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Editing gene: RABGAP1L-IT1 (CAeditome ID:106480742)

Gene summary for RABGAP1L-IT1

Gene summary

Gene information	Gene symbol	RABGAP1L-IT1
	Gene ID	106480742
	Gene name	RABGAP1L intronic transcript 1
	Synonyms	-
	Cytomap	1q25.1
	Type of gene	ncRNA
	Description	RABGAP1L intronic transcript 1 (non-protein coding)
	Modification date	20190324
	UniProtAcc	.
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for RABGAP1L-IT1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000223525.1

RNA A-to-I editing events in Cancer.

CAediting_122447(174897716, +), CAediting_122448(174897728, +), CAediting_122449(174897734, +), CAediting_122450(174897735, +), CAediting_122451(174897751, +), CAediting_122452(174897761, +), CAediting_122453(174897765, +), CAediting_122454(174897770, +), CAediting_122455(174897775, +), CAediting_122456(174897779, +), CAediting_122457(174897780, +), CAediting_122458(174897789, +), CAediting_122459(174897791, +), CAediting_122460(174897794, +), CAediting_122461(174897808, +), CAediting_122462(174897813, +), CAediting_122463(174897814, +), CAediting_122464(174897835, +), CAediting_122465(174897850, +), CAediting_122466(174897860, +), CAediting_122467(174897861, +), CAediting_122468(174897866, +), CAediting_122469(174897887, +), CAediting_122470(174897893, +), CAediting_122471(174897899, +), CAediting_122472(174897900, +), CAediting_122473(174897908, +), CAediting_122474(174897934, +), CAediting_122475(174897936, +),

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RNA editing positional annotations for RABGAP1L-IT1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_122447	chr1_174897716_+	ncRNA_intronic
CAediting_122448	chr1_174897728_+	ncRNA_intronic
CAediting_122449	chr1_174897734_+	ncRNA_intronic
CAediting_122450	chr1_174897735_+	ncRNA_intronic
CAediting_122451	chr1_174897751_+	ncRNA_intronic
CAediting_122452	chr1_174897761_+	ncRNA_intronic
CAediting_122453	chr1_174897765_+	ncRNA_intronic
CAediting_122454	chr1_174897770_+	ncRNA_intronic
CAediting_122455	chr1_174897775_+	ncRNA_splicing
CAediting_122456	chr1_174897779_+	ncRNA_exonic
CAediting_122457	chr1_174897780_+	ncRNA_exonic
CAediting_122458	chr1_174897789_+	ncRNA_exonic
CAediting_122459	chr1_174897791_+	ncRNA_exonic
CAediting_122460	chr1_174897794_+	ncRNA_exonic
CAediting_122461	chr1_174897808_+	ncRNA_exonic
CAediting_122462	chr1_174897813_+	ncRNA_exonic
CAediting_122463	chr1_174897814_+	ncRNA_exonic
CAediting_122464	chr1_174897835_+	ncRNA_exonic
CAediting_122465	chr1_174897850_+	ncRNA_exonic
CAediting_122466	chr1_174897860_+	ncRNA_exonic
CAediting_122467	chr1_174897861_+	ncRNA_exonic
CAediting_122468	chr1_174897866_+	ncRNA_exonic
CAediting_122469	chr1_174897887_+	ncRNA_exonic
CAediting_122470	chr1_174897893_+	ncRNA_exonic
CAediting_122471	chr1_174897899_+	ncRNA_exonic
CAediting_122472	chr1_174897900_+	ncRNA_exonic
CAediting_122473	chr1_174897908_+	ncRNA_exonic
CAediting_122474	chr1_174897934_+	ncRNA_exonic
CAediting_122475	chr1_174897936_+	ncRNA_exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_122447	chr1_174897716_+	SINE	Alu	AluSx1
CAediting_122448	chr1_174897728_+	SINE	Alu	AluSx1
CAediting_122449	chr1_174897734_+	SINE	Alu	AluSx1
CAediting_122450	chr1_174897735_+	SINE	Alu	AluSx1
CAediting_122451	chr1_174897751_+	SINE	Alu	AluSx1
CAediting_122452	chr1_174897761_+	SINE	Alu	AluSx1
CAediting_122453	chr1_174897765_+	SINE	Alu	AluSx1
CAediting_122454	chr1_174897770_+	SINE	Alu	AluSx1
CAediting_122455	chr1_174897775_+	SINE	Alu	AluSx1
CAediting_122456	chr1_174897779_+	SINE	Alu	AluSx1
CAediting_122457	chr1_174897780_+	SINE	Alu	AluSx1
CAediting_122458	chr1_174897789_+	SINE	Alu	AluSx1
CAediting_122459	chr1_174897791_+	SINE	Alu	AluSx1
CAediting_122460	chr1_174897794_+	SINE	Alu	AluSx1
CAediting_122461	chr1_174897808_+	SINE	Alu	AluSx1
CAediting_122462	chr1_174897813_+	SINE	Alu	AluSx1
CAediting_122463	chr1_174897814_+	SINE	Alu	AluSx1
CAediting_122464	chr1_174897835_+	SINE	Alu	AluSx1
CAediting_122465	chr1_174897850_+	SINE	Alu	AluSx1
CAediting_122466	chr1_174897860_+	SINE	Alu	AluSx1
CAediting_122467	chr1_174897861_+	SINE	Alu	AluSx1
CAediting_122468	chr1_174897866_+	SINE	Alu	AluSx1
CAediting_122469	chr1_174897887_+	SINE	Alu	AluSx1
CAediting_122470	chr1_174897893_+	SINE	Alu	AluSx1
CAediting_122471	chr1_174897899_+	SINE	Alu	AluSx1
CAediting_122472	chr1_174897900_+	SINE	Alu	AluSx1
CAediting_122473	chr1_174897908_+	SINE	Alu	AluSx1
CAediting_122474	chr1_174897934_+	SINE	Alu	AluSx1
CAediting_122475	chr1_174897936_+	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for RABGAP1L-IT1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000223525.1.RABGAP1L-IT1.

Correlation between RNA A-to-I editing and PSI for ENSG00000223525.1.RABGAP1L-IT1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RABGAP1L-IT1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for RABGAP1L-IT1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for RABGAP1L-IT1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_122461	chr1_174897808_+	ENSG00000223525.1	ENST00000414890.1	hsa-miR-4716-5p	174897803	174897809	7mer-m8	174897788	174897810	146	-14.19
CAediting_122466	chr1_174897860_+	ENSG00000223525.1	ENST00000414890.1	hsa-miR-513a-5p	174897855	174897861	7mer-m8	174897845	174897862	147	-14.22
CAediting_122466	chr1_174897860_+	ENSG00000223525.1	ENST00000414890.1	hsa-miR-638	174897860	174897866	7mer-1a	174897843	174897866	153	-35.39
CAediting_122467	chr1_174897861_+	ENSG00000223525.1	ENST00000414890.1	hsa-miR-8052	174897860	174897866	7mer-1a	174897846	174897866	141	-21.02
CAediting_122456	chr1_174897779_+	ENSG00000223525.1	ENST00000414890.1	hsa-miR-1229-3p	174897474	174897783	8mer-1a	174897458	174897783	143	-14.07
CAediting_122457	chr1_174897780_+	ENSG00000223525.1	ENST00000414890.1	hsa-miR-155-3p	174897777	174897783	7mer-1a	174897460	174897783	145	-16.96
CAediting_122457	chr1_174897780_+	ENSG00000223525.1	ENST00000414890.1	hsa-miR-3685	174897777	174897783	7mer-m8	174897459	174897784	146	-15.05
CAediting_122459	chr1_174897791_+	ENSG00000223525.1	ENST00000414890.1	hsa-miR-3176	174897789	174897795	7mer-m8	174897778	174897796	156	-20.11
CAediting_122459	chr1_174897791_+	ENSG00000223525.1	ENST00000414890.1	hsa-miR-3922-3p	174897789	174897795	7mer-m8	174897472	174897796	153	-17.56
CAediting_122459	chr1_174897791_+	ENSG00000223525.1	ENST00000414890.1	hsa-miR-6878-3p	174897788	174897794	7mer-m8	174897471	174897795	154	-26.19
CAediting_122462	chr1_174897813_+	ENSG00000223525.1	ENST00000414890.1	hsa-miR-1182	174897812	174897818	7mer-m8	174897798	174897819	146	-13.99
CAediting_122463	chr1_174897814_+	ENSG00000223525.1	ENST00000414890.1	hsa-miR-3158-3p	174897812	174897818	7mer-m8	174897794	174897819	153	-21.42
CAediting_122463	chr1_174897814_+	ENSG00000223525.1	ENST00000414890.1	hsa-miR-6837-3p	174897808	174897814	7mer-m8	174897790	174897815	154	-20.32
CAediting_122464	chr1_174897835_+	ENSG00000223525.1	ENST00000414890.1	hsa-miR-3190-5p	174897834	174897840	7mer-m8	174897822	174897841	143	-15.18
CAediting_122464	chr1_174897835_+	ENSG00000223525.1	ENST00000414890.1	hsa-miR-548s	174897833	174897839	7mer-m8	174897814	174897840	142	-13.7

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_122464	chr1_174897835_+	ENSG00000223525.1	ENST00000414890.1	hsa-miR-4775	174897829	174897835	7mer-m8	174897816	174897836	150	-6.88

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_980496	chr14_31014685_-	ENSG00000223525.1	ENST00000414890.1	hsa-miR-624-3p	174897814	174897820	7mer-m8	174897801	174897821	156	-13.04
CAediting_1306323	chr19_13836462_-	ENSG00000223525.1	ENST00000414890.1	hsa-miR-27a-3p	174897919	174897924	6mer	174897903	174897925	146	-21.93

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for RABGAP1L-IT1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000414890.1	sense_intronic

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_122456	ENST00000414890.1	chr1_174897779_+	-182.30	-183.20	-199.30
CAediting_122457	ENST00000414890.1	chr1_174897780_+	-182.90	-183.20	-199.30
CAediting_122458	ENST00000414890.1	chr1_174897789_+	-184.00	-183.20	-199.30
CAediting_122459	ENST00000414890.1	chr1_174897791_+	-185.70	-183.20	-199.30
CAediting_122460	ENST00000414890.1	chr1_174897794_+	-182.50	-183.20	-199.30
CAediting_122461	ENST00000414890.1	chr1_174897808_+	-184.20	-183.20	-199.30
CAediting_122462	ENST00000414890.1	chr1_174897813_+	-187.40	-183.20	-199.30
CAediting_122463	ENST00000414890.1	chr1_174897814_+	-187.40	-183.20	-199.30
CAediting_122464	ENST00000414890.1	chr1_174897835_+	-183.90	-183.20	-199.30
CAediting_122465	ENST00000414890.1	chr1_174897850_+	-183.50	-183.20	-199.30
CAediting_122466	ENST00000414890.1	chr1_174897860_+	-185.10	-183.20	-199.30
CAediting_122467	ENST00000414890.1	chr1_174897861_+	-183.00	-183.20	-199.30
CAediting_122468	ENST00000414890.1	chr1_174897866_+	-185.60	-183.20	-199.30
CAediting_122469	ENST00000414890.1	chr1_174897887_+	-183.20	-183.20	-199.30
CAediting_122470	ENST00000414890.1	chr1_174897893_+	-187.20	-183.20	-199.30
CAediting_122471	ENST00000414890.1	chr1_174897899_+	-187.30	-183.20	-199.30
CAediting_122472	ENST00000414890.1	chr1_174897900_+	-186.90	-183.20	-199.30
CAediting_122473	ENST00000414890.1	chr1_174897908_+	-186.10	-183.20	-199.30
CAediting_122474	ENST00000414890.1	chr1_174897934_+	-184.00	-183.20	-199.30
CAediting_122475	ENST00000414890.1	chr1_174897936_+	-184.50	-183.20	-199.30

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Relation with ADAR for RABGAP1L-IT1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for RABGAP1L-IT1

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for RABGAP1L-IT1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for RABGAP1L-IT1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for RABGAP1L-IT1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene