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Editing gene: CPQ (CAeditome ID:10404)

Gene summary for CPQ

Gene summary

Gene information	Gene symbol	CPQ
	Gene ID	10404
	Gene name	carboxypeptidase Q
	Synonyms	LDP\|PGCP
	Cytomap	8q22.1
	Type of gene	protein-coding
	Description	carboxypeptidase QSer-Met dipeptidaseaminopeptidaseblood plasma glutamate carboxypeptidaselysosomal dipeptidase
	Modification date	20210518
	UniProtAcc	Q9Y646
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CPQ	GO:0042803	Carboxypeptidase Q	12675526
CPQ	GO:0070573	Carboxypeptidase Q	10206990
CPQ	GO:0006508	Carboxypeptidase Q	10206990
CPQ	GO:0043171	Carboxypeptidase Q	10206990
CPQ	GO:0005615	Carboxypeptidase Q	10206990
CPQ	GO:0005737	Carboxypeptidase Q	10206990
CPQ	GO:0005794	Carboxypeptidase Q	0000052
CPQ	GO:0043231	Carboxypeptidase Q	0000052

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RNA A-to-I events for CPQ

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000104324.14

RNA A-to-I editing events in Cancer.

CAediting_650861(96724750, +), CAediting_650862(96724762, +), CAediting_650863(96724770, +), CAediting_650864(96725755, +), CAediting_650865(96725758, +), CAediting_650866(96770794, +), CAediting_650867(96770798, +), CAediting_650868(96770803, +), CAediting_650869(96770879, +), CAediting_650870(96771670, +), CAediting_650871(96771697, +), CAediting_650872(96771703, +), CAediting_650873(96771742, +), CAediting_650874(96798194, +), CAediting_650875(96798204, +), CAediting_650876(96798209, +), CAediting_650877(96798420, +), CAediting_650878(96943253, +), CAediting_650879(96943254, +), CAediting_650880(96945383, +), CAediting_650881(97014567, +), CAediting_650882(97068583, +), CAediting_650883(97089011, +), CAediting_650884(97117729, +), CAediting_650885(97119051, +), CAediting_650886(97119065, +), CAediting_650887(97119067, +), CAediting_650888(97119079, +), CAediting_650889(97119119, +), CAediting_650890(97119208, +), CAediting_650891(97119209, +), CAediting_650892(97124183, +), CAediting_650893(97143166, +), CAediting_650894(97145739, +), CAediting_650895(97147260, +), CAediting_650896(97147286, +), CAediting_650897(97147415, +), CAediting_650898(97147420, +), CAediting_650899(97147430, +), CAediting_650900(97147441, +), CAediting_650901(97147459, +),

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RNA editing positional annotations for CPQ using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_650861	chr8_96724750_+	intronic
CAediting_650862	chr8_96724762_+	intronic
CAediting_650863	chr8_96724770_+	intronic
CAediting_650864	chr8_96725755_+	intronic
CAediting_650865	chr8_96725758_+	intronic
CAediting_650866	chr8_96770794_+	ncRNA_intronic
CAediting_650867	chr8_96770798_+	ncRNA_intronic
CAediting_650868	chr8_96770803_+	ncRNA_intronic
CAediting_650869	chr8_96770879_+	ncRNA_intronic
CAediting_650870	chr8_96771670_+	ncRNA_intronic
CAediting_650871	chr8_96771697_+	ncRNA_intronic
CAediting_650872	chr8_96771703_+	ncRNA_intronic
CAediting_650873	chr8_96771742_+	ncRNA_intronic
CAediting_650874	chr8_96798194_+	intronic
CAediting_650875	chr8_96798204_+	intronic
CAediting_650876	chr8_96798209_+	intronic
CAediting_650877	chr8_96798420_+	intronic
CAediting_650878	chr8_96943253_+	intronic
CAediting_650879	chr8_96943254_+	intronic
CAediting_650880	chr8_96945383_+	intronic
CAediting_650881	chr8_97014567_+	intronic
CAediting_650882	chr8_97068583_+	ncRNA_intronic
CAediting_650883	chr8_97089011_+	ncRNA_intronic
CAediting_650884	chr8_97117729_+	intronic
CAediting_650885	chr8_97119051_+	intronic
CAediting_650886	chr8_97119065_+	intronic
CAediting_650887	chr8_97119067_+	intronic
CAediting_650888	chr8_97119079_+	intronic
CAediting_650889	chr8_97119119_+	intronic
CAediting_650890	chr8_97119208_+	intronic
CAediting_650891	chr8_97119209_+	intronic
CAediting_650892	chr8_97124183_+	intronic
CAediting_650893	chr8_97143166_+	exonic
CAediting_650894	chr8_97145739_+	intronic
CAediting_650895	chr8_97147260_+	intronic
CAediting_650896	chr8_97147286_+	intronic
CAediting_650897	chr8_97147415_+	intronic
CAediting_650898	chr8_97147420_+	intronic
CAediting_650899	chr8_97147430_+	intronic
CAediting_650900	chr8_97147441_+	intronic
CAediting_650901	chr8_97147459_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_650861	chr8_96724750_+	LINE	L1	L1PA16
CAediting_650862	chr8_96724762_+	LINE	L1	L1PA16
CAediting_650863	chr8_96724770_+	LINE	L1	L1PA16
CAediting_650864	chr8_96725755_+	LINE	L1	L1PA16
CAediting_650865	chr8_96725758_+	LINE	L1	L1PA16
CAediting_650874	chr8_96798194_+	SINE	Alu	AluJb
CAediting_650875	chr8_96798204_+	SINE	Alu	AluJb
CAediting_650876	chr8_96798209_+	SINE	Alu	AluJb
CAediting_650877	chr8_96798420_+	SINE	Alu	AluJb
CAediting_650881	chr8_97014567_+	SINE	Alu	AluSz6
CAediting_650882	chr8_97068583_+	SINE	Alu	AluSq
CAediting_650883	chr8_97089011_+	SINE	Alu	AluSp
CAediting_650884	chr8_97117729_+	SINE	Alu	AluJb
CAediting_650885	chr8_97119051_+	SINE	Alu	AluSx1
CAediting_650886	chr8_97119065_+	SINE	Alu	AluSx1
CAediting_650887	chr8_97119067_+	SINE	Alu	AluSx1
CAediting_650888	chr8_97119079_+	SINE	Alu	AluSx1
CAediting_650889	chr8_97119119_+	SINE	Alu	AluSx1
CAediting_650890	chr8_97119208_+	SINE	Alu	AluSx1
CAediting_650891	chr8_97119209_+	SINE	Alu	AluSx1
CAediting_650892	chr8_97124183_+	SINE	Alu	AluSx1
CAediting_650894	chr8_97145739_+	SINE	Alu	AluJr
CAediting_650895	chr8_97147260_+	SINE	Alu	AluSx
CAediting_650896	chr8_97147286_+	SINE	Alu	AluSx
CAediting_650897	chr8_97147415_+	SINE	Alu	AluSx
CAediting_650898	chr8_97147420_+	SINE	Alu	AluSx
CAediting_650899	chr8_97147430_+	SINE	Alu	AluSx
CAediting_650900	chr8_97147441_+	SINE	Alu	AluSx
CAediting_650901	chr8_97147459_+	SINE	Alu	AluSx

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RNA A-to-I editing events in the alternative splicing sites for CPQ

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000104324.14.CPQ.

Correlation between RNA A-to-I editing and PSI for ENSG00000104324.14.CPQ.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CPQ

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CPQ

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CPQ

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1160181	chr17_7017644_-	ENSG00000104324.14	ENST00000220763	hsa-miR-195-3p	97143446	97143452	7mer-m8	97143432	97143453	140	-8.77

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CPQ

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000220763.8	protein_coding
ENST00000522617.3	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_650893	ENST00000220763.8	chr8_97143166_+	-637.10	-636.30	-637.10
CAediting_650893	ENST00000522617.3	chr8_97143166_+	-139.90	-140.00	-139.90

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Relation with ADAR for CPQ

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for CPQ

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CPQ

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CPQ

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
CPQ	Q9Y646	DB00142	Glutamic acid	Carboxypeptidase Q	SmallMoleculeDrug	approved\|nutraceutical

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RelatedDiseases for CPQ

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CPQ	C0007134	Renal Cell Carcinoma	1	CTD_human
CPQ	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
CPQ	C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	1	CTD_human
CPQ	C1266042	Chromophobe Renal Cell Carcinoma	1	CTD_human
CPQ	C1266043	Sarcomatoid Renal Cell Carcinoma	1	CTD_human
CPQ	C1266044	Collecting Duct Carcinoma of the Kidney	1	CTD_human
CPQ	C1306837	Papillary Renal Cell Carcinoma	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene