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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: SPTLC1 (CAeditome ID:10558)

Gene summary for SPTLC1

check button Gene summary
Gene informationGene symbol

SPTLC1

Gene ID

10558

Gene nameserine palmitoyltransferase long chain base subunit 1
SynonymsHSAN1|HSN1|LBC1|LCB1|SPT1|SPTI
Cytomap

9q22.31

Type of geneprotein-coding
Descriptionserine palmitoyltransferase 1long chain base biosynthesis protein 1serine C-palmitoyltransferaseserine-palmitoyl-CoA transferase 1
Modification date20210518
UniProtAcc

O15269

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
SPTLC1

GO:0030148

Serine palmitoyltransferase 1

25332431

SPTLC1

GO:0046513

Serine palmitoyltransferase 1

25691431

SPTLC1

GO:1904504

Serine palmitoyltransferase 1

25332431

SPTLC1

GO:0004758

Serine palmitoyltransferase 1

25332431

SPTLC1

GO:0004758

Serine palmitoyltransferase 1

25691431

SPTLC1

GO:0004758

Serine palmitoyltransferase 1

19416851

SPTLC1

GO:0005783

Serine palmitoyltransferase 1

0000052

SPTLC1

GO:0017059

Serine palmitoyltransferase 1

19416851

SPTLC1

GO:0035339

Serine palmitoyltransferase 1

20182505

SPTLC1

GO:0035339

Serine palmitoyltransferase 1

25691431


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RNA A-to-I events for SPTLC1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000090054.12
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_694451(92032619, -), CAediting_694452(92032621, -), CAediting_694453(92032633, -), CAediting_694454(92032651, -), CAediting_694455(92032687, -), CAediting_694456(92032752, -), CAediting_694457(92032764, -), CAediting_694458(92032767, -), CAediting_694459(92033618, -), CAediting_694460(92033628, -), CAediting_694461(92033720, -), CAediting_694462(92033740, -), CAediting_694463(92033741, -), CAediting_694464(92033750, -), CAediting_694465(92033763, -), CAediting_694466(92033765, -), CAediting_694467(92033766, -), CAediting_694468(92033789, -), CAediting_694469(92033812, -), CAediting_694470(92033813, -), CAediting_694471(92033819, -), CAediting_694472(92033825, -), CAediting_694473(92033841, -), CAediting_694474(92050873, -), CAediting_694475(92050881, -), CAediting_694476(92050889, -), CAediting_694477(92050915, -), CAediting_694478(92050924, -), CAediting_694479(92050944, -), CAediting_694480(92050950, -), CAediting_694481(92050957, -), CAediting_694482(92054025, -), CAediting_694483(92054037, -), CAediting_694484(92054156, -), CAediting_694485(92054159, -), CAediting_694486(92054669, -), CAediting_694487(92054962, -), CAediting_694488(92071115, -), CAediting_694489(92071124, -), CAediting_694490(92071133, -), CAediting_694491(92071173, -), CAediting_694492(92071272, -), CAediting_694493(92071278, -), CAediting_694494(92071288, -), CAediting_694495(92071353, -), CAediting_694496(92071387, -), CAediting_694497(92071399, -), CAediting_694498(92078534, -), CAediting_694499(92078570, -), CAediting_694500(92078583, -), CAediting_694501(92078587, -), CAediting_694502(92078597, -), CAediting_694503(92078610, -), CAediting_694504(92078728, -), CAediting_694505(92078744, -), CAediting_694506(92079106, -), CAediting_694507(92079138, -), CAediting_694508(92079141, -), CAediting_694509(92079159, -), CAediting_694510(92079165, -), CAediting_694511(92079172, -), CAediting_694512(92079173, -), CAediting_694513(92079181, -), CAediting_694514(92079182, -), CAediting_694515(92079191, -), CAediting_694516(92079197, -), CAediting_694517(92079204, -), CAediting_694518(92079213, -), CAediting_694519(92079243, -), CAediting_694520(92079244, -), CAediting_694521(92079249, -), CAediting_694522(92079252, -), CAediting_694523(92079253, -), CAediting_694524(92079254, -), CAediting_694525(92079258, -), CAediting_694526(92079269, -), CAediting_694527(92079270, -), CAediting_694528(92079277, -), CAediting_694529(92079279, -), CAediting_694530(92079280, -), CAediting_694531(92079289, -), CAediting_694532(92079293, -), CAediting_694533(92079294, -), CAediting_694534(92079300, -), CAediting_694535(92079303, -), CAediting_694536(92079308, -), CAediting_694537(92079313, -), CAediting_694538(92079318, -), CAediting_694539(92079322, -), CAediting_694540(92079326, -), CAediting_694541(92079332, -), CAediting_694542(92079333, -), CAediting_694543(92079334, -), CAediting_694544(92079340, -), CAediting_694545(92079349, -), CAediting_694546(92079367, -), CAediting_694547(92107496, -), CAediting_694548(92107508, -), CAediting_694549(92107563, -), CAediting_694550(92107577, -), CAediting_694551(92107585, -), CAediting_694552(92107588, -), CAediting_694553(92107652, -), CAediting_694554(92107670, -), CAediting_694555(92107705, -), CAediting_694556(92107706, -),

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RNA editing positional annotations for SPTLC1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_694451chr9_92032619_-ncRNA_intronic
CAediting_694452chr9_92032621_-ncRNA_intronic
CAediting_694453chr9_92032633_-ncRNA_intronic
CAediting_694454chr9_92032651_-ncRNA_intronic
CAediting_694455chr9_92032687_-ncRNA_intronic
CAediting_694456chr9_92032752_-ncRNA_intronic
CAediting_694457chr9_92032764_-ncRNA_intronic
CAediting_694458chr9_92032767_-ncRNA_intronic
CAediting_694459chr9_92033618_-ncRNA_intronic
CAediting_694460chr9_92033628_-ncRNA_intronic
CAediting_694461chr9_92033720_-ncRNA_intronic
CAediting_694462chr9_92033740_-ncRNA_intronic
CAediting_694463chr9_92033741_-ncRNA_intronic
CAediting_694464chr9_92033750_-ncRNA_intronic
CAediting_694465chr9_92033763_-ncRNA_intronic
CAediting_694466chr9_92033765_-ncRNA_intronic
CAediting_694467chr9_92033766_-ncRNA_intronic
CAediting_694468chr9_92033789_-ncRNA_intronic
CAediting_694469chr9_92033812_-ncRNA_intronic
CAediting_694470chr9_92033813_-ncRNA_intronic
CAediting_694471chr9_92033819_-ncRNA_intronic
CAediting_694472chr9_92033825_-ncRNA_intronic
CAediting_694473chr9_92033841_-ncRNA_intronic
CAediting_694474chr9_92050873_-intronic
CAediting_694475chr9_92050881_-intronic
CAediting_694476chr9_92050889_-intronic
CAediting_694477chr9_92050915_-intronic
CAediting_694478chr9_92050924_-intronic
CAediting_694479chr9_92050944_-intronic
CAediting_694480chr9_92050950_-intronic
CAediting_694481chr9_92050957_-intronic
CAediting_694482chr9_92054025_-intronic
CAediting_694483chr9_92054037_-intronic
CAediting_694484chr9_92054156_-intronic
CAediting_694485chr9_92054159_-intronic
CAediting_694486chr9_92054669_-intronic
CAediting_694487chr9_92054962_-intronic
CAediting_694488chr9_92071115_-ncRNA_intronic
CAediting_694489chr9_92071124_-ncRNA_intronic
CAediting_694490chr9_92071133_-ncRNA_intronic
CAediting_694491chr9_92071173_-ncRNA_intronic
CAediting_694492chr9_92071272_-ncRNA_intronic
CAediting_694493chr9_92071278_-ncRNA_intronic
CAediting_694494chr9_92071288_-ncRNA_intronic
CAediting_694495chr9_92071353_-ncRNA_intronic
CAediting_694496chr9_92071387_-ncRNA_intronic
CAediting_694497chr9_92071399_-ncRNA_intronic
CAediting_694498chr9_92078534_-ncRNA_intronic
CAediting_694499chr9_92078570_-ncRNA_intronic
CAediting_694500chr9_92078583_-ncRNA_intronic
CAediting_694501chr9_92078587_-ncRNA_intronic
CAediting_694502chr9_92078597_-ncRNA_intronic
CAediting_694503chr9_92078610_-ncRNA_intronic
CAediting_694504chr9_92078728_-ncRNA_intronic
CAediting_694505chr9_92078744_-ncRNA_intronic
CAediting_694506chr9_92079106_-ncRNA_intronic
CAediting_694507chr9_92079138_-ncRNA_intronic
CAediting_694508chr9_92079141_-ncRNA_intronic
CAediting_694509chr9_92079159_-ncRNA_intronic
CAediting_694510chr9_92079165_-ncRNA_intronic
CAediting_694511chr9_92079172_-ncRNA_intronic
CAediting_694512chr9_92079173_-ncRNA_intronic
CAediting_694513chr9_92079181_-ncRNA_intronic
CAediting_694514chr9_92079182_-ncRNA_intronic
CAediting_694515chr9_92079191_-ncRNA_intronic
CAediting_694516chr9_92079197_-ncRNA_intronic
CAediting_694517chr9_92079204_-ncRNA_intronic
CAediting_694518chr9_92079213_-ncRNA_intronic
CAediting_694519chr9_92079243_-ncRNA_intronic
CAediting_694520chr9_92079244_-ncRNA_intronic
CAediting_694521chr9_92079249_-ncRNA_intronic
CAediting_694522chr9_92079252_-ncRNA_intronic
CAediting_694523chr9_92079253_-ncRNA_intronic
CAediting_694524chr9_92079254_-ncRNA_intronic
CAediting_694525chr9_92079258_-ncRNA_intronic
CAediting_694526chr9_92079269_-ncRNA_intronic
CAediting_694527chr9_92079270_-ncRNA_intronic
CAediting_694528chr9_92079277_-ncRNA_intronic
CAediting_694529chr9_92079279_-ncRNA_intronic
CAediting_694530chr9_92079280_-ncRNA_intronic
CAediting_694531chr9_92079289_-ncRNA_intronic
CAediting_694532chr9_92079293_-ncRNA_intronic
CAediting_694533chr9_92079294_-ncRNA_intronic
CAediting_694534chr9_92079300_-ncRNA_intronic
CAediting_694535chr9_92079303_-ncRNA_intronic
CAediting_694536chr9_92079308_-ncRNA_intronic
CAediting_694537chr9_92079313_-ncRNA_intronic
CAediting_694538chr9_92079318_-ncRNA_intronic
CAediting_694539chr9_92079322_-ncRNA_intronic
CAediting_694540chr9_92079326_-ncRNA_intronic
CAediting_694541chr9_92079332_-ncRNA_intronic
CAediting_694542chr9_92079333_-ncRNA_intronic
CAediting_694543chr9_92079334_-ncRNA_intronic
CAediting_694544chr9_92079340_-ncRNA_intronic
CAediting_694545chr9_92079349_-ncRNA_intronic
CAediting_694546chr9_92079367_-ncRNA_intronic
CAediting_694547chr9_92107496_-ncRNA_intronic
CAediting_694548chr9_92107508_-ncRNA_intronic
CAediting_694549chr9_92107563_-ncRNA_intronic
CAediting_694550chr9_92107577_-ncRNA_intronic
CAediting_694551chr9_92107585_-ncRNA_intronic
CAediting_694552chr9_92107588_-ncRNA_intronic
CAediting_694553chr9_92107652_-ncRNA_intronic
CAediting_694554chr9_92107670_-ncRNA_intronic
CAediting_694555chr9_92107705_-ncRNA_intronic
CAediting_694556chr9_92107706_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_694451chr9_92032619_-SINEAluAluY
CAediting_694452chr9_92032621_-SINEAluAluY
CAediting_694453chr9_92032633_-SINEAluAluY
CAediting_694454chr9_92032651_-SINEAluAluY
CAediting_694455chr9_92032687_-SINEAluAluY
CAediting_694456chr9_92032752_-SINEAluAluY
CAediting_694457chr9_92032764_-SINEAluAluY
CAediting_694458chr9_92032767_-SINEAluAluY
CAediting_694459chr9_92033618_-SINEAluAluJb
CAediting_694460chr9_92033628_-SINEAluAluJb
CAediting_694461chr9_92033720_-SINEAluAluJb
CAediting_694462chr9_92033740_-SINEAluAluJb
CAediting_694463chr9_92033741_-SINEAluAluJb
CAediting_694464chr9_92033750_-SINEAluAluJb
CAediting_694465chr9_92033763_-SINEAluAluJb
CAediting_694466chr9_92033765_-SINEAluAluJb
CAediting_694467chr9_92033766_-SINEAluAluJb
CAediting_694468chr9_92033789_-SINEAluAluJb
CAediting_694469chr9_92033812_-SINEAluAluJb
CAediting_694470chr9_92033813_-SINEAluAluJb
CAediting_694471chr9_92033819_-SINEAluAluJb
CAediting_694472chr9_92033825_-SINEAluAluJb
CAediting_694473chr9_92033841_-SINEAluAluJb
CAediting_694474chr9_92050873_-SINEAluAluJb
CAediting_694475chr9_92050881_-SINEAluAluJb
CAediting_694476chr9_92050889_-SINEAluAluJb
CAediting_694477chr9_92050915_-SINEAluAluJb
CAediting_694478chr9_92050924_-SINEAluAluJb
CAediting_694479chr9_92050944_-SINEAluAluJb
CAediting_694480chr9_92050950_-SINEAluAluJb
CAediting_694481chr9_92050957_-SINEAluAluJb
CAediting_694482chr9_92054025_-SINEAluAluSp
CAediting_694483chr9_92054037_-SINEAluAluSp
CAediting_694484chr9_92054156_-SINEAluAluSp
CAediting_694485chr9_92054159_-SINEAluAluSp
CAediting_694486chr9_92054669_-SINEAluAluSc
CAediting_694487chr9_92054962_-SINEAluAluJo
CAediting_694488chr9_92071115_-SINEAluAluSp
CAediting_694489chr9_92071124_-SINEAluAluSp
CAediting_694490chr9_92071133_-SINEAluAluSp
CAediting_694491chr9_92071173_-SINEAluAluSp
CAediting_694492chr9_92071272_-SINEAluAluSp
CAediting_694493chr9_92071278_-SINEAluAluSp
CAediting_694494chr9_92071288_-SINEAluAluSp
CAediting_694495chr9_92071353_-SINEAluAluSp
CAediting_694496chr9_92071387_-SINEAluAluSp
CAediting_694497chr9_92071399_-SINEAluAluSp
CAediting_694498chr9_92078534_-SINEAluAluJb
CAediting_694499chr9_92078570_-SINEAluAluJb
CAediting_694500chr9_92078583_-SINEAluAluJb
CAediting_694501chr9_92078587_-SINEAluAluJb
CAediting_694502chr9_92078597_-SINEAluAluJb
CAediting_694503chr9_92078610_-SINEAluAluJb
CAediting_694504chr9_92078728_-SINEAluAluJb
CAediting_694505chr9_92078744_-SINEAluAluJb
CAediting_694506chr9_92079106_-SINEAluAluSx1
CAediting_694507chr9_92079138_-SINEAluAluSx1
CAediting_694508chr9_92079141_-SINEAluAluSx1
CAediting_694509chr9_92079159_-SINEAluAluSx1
CAediting_694510chr9_92079165_-SINEAluAluSx1
CAediting_694511chr9_92079172_-SINEAluAluSx1
CAediting_694512chr9_92079173_-SINEAluAluSx1
CAediting_694513chr9_92079181_-SINEAluAluSx1
CAediting_694514chr9_92079182_-SINEAluAluSx1
CAediting_694515chr9_92079191_-SINEAluAluSx1
CAediting_694516chr9_92079197_-SINEAluAluSx1
CAediting_694517chr9_92079204_-SINEAluAluSx1
CAediting_694518chr9_92079213_-SINEAluAluSx1
CAediting_694519chr9_92079243_-SINEAluAluSx1
CAediting_694520chr9_92079244_-SINEAluAluSx1
CAediting_694521chr9_92079249_-SINEAluAluSx1
CAediting_694522chr9_92079252_-SINEAluAluSx1
CAediting_694523chr9_92079253_-SINEAluAluSx1
CAediting_694524chr9_92079254_-SINEAluAluSx1
CAediting_694525chr9_92079258_-SINEAluAluSx1
CAediting_694526chr9_92079269_-SINEAluAluSx1
CAediting_694527chr9_92079270_-SINEAluAluSx1
CAediting_694528chr9_92079277_-SINEAluAluSx1
CAediting_694529chr9_92079279_-SINEAluAluSx1
CAediting_694530chr9_92079280_-SINEAluAluSx1
CAediting_694531chr9_92079289_-SINEAluAluSx1
CAediting_694532chr9_92079293_-SINEAluAluSx1
CAediting_694533chr9_92079294_-SINEAluAluSx1
CAediting_694534chr9_92079300_-SINEAluAluSx1
CAediting_694535chr9_92079303_-SINEAluAluSx1
CAediting_694536chr9_92079308_-SINEAluAluSx1
CAediting_694537chr9_92079313_-SINEAluAluSx1
CAediting_694538chr9_92079318_-SINEAluAluSx1
CAediting_694539chr9_92079322_-SINEAluAluSx1
CAediting_694540chr9_92079326_-SINEAluAluSx1
CAediting_694541chr9_92079332_-SINEAluAluSx1
CAediting_694542chr9_92079333_-SINEAluAluSx1
CAediting_694543chr9_92079334_-SINEAluAluSx1
CAediting_694544chr9_92079340_-SINEAluAluSx1
CAediting_694545chr9_92079349_-SINEAluAluSx1
CAediting_694546chr9_92079367_-SINEAluAluSx1
CAediting_694547chr9_92107496_-SINEAluAluY
CAediting_694548chr9_92107508_-SINEAluAluY
CAediting_694549chr9_92107563_-SINEAluAluY
CAediting_694550chr9_92107577_-SINEAluAluY
CAediting_694551chr9_92107585_-SINEAluAluY
CAediting_694552chr9_92107588_-SINEAluAluY
CAediting_694553chr9_92107652_-SINEAluAluY
CAediting_694554chr9_92107670_-SINEAluAluY
CAediting_694555chr9_92107705_-SINEAluAluY
CAediting_694556chr9_92107706_-SINEAluAluY

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RNA A-to-I editing events in the alternative splicing sites for SPTLC1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_694473chr9_92033841_-92033833:920338415SS3+0iAGGTGCAGT-10.3GGGTGCAGT-12.16

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000090054.12.SPTLC1.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000090054.12.SPTLC1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SPTLC1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SPTLC1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for SPTLC1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_694511chr9_92079172_-ENSG00000090054.12ENST00000337841hsa-miR-392992079169920791757mer-m89207916892079190157.00-19.47
CAediting_694511chr9_92079172_-ENSG00000090054.12ENST00000337841hsa-miR-447892079169920791757mer-m89207916892079184145.00-12.39
CAediting_694513chr9_92079181_-ENSG00000090054.12ENST00000337841hsa-miR-6845-3p92079181920791866mer9207918092079200147.00-25.05
CAediting_694513chr9_92079181_-ENSG00000090054.12ENST00000337841hsa-miR-891b92079177920791826mer9207917692079197142.00-20.32
CAediting_694517chr9_92079204_-ENSG00000090054.12ENST00000337841hsa-miR-1207-3p92079204920792107mer-m89207920392079220140.00-12.56
CAediting_694520chr9_92079244_-ENSG00000090054.12ENST00000337841hsa-miR-684492079243920792497mer-m89207924292079263155.00-7.49
CAediting_694521chr9_92079249_-ENSG00000090054.12ENST00000337841hsa-miR-3680-3p92079244920792518mer-1a9207924492079266140.00-13.99
CAediting_694521chr9_92079249_-ENSG00000090054.12ENST00000337841hsa-miR-3680-3p92079244920792518mer-1a9207924492079266140.00-13.99
CAediting_694525chr9_92079258_-ENSG00000090054.12ENST00000337841hsa-miR-2467-3p92079257920792626mer9207925692079275140.00-27.17
CAediting_694525chr9_92079258_-ENSG00000090054.12ENST00000337841hsa-miR-374b-3p92079253920792608mer-1a9207925392079275147.00-11.32
CAediting_694526chr9_92079269_-ENSG00000090054.12ENST00000337841hsa-miR-318892079265920792717mer-m89207926492079285144.00-17.05
CAediting_694538chr9_92079318_-ENSG00000090054.12ENST00000337841hsa-miR-4485-5p92079316920793238mer-1a9207931692079332157.00-26.74
CAediting_694539chr9_92079322_-ENSG00000090054.12ENST00000337841hsa-miR-4707-3p92079318920793258mer-1a9207931892079339162.00-26.96
CAediting_694540chr9_92079326_-ENSG00000090054.12ENST00000337841hsa-miR-191392079321920793277mer-m89207932092079341148.00-22.76
CAediting_694540chr9_92079326_-ENSG00000090054.12ENST00000337841hsa-miR-6849-3p92079326920793327mer-m89207932592079346147.00-14.69
CAediting_694541chr9_92079332_-ENSG00000090054.12ENST00000337841hsa-miR-129-1-3p92079328920793347mer-m89207932792079348140.00-11.04
CAediting_694541chr9_92079332_-ENSG00000090054.12ENST00000337841hsa-miR-129-2-3p92079328920793347mer-m89207932792079348140.00-10.59
CAediting_694541chr9_92079332_-ENSG00000090054.12ENST00000337841hsa-miR-478092079330920793367mer-m89207932992079350147.00-14.80
CAediting_694545chr9_92079349_-ENSG00000090054.12ENST00000337841hsa-miR-513a-5p92079348920793547mer-m89207934792079364152.00-17.32
CAediting_694545chr9_92079349_-ENSG00000090054.12ENST00000337841hsa-miR-513a-5p92079348920793547mer-m89207934792079364152.00-17.32
CAediting_694545chr9_92079349_-ENSG00000090054.12ENST00000337841hsa-miR-63892079343920793497mer-1a9207934392079367155.00-34.38
CAediting_694507chr9_92079138_-ENSG00000090054.12ENST00000337841hsa-miR-56492079133920791397mer-1a9207913392079151143.00-19.46
CAediting_694508chr9_92079141_-ENSG00000090054.12ENST00000337841hsa-miR-6790-3p92079138920791458mer-1a9207913892079158150.00-23.03
CAediting_694509chr9_92079159_-ENSG00000090054.12ENST00000337841hsa-miR-6747-3p92079159920791657mer-m89207915892079178151.00-22.26
CAediting_694509chr9_92079159_-ENSG00000090054.12ENST00000337841hsa-miR-6752-3p92079158920791647mer-m89207915792079178151.00-25.45
CAediting_694509chr9_92079159_-ENSG00000090054.12ENST00000337841hsa-miR-6801-3p92079157920791637mer-m89207915692079175158.00-26.95
CAediting_694509chr9_92079159_-ENSG00000090054.12ENST00000337841hsa-miR-6810-3p92079157920791637mer-m89207915692079179160.00-26.81
CAediting_694510chr9_92079165_-ENSG00000090054.12ENST00000337841hsa-miR-191392079159920791668mer-1a9207915992079180156.00-24.01
CAediting_694510chr9_92079165_-ENSG00000090054.12ENST00000337841hsa-miR-361-3p92079164920791707mer-m89207916392079189161.00-27.12
CAediting_694515chr9_92079191_-ENSG00000090054.12ENST00000337841hsa-miR-6849-3p92079191920791977mer-m89207919092079208146.00-20.01
CAediting_694516chr9_92079197_-ENSG00000090054.12ENST00000337841hsa-miR-394392079193920791997mer-m89207919292079213147.00-22.28
CAediting_694523chr9_92079253_-ENSG00000090054.12ENST00000337841hsa-miR-63092079247920792548mer-1a9207924792079267158.00-12.84
CAediting_694524chr9_92079254_-ENSG00000090054.12ENST00000337841hsa-miR-32592079253920792608mer-1a9207925392079274146.00-10.69
CAediting_694528chr9_92079277_-ENSG00000090054.12ENST00000337841hsa-miR-1306-3p92079277920792837mer-m89207927692079293152.00-23.70
CAediting_694529chr9_92079279_-ENSG00000090054.12ENST00000337841hsa-miR-3190-5p92079279920792857mer-m89207927892079297147.00-16.73
CAediting_694532chr9_92079293_-ENSG00000090054.12ENST00000337841hsa-miR-3663-5p92079288920792947mer-m89207928792079303141.00-19.69
CAediting_694533chr9_92079294_-ENSG00000090054.12ENST00000337841hsa-miR-1211392079293920793008mer-1a9207929392079313147.00-20.20
CAediting_694533chr9_92079294_-ENSG00000090054.12ENST00000337841hsa-miR-152-5p92079289920792968mer-1a9207928992079311143.00-22.00
CAediting_694533chr9_92079294_-ENSG00000090054.12ENST00000337841hsa-miR-453992079293920793008mer-1a9207929392079312151.00-20.59
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-518a-3p92079336920793427mer-m89207933592079356145.00-21.07
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-518a-3p92079336920793427mer-m89207933592079356145.00-21.07
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-518b92079336920793427mer-m89207933592079355146.00-17.37
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-518c-3p92079336920793427mer-m89207933592079356146.00-13.66
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-518d-3p92079336920793427mer-m89207933592079355145.00-13.42
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-518e-3p92079337920793437mer-m89207933692079357144.00-14.43
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-518f-3p92079336920793427mer-m89207933592079355145.00-21.40
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-526a-3p92079336920793427mer-m89207933592079355146.00-21.63
CAediting_694514chr9_92079182_-ENSG00000090054.12ENST00000337841hsa-miR-500a-5p92079179920791846mer9207917892079199145.00-22.20
CAediting_694514chr9_92079182_-ENSG00000090054.12ENST00000337841hsa-miR-6749-3p92079181920791877mer-m89207918092079199150.00-23.29
CAediting_694534chr9_92079300_-ENSG00000090054.12ENST00000337841hsa-miR-4732-3p92079300920793067mer-m89207929992079319155.00-23.59
CAediting_694536chr9_92079308_-ENSG00000090054.12ENST00000337841hsa-miR-4726-3p92079307920793137mer-m89207930692079328150.00-23.19
CAediting_694542chr9_92079333_-ENSG00000090054.12ENST00000337841hsa-miR-146a-3p92079331920793377mer-m89207933092079351147.00-14.90
CAediting_694542chr9_92079333_-ENSG00000090054.12ENST00000337841hsa-miR-4766-5p92079332920793398mer-1a9207933292079352149.00-16.71
CAediting_694542chr9_92079333_-ENSG00000090054.12ENST00000337841hsa-miR-6819-3p92079328920793347mer-m89207932792079347145.00-14.15
CAediting_694542chr9_92079333_-ENSG00000090054.12ENST00000337841hsa-miR-6877-3p92079328920793347mer-m89207932792079347145.00-21.47

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_694545chr9_92079349_-ENSG00000090054.12ENST00000337841hsa-miR-10399-5p92079347920793537mer-m89207934692079367144-10.26
CAediting_694518chr9_92079213_-ENSG00000090054.12ENST00000337841hsa-miR-10399-5p92079212920792187mer-m89207921192079230145-10.21
CAediting_694537chr9_92079313_-ENSG00000090054.12ENST00000337841hsa-miR-125a-3p92079308920793158mer-1a9207930892079329152-17.79
CAediting_694532chr9_92079293_-ENSG00000090054.12ENST00000337841hsa-miR-205292079291920792977mer-m89207929092079309140-5.37
CAediting_694533chr9_92079294_-ENSG00000090054.12ENST00000337841hsa-miR-205292079291920792977mer-m89207929092079309140-5.37
CAediting_694531chr9_92079289_-ENSG00000090054.12ENST00000337841hsa-miR-29b-1-5p92079288920792947mer-m89207928792079311144-16.09
CAediting_694532chr9_92079293_-ENSG00000090054.12ENST00000337841hsa-miR-29b-1-5p92079288920792947mer-m89207928792079311144-16.09
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-302a-3p92079337920793437mer-m89207933692079357143-11.02
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-302b-3p92079337920793437mer-m89207933692079358141-9.54
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-302c-3p92079337920793437mer-m89207933692079356145-11.96
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-302d-3p92079337920793437mer-m89207933692079363148-13.74
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-302e92079337920793437mer-m89207933692079352141-8.62
CAediting_694526chr9_92079269_-ENSG00000090054.12ENST00000337841hsa-miR-30d-3p92079269920792746mer9207926892079286140-11.32
CAediting_694527chr9_92079270_-ENSG00000090054.12ENST00000337841hsa-miR-30d-3p92079269920792746mer9207926892079286140-11.32
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-360992079336920793416mer9207933592079357140-13.56
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-372-3p92079337920793437mer-m89207933692079363155-21.14
CAediting_694506chr9_92079106_-ENSG00000090054.12ENST00000337841hsa-miR-431-5p92079102920791087mer-m89207910192079121140-13.39
CAediting_694530chr9_92079280_-ENSG00000090054.12ENST00000337841hsa-miR-443592079279920792868mer-1a9207927992079299146-17.76
CAediting_694530chr9_92079280_-ENSG00000090054.12ENST00000337841hsa-miR-443592079279920792868mer-1a9207927992079299146-17.76
CAediting_694534chr9_92079300_-ENSG00000090054.12ENST00000337841hsa-miR-4680-5p92079295920793017mer-1a9207929592079315146-20.51
CAediting_694519chr9_92079243_-ENSG00000090054.12ENST00000337841hsa-miR-4735-5p92079239920792457mer-m89207923892079259140-5.48
CAediting_694520chr9_92079244_-ENSG00000090054.12ENST00000337841hsa-miR-4735-5p92079239920792457mer-m89207923892079259140-5.48
CAediting_694528chr9_92079277_-ENSG00000090054.12ENST00000337841hsa-miR-4781-3p92079276920792827mer-m89207927592079293144-13.86
CAediting_694529chr9_92079279_-ENSG00000090054.12ENST00000337841hsa-miR-4781-3p92079276920792827mer-m89207927592079293144-13.86
CAediting_694530chr9_92079280_-ENSG00000090054.12ENST00000337841hsa-miR-4781-3p92079276920792827mer-m89207927592079293144-13.86
CAediting_694538chr9_92079318_-ENSG00000090054.12ENST00000337841hsa-miR-5001-3p92079316920793227mer-m89207931592079335146-20.82
CAediting_694518chr9_92079213_-ENSG00000090054.12ENST00000337841hsa-miR-5089-5p92079208920792147mer-m89207920792079226152-13.68
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-512-3p92079338920793447mer-m89207933792079358149-15
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-512-3p92079338920793447mer-m89207933792079358149-15
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-519d-3p92079336920793427mer-m89207933592079355146-10.11
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-520a-3p92079337920793437mer-m89207933692079357140-11.03
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-520b-3p92079337920793437mer-m89207933692079355141-16.52
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-520c-3p92079337920793437mer-m89207933692079356146-16.52
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-520d-3p92079337920793437mer-m89207933692079357140-13.09
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-520e-3p92079337920793437mer-m89207933692079356140-13.32
CAediting_694544chr9_92079340_-ENSG00000090054.12ENST00000337841hsa-miR-526b-3p92079336920793427mer-m89207933592079355146-20.58
CAediting_694513chr9_92079181_-ENSG00000090054.12ENST00000337841hsa-miR-5571-5p92079179920791857mer-m89207917892079200150-27.21
CAediting_694514chr9_92079182_-ENSG00000090054.12ENST00000337841hsa-miR-5571-5p92079179920791857mer-m89207917892079200150-27.21
CAediting_694506chr9_92079106_-ENSG00000090054.12ENST00000337841hsa-miR-569192079105920791128mer-1a9207910592079127146-19.21
CAediting_694518chr9_92079213_-ENSG00000090054.12ENST00000337841hsa-miR-6504-3p92079212920792187mer-m89207921192079229144-11.57
CAediting_694539chr9_92079322_-ENSG00000090054.12ENST00000337841hsa-miR-6747-3p92079320920793267mer-m89207931992079341152-18.45
CAediting_694516chr9_92079197_-ENSG00000090054.12ENST00000337841hsa-miR-6778-3p92079194920792007mer-m89207919392079213140-16.13
CAediting_694510chr9_92079165_-ENSG00000090054.12ENST00000337841hsa-miR-6778-3p92079161920791688mer-1a9207916192079181142-17.51
CAediting_694516chr9_92079197_-ENSG00000090054.12ENST00000337841hsa-miR-6829-3p92079194920791996mer9207919392079212147-23.64
CAediting_694525chr9_92079258_-ENSG00000090054.12ENST00000337841hsa-miR-6832-5p92079257920792637mer-m89207925692079278151-18.4
CAediting_694510chr9_92079165_-ENSG00000090054.12ENST00000337841hsa-miR-6836-3p92079161920791677mer-m89207916092079180145-20.12
CAediting_694546chr9_92079367_-ENSG00000090054.12ENST00000337841hsa-miR-6872-3p92079364920793707mer-m89207936392079385144-19.72
CAediting_694538chr9_92079318_-ENSG00000090054.12ENST00000337841hsa-miR-6894-3p92079318920793247mer-m89207931792079336155-23.54
CAediting_694539chr9_92079322_-ENSG00000090054.12ENST00000337841hsa-miR-6894-3p92079318920793247mer-m89207931792079336155-23.54
CAediting_694545chr9_92079349_-ENSG00000090054.12ENST00000337841hsa-miR-7151-3p92079348920793558mer-1a9207934892079364146-17.62

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SPTLC1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for SPTLC1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BLCACAediting_694513chr9_92079181_-0.03703799365762270.2654693398632070.04496638624272440.255586381913636..
BRCACAediting_694513chr9_92079181_-....0.02147358175266690.229758427126633
GBMCAediting_694513chr9_92079181_-....0.004968958749621270.364022299751846
THCACAediting_694513chr9_92079181_-0.008486238947740620.278976188025768....
BLCACAediting_694517chr9_92079204_-..0.004830137780490980.322101005975527..
GBMCAediting_694517chr9_92079204_-..0.002982003224499010.403922701380224..
HNSCCAediting_694517chr9_92079204_-..0.00256262417892170.33074966451522..
STADCAediting_694517chr9_92079204_-..0.0001739141704024970.46619761961113..
THCACAediting_694517chr9_92079204_-8.40490452926361e-050.3004144758724540.0003000281617479260.277176075062375..
SKCMCAediting_694517chr9_92079204_-0.03850237747023810.2479363082558370.0004085194514845220.411022406472191..
STADCAediting_694518chr9_92079213_-..0.00420663913013240.233983204948623..
THCACAediting_694518chr9_92079213_-..0.0192181398215090.1654474181442870.04516859125880620.141811468272738
ESCACAediting_694518chr9_92079213_-..0.00488252077560550.266541448274362..
TGCTCAediting_694518chr9_92079213_-0.02027907684743530.294215794565014....
BLCACAediting_694546chr9_92079367_-0.009388318131517960.191549787244504....
LGGCAediting_694546chr9_92079367_-....0.02430545242420210.152525974819659
BRCACAediting_694546chr9_92079367_-0.004883977502353380.117944868978886....
CESCCAediting_694546chr9_92079367_-0.04526068147857820.157545714258244....
HNSCCAediting_694546chr9_92079367_-0.002918205272178880.203468379041619..0.04802467465056120.135963846584207
THCACAediting_694546chr9_92079367_-0.01642607788136260.122697224083197....
PCPGCAediting_694546chr9_92079367_-....0.0355011220780530.192966035114441
SARCCAediting_694546chr9_92079367_-0.0008605715196964530.268433856336215....
TGCTCAediting_694546chr9_92079367_-0.004516759617342970.290429112353511....

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Relation with cancer stages for SPTLC1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
BRCApathologic_stageCAediting_694526chr9_92079269_-0.02619792316752620.20554785716282
HNSCclinical_stageCAediting_694513chr9_92079181_-0.03325478833394340.275307601288423
LUSCpathologic_stageCAediting_694513chr9_92079181_-0.0322527712536157-0.281575259144118

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Relation with survival for SPTLC1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
SKCMCAediting_694546chr9_92079367_-0.009777520712650370.0018895159.9989

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RelatedDrugs for SPTLC1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
SPTLC1O15269DB00114Pyridoxal phosphateSerine palmitoyltransferase 1 SmallMoleculeDrugapproved|investigational|nutraceutical

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RelatedDiseases for SPTLC1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
SPTLC1C0020071Hereditary Sensory Autonomic Neuropathy, Type 111CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
SPTLC1C0270914Hereditary Motor and Sensory-Neuropathy Type II2GENOMICS_ENGLAND
SPTLC1C0007959Charcot-Marie-Tooth Disease1GENOMICS_ENGLAND
SPTLC1C0013364Dysautonomia, Familial1GENOMICS_ENGLAND