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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: TXNIP (CAeditome ID:10628) |
Gene summary for TXNIP |
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Gene information | Gene symbol | TXNIP | Gene ID | 10628 |
Gene name | thioredoxin interacting protein | |
Synonyms | ARRDC6|EST01027|HHCPA78|THIF|VDUP1 | |
Cytomap | 1q21.1 | |
Type of gene | protein-coding | |
Description | thioredoxin-interacting proteinthioredoxin binding protein 2upregulated by 1,25-dihydroxyvitamin D-3vitamin D3 up-regulated protein 1 | |
Modification date | 20210524 | |
UniProtAcc | Q9H3M7 | |
Context | - 33901495(MondoA-TXNIP axis maintains regulatory T cell identity and function in colorectal cancer microenvironment) |
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Gene | GO ID | GO term | PubMed ID |
TXNIP | GO:0030216 | Thioredoxin-interacting protein | 14632196 |
TXNIP | GO:0051782 | Thioredoxin-interacting protein | 18541147 |
TXNIP | GO:0071228 | Thioredoxin-interacting protein | 18541147 |
TXNIP | GO:0005737 | Thioredoxin-interacting protein | 14632196 |
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RNA A-to-I events for TXNIP |
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CAediting_92967(145992774, -), CAediting_92968(145994338, -), |
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RNA editing positional annotations for TXNIP using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
CAediting_92968 | chr1_145994338_- | nonsynonymous SNV | ENST00000425134.2 | c.A766G | p.S256G | D | . | D |
CAediting_92968 | chr1_145994338_- | nonsynonymous SNV | ENST00000582401.4 | c.A931G | p.S311G | D | . | D |
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CAeditome ID | Position | Variant type |
CAediting_92967 | chr1_145992774_- | UTR3 |
CAediting_92968 | chr1_145994338_- | exonic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
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RNA A-to-I editing events in the alternative splicing sites for TXNIP |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TXNIP |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for TXNIP |
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The effects of the RNA editing to the miRNA binding sites for TXNIP |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_92967 | chr1_145992774_- | ENSG00000265972.4 | ENST00000582401 | hsa-miR-145-5p | 145992772 | 145992778 | 7mer-m8 | 145992771 | 145992793 | 154.00 | -15.16 |
CAediting_92967 | chr1_145992774_- | ENSG00000265972.4 | ENST00000582401 | hsa-miR-3925-3p | 145992771 | 145992777 | 7mer-m8 | 145992770 | 145992790 | 151.00 | -16.58 |
CAediting_92967 | chr1_145992774_- | ENSG00000265972.4 | ENST00000582401 | hsa-miR-5195-3p | 145992772 | 145992778 | 7mer-m8 | 145992771 | 145992790 | 155.00 | -19.09 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_980496 | chr14_31014685_- | ENSG00000265972.4 | ENST00000582401 | hsa-miR-624-3p | 145992808 | 145992814 | 7mer-m8 | 145992807 | 145992826 | 155 | -21.7 |
CAediting_1229413 | chr17_67471544_+ | ENSG00000265972.4 | ENST00000582401 | hsa-miR-548aa | 145992564 | 145992571 | 8mer-1a | 145992564 | 145992587 | 155 | -17.65 |
CAediting_1229415 | chr17_67471547_+ | ENSG00000265972.4 | ENST00000582401 | hsa-miR-548aa | 145993206 | 145993212 | 7mer-m8 | 145993205 | 145993229 | 147 | -11.31 |
CAediting_1351755 | chr19_40282625_- | ENSG00000265972.4 | ENST00000582401 | hsa-miR-641 | 145992978 | 145992983 | 6mer | 145992977 | 145993003 | 144 | -22.84 |
CAediting_86358 | chr1_109598906_+ | ENSG00000265972.4 | ENST00000582401 | hsa-miR-197-5p | 145992617 | 145992623 | 7mer-m8 | 145992616 | 145992641 | 152 | -25.76 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_1229413 | chr17_67471544_+ | ENSG00000265972.4 | ENST00000582401 | hsa-miR-548aa | 145993102 | 145993108 | 7mer-m8 | 145993101 | 145993125 | 150 | -8.91 |
CAediting_1229414 | chr17_67471546_+ | ENSG00000265972.4 | ENST00000582401 | hsa-miR-548aa | 145993102 | 145993108 | 7mer-m8 | 145993101 | 145993125 | 150 | -8.91 |
CAediting_1229415 | chr17_67471547_+ | ENSG00000265972.4 | ENST00000582401 | hsa-miR-548aa | 145993102 | 145993108 | 7mer-m8 | 145993101 | 145993125 | 150 | -8.91 |
CAediting_228905 | chr2_188297554_+ | ENSG00000265972.4 | ENST00000582401 | hsa-miR-561-3p | 145993381 | 145993387 | 7mer-m8 | 145993380 | 145993401 | 140 | -8.82 |
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The effects of the RNA editing to the stability of the RNA structures for TXNIP |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
ENST00000582401.4 | protein_coding | ![]() | ![]() |
ENST00000425134.2 | protein_coding | ![]() | ![]() |
ENST00000488537.1 | retained_intron | ![]() | ![]() |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
CAediting_92967 | ENST00000582401.4 | chr1_145992774_- | -880.10 | -879.50 | -881.90 |
CAediting_92968 | ENST00000582401.4 | chr1_145994338_- | -881.30 | -879.50 | -881.90 |
CAediting_92968 | ENST00000425134.2 | chr1_145994338_- | -358.50 | -356.70 | -358.50 |
CAediting_92968 | ENST00000488537.1 | chr1_145994338_- | -475.30 | -471.30 | -475.30 |
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Relation with ADAR for TXNIP |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for TXNIP |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for TXNIP |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for TXNIP |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TXNIP |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
TXNIP | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
TXNIP | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
TXNIP | C0014175 | Endometriosis | 1 | CTD_human |
TXNIP | C0017667 | Nodular glomerulosclerosis | 1 | CTD_human |
TXNIP | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
TXNIP | C0235874 | Disease Exacerbation | 1 | CTD_human |
TXNIP | C0269102 | Endometrioma | 1 | CTD_human |