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Editing gene: POLR3C (CAeditome ID:10623)

Gene summary for POLR3C

Gene summary

Gene information	Gene symbol	POLR3C
	Gene ID	10623
	Gene name	RNA polymerase III subunit C
	Synonyms	C82\|RPC3\|RPC62
	Cytomap	1q21.1
	Type of gene	protein-coding
	Description	DNA-directed RNA polymerase III subunit RPC3DNA-directed III 62 kDa polypeptideDNA-directed RNA polymerase III subunit CRNA polymerase III 62 kDa subunitRNA polymerase III subunit C3polymerase (RNA) III (DNA directed) polypeptide C (62kD)polymerase
	Modification date	20210518
	UniProtAcc	Q9BUI4
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
POLR3C	GO:0003697	DNA-directed RNA polymerase III subunit RPC3	21358628
POLR3C	GO:0005654	DNA-directed RNA polymerase III subunit RPC3	0000052
POLR3C	GO:0005666	DNA-directed RNA polymerase III subunit RPC3	24107381

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RNA A-to-I events for POLR3C

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000186141.7

RNA A-to-I editing events in Cancer.

CAediting_92695(145831510, +), CAediting_92696(145834528, +), CAediting_92697(145834596, +), CAediting_92698(145834600, +), CAediting_92699(145834862, +), CAediting_92700(145834884, +), CAediting_92701(145834885, +), CAediting_92702(145834893, +), CAediting_92703(145834911, +), CAediting_92704(145834913, +), CAediting_92705(145834914, +), CAediting_92706(145834925, +), CAediting_92707(145834930, +), CAediting_92708(145834938, +), CAediting_92709(145834961, +), CAediting_92710(145834999, +), CAediting_92711(145835017, +), CAediting_92712(145835025, +), CAediting_92713(145835029, +), CAediting_92714(145835031, +), CAediting_92715(145835040, +), CAediting_92716(145835052, +), CAediting_92717(145835066, +), CAediting_92718(145835071, +), CAediting_92719(145835072, +), CAediting_92720(145835086, +), CAediting_92721(145835100, +), CAediting_92722(145835132, +), CAediting_92723(145835180, +), CAediting_92724(145835193, +), CAediting_92725(145835194, +), CAediting_92726(145835216, +), CAediting_92727(145835220, +), CAediting_92728(145835224, +), CAediting_92729(145835242, +), CAediting_92730(145835243, +), CAediting_92731(145835245, +), CAediting_92732(145835269, +), CAediting_92733(145835274, +), CAediting_92734(145835280, +), CAediting_92735(145835283, +), CAediting_92736(145835284, +), CAediting_92737(145835285, +), CAediting_92738(145835286, +), CAediting_92739(145835289, +), CAediting_92740(145835295, +), CAediting_92741(145835298, +), CAediting_92742(145835302, +), CAediting_92743(145835324, +), CAediting_92744(145835330, +), CAediting_92745(145835390, +), CAediting_92746(145835633, +), CAediting_92747(145835638, +), CAediting_92748(145835644, +), CAediting_92749(145835715, +), CAediting_92750(145835719, +), CAediting_92751(145835739, +), CAediting_92752(145835740, +), CAediting_92753(145835754, +), CAediting_92754(145835757, +), CAediting_92755(145835763, +), CAediting_92756(145835809, +), CAediting_92757(145836322, +), CAediting_92758(145836354, +), CAediting_92759(145836372, +), CAediting_92760(145837051, +), CAediting_92761(145837102, +), CAediting_92762(145837129, +), CAediting_92763(145837137, +), CAediting_92764(145837152, +), CAediting_92765(145837161, +), CAediting_92766(145837192, +), CAediting_92767(145837200, +), CAediting_92768(145837225, +), CAediting_92769(145837232, +), CAediting_92770(145837237, +), CAediting_92771(145837239, +), CAediting_92772(145837251, +), CAediting_92773(145837278, +), CAediting_92774(145837304, +), CAediting_92775(145838518, +), CAediting_92776(145838560, +), CAediting_92777(145838562, +), CAediting_92778(145838568, +), CAediting_92779(145838612, +), CAediting_92780(145840285, +),

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RNA editing positional annotations for POLR3C using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_92695	chr1_145831510_+	ncRNA_intronic
CAediting_92696	chr1_145834528_+	ncRNA_intronic
CAediting_92697	chr1_145834596_+	ncRNA_intronic
CAediting_92698	chr1_145834600_+	ncRNA_intronic
CAediting_92699	chr1_145834862_+	ncRNA_intronic
CAediting_92700	chr1_145834884_+	ncRNA_intronic
CAediting_92701	chr1_145834885_+	ncRNA_intronic
CAediting_92702	chr1_145834893_+	ncRNA_intronic
CAediting_92703	chr1_145834911_+	ncRNA_intronic
CAediting_92704	chr1_145834913_+	ncRNA_intronic
CAediting_92705	chr1_145834914_+	ncRNA_intronic
CAediting_92706	chr1_145834925_+	ncRNA_intronic
CAediting_92707	chr1_145834930_+	ncRNA_intronic
CAediting_92708	chr1_145834938_+	ncRNA_intronic
CAediting_92709	chr1_145834961_+	ncRNA_intronic
CAediting_92710	chr1_145834999_+	ncRNA_intronic
CAediting_92711	chr1_145835017_+	ncRNA_intronic
CAediting_92712	chr1_145835025_+	ncRNA_intronic
CAediting_92713	chr1_145835029_+	ncRNA_intronic
CAediting_92714	chr1_145835031_+	ncRNA_intronic
CAediting_92715	chr1_145835040_+	ncRNA_intronic
CAediting_92716	chr1_145835052_+	ncRNA_intronic
CAediting_92717	chr1_145835066_+	ncRNA_intronic
CAediting_92718	chr1_145835071_+	ncRNA_intronic
CAediting_92719	chr1_145835072_+	ncRNA_intronic
CAediting_92720	chr1_145835086_+	ncRNA_intronic
CAediting_92721	chr1_145835100_+	ncRNA_intronic
CAediting_92722	chr1_145835132_+	ncRNA_intronic
CAediting_92723	chr1_145835180_+	ncRNA_intronic
CAediting_92724	chr1_145835193_+	ncRNA_intronic
CAediting_92725	chr1_145835194_+	ncRNA_intronic
CAediting_92726	chr1_145835216_+	ncRNA_intronic
CAediting_92727	chr1_145835220_+	ncRNA_intronic
CAediting_92728	chr1_145835224_+	ncRNA_intronic
CAediting_92729	chr1_145835242_+	ncRNA_intronic
CAediting_92730	chr1_145835243_+	ncRNA_intronic
CAediting_92731	chr1_145835245_+	ncRNA_intronic
CAediting_92732	chr1_145835269_+	ncRNA_intronic
CAediting_92733	chr1_145835274_+	ncRNA_intronic
CAediting_92734	chr1_145835280_+	ncRNA_intronic
CAediting_92735	chr1_145835283_+	ncRNA_intronic
CAediting_92736	chr1_145835284_+	ncRNA_intronic
CAediting_92737	chr1_145835285_+	ncRNA_intronic
CAediting_92738	chr1_145835286_+	ncRNA_intronic
CAediting_92739	chr1_145835289_+	ncRNA_intronic
CAediting_92740	chr1_145835295_+	ncRNA_intronic
CAediting_92741	chr1_145835298_+	ncRNA_intronic
CAediting_92742	chr1_145835302_+	ncRNA_intronic
CAediting_92743	chr1_145835324_+	ncRNA_intronic
CAediting_92744	chr1_145835330_+	ncRNA_intronic
CAediting_92745	chr1_145835390_+	ncRNA_intronic
CAediting_92746	chr1_145835633_+	ncRNA_intronic
CAediting_92747	chr1_145835638_+	ncRNA_intronic
CAediting_92748	chr1_145835644_+	ncRNA_intronic
CAediting_92749	chr1_145835715_+	ncRNA_intronic
CAediting_92750	chr1_145835719_+	ncRNA_intronic
CAediting_92751	chr1_145835739_+	ncRNA_intronic
CAediting_92752	chr1_145835740_+	ncRNA_intronic
CAediting_92753	chr1_145835754_+	ncRNA_intronic
CAediting_92754	chr1_145835757_+	ncRNA_intronic
CAediting_92755	chr1_145835763_+	ncRNA_intronic
CAediting_92756	chr1_145835809_+	ncRNA_intronic
CAediting_92757	chr1_145836322_+	ncRNA_intronic
CAediting_92758	chr1_145836354_+	ncRNA_intronic
CAediting_92759	chr1_145836372_+	ncRNA_intronic
CAediting_92760	chr1_145837051_+	ncRNA_intronic
CAediting_92761	chr1_145837102_+	ncRNA_intronic
CAediting_92762	chr1_145837129_+	ncRNA_intronic
CAediting_92763	chr1_145837137_+	ncRNA_intronic
CAediting_92764	chr1_145837152_+	ncRNA_intronic
CAediting_92765	chr1_145837161_+	ncRNA_intronic
CAediting_92766	chr1_145837192_+	ncRNA_intronic
CAediting_92767	chr1_145837200_+	ncRNA_intronic
CAediting_92768	chr1_145837225_+	ncRNA_intronic
CAediting_92769	chr1_145837232_+	ncRNA_intronic
CAediting_92770	chr1_145837237_+	ncRNA_intronic
CAediting_92771	chr1_145837239_+	ncRNA_intronic
CAediting_92772	chr1_145837251_+	ncRNA_intronic
CAediting_92773	chr1_145837278_+	ncRNA_intronic
CAediting_92774	chr1_145837304_+	ncRNA_intronic
CAediting_92775	chr1_145838518_+	ncRNA_intronic
CAediting_92776	chr1_145838560_+	ncRNA_intronic
CAediting_92777	chr1_145838562_+	ncRNA_intronic
CAediting_92778	chr1_145838568_+	ncRNA_intronic
CAediting_92779	chr1_145838612_+	ncRNA_intronic
CAediting_92780	chr1_145840285_+	ncRNA_exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_92695	chr1_145831510_+	SINE	Alu	AluSx
CAediting_92696	chr1_145834528_+	SINE	Alu	AluSx
CAediting_92697	chr1_145834596_+	SINE	Alu	AluSx
CAediting_92698	chr1_145834600_+	SINE	Alu	AluSx
CAediting_92699	chr1_145834862_+	SINE	Alu	AluJr4
CAediting_92700	chr1_145834884_+	SINE	Alu	AluJr4
CAediting_92701	chr1_145834885_+	SINE	Alu	AluJr4
CAediting_92702	chr1_145834893_+	SINE	Alu	AluJr4
CAediting_92703	chr1_145834911_+	SINE	Alu	AluJr4
CAediting_92704	chr1_145834913_+	SINE	Alu	AluJr4
CAediting_92705	chr1_145834914_+	SINE	Alu	AluJr4
CAediting_92706	chr1_145834925_+	SINE	Alu	AluJr4
CAediting_92707	chr1_145834930_+	SINE	Alu	AluJr4
CAediting_92708	chr1_145834938_+	SINE	Alu	AluJr4
CAediting_92709	chr1_145834961_+	SINE	Alu	AluJr4
CAediting_92710	chr1_145834999_+	SINE	Alu	AluJr4
CAediting_92711	chr1_145835017_+	SINE	Alu	AluJr4
CAediting_92712	chr1_145835025_+	SINE	Alu	AluJr4
CAediting_92713	chr1_145835029_+	SINE	Alu	AluJr4
CAediting_92714	chr1_145835031_+	SINE	Alu	AluJr4
CAediting_92715	chr1_145835040_+	SINE	Alu	AluJr4
CAediting_92716	chr1_145835052_+	SINE	Alu	AluJr4
CAediting_92717	chr1_145835066_+	SINE	Alu	AluJr4
CAediting_92718	chr1_145835071_+	SINE	Alu	AluJr4
CAediting_92719	chr1_145835072_+	SINE	Alu	AluJr4
CAediting_92720	chr1_145835086_+	SINE	Alu	AluJr4
CAediting_92721	chr1_145835100_+	SINE	Alu	AluJr4
CAediting_92722	chr1_145835132_+	SINE	Alu	AluJr4
CAediting_92723	chr1_145835180_+	SINE	Alu	AluSx1
CAediting_92724	chr1_145835193_+	SINE	Alu	AluSx1
CAediting_92725	chr1_145835194_+	SINE	Alu	AluSx1
CAediting_92726	chr1_145835216_+	SINE	Alu	AluSx1
CAediting_92727	chr1_145835220_+	SINE	Alu	AluSx1
CAediting_92728	chr1_145835224_+	SINE	Alu	AluSx1
CAediting_92729	chr1_145835242_+	SINE	Alu	AluSx1
CAediting_92730	chr1_145835243_+	SINE	Alu	AluSx1
CAediting_92731	chr1_145835245_+	SINE	Alu	AluSx1
CAediting_92732	chr1_145835269_+	SINE	Alu	AluSx1
CAediting_92733	chr1_145835274_+	SINE	Alu	AluSx1
CAediting_92734	chr1_145835280_+	SINE	Alu	AluSx1
CAediting_92735	chr1_145835283_+	SINE	Alu	AluSx1
CAediting_92736	chr1_145835284_+	SINE	Alu	AluSx1
CAediting_92737	chr1_145835285_+	SINE	Alu	AluSx1
CAediting_92738	chr1_145835286_+	SINE	Alu	AluSx1
CAediting_92739	chr1_145835289_+	SINE	Alu	AluSx1
CAediting_92740	chr1_145835295_+	SINE	Alu	AluSx1
CAediting_92741	chr1_145835298_+	SINE	Alu	AluSx1
CAediting_92742	chr1_145835302_+	SINE	Alu	AluSx1
CAediting_92743	chr1_145835324_+	SINE	Alu	AluSx1
CAediting_92744	chr1_145835330_+	SINE	Alu	AluSx1
CAediting_92745	chr1_145835390_+	SINE	Alu	AluSx1
CAediting_92746	chr1_145835633_+	SINE	Alu	AluSz
CAediting_92747	chr1_145835638_+	SINE	Alu	AluSz
CAediting_92748	chr1_145835644_+	SINE	Alu	AluSz
CAediting_92749	chr1_145835715_+	SINE	Alu	AluSz
CAediting_92750	chr1_145835719_+	SINE	Alu	AluSz
CAediting_92751	chr1_145835739_+	SINE	Alu	AluSz
CAediting_92752	chr1_145835740_+	SINE	Alu	AluSz
CAediting_92753	chr1_145835754_+	SINE	Alu	AluSz
CAediting_92754	chr1_145835757_+	SINE	Alu	AluSz
CAediting_92755	chr1_145835763_+	SINE	Alu	AluSz
CAediting_92756	chr1_145835809_+	SINE	Alu	AluSz
CAediting_92757	chr1_145836322_+	SINE	Alu	AluSq2
CAediting_92758	chr1_145836354_+	SINE	Alu	AluSq2
CAediting_92759	chr1_145836372_+	SINE	Alu	AluSq2
CAediting_92761	chr1_145837102_+	SINE	Alu	AluJo
CAediting_92762	chr1_145837129_+	SINE	Alu	AluJo
CAediting_92763	chr1_145837137_+	SINE	Alu	AluJo
CAediting_92764	chr1_145837152_+	SINE	Alu	AluJo
CAediting_92765	chr1_145837161_+	SINE	Alu	AluJo
CAediting_92766	chr1_145837192_+	SINE	Alu	AluJo
CAediting_92767	chr1_145837200_+	SINE	Alu	AluJo
CAediting_92768	chr1_145837225_+	SINE	Alu	AluJo
CAediting_92769	chr1_145837232_+	SINE	Alu	AluJo
CAediting_92770	chr1_145837237_+	SINE	Alu	AluJo
CAediting_92771	chr1_145837239_+	SINE	Alu	AluJo
CAediting_92772	chr1_145837251_+	SINE	Alu	AluJo
CAediting_92773	chr1_145837278_+	SINE	Alu	AluJo
CAediting_92774	chr1_145837304_+	SINE	Alu	AluJo
CAediting_92775	chr1_145838518_+	SINE	Alu	AluSz
CAediting_92776	chr1_145838560_+	SINE	Alu	AluSz
CAediting_92777	chr1_145838562_+	SINE	Alu	AluSz
CAediting_92778	chr1_145838568_+	SINE	Alu	AluSz
CAediting_92779	chr1_145838612_+	SINE	Alu	AluSz
CAediting_92780	chr1_145840285_+	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for POLR3C

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000186141.7.POLR3C.

Correlation between RNA A-to-I editing and PSI for ENSG00000186141.7.POLR3C.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for POLR3C

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for POLR3C

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for POLR3C

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for POLR3C

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000489436.1	processed_transcript

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_92780	ENST00000489436.1	chr1_145840285_+	-244.50	-241.90	-244.50

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Relation with ADAR for POLR3C

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
STAD	CAediting_92712	chr1_145835025_+	0.0365243510020088	0.285287030915466	.	.	.	.

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Relation with cancer stages for POLR3C

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for POLR3C

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for POLR3C

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for POLR3C

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene