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Editing gene: ADARB1 (CAeditome ID:104)

Gene summary for ADARB1

Gene summary

Gene information	Gene symbol	ADARB1
	Gene ID	104
	Gene name	adenosine deaminase RNA specific B1
	Synonyms	ADAR2\|DRABA2\|DRADA2\|NEDHYMS\|RED1
	Cytomap	21q22.3
	Type of gene	protein-coding
	Description	double-stranded RNA-specific editase 1RNA editing deaminase 1RNA-editing enzyme 1adenosine deaminase, RNA-specific, B1 (homolog of rat RED1)dsRNA adenosine deaminase DRADA2
	Modification date	20210524
	UniProtAcc	P78563
	Context	- 31491024(Function of low ADARB1 expression in lung adenocarcinoma)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
ADARB1	GO:0003726	Double-stranded RNA-specific editase 1	32220291
ADARB1	GO:0006382	Double-stranded RNA-specific editase 1	18178553
ADARB1	GO:0006382	Double-stranded RNA-specific editase 1	21289159
ADARB1	GO:0006382	Double-stranded RNA-specific editase 1	32220291
ADARB1	GO:0006396	Double-stranded RNA-specific editase 1	32220291
ADARB1	GO:0008285	Double-stranded RNA-specific editase 1	18178553
ADARB1	GO:0016553	Double-stranded RNA-specific editase 1	32220291
ADARB1	GO:0030336	Double-stranded RNA-specific editase 1	18178553
ADARB1	GO:0044387	Double-stranded RNA-specific editase 1	21289159
ADARB1	GO:0051726	Double-stranded RNA-specific editase 1	18178553
ADARB1	GO:0005634	Double-stranded RNA-specific editase 1	32220291
ADARB1	GO:0005654	Double-stranded RNA-specific editase 1	0000052
ADARB1	GO:0005730	Double-stranded RNA-specific editase 1	18178553
ADARB1	GO:0005730	Double-stranded RNA-specific editase 1	21289159
ADARB1	GO:0005730	Double-stranded RNA-specific editase 1	32220291
ADARB1	GO:0005829	Double-stranded RNA-specific editase 1	0000052

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RNA A-to-I events for ADARB1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000197381.14

RNA A-to-I editing events in Cancer.

CAediting_1456647(45077546, +), CAediting_1456648(45099521, +), CAediting_1456649(45107994, +), CAediting_1456650(45124474, +), CAediting_1456651(45150006, +), CAediting_1456652(45173787, +), CAediting_1456653(45173795, +), CAediting_1456654(45175692, +), CAediting_1456655(45175705, +), CAediting_1456656(45175706, +), CAediting_1456657(45184568, +), CAediting_1456658(45187594, +), CAediting_1456659(45193799, +), CAediting_1456660(45193939, +), CAediting_1456661(45195953, +), CAediting_1456662(45196246, +), CAediting_1456663(45196278, +), CAediting_1456664(45196694, +), CAediting_1456665(45196706, +), CAediting_1456666(45197487, +), CAediting_1456667(45197559, +), CAediting_1456668(45215047, +), CAediting_1456669(45225236, +), CAediting_1456670(45225520, +),

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RNA editing positional annotations for ADARB1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1456647	chr21_45077546_+	ncRNA_intronic
CAediting_1456648	chr21_45099521_+	ncRNA_intronic
CAediting_1456649	chr21_45107994_+	ncRNA_intronic
CAediting_1456650	chr21_45124474_+	ncRNA_intronic
CAediting_1456651	chr21_45150006_+	ncRNA_intronic
CAediting_1456652	chr21_45173787_+	intronic
CAediting_1456653	chr21_45173795_+	intronic
CAediting_1456654	chr21_45175692_+	intronic
CAediting_1456655	chr21_45175705_+	intronic
CAediting_1456656	chr21_45175706_+	intronic
CAediting_1456657	chr21_45184568_+	exonic
CAediting_1456658	chr21_45187594_+	intronic
CAediting_1456659	chr21_45193799_+	intronic
CAediting_1456660	chr21_45193939_+	intronic
CAediting_1456661	chr21_45195953_+	intronic
CAediting_1456662	chr21_45196246_+	intronic
CAediting_1456663	chr21_45196278_+	intronic
CAediting_1456664	chr21_45196694_+	intronic
CAediting_1456665	chr21_45196706_+	intronic
CAediting_1456666	chr21_45197487_+	intronic
CAediting_1456667	chr21_45197559_+	intronic
CAediting_1456668	chr21_45215047_+	intronic
CAediting_1456669	chr21_45225236_+	UTR3
CAediting_1456670	chr21_45225520_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1456647	chr21_45077546_+	SINE	Alu	AluY
CAediting_1456648	chr21_45099521_+	SINE	Alu	AluSz
CAediting_1456649	chr21_45107994_+	SINE	Alu	AluJb
CAediting_1456650	chr21_45124474_+	SINE	Alu	AluJb
CAediting_1456651	chr21_45150006_+	SINE	Alu	AluSx
CAediting_1456657	chr21_45184568_+	SINE	Alu	AluJb
CAediting_1456658	chr21_45187594_+	LINE	L1	L1ME3Cz
CAediting_1456659	chr21_45193799_+	LINE	L1	L1ME1
CAediting_1456660	chr21_45193939_+	LINE	L1	L1ME1
CAediting_1456661	chr21_45195953_+	LINE	L1	L1MC1
CAediting_1456662	chr21_45196246_+	LINE	L1	L1ME1
CAediting_1456663	chr21_45196278_+	LINE	L1	L1ME1
CAediting_1456664	chr21_45196694_+	LINE	L1	L1ME1
CAediting_1456665	chr21_45196706_+	LINE	L1	L1ME1
CAediting_1456666	chr21_45197487_+	SINE	Alu	AluSx4
CAediting_1456667	chr21_45197559_+	LINE	L1	L1ME1
CAediting_1456668	chr21_45215047_+	SINE	Alu	AluJr4

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RNA A-to-I editing events in the alternative splicing sites for ADARB1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000197381.14.ADARB1.

Correlation between RNA A-to-I editing and PSI for ENSG00000197381.14.ADARB1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ADARB1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ADARB1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ADARB1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1456669	chr21_45225236_+	ENSG00000197381.14	ENST00000348831	hsa-miR-4535	45225229	45225235	7mer-m8	45225218	45225236	152	-20.47
CAediting_1456670	chr21_45225520_+	ENSG00000197381.14	ENST00000348831	hsa-miR-6760-3p	45225516	45225522	7mer-m8	45225503	45225523	140	-13.82
CAediting_1456669	chr21_45225236_+	ENSG00000197381.14	ENST00000360697	hsa-miR-4535	45225229	45225235	7mer-m8	45225218	45225236	152	-20.47
CAediting_1456670	chr21_45225520_+	ENSG00000197381.14	ENST00000360697	hsa-miR-6760-3p	45225516	45225522	7mer-m8	45225503	45225523	140	-13.82

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000197381.14	ENST00000348831	hsa-miR-200b-3p	45222436	45222442	7mer-m8	45222424	45222443	152	-17.11
CAediting_393	chr1_1167164_+	ENSG00000197381.14	ENST00000437626	hsa-miR-200b-3p	45222436	45222442	7mer-m8	45222424	45222443	152	-17.11
CAediting_393	chr1_1167164_+	ENSG00000197381.14	ENST00000492414	hsa-miR-200b-3p	45222436	45222442	7mer-m8	45222424	45222443	152	-17.11
CAediting_393	chr1_1167164_+	ENSG00000197381.14	ENST00000496664	hsa-miR-200b-3p	45222436	45222442	7mer-m8	45222424	45222443	152	-17.11
CAediting_393	chr1_1167164_+	ENSG00000197381.14	ENST00000629643	hsa-miR-200b-3p	45222436	45222442	7mer-m8	45222424	45222443	152	-17.11
CAediting_393	chr1_1167164_+	ENSG00000197381.14	ENST00000360697	hsa-miR-200b-3p	45222436	45222442	7mer-m8	45222424	45222443	152	-17.11
CAediting_1054808	chr15_66496985_-	ENSG00000197381.14	ENST00000348831	hsa-miR-4512	45222899	45222905	7mer-m8	45222887	45222906	145	-22.17
CAediting_1229413	chr17_67471544_+	ENSG00000197381.14	ENST00000348831	hsa-miR-548aa	45224706	45224712	7mer-m8	45224690	45224713	154	-15.24
CAediting_1229415	chr17_67471547_+	ENSG00000197381.14	ENST00000348831	hsa-miR-548aa	45224063	45224069	7mer-m8	45224045	45224070	146	-13.27
CAediting_1229415	chr17_67471547_+	ENSG00000197381.14	ENST00000348831	hsa-miR-548aa	45224260	45224266	7mer-m8	45224243	45224267	152	-11.41
CAediting_1229415	chr17_67471547_+	ENSG00000197381.14	ENST00000348831	hsa-miR-548aa	45224959	45224965	7mer-m8	45224943	45224966	152	-16.59
CAediting_1160181	chr17_7017644_-	ENSG00000197381.14	ENST00000348831	hsa-miR-195-3p	45223327	45223333	7mer-1a	45223310	45223333	145	-22
CAediting_1351755	chr19_40282625_-	ENSG00000197381.14	ENST00000348831	hsa-miR-641	45225641	45225648	8mer-1a	45225627	45225648	155	-20.07
CAediting_1368054	chr19_46709310_-	ENSG00000197381.14	ENST00000348831	hsa-miR-320e	45223548	45223554	7mer-m8	45223538	45223555	146	-17.75
CAediting_77128	chr1_85133844_+	ENSG00000197381.14	ENST00000348831	hsa-miR-4423-3p	45223544	45223550	7mer-m8	45223531	45223551	140	-13.77
CAediting_228905	chr2_188297554_+	ENSG00000197381.14	ENST00000348831	hsa-miR-561-3p	45225998	45226004	7mer-m8	45225984	45226005	140	-12.04
CAediting_524911	chr7_5495852_-	ENSG00000197381.14	ENST00000348831	hsa-miR-589-3p	45223525	45223531	7mer-m8	45223507	45223532	150	-23.72
CAediting_573001	chr7_92204086_-	ENSG00000197381.14	ENST00000348831	hsa-miR-1285-5p	45224844	45224851	8mer-1a	45224831	45224851	140	-15.05
CAediting_1054808	chr15_66496985_-	ENSG00000197381.14	ENST00000437626	hsa-miR-4512	45222899	45222905	7mer-m8	45222887	45222906	145	-22.17
CAediting_1160181	chr17_7017644_-	ENSG00000197381.14	ENST00000437626	hsa-miR-195-3p	45223327	45223333	7mer-1a	45223310	45223333	145	-22
CAediting_1368054	chr19_46709310_-	ENSG00000197381.14	ENST00000437626	hsa-miR-320e	45223548	45223554	7mer-m8	45223538	45223555	146	-17.75
CAediting_77128	chr1_85133844_+	ENSG00000197381.14	ENST00000437626	hsa-miR-4423-3p	45223544	45223550	7mer-m8	45223531	45223551	140	-13.77
CAediting_524911	chr7_5495852_-	ENSG00000197381.14	ENST00000437626	hsa-miR-589-3p	45223525	45223531	7mer-m8	45223507	45223532	150	-23.72
CAediting_1351755	chr19_40282625_-	ENSG00000197381.14	ENST00000437626	hsa-miR-641	45225641	45225648	8mer-1a	45225627	45225648	155	-20.07
CAediting_228905	chr2_188297554_+	ENSG00000197381.14	ENST00000437626	hsa-miR-561-3p	45225998	45226004	7mer-m8	45225984	45226005	140	-12.04
CAediting_1351755	chr19_40282625_-	ENSG00000197381.14	ENST00000389863	hsa-miR-641	45225641	45225648	8mer-1a	45225627	45225648	155	-20.07
CAediting_228905	chr2_188297554_+	ENSG00000197381.14	ENST00000389863	hsa-miR-561-3p	45225998	45226004	7mer-m8	45225984	45226005	140	-12.04
CAediting_1054808	chr15_66496985_-	ENSG00000197381.14	ENST00000492414	hsa-miR-4512	45222899	45222905	7mer-m8	45222887	45222906	145	-22.17
CAediting_1160181	chr17_7017644_-	ENSG00000197381.14	ENST00000492414	hsa-miR-195-3p	45223327	45223333	7mer-1a	45223310	45223333	145	-22
CAediting_1368054	chr19_46709310_-	ENSG00000197381.14	ENST00000492414	hsa-miR-320e	45223548	45223554	7mer-m8	45223538	45223555	146	-17.75
CAediting_77128	chr1_85133844_+	ENSG00000197381.14	ENST00000492414	hsa-miR-4423-3p	45223544	45223550	7mer-m8	45223531	45223551	140	-13.77
CAediting_524911	chr7_5495852_-	ENSG00000197381.14	ENST00000492414	hsa-miR-589-3p	45223525	45223531	7mer-m8	45223507	45223532	150	-23.72
CAediting_1351755	chr19_40282625_-	ENSG00000197381.14	ENST00000492414	hsa-miR-641	45225641	45225648	8mer-1a	45225627	45225648	155	-20.07
CAediting_228905	chr2_188297554_+	ENSG00000197381.14	ENST00000492414	hsa-miR-561-3p	45225998	45226004	7mer-m8	45225984	45226005	140	-12.04
CAediting_1054808	chr15_66496985_-	ENSG00000197381.14	ENST00000496664	hsa-miR-4512	45222899	45222905	7mer-m8	45222887	45222906	145	-22.17
CAediting_1160181	chr17_7017644_-	ENSG00000197381.14	ENST00000496664	hsa-miR-195-3p	45223327	45223333	7mer-1a	45223310	45223333	145	-22
CAediting_1368054	chr19_46709310_-	ENSG00000197381.14	ENST00000496664	hsa-miR-320e	45223548	45223554	7mer-m8	45223538	45223555	146	-17.75
CAediting_77128	chr1_85133844_+	ENSG00000197381.14	ENST00000496664	hsa-miR-4423-3p	45223544	45223550	7mer-m8	45223531	45223551	140	-13.77
CAediting_524911	chr7_5495852_-	ENSG00000197381.14	ENST00000496664	hsa-miR-589-3p	45223525	45223531	7mer-m8	45223507	45223532	150	-23.72
CAediting_1351755	chr19_40282625_-	ENSG00000197381.14	ENST00000496664	hsa-miR-641	45225641	45225648	8mer-1a	45225627	45225648	155	-20.07
CAediting_228905	chr2_188297554_+	ENSG00000197381.14	ENST00000496664	hsa-miR-561-3p	45225998	45226004	7mer-m8	45225984	45226005	140	-12.04
CAediting_1054808	chr15_66496985_-	ENSG00000197381.14	ENST00000629643	hsa-miR-4512	45222899	45222905	7mer-m8	45222887	45222906	145	-22.17
CAediting_1160181	chr17_7017644_-	ENSG00000197381.14	ENST00000629643	hsa-miR-195-3p	45223327	45223333	7mer-1a	45223310	45223333	145	-22
CAediting_1368054	chr19_46709310_-	ENSG00000197381.14	ENST00000629643	hsa-miR-320e	45223548	45223554	7mer-m8	45223538	45223555	146	-17.75
CAediting_77128	chr1_85133844_+	ENSG00000197381.14	ENST00000629643	hsa-miR-4423-3p	45223544	45223550	7mer-m8	45223531	45223551	140	-13.77
CAediting_524911	chr7_5495852_-	ENSG00000197381.14	ENST00000629643	hsa-miR-589-3p	45223525	45223531	7mer-m8	45223507	45223532	150	-23.72
CAediting_1351755	chr19_40282625_-	ENSG00000197381.14	ENST00000629643	hsa-miR-641	45225641	45225648	8mer-1a	45225627	45225648	155	-20.07
CAediting_228905	chr2_188297554_+	ENSG00000197381.14	ENST00000629643	hsa-miR-561-3p	45225998	45226004	7mer-m8	45225984	45226005	140	-12.04
CAediting_1054808	chr15_66496985_-	ENSG00000197381.14	ENST00000360697	hsa-miR-4512	45222899	45222905	7mer-m8	45222887	45222906	145	-22.17
CAediting_1229413	chr17_67471544_+	ENSG00000197381.14	ENST00000360697	hsa-miR-548aa	45224706	45224712	7mer-m8	45224690	45224713	154	-15.24
CAediting_1229415	chr17_67471547_+	ENSG00000197381.14	ENST00000360697	hsa-miR-548aa	45224063	45224069	7mer-m8	45224045	45224070	146	-13.27
CAediting_1229415	chr17_67471547_+	ENSG00000197381.14	ENST00000360697	hsa-miR-548aa	45224260	45224266	7mer-m8	45224243	45224267	152	-11.41
CAediting_1229415	chr17_67471547_+	ENSG00000197381.14	ENST00000360697	hsa-miR-548aa	45224959	45224965	7mer-m8	45224943	45224966	152	-16.59
CAediting_1160181	chr17_7017644_-	ENSG00000197381.14	ENST00000360697	hsa-miR-195-3p	45223327	45223333	7mer-1a	45223310	45223333	145	-22
CAediting_1351755	chr19_40282625_-	ENSG00000197381.14	ENST00000360697	hsa-miR-641	45225641	45225648	8mer-1a	45225627	45225648	155	-20.07
CAediting_1368054	chr19_46709310_-	ENSG00000197381.14	ENST00000360697	hsa-miR-320e	45223548	45223554	7mer-m8	45223538	45223555	146	-17.75
CAediting_77128	chr1_85133844_+	ENSG00000197381.14	ENST00000360697	hsa-miR-4423-3p	45223544	45223550	7mer-m8	45223531	45223551	140	-13.77
CAediting_228905	chr2_188297554_+	ENSG00000197381.14	ENST00000360697	hsa-miR-561-3p	45225998	45226004	7mer-m8	45225984	45226005	140	-12.04
CAediting_524911	chr7_5495852_-	ENSG00000197381.14	ENST00000360697	hsa-miR-589-3p	45223525	45223531	7mer-m8	45223507	45223532	150	-23.72
CAediting_573001	chr7_92204086_-	ENSG00000197381.14	ENST00000360697	hsa-miR-1285-5p	45224844	45224851	8mer-1a	45224831	45224851	140	-15.05
CAediting_468389	chr6_31355314_-	ENSG00000197381.14	ENST00000348831	hsa-miR-6891-5p	45223919	45223925	7mer-m8	45223911	45223929	158	-24.49
CAediting_468389	chr6_31355314_-	ENSG00000197381.14	ENST00000348831	hsa-miR-6891-5p	45223922	45223928	7mer-m8	45223911	45223929	158	-24.49
CAediting_468389	chr6_31355314_-	ENSG00000197381.14	ENST00000348831	hsa-miR-6891-5p	45222918	45222924	7mer-m8	45222907	45222925	146	-26.85
CAediting_468389	chr6_31355314_-	ENSG00000197381.14	ENST00000437626	hsa-miR-6891-5p	45222918	45222924	7mer-m8	45222907	45222925	146	-26.85
CAediting_468389	chr6_31355314_-	ENSG00000197381.14	ENST00000492414	hsa-miR-6891-5p	45222918	45222924	7mer-m8	45222907	45222925	146	-26.85
CAediting_468389	chr6_31355314_-	ENSG00000197381.14	ENST00000496664	hsa-miR-6891-5p	45222918	45222924	7mer-m8	45222907	45222925	146	-26.85
CAediting_468389	chr6_31355314_-	ENSG00000197381.14	ENST00000629643	hsa-miR-6891-5p	45222918	45222924	7mer-m8	45222907	45222925	146	-26.85
CAediting_468389	chr6_31355314_-	ENSG00000197381.14	ENST00000360697	hsa-miR-6891-5p	45223919	45223925	7mer-m8	45223911	45223929	158	-24.49
CAediting_468389	chr6_31355314_-	ENSG00000197381.14	ENST00000360697	hsa-miR-6891-5p	45223922	45223928	7mer-m8	45223911	45223929	158	-24.49
CAediting_468389	chr6_31355314_-	ENSG00000197381.14	ENST00000360697	hsa-miR-6891-5p	45222918	45222924	7mer-m8	45222907	45222925	146	-26.85

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1368054	chr19_46709310_-	ENSG00000197381.14	ENST00000348831	hsa-miR-320e	45223239	45223245	7mer-m8	45223228	45223246	143	-12.53
CAediting_604450	chr7_133034877_-	ENSG00000197381.14	ENST00000348831	hsa-miR-3654	45222457	45222463	7mer-m8	45222447	45222464	143	-14.68
CAediting_604450	chr7_133034877_-	ENSG00000197381.14	ENST00000348831	hsa-miR-3654	45225847	45225853	7mer-m8	45225836	45225854	148	-19.86
CAediting_688081	chr9_63819627_+	ENSG00000197381.14	ENST00000348831	hsa-miR-4477b	45222518	45222524	7mer-m8	45222505	45222525	142	-11.12
CAediting_688080	chr9_63819626_+	ENSG00000197381.14	ENST00000348831	hsa-miR-4477b	45222518	45222524	7mer-m8	45222505	45222525	142	-11.12
CAediting_228905	chr2_188297554_+	ENSG00000197381.14	ENST00000348831	hsa-miR-561-3p	45222963	45222969	7mer-m8	45222948	45222970	147	-8.47
CAediting_228905	chr2_188297554_+	ENSG00000197381.14	ENST00000348831	hsa-miR-561-3p	45223056	45223061	6mer	45223041	45223062	152	-11.9
CAediting_524911	chr7_5495852_-	ENSG00000197381.14	ENST00000348831	hsa-miR-589-3p	45225205	45225211	7mer-m8	45225193	45225212	152	-24.02
CAediting_980496	chr14_31014685_-	ENSG00000197381.14	ENST00000348831	hsa-miR-624-3p	45223483	45223488	6mer	45223468	45223489	141	-16.36
CAediting_980496	chr14_31014685_-	ENSG00000197381.14	ENST00000348831	hsa-miR-624-3p	45224105	45224112	8mer-1a	45224092	45224112	154	-9.15
CAediting_980496	chr14_31014685_-	ENSG00000197381.14	ENST00000348831	hsa-miR-624-3p	45224338	45224344	7mer-m8	45224325	45224345	148	-21.23
CAediting_580943	chr7_100356700_+	ENSG00000197381.14	ENST00000348831	hsa-miR-6840-3p	45223584	45223590	7mer-m8	45223570	45223591	140	-15.69
CAediting_1368054	chr19_46709310_-	ENSG00000197381.14	ENST00000437626	hsa-miR-320e	45223239	45223245	7mer-m8	45223228	45223246	143	-12.53
CAediting_604450	chr7_133034877_-	ENSG00000197381.14	ENST00000437626	hsa-miR-3654	45222457	45222463	7mer-m8	45222447	45222464	143	-14.68
CAediting_980496	chr14_31014685_-	ENSG00000197381.14	ENST00000437626	hsa-miR-624-3p	45223483	45223488	6mer	45223468	45223489	141	-16.36
CAediting_1368054	chr19_46709310_-	ENSG00000197381.14	ENST00000492414	hsa-miR-320e	45223239	45223245	7mer-m8	45223228	45223246	143	-12.53
CAediting_604450	chr7_133034877_-	ENSG00000197381.14	ENST00000492414	hsa-miR-3654	45222457	45222463	7mer-m8	45222447	45222464	143	-14.68
CAediting_980496	chr14_31014685_-	ENSG00000197381.14	ENST00000492414	hsa-miR-624-3p	45223483	45223488	6mer	45223468	45223489	141	-16.36
CAediting_1368054	chr19_46709310_-	ENSG00000197381.14	ENST00000496664	hsa-miR-320e	45223239	45223245	7mer-m8	45223228	45223246	143	-12.53
CAediting_604450	chr7_133034877_-	ENSG00000197381.14	ENST00000496664	hsa-miR-3654	45222457	45222463	7mer-m8	45222447	45222464	143	-14.68
CAediting_980496	chr14_31014685_-	ENSG00000197381.14	ENST00000496664	hsa-miR-624-3p	45223483	45223488	6mer	45223468	45223489	141	-16.36
CAediting_1368054	chr19_46709310_-	ENSG00000197381.14	ENST00000629643	hsa-miR-320e	45223239	45223245	7mer-m8	45223228	45223246	143	-12.53
CAediting_604450	chr7_133034877_-	ENSG00000197381.14	ENST00000629643	hsa-miR-3654	45222457	45222463	7mer-m8	45222447	45222464	143	-14.68
CAediting_980496	chr14_31014685_-	ENSG00000197381.14	ENST00000629643	hsa-miR-624-3p	45223483	45223488	6mer	45223468	45223489	141	-16.36
CAediting_1368054	chr19_46709310_-	ENSG00000197381.14	ENST00000360697	hsa-miR-320e	45223239	45223245	7mer-m8	45223228	45223246	143	-12.53
CAediting_604450	chr7_133034877_-	ENSG00000197381.14	ENST00000360697	hsa-miR-3654	45222457	45222463	7mer-m8	45222447	45222464	143	-14.68
CAediting_604450	chr7_133034877_-	ENSG00000197381.14	ENST00000360697	hsa-miR-3654	45225847	45225853	7mer-m8	45225836	45225854	148	-19.86
CAediting_688081	chr9_63819627_+	ENSG00000197381.14	ENST00000360697	hsa-miR-4477b	45222518	45222524	7mer-m8	45222505	45222525	142	-11.12
CAediting_688080	chr9_63819626_+	ENSG00000197381.14	ENST00000360697	hsa-miR-4477b	45222518	45222524	7mer-m8	45222505	45222525	142	-11.12
CAediting_228905	chr2_188297554_+	ENSG00000197381.14	ENST00000360697	hsa-miR-561-3p	45222963	45222969	7mer-m8	45222948	45222970	147	-8.47
CAediting_228905	chr2_188297554_+	ENSG00000197381.14	ENST00000360697	hsa-miR-561-3p	45223056	45223061	6mer	45223041	45223062	152	-11.9
CAediting_524911	chr7_5495852_-	ENSG00000197381.14	ENST00000360697	hsa-miR-589-3p	45225205	45225211	7mer-m8	45225193	45225212	152	-24.02
CAediting_980496	chr14_31014685_-	ENSG00000197381.14	ENST00000360697	hsa-miR-624-3p	45223483	45223488	6mer	45223468	45223489	141	-16.36
CAediting_980496	chr14_31014685_-	ENSG00000197381.14	ENST00000360697	hsa-miR-624-3p	45224105	45224112	8mer-1a	45224092	45224112	154	-9.15
CAediting_980496	chr14_31014685_-	ENSG00000197381.14	ENST00000360697	hsa-miR-624-3p	45224338	45224344	7mer-m8	45224325	45224345	148	-21.23
CAediting_580943	chr7_100356700_+	ENSG00000197381.14	ENST00000360697	hsa-miR-6840-3p	45223584	45223590	7mer-m8	45223570	45223591	140	-15.69

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ADARB1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for ADARB1

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BRCA	CAediting_1456669	chr21_45225236_+	4.31679865349795e-06	0.313961921195669	.	.	0.00292536918829485	0.206331168820824
LUAD	CAediting_1456669	chr21_45225236_+	0.0475927432233952	0.270853509980979	.	.	.	.
BRCA	CAediting_1456670	chr21_45225520_+	0.00335742495588907	0.403108893514253	.	.	.	.

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Relation with cancer stages for ADARB1

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BRCA	pathologic_stage	CAediting_1456669	chr21_45225236_+	0.030897482639737	0.151549075225953
KIRC	pathologic_stage	CAediting_1456669	chr21_45225236_+	0.0128002684881816	0.251923173842933
LUAD	pathologic_stage	CAediting_1456669	chr21_45225236_+	0.00394939330688338	0.385925773902861

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Relation with survival for ADARB1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for ADARB1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ADARB1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
ADARB1	C0005586	Bipolar Disorder	3	PSYGENET
ADARB1	C0036341	Schizophrenia	2	PSYGENET
ADARB1	C0032460	Polycystic Ovary Syndrome	1	CTD_human
ADARB1	C0033975	Psychotic Disorders	1	PSYGENET
ADARB1	C1136382	Sclerocystic Ovaries	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene