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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: NDRG1 (CAeditome ID:10397)

Gene summary for NDRG1

check button Gene summary
Gene informationGene symbol

NDRG1

Gene ID

10397

Gene nameN-myc downstream regulated 1
SynonymsCAP43|CMT4D|DRG-1|DRG1|GC4|HMSNL|NDR1|NMSL|PROXY1|RIT42|RTP|TARG1|TDD5
Cytomap

8q24.22

Type of geneprotein-coding
Descriptionprotein NDRG1N-myc downstream-regulated gene 1 proteindifferentiation-related gene 1 proteinnickel-specific induction protein Cap43protein regulated by oxygen-1reducing agents and tunicamycin-responsive protein
Modification date20210531
UniProtAcc

Q92597

Context- 34099022(NDRG1 regulates osteosarcoma cells via mediating the mitochondrial function and CSCs differentiation)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
NDRG1

GO:0008017

Protein NDRG1

15247272

NDRG1

GO:0031267

Protein NDRG1

17786215

NDRG1

GO:0043015

Protein NDRG1

15247272

NDRG1

GO:0045296

Protein NDRG1

17786215

NDRG1

GO:0005634

Protein NDRG1

9766676

NDRG1

GO:0005737

Protein NDRG1

9766676

NDRG1

GO:0005813

Protein NDRG1

15247272

NDRG1

GO:0005829

Protein NDRG1

0000052

NDRG1

GO:0005874

Protein NDRG1

15247272

NDRG1

GO:0005886

Protein NDRG1

12432451

NDRG1

GO:0005912

Protein NDRG1

12432451

NDRG1

GO:0015630

Protein NDRG1

0000052

NDRG1

GO:0048471

Protein NDRG1

17786215

NDRG1

GO:0055038

Protein NDRG1

17786215


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RNA A-to-I events for NDRG1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000104419.13

check button RNA A-to-I editing events in Cancer.
CAediting_666772(133238401, -), CAediting_666773(133239207, -), CAediting_666774(133271685, -), CAediting_666775(133277307, -), CAediting_666776(133277319, -), CAediting_666777(133277329, -), CAediting_666778(133277342, -), CAediting_666779(133277346, -), CAediting_666780(133277347, -), CAediting_666781(133277352, -), CAediting_666782(133277359, -), CAediting_666783(133277360, -), CAediting_666784(133277372, -), CAediting_666785(133277397, -), CAediting_666786(133277400, -), CAediting_666787(133277406, -), CAediting_666788(133277415, -), CAediting_666789(133277425, -), CAediting_666790(133277428, -), CAediting_666791(133277439, -), CAediting_666792(133277441, -), CAediting_666793(133277463, -), CAediting_666794(133277477, -), CAediting_666795(133277481, -), CAediting_666796(133277494, -), CAediting_666797(133277520, -), CAediting_666798(133277534, -), CAediting_666799(133277559, -), CAediting_666800(133277563, -), CAediting_666801(133277565, -), CAediting_666802(133278953, -), CAediting_666803(133278980, -), CAediting_666804(133278987, -), CAediting_666805(133278996, -), CAediting_666806(133279022, -), CAediting_666807(133279027, -), CAediting_666808(133279028, -), CAediting_666809(133279030, -), CAediting_666810(133279034, -), CAediting_666811(133279037, -), CAediting_666812(133279038, -), CAediting_666813(133279046, -), CAediting_666814(133279050, -), CAediting_666815(133279054, -), CAediting_666816(133279057, -), CAediting_666817(133279058, -), CAediting_666818(133279059, -), CAediting_666819(133279060, -), CAediting_666820(133279063, -), CAediting_666821(133279065, -), CAediting_666822(133279066, -), CAediting_666823(133279068, -), CAediting_666824(133279069, -), CAediting_666825(133279083, -), CAediting_666826(133279091, -), CAediting_666827(133279103, -), CAediting_666828(133279108, -), CAediting_666829(133279114, -), CAediting_666830(133279117, -), CAediting_666831(133279127, -), CAediting_666832(133279136, -), CAediting_666833(133279146, -), CAediting_666834(133279147, -), CAediting_666835(133279154, -), CAediting_666836(133279162, -), CAediting_666837(133279163, -), CAediting_666838(133280459, -), CAediting_666839(133280470, -), CAediting_666840(133280476, -), CAediting_666841(133280486, -), CAediting_666842(133280496, -), CAediting_666843(133280548, -), CAediting_666844(133280552, -), CAediting_666845(133280556, -), CAediting_666846(133280562, -), CAediting_666847(133280630, -), CAediting_666848(133280631, -), CAediting_666849(133280639, -), CAediting_666850(133280659, -), CAediting_666851(133280680, -), CAediting_666852(133280698, -), CAediting_666853(133280701, -), CAediting_666854(133280707, -), CAediting_666855(133280708, -), CAediting_666856(133280714, -), CAediting_666857(133280716, -), CAediting_666858(133280726, -), CAediting_666859(133281082, -), CAediting_666860(133281100, -), CAediting_666861(133281105, -), CAediting_666862(133281112, -), CAediting_666863(133281113, -), CAediting_666864(133281235, -), CAediting_666865(133281245, -),

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RNA editing positional annotations for NDRG1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_666772chr8_133238401_-ncRNA_exonic
CAediting_666773chr8_133239207_-ncRNA_exonic
CAediting_666774chr8_133271685_-ncRNA_intronic
CAediting_666775chr8_133277307_-ncRNA_intronic
CAediting_666776chr8_133277319_-ncRNA_intronic
CAediting_666777chr8_133277329_-ncRNA_intronic
CAediting_666778chr8_133277342_-ncRNA_intronic
CAediting_666779chr8_133277346_-ncRNA_intronic
CAediting_666780chr8_133277347_-ncRNA_intronic
CAediting_666781chr8_133277352_-ncRNA_intronic
CAediting_666782chr8_133277359_-ncRNA_intronic
CAediting_666783chr8_133277360_-ncRNA_intronic
CAediting_666784chr8_133277372_-ncRNA_intronic
CAediting_666785chr8_133277397_-ncRNA_intronic
CAediting_666786chr8_133277400_-ncRNA_intronic
CAediting_666787chr8_133277406_-ncRNA_intronic
CAediting_666788chr8_133277415_-ncRNA_intronic
CAediting_666789chr8_133277425_-ncRNA_intronic
CAediting_666790chr8_133277428_-ncRNA_intronic
CAediting_666791chr8_133277439_-ncRNA_intronic
CAediting_666792chr8_133277441_-ncRNA_intronic
CAediting_666793chr8_133277463_-ncRNA_intronic
CAediting_666794chr8_133277477_-ncRNA_intronic
CAediting_666795chr8_133277481_-ncRNA_intronic
CAediting_666796chr8_133277494_-ncRNA_intronic
CAediting_666797chr8_133277520_-ncRNA_intronic
CAediting_666798chr8_133277534_-ncRNA_intronic
CAediting_666799chr8_133277559_-ncRNA_intronic
CAediting_666800chr8_133277563_-ncRNA_intronic
CAediting_666801chr8_133277565_-ncRNA_intronic
CAediting_666802chr8_133278953_-ncRNA_intronic
CAediting_666803chr8_133278980_-ncRNA_intronic
CAediting_666804chr8_133278987_-ncRNA_intronic
CAediting_666805chr8_133278996_-ncRNA_intronic
CAediting_666806chr8_133279022_-ncRNA_intronic
CAediting_666807chr8_133279027_-ncRNA_intronic
CAediting_666808chr8_133279028_-ncRNA_intronic
CAediting_666809chr8_133279030_-ncRNA_intronic
CAediting_666810chr8_133279034_-ncRNA_intronic
CAediting_666811chr8_133279037_-ncRNA_intronic
CAediting_666812chr8_133279038_-ncRNA_intronic
CAediting_666813chr8_133279046_-ncRNA_intronic
CAediting_666814chr8_133279050_-ncRNA_intronic
CAediting_666815chr8_133279054_-ncRNA_intronic
CAediting_666816chr8_133279057_-ncRNA_intronic
CAediting_666817chr8_133279058_-ncRNA_intronic
CAediting_666818chr8_133279059_-ncRNA_intronic
CAediting_666819chr8_133279060_-ncRNA_intronic
CAediting_666820chr8_133279063_-ncRNA_intronic
CAediting_666821chr8_133279065_-ncRNA_intronic
CAediting_666822chr8_133279066_-ncRNA_intronic
CAediting_666823chr8_133279068_-ncRNA_intronic
CAediting_666824chr8_133279069_-ncRNA_intronic
CAediting_666825chr8_133279083_-ncRNA_intronic
CAediting_666826chr8_133279091_-ncRNA_intronic
CAediting_666827chr8_133279103_-ncRNA_intronic
CAediting_666828chr8_133279108_-ncRNA_intronic
CAediting_666829chr8_133279114_-ncRNA_intronic
CAediting_666830chr8_133279117_-ncRNA_intronic
CAediting_666831chr8_133279127_-ncRNA_intronic
CAediting_666832chr8_133279136_-ncRNA_intronic
CAediting_666833chr8_133279146_-ncRNA_intronic
CAediting_666834chr8_133279147_-ncRNA_intronic
CAediting_666835chr8_133279154_-ncRNA_intronic
CAediting_666836chr8_133279162_-ncRNA_intronic
CAediting_666837chr8_133279163_-ncRNA_intronic
CAediting_666838chr8_133280459_-ncRNA_intronic
CAediting_666839chr8_133280470_-ncRNA_intronic
CAediting_666840chr8_133280476_-ncRNA_intronic
CAediting_666841chr8_133280486_-ncRNA_intronic
CAediting_666842chr8_133280496_-ncRNA_intronic
CAediting_666843chr8_133280548_-ncRNA_intronic
CAediting_666844chr8_133280552_-ncRNA_intronic
CAediting_666845chr8_133280556_-ncRNA_intronic
CAediting_666846chr8_133280562_-ncRNA_intronic
CAediting_666847chr8_133280630_-ncRNA_intronic
CAediting_666848chr8_133280631_-ncRNA_intronic
CAediting_666849chr8_133280639_-ncRNA_intronic
CAediting_666850chr8_133280659_-ncRNA_intronic
CAediting_666851chr8_133280680_-ncRNA_intronic
CAediting_666852chr8_133280698_-ncRNA_intronic
CAediting_666853chr8_133280701_-ncRNA_intronic
CAediting_666854chr8_133280707_-ncRNA_intronic
CAediting_666855chr8_133280708_-ncRNA_intronic
CAediting_666856chr8_133280714_-ncRNA_intronic
CAediting_666857chr8_133280716_-ncRNA_intronic
CAediting_666858chr8_133280726_-ncRNA_intronic
CAediting_666859chr8_133281082_-ncRNA_intronic
CAediting_666860chr8_133281100_-ncRNA_intronic
CAediting_666861chr8_133281105_-ncRNA_intronic
CAediting_666862chr8_133281112_-ncRNA_intronic
CAediting_666863chr8_133281113_-ncRNA_intronic
CAediting_666864chr8_133281235_-ncRNA_intronic
CAediting_666865chr8_133281245_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_666774chr8_133271685_-SINEAluAluJb
CAediting_666775chr8_133277307_-SINEAluAluSz6
CAediting_666776chr8_133277319_-SINEAluAluSz6
CAediting_666777chr8_133277329_-SINEAluAluSz6
CAediting_666778chr8_133277342_-SINEAluAluSz6
CAediting_666779chr8_133277346_-SINEAluAluSz6
CAediting_666780chr8_133277347_-SINEAluAluSz6
CAediting_666781chr8_133277352_-SINEAluAluSz6
CAediting_666782chr8_133277359_-SINEAluAluSz6
CAediting_666783chr8_133277360_-SINEAluAluSz6
CAediting_666784chr8_133277372_-SINEAluAluSz6
CAediting_666785chr8_133277397_-SINEAluAluSz6
CAediting_666786chr8_133277400_-SINEAluAluSz6
CAediting_666787chr8_133277406_-SINEAluAluSz6
CAediting_666788chr8_133277415_-SINEAluAluSz6
CAediting_666789chr8_133277425_-SINEAluAluSz6
CAediting_666790chr8_133277428_-SINEAluAluSz6
CAediting_666791chr8_133277439_-SINEAluAluSz6
CAediting_666792chr8_133277441_-SINEAluAluSz6
CAediting_666793chr8_133277463_-SINEAluAluSz6
CAediting_666794chr8_133277477_-SINEAluAluSz6
CAediting_666795chr8_133277481_-SINEAluAluSz6
CAediting_666796chr8_133277494_-SINEAluAluSz6
CAediting_666797chr8_133277520_-SINEAluAluSz6
CAediting_666798chr8_133277534_-SINEAluAluSz6
CAediting_666799chr8_133277559_-SINEAluAluSz6
CAediting_666800chr8_133277563_-SINEAluAluSz6
CAediting_666801chr8_133277565_-SINEAluAluSz6
CAediting_666802chr8_133278953_-SINEAluAluSq2
CAediting_666803chr8_133278980_-SINEAluAluSq2
CAediting_666804chr8_133278987_-SINEAluAluSq2
CAediting_666805chr8_133278996_-SINEAluAluSq2
CAediting_666806chr8_133279022_-SINEAluAluSq2
CAediting_666807chr8_133279027_-SINEAluAluSq2
CAediting_666808chr8_133279028_-SINEAluAluSq2
CAediting_666809chr8_133279030_-SINEAluAluSq2
CAediting_666810chr8_133279034_-SINEAluAluSq2
CAediting_666811chr8_133279037_-SINEAluAluSq2
CAediting_666812chr8_133279038_-SINEAluAluSq2
CAediting_666813chr8_133279046_-SINEAluAluSq2
CAediting_666814chr8_133279050_-SINEAluAluSq2
CAediting_666815chr8_133279054_-SINEAluAluSq2
CAediting_666816chr8_133279057_-SINEAluAluSq2
CAediting_666817chr8_133279058_-SINEAluAluSq2
CAediting_666818chr8_133279059_-SINEAluAluSq2
CAediting_666819chr8_133279060_-SINEAluAluSq2
CAediting_666820chr8_133279063_-SINEAluAluSq2
CAediting_666821chr8_133279065_-SINEAluAluSq2
CAediting_666822chr8_133279066_-SINEAluAluSq2
CAediting_666823chr8_133279068_-SINEAluAluSq2
CAediting_666824chr8_133279069_-SINEAluAluSq2
CAediting_666825chr8_133279083_-SINEAluAluSq2
CAediting_666826chr8_133279091_-SINEAluAluSq2
CAediting_666827chr8_133279103_-SINEAluAluSq2
CAediting_666828chr8_133279108_-SINEAluAluSq2
CAediting_666829chr8_133279114_-SINEAluAluSq2
CAediting_666830chr8_133279117_-SINEAluAluSq2
CAediting_666831chr8_133279127_-SINEAluAluSq2
CAediting_666832chr8_133279136_-SINEAluAluSq2
CAediting_666833chr8_133279146_-SINEAluAluSq2
CAediting_666834chr8_133279147_-SINEAluAluSq2
CAediting_666835chr8_133279154_-SINEAluAluSq2
CAediting_666836chr8_133279162_-SINEAluAluSq2
CAediting_666837chr8_133279163_-SINEAluAluSq2
CAediting_666838chr8_133280459_-SINEAluAluY
CAediting_666839chr8_133280470_-SINEAluAluY
CAediting_666840chr8_133280476_-SINEAluAluY
CAediting_666841chr8_133280486_-SINEAluAluY
CAediting_666842chr8_133280496_-SINEAluAluY
CAediting_666843chr8_133280548_-SINEAluAluY
CAediting_666844chr8_133280552_-SINEAluAluY
CAediting_666845chr8_133280556_-SINEAluAluY
CAediting_666846chr8_133280562_-SINEAluAluY
CAediting_666847chr8_133280630_-SINEAluAluY
CAediting_666848chr8_133280631_-SINEAluAluY
CAediting_666849chr8_133280639_-SINEAluAluY
CAediting_666850chr8_133280659_-SINEAluAluY
CAediting_666851chr8_133280680_-SINEAluAluY
CAediting_666852chr8_133280698_-SINEAluAluY
CAediting_666853chr8_133280701_-SINEAluAluY
CAediting_666854chr8_133280707_-SINEAluAluY
CAediting_666855chr8_133280708_-SINEAluAluY
CAediting_666856chr8_133280714_-SINEAluAluY
CAediting_666857chr8_133280716_-SINEAluAluY
CAediting_666858chr8_133280726_-SINEAluAluY
CAediting_666859chr8_133281082_-SINEAluAluSp
CAediting_666860chr8_133281100_-SINEAluAluSp
CAediting_666861chr8_133281105_-SINEAluAluSp
CAediting_666862chr8_133281112_-SINEAluAluSp
CAediting_666863chr8_133281113_-SINEAluAluSp
CAediting_666864chr8_133281235_-SINEAluAluSp
CAediting_666865chr8_133281245_-SINEAluAluSp

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RNA A-to-I editing events in the alternative splicing sites for NDRG1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000104419.13.NDRG1.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000104419.13.NDRG1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for NDRG1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for NDRG1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for NDRG1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_666772chr8_133238401_-ENSG00000104419.13ENST00000517599hsa-miR-6802-3p1332384001332384067mer-m8133238399133238420170.00-30.66
CAediting_666772chr8_133238401_-ENSG00000104419.13ENST00000414097hsa-miR-6802-3p1332384001332384067mer-m8133238399133238420170.00-30.66

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_666772chr8_133238401_-ENSG00000104419.13ENST00000517599hsa-miR-556-3p1332383981332384047mer-m8133238397133238418144-12.92
CAediting_666772chr8_133238401_-ENSG00000104419.13ENST00000414097hsa-miR-556-3p1332383981332384047mer-m8133238397133238418144-12.92

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_688080chr9_63819626_+ENSG00000104419.13ENST00000517599hsa-miR-4477b1332466171332466237mer-m8133246616133246637160-11.85
CAediting_748296chr10_51299626_+ENSG00000104419.13ENST00000517599hsa-miR-605-3p1332387041332387107mer-m8133238703133238725156-23.31
CAediting_846604chr11_93733708_-ENSG00000104419.13ENST00000517599hsa-miR-1304-3p1332389891332389957mer-m8133238988133239009140-14.08
CAediting_846604chr11_93733708_-ENSG00000104419.13ENST00000517599hsa-miR-1304-3p1332389591332389657mer-m8133238958133238978141-16.29
CAediting_846604chr11_93733708_-ENSG00000104419.13ENST00000517599hsa-miR-1304-3p1332390191332390257mer-m8133239018133239039140-14.08
CAediting_688081chr9_63819627_+ENSG00000104419.13ENST00000517599hsa-miR-4477b1332375881332375947mer-m8133237587133237609141-9.13
CAediting_748296chr10_51299626_+ENSG00000104419.13ENST00000414097hsa-miR-605-3p1332387041332387107mer-m8133238703133238725156-23.31
CAediting_688081chr9_63819627_+ENSG00000104419.13ENST00000414097hsa-miR-4477b1332375881332375947mer-m8133237587133237609141-9.13
CAediting_748296chr10_51299626_+ENSG00000104419.13ENST00000518176hsa-miR-605-3p1332387041332387107mer-m8133238703133238725156-23.31
CAediting_748296chr10_51299626_+ENSG00000104419.13ENST00000522476hsa-miR-605-3p1332387041332387107mer-m8133238703133238725156-23.31
CAediting_396018chr5_1062918_-ENSG00000104419.13ENST00000517599hsa-miR-46351332466161332466227mer-m8133246616133246635144-13.19
CAediting_1229415chr17_67471547_+ENSG00000104419.13ENST00000517599hsa-miR-548aa1332381681332381758mer-1a133238168133238190148-11.34
CAediting_228905chr2_188297554_+ENSG00000104419.13ENST00000517599hsa-miR-561-3p1332377161332377216mer133237715133237738147-16.42
CAediting_442554chr5_154685830_+ENSG00000104419.13ENST00000517599hsa-miR-13031332386981332387058mer-1a133238698133238718153-20.8
CAediting_604450chr7_133034877_-ENSG00000104419.13ENST00000517599hsa-miR-36541332373791332373857mer-m8133237378133237395143-16.73
CAediting_1229415chr17_67471547_+ENSG00000104419.13ENST00000414097hsa-miR-548aa1332381681332381758mer-1a133238168133238190148-11.34
CAediting_228905chr2_188297554_+ENSG00000104419.13ENST00000414097hsa-miR-561-3p1332377161332377216mer133237715133237738147-16.42
CAediting_442554chr5_154685830_+ENSG00000104419.13ENST00000414097hsa-miR-13031332386981332387058mer-1a133238698133238718153-20.8
CAediting_604450chr7_133034877_-ENSG00000104419.13ENST00000414097hsa-miR-36541332373791332373857mer-m8133237378133237395143-16.73
CAediting_442554chr5_154685830_+ENSG00000104419.13ENST00000518176hsa-miR-13031332386981332387058mer-1a133238698133238718153-20.8
CAediting_442554chr5_154685830_+ENSG00000104419.13ENST00000522476hsa-miR-13031332386981332387058mer-1a133238698133238718153-20.8
CAediting_468389chr6_31355314_-ENSG00000104419.13ENST00000517599hsa-miR-6891-5p1332380941332380996mer133238093133238111145-23.75
CAediting_468389chr6_31355314_-ENSG00000104419.13ENST00000517599hsa-miR-6891-5p1332388231332388297mer-m8133238822133238840155-24.32
CAediting_468389chr6_31355314_-ENSG00000104419.13ENST00000414097hsa-miR-6891-5p1332388231332388297mer-m8133238822133238840155-24.32
CAediting_468389chr6_31355314_-ENSG00000104419.13ENST00000414097hsa-miR-6891-5p1332380941332380996mer133238093133238111145-23.75
CAediting_468389chr6_31355314_-ENSG00000104419.13ENST00000518176hsa-miR-6891-5p1332388231332388297mer-m8133238822133238840155-24.32
CAediting_468389chr6_31355314_-ENSG00000104419.13ENST00000522476hsa-miR-6891-5p1332388231332388297mer-m8133238822133238840155-24.32
CAediting_468389chr6_31355314_-ENSG00000104419.13ENST00000518066hsa-miR-6891-5p1332388231332388297mer-m8133238822133238840155-24.32

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1160181chr17_7017644_-ENSG00000104419.13ENST00000517599hsa-miR-195-3p1332374441332374507mer-m8133237443133237463150-8.06
CAediting_1229415chr17_67471547_+ENSG00000104419.13ENST00000517599hsa-miR-548aa1332381271332381337mer-m8133238126133238154152-13.74
CAediting_117844chr1_162342605_+ENSG00000104419.13ENST00000517599hsa-miR-556-3p1332383981332384047mer-m8133238397133238418144-12.92
CAediting_1160181chr17_7017644_-ENSG00000104419.13ENST00000414097hsa-miR-195-3p1332374441332374507mer-m8133237443133237463150-8.06
CAediting_1229415chr17_67471547_+ENSG00000104419.13ENST00000414097hsa-miR-548aa1332381271332381337mer-m8133238126133238154152-13.74
CAediting_117844chr1_162342605_+ENSG00000104419.13ENST00000414097hsa-miR-556-3p1332383981332384047mer-m8133238397133238418144-12.92

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for NDRG1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000323851.10protein_codingSoverviewSoverview
ENST00000414097.5protein_codingSoverviewSoverview
ENST00000517599.4nonsense_mediated_decaySoverviewSoverview
ENST00000519278.4retained_intronSoverviewSoverview
ENST00000521026.4retained_intronSoverviewSoverview
ENST00000521414.4processed_transcriptSoverviewSoverview
ENST00000521438.1retained_intronSoverviewSoverview
ENST00000537882.2protein_codingSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_666772ENST00000323851.10chr8_133238401_--1124.10-1122.90-1124.10
CAediting_666772ENST00000414097.5chr8_133238401_--1536.10-1534.90-1536.10
CAediting_666772ENST00000517599.4chr8_133238401_--1088.00-1086.80-1088.00
CAediting_666772ENST00000519278.4chr8_133238401_--1475.90-1474.70-1475.90
CAediting_666772ENST00000521026.4chr8_133238401_--794.90-793.70-794.90
CAediting_666772ENST00000521414.4chr8_133238401_--876.80-875.60-876.80
CAediting_666773ENST00000521438.1chr8_133239207_--1038.50-1037.60-1038.50
CAediting_666772ENST00000537882.2chr8_133238401_--1118.30-1117.10-1118.30

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Relation with ADAR for NDRG1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
STADCAediting_666846chr8_133280562_-..0.03797050379933840.226858052747128..

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Relation with cancer stages for NDRG1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
STADpathologic_stageCAediting_666813chr8_133279046_-0.0440129900283405-0.258804622148419

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Relation with survival for NDRG1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
ESCACAediting_666813chr8_133279046_-0.003981187414697220.018221285.7031

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RelatedDrugs for NDRG1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for NDRG1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
NDRG1C0027627Neoplasm Metastasis2CTD_human
NDRG1C1832334CHARCOT-MARIE-TOOTH DISEASE, TYPE 4D2CTD_human;GENOMICS_ENGLAND;ORPHANET
NDRG1C0004114Astrocytoma1CTD_human
NDRG1C0006142Malignant neoplasm of breast1CTD_human
NDRG1C0007131Non-Small Cell Lung Carcinoma1CTD_human
NDRG1C0007134Renal Cell Carcinoma1CTD_human
NDRG1C0017636Glioblastoma1CTD_human
NDRG1C0022665Kidney Neoplasm1CTD_human
NDRG1C0023893Liver Cirrhosis, Experimental1CTD_human
NDRG1C0023903Liver neoplasms1CTD_human
NDRG1C0025202melanoma1CTD_human
NDRG1C0026640Mouth Neoplasms1CTD_human
NDRG1C0029295Oropharyngeal Neoplasms1CTD_human
NDRG1C0033578Prostatic Neoplasms1CTD_human
NDRG1C0149925Small cell carcinoma of lung1CTD_human
NDRG1C0153381Malignant neoplasm of mouth1CTD_human
NDRG1C0205768Subependymal Giant Cell Astrocytoma1CTD_human
NDRG1C0206658Smooth Muscle Tumor1CTD_human
NDRG1C0206734Hemangioblastoma1CTD_human
NDRG1C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
NDRG1C0280783Juvenile Pilocytic Astrocytoma1CTD_human
NDRG1C0280785Diffuse Astrocytoma1CTD_human
NDRG1C0334579Anaplastic astrocytoma1CTD_human
NDRG1C0334580Protoplasmic astrocytoma1CTD_human
NDRG1C0334581Gemistocytic astrocytoma1CTD_human
NDRG1C0334582Fibrillary Astrocytoma1CTD_human
NDRG1C0334583Pilocytic Astrocytoma1CTD_human
NDRG1C0334588Giant Cell Glioblastoma1CTD_human
NDRG1C0338070Childhood Cerebral Astrocytoma1CTD_human
NDRG1C0345904Malignant neoplasm of liver1CTD_human
NDRG1C0376358Malignant neoplasm of prostate1CTD_human
NDRG1C0547065Mixed oligoastrocytoma1CTD_human
NDRG1C0678222Breast Carcinoma1CTD_human
NDRG1C0740457Malignant neoplasm of kidney1CTD_human
NDRG1C0750935Cerebral Astrocytoma1CTD_human
NDRG1C0750936Intracranial Astrocytoma1CTD_human
NDRG1C0751692Multiple Hemangioblastomas1CTD_human
NDRG1C0887833Carcinoma, Pancreatic Ductal1CTD_human
NDRG1C1168401Squamous cell carcinoma of the head and neck1CTD_human
NDRG1C1257931Mammary Neoplasms, Human1CTD_human
NDRG1C1266042Chromophobe Renal Cell Carcinoma1CTD_human
NDRG1C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
NDRG1C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
NDRG1C1306837Papillary Renal Cell Carcinoma1CTD_human
NDRG1C1458155Mammary Neoplasms1CTD_human
NDRG1C1621958Glioblastoma Multiforme1CTD_human
NDRG1C1704230Grade I Astrocytoma1CTD_human
NDRG1C2349952Oropharyngeal Carcinoma1CTD_human
NDRG1C4704874Mammary Carcinoma, Human1CTD_human