaTCP-1-thetachaperonin containing T-complex polypeptide 1 subunit 8chaperonin containing TCP1, subunit 8 (theta)renal carcinoma antigen NY-REN-15
	Modification date	20210518
	UniProtAcc	P50990
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CCT8	GO:0044183	T-complex protein 1 subunit theta	30955883
CCT8	GO:0006457	T-complex protein 1 subunit theta	30955883
CCT8	GO:0005654	T-complex protein 1 subunit theta	0000052
CCT8	GO:0005737	T-complex protein 1 subunit theta	25468996
CCT8	GO:0005813	T-complex protein 1 subunit theta	20080638
CCT8	GO:0005829	T-complex protein 1 subunit theta	0000052
CCT8	GO:0005874	T-complex protein 1 subunit theta	21525035
CCT8	GO:0045111	T-complex protein 1 subunit theta	0000052
CCT8	GO:0005832	T-complex protein 1 subunit theta	23011926
CCT8	GO:0005832	T-complex protein 1 subunit theta	30955883

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RNA A-to-I events for CCT8

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000156261.11

RNA A-to-I editing events in Cancer.

CAediting_1446227(29057217, -), CAediting_1446228(29057296, -), CAediting_1446229(29057440, -), CAediting_1446230(29057444, -), CAediting_1446231(29057526, -), CAediting_1446232(29057532, -), CAediting_1446233(29057533, -), CAediting_1446234(29057586, -), CAediting_1446235(29057770, -), CAediting_1446236(29057786, -), CAediting_1446237(29057799, -), CAediting_1446238(29057914, -), CAediting_1446239(29057975, -), CAediting_1446240(29057997, -), CAediting_1446241(29058005, -), CAediting_1446242(29058012, -), CAediting_1446243(29058013, -), CAediting_1446244(29058319, -), CAediting_1446245(29058649, -), CAediting_1446246(29058659, -), CAediting_1446247(29058668, -), CAediting_1446248(29058688, -), CAediting_1446249(29058700, -), CAediting_1446250(29058703, -), CAediting_1446251(29058707, -), CAediting_1446252(29058730, -), CAediting_1446253(29058756, -), CAediting_1446254(29058773, -), CAediting_1446255(29058789, -), CAediting_1446256(29058797, -), CAediting_1446257(29058807, -), CAediting_1446258(29058864, -), CAediting_1446259(29058865, -), CAediting_1446260(29058873, -), CAediting_1446261(29059006, -), CAediting_1446262(29059058, -), CAediting_1446263(29063133, -), CAediting_1446264(29063805, -), CAediting_1446265(29063852, -), CAediting_1446266(29063860, -), CAediting_1446267(29063863, -), CAediting_1446268(29063864, -), CAediting_1446269(29063904, -), CAediting_1446270(29063949, -), CAediting_1446271(29063960, -), CAediting_1446272(29063961, -), CAediting_1446273(29063962, -), CAediting_1446274(29063968, -), CAediting_1446275(29063970, -), CAediting_1446276(29063980, -), CAediting_1446277(29063985, -), CAediting_1446278(29063991, -), CAediting_1446279(29063994, -), CAediting_1446280(29064006, -), CAediting_1446281(29064007, -), CAediting_1446282(29064011, -), CAediting_1446283(29064015, -), CAediting_1446284(29064031, -), CAediting_1446285(29064032, -), CAediting_1446286(29064045, -), CAediting_1446287(29064050, -), CAediting_1446288(29064200, -), CAediting_1446289(29064207, -), CAediting_1446290(29064209, -), CAediting_1446291(29064212, -), CAediting_1446292(29064215, -), CAediting_1446293(29064221, -), CAediting_1446294(29064240, -), CAediting_1446295(29064254, -), CAediting_1446296(29064262, -), CAediting_1446297(29064272, -), CAediting_1446298(29064274, -), CAediting_1446299(29064283, -), CAediting_1446300(29064286, -), CAediting_1446301(29064292, -), CAediting_1446302(29064294, -), CAediting_1446303(29064296, -), CAediting_1446304(29064298, -), CAediting_1446305(29064300, -), CAediting_1446306(29064302, -), CAediting_1446307(29064303, -), CAediting_1446308(29064317, -), CAediting_1446309(29064318, -), CAediting_1446310(29064332, -), CAediting_1446311(29064353, -),

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RNA editing positional annotations for CCT8 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1446227	chr21_29057217_-	ncRNA_intronic
CAediting_1446228	chr21_29057296_-	ncRNA_intronic
CAediting_1446229	chr21_29057440_-	ncRNA_intronic
CAediting_1446230	chr21_29057444_-	ncRNA_intronic
CAediting_1446231	chr21_29057526_-	ncRNA_intronic
CAediting_1446232	chr21_29057532_-	ncRNA_intronic
CAediting_1446233	chr21_29057533_-	ncRNA_intronic
CAediting_1446234	chr21_29057586_-	ncRNA_intronic
CAediting_1446235	chr21_29057770_-	ncRNA_intronic
CAediting_1446236	chr21_29057786_-	ncRNA_intronic
CAediting_1446237	chr21_29057799_-	ncRNA_intronic
CAediting_1446238	chr21_29057914_-	ncRNA_intronic
CAediting_1446239	chr21_29057975_-	ncRNA_intronic
CAediting_1446240	chr21_29057997_-	ncRNA_intronic
CAediting_1446241	chr21_29058005_-	ncRNA_intronic
CAediting_1446242	chr21_29058012_-	ncRNA_intronic
CAediting_1446243	chr21_29058013_-	ncRNA_intronic
CAediting_1446244	chr21_29058319_-	ncRNA_intronic
CAediting_1446245	chr21_29058649_-	ncRNA_intronic
CAediting_1446246	chr21_29058659_-	ncRNA_intronic
CAediting_1446247	chr21_29058668_-	ncRNA_intronic
CAediting_1446248	chr21_29058688_-	ncRNA_intronic
CAediting_1446249	chr21_29058700_-	ncRNA_intronic
CAediting_1446250	chr21_29058703_-	ncRNA_intronic
CAediting_1446251	chr21_29058707_-	ncRNA_intronic
CAediting_1446252	chr21_29058730_-	ncRNA_intronic
CAediting_1446253	chr21_29058756_-	ncRNA_intronic
CAediting_1446254	chr21_29058773_-	ncRNA_intronic
CAediting_1446255	chr21_29058789_-	ncRNA_intronic
CAediting_1446256	chr21_29058797_-	ncRNA_intronic
CAediting_1446257	chr21_29058807_-	ncRNA_intronic
CAediting_1446258	chr21_29058864_-	ncRNA_intronic
CAediting_1446259	chr21_29058865_-	ncRNA_intronic
CAediting_1446260	chr21_29058873_-	ncRNA_intronic
CAediting_1446261	chr21_29059006_-	ncRNA_intronic
CAediting_1446262	chr21_29059058_-	ncRNA_intronic
CAediting_1446263	chr21_29063133_-	ncRNA_intronic
CAediting_1446264	chr21_29063805_-	ncRNA_intronic
CAediting_1446265	chr21_29063852_-	ncRNA_intronic
CAediting_1446266	chr21_29063860_-	ncRNA_intronic
CAediting_1446267	chr21_29063863_-	ncRNA_intronic
CAediting_1446268	chr21_29063864_-	ncRNA_intronic
CAediting_1446269	chr21_29063904_-	ncRNA_intronic
CAediting_1446270	chr21_29063949_-	ncRNA_intronic
CAediting_1446271	chr21_29063960_-	ncRNA_intronic
CAediting_1446272	chr21_29063961_-	ncRNA_intronic
CAediting_1446273	chr21_29063962_-	ncRNA_intronic
CAediting_1446274	chr21_29063968_-	ncRNA_intronic
CAediting_1446275	chr21_29063970_-	ncRNA_intronic
CAediting_1446276	chr21_29063980_-	ncRNA_intronic
CAediting_1446277	chr21_29063985_-	ncRNA_intronic
CAediting_1446278	chr21_29063991_-	ncRNA_intronic
CAediting_1446279	chr21_29063994_-	ncRNA_intronic
CAediting_1446280	chr21_29064006_-	ncRNA_intronic
CAediting_1446281	chr21_29064007_-	ncRNA_intronic
CAediting_1446282	chr21_29064011_-	ncRNA_intronic
CAediting_1446283	chr21_29064015_-	ncRNA_intronic
CAediting_1446284	chr21_29064031_-	ncRNA_intronic
CAediting_1446285	chr21_29064032_-	ncRNA_intronic
CAediting_1446286	chr21_29064045_-	ncRNA_intronic
CAediting_1446287	chr21_29064050_-	ncRNA_intronic
CAediting_1446288	chr21_29064200_-	ncRNA_intronic
CAediting_1446289	chr21_29064207_-	ncRNA_intronic
CAediting_1446290	chr21_29064209_-	ncRNA_intronic
CAediting_1446291	chr21_29064212_-	ncRNA_intronic
CAediting_1446292	chr21_29064215_-	ncRNA_intronic
CAediting_1446293	chr21_29064221_-	ncRNA_intronic
CAediting_1446294	chr21_29064240_-	ncRNA_intronic
CAediting_1446295	chr21_29064254_-	ncRNA_intronic
CAediting_1446296	chr21_29064262_-	ncRNA_intronic
CAediting_1446297	chr21_29064272_-	ncRNA_intronic
CAediting_1446298	chr21_29064274_-	ncRNA_intronic
CAediting_1446299	chr21_29064283_-	ncRNA_intronic
CAediting_1446300	chr21_29064286_-	ncRNA_intronic
CAediting_1446301	chr21_29064292_-	ncRNA_intronic
CAediting_1446302	chr21_29064294_-	ncRNA_intronic
CAediting_1446303	chr21_29064296_-	ncRNA_intronic
CAediting_1446304	chr21_29064298_-	ncRNA_intronic
CAediting_1446305	chr21_29064300_-	ncRNA_intronic
CAediting_1446306	chr21_29064302_-	ncRNA_intronic
CAediting_1446307	chr21_29064303_-	ncRNA_intronic
CAediting_1446308	chr21_29064317_-	ncRNA_intronic
CAediting_1446309	chr21_29064318_-	ncRNA_intronic
CAediting_1446310	chr21_29064332_-	ncRNA_intronic
CAediting_1446311	chr21_29064353_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1446227	chr21_29057217_-	SINE	Alu	AluSx1
CAediting_1446228	chr21_29057296_-	SINE	Alu	AluSx1
CAediting_1446229	chr21_29057440_-	SINE	Alu	AluSx1
CAediting_1446230	chr21_29057444_-	SINE	Alu	AluSx1
CAediting_1446231	chr21_29057526_-	SINE	Alu	AluJr4
CAediting_1446232	chr21_29057532_-	SINE	Alu	AluJr4
CAediting_1446233	chr21_29057533_-	SINE	Alu	AluJr4
CAediting_1446234	chr21_29057586_-	SINE	Alu	AluJr4
CAediting_1446235	chr21_29057770_-	Simple_repeat	Simple_repeat	(TA)n
CAediting_1446236	chr21_29057786_-	Simple_repeat	Simple_repeat	(TA)n
CAediting_1446237	chr21_29057799_-	Simple_repeat	Simple_repeat	(TA)n
CAediting_1446238	chr21_29057914_-	SINE	Alu	AluJo
CAediting_1446239	chr21_29057975_-	SINE	Alu	AluJo
CAediting_1446240	chr21_29057997_-	SINE	Alu	AluJo
CAediting_1446241	chr21_29058005_-	SINE	Alu	AluJo
CAediting_1446242	chr21_29058012_-	SINE	Alu	AluJo
CAediting_1446243	chr21_29058013_-	SINE	Alu	AluJo
CAediting_1446244	chr21_29058319_-	SINE	Alu	AluSc
CAediting_1446245	chr21_29058649_-	SINE	Alu	AluY
CAediting_1446246	chr21_29058659_-	SINE	Alu	AluY
CAediting_1446247	chr21_29058668_-	SINE	Alu	AluY
CAediting_1446248	chr21_29058688_-	SINE	Alu	AluY
CAediting_1446249	chr21_29058700_-	SINE	Alu	AluY
CAediting_1446250	chr21_29058703_-	SINE	Alu	AluY
CAediting_1446251	chr21_29058707_-	SINE	Alu	AluY
CAediting_1446252	chr21_29058730_-	SINE	Alu	AluY
CAediting_1446253	chr21_29058756_-	SINE	Alu	AluY
CAediting_1446254	chr21_29058773_-	SINE	Alu	AluY
CAediting_1446255	chr21_29058789_-	SINE	Alu	AluY
CAediting_1446256	chr21_29058797_-	SINE	Alu	AluY
CAediting_1446257	chr21_29058807_-	SINE	Alu	AluY
CAediting_1446258	chr21_29058864_-	SINE	Alu	AluY
CAediting_1446259	chr21_29058865_-	SINE	Alu	AluY
CAediting_1446260	chr21_29058873_-	SINE	Alu	AluY
CAediting_1446261	chr21_29059006_-	SINE	Alu	FRAM
CAediting_1446262	chr21_29059058_-	SINE	Alu	FRAM
CAediting_1446263	chr21_29063133_-	LINE	L2	L2c
CAediting_1446264	chr21_29063805_-	SINE	Alu	AluSc5
CAediting_1446265	chr21_29063852_-	SINE	Alu	AluSc5
CAediting_1446266	chr21_29063860_-	SINE	Alu	AluSc5
CAediting_1446267	chr21_29063863_-	SINE	Alu	AluSc5
CAediting_1446268	chr21_29063864_-	SINE	Alu	AluSc5
CAediting_1446269	chr21_29063904_-	SINE	Alu	AluSc5
CAediting_1446270	chr21_29063949_-	SINE	Alu	AluSc5
CAediting_1446271	chr21_29063960_-	SINE	Alu	AluSc5
CAediting_1446272	chr21_29063961_-	SINE	Alu	AluSc5
CAediting_1446273	chr21_29063962_-	SINE	Alu	AluSc5
CAediting_1446274	chr21_29063968_-	SINE	Alu	AluSc5
CAediting_1446275	chr21_29063970_-	SINE	Alu	AluSc5
CAediting_1446276	chr21_29063980_-	SINE	Alu	AluSc5
CAediting_1446277	chr21_29063985_-	SINE	Alu	AluSc5
CAediting_1446278	chr21_29063991_-	SINE	Alu	AluSc5
CAediting_1446279	chr21_29063994_-	SINE	Alu	AluSc5
CAediting_1446280	chr21_29064006_-	SINE	Alu	AluSc5
CAediting_1446281	chr21_29064007_-	SINE	Alu	AluSc5
CAediting_1446282	chr21_29064011_-	SINE	Alu	AluSc5
CAediting_1446283	chr21_29064015_-	SINE	Alu	AluSc5
CAediting_1446284	chr21_29064031_-	SINE	Alu	AluSc5
CAediting_1446285	chr21_29064032_-	SINE	Alu	AluSc5
CAediting_1446286	chr21_29064045_-	SINE	Alu	AluSc5
CAediting_1446287	chr21_29064050_-	SINE	Alu	AluSc5
CAediting_1446288	chr21_29064200_-	SINE	Alu	AluSz
CAediting_1446289	chr21_29064207_-	SINE	Alu	AluSz
CAediting_1446290	chr21_29064209_-	SINE	Alu	AluSz
CAediting_1446291	chr21_29064212_-	SINE	Alu	AluSz
CAediting_1446292	chr21_29064215_-	SINE	Alu	AluSz
CAediting_1446293	chr21_29064221_-	SINE	Alu	AluSz
CAediting_1446294	chr21_29064240_-	SINE	Alu	AluSz
CAediting_1446295	chr21_29064254_-	SINE	Alu	AluSz
CAediting_1446296	chr21_29064262_-	SINE	Alu	AluSz
CAediting_1446297	chr21_29064272_-	SINE	Alu	AluSz
CAediting_1446298	chr21_29064274_-	SINE	Alu	AluSz
CAediting_1446299	chr21_29064283_-	SINE	Alu	AluSz
CAediting_1446300	chr21_29064286_-	SINE	Alu	AluSz
CAediting_1446301	chr21_29064292_-	SINE	Alu	AluSz
CAediting_1446302	chr21_29064294_-	SINE	Alu	AluSz
CAediting_1446303	chr21_29064296_-	SINE	Alu	AluSz
CAediting_1446304	chr21_29064298_-	SINE	Alu	AluSz
CAediting_1446305	chr21_29064300_-	SINE	Alu	AluSz
CAediting_1446306	chr21_29064302_-	SINE	Alu	AluSz
CAediting_1446307	chr21_29064303_-	SINE	Alu	AluSz
CAediting_1446308	chr21_29064317_-	SINE	Alu	AluSz
CAediting_1446309	chr21_29064318_-	SINE	Alu	AluSz
CAediting_1446310	chr21_29064332_-	SINE	Alu	AluSz
CAediting_1446311	chr21_29064353_-	SINE	Alu	AluSz

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RNA A-to-I editing events in the alternative splicing sites for CCT8

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000156261.11.CCT8.

Correlation between RNA A-to-I editing and PSI for ENSG00000156261.11.CCT8.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CCT8

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CCT8

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CCT8

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CCT8

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for CCT8

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BLCA	CAediting_1446265	chr21_29063852_-	0.00304555581034813	0.35416978493189	.	.	.	.
BRCA	CAediting_1446265	chr21_29063852_-	0.0010194694197021	0.307690211890921	.	.	.	.
LUSC	CAediting_1446265	chr21_29063852_-	0.0417270522263463	0.226815536513728	0.0249511946569598	0.249059865844276	.	.

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Relation with cancer stages for CCT8

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CCT8

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CCT8

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CCT8

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene