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| Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: CDKN1B (CAeditome ID:1027) |
Gene summary for CDKN1B |
 Gene summary |
| Gene information | Gene symbol | CDKN1B | Gene ID | 1027 |
| Gene name | cyclin dependent kinase inhibitor 1B | |
| Synonyms | CDKN4|KIP1|MEN1B|MEN4|P27KIP1 | |
| Cytomap | 12p13.1 | |
| Type of gene | protein-coding | |
| Description | cyclin-dependent kinase inhibitor 1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1) | |
| Modification date | 20210518 | |
| UniProtAcc | P46527 | |
| Context | - 33926470(miR-190 promotes malignant transformation and progression of human urothelial cells through CDKN1B/p27 inhibition) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CDKN1B | GO:0045732 | Cyclin-dependent kinase inhibitor 1B | 19056892 |
| CDKN1B | GO:0071285 | Cyclin-dependent kinase inhibitor 1B | 19056892 |
| CDKN1B | GO:0004861 | Cyclin-dependent kinase inhibitor 1B | 10918569 |
| CDKN1B | GO:0004861 | Cyclin-dependent kinase inhibitor 1B | 28666995 |
| CDKN1B | GO:0004861 | Cyclin-dependent kinase inhibitor 1B | 8033212 |
| CDKN1B | GO:0000079 | Cyclin-dependent kinase inhibitor 1B | 8033212 |
| CDKN1B | GO:0000082 | Cyclin-dependent kinase inhibitor 1B | 10208428 |
| CDKN1B | GO:0008285 | Cyclin-dependent kinase inhibitor 1B | 19266349 |
| CDKN1B | GO:0010942 | Cyclin-dependent kinase inhibitor 1B | 19266349 |
| CDKN1B | GO:0030308 | Cyclin-dependent kinase inhibitor 1B | 10208428 |
| CDKN1B | GO:0033673 | Cyclin-dependent kinase inhibitor 1B | 19170105 |
| CDKN1B | GO:0042326 | Cyclin-dependent kinase inhibitor 1B | 10208428 |
| CDKN1B | GO:0045736 | Cyclin-dependent kinase inhibitor 1B | 28666995 |
| CDKN1B | GO:0045892 | Cyclin-dependent kinase inhibitor 1B | 19170105 |
| CDKN1B | GO:0045930 | Cyclin-dependent kinase inhibitor 1B | 19266349 |
| CDKN1B | GO:0048102 | Cyclin-dependent kinase inhibitor 1B | 12698196 |
| CDKN1B | GO:0051726 | Cyclin-dependent kinase inhibitor 1B | 19266349 |
| CDKN1B | GO:0005634 | Cyclin-dependent kinase inhibitor 1B | 11800646 |
| CDKN1B | GO:0005634 | Cyclin-dependent kinase inhibitor 1B | 12093740 |
| CDKN1B | GO:0005654 | Cyclin-dependent kinase inhibitor 1B | 0000052 |
| CDKN1B | GO:0005737 | Cyclin-dependent kinase inhibitor 1B | 12093740 |
| CDKN1B | GO:0043231 | Cyclin-dependent kinase inhibitor 1B | 0000052 |
| CDKN1B | GO:0031464 | Cyclin-dependent kinase inhibitor 1B | 21628527 |
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RNA A-to-I events for CDKN1B |
| RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure. |
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| RNA editing frequencies across 33 cancers of gene: ENSG00000111276.9 |
| RNA A-to-I editing events in Cancer. |
| CAediting_869452(12719249, +), CAediting_869453(12721154, +), |
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RNA editing positional annotations for CDKN1B using Annovar |
| Protein coding RNA editing(s). |
| CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| CAediting_869453 | chr12_12721154_+ | nonsynonymous SNV | ENST00000396340.1 | c.A565G | p.S189G | D | . | N |
| Gene structure information of RNA editing(s). |
| CAeditome ID | Position | Variant type |
| CAediting_869452 | chr12_12719249_+ | ncRNA_exonic |
| CAediting_869453 | chr12_12721154_+ | exonic |
| Repat-regional RNA editing(s). |
| CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
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RNA A-to-I editing events in the alternative splicing sites for CDKN1B |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000111276.9.CDKN1B. |
| Correlation between RNA A-to-I editing and PSI for ENSG00000111276.9.CDKN1B. |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CDKN1B |
| Differential gene expressions between RNA A-to-I edited and non-edited tumor samples. * The grey color means N/A. |
| Correlation between RNA A-to-I editing and gene expression. |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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Protein coding region RNA A-to-I editings for CDKN1B |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for CDKN1B |
| **If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| CAediting_869453 | chr12_12721154_+ | ENSG00000111276.9 | ENST00000442489 | hsa-miR-1284 | 12721147 | 12721153 | 7mer-m8 | 12721133 | 12721154 | 145.00 | -14.26 |
| CAediting_869453 | chr12_12721154_+ | ENSG00000111276.9 | ENST00000442489 | hsa-miR-33b-3p | 12721152 | 12721158 | 7mer-m8 | 12721138 | 12721159 | 150.00 | -22.33 |
| CAediting_869453 | chr12_12721154_+ | ENSG00000111276.9 | ENST00000442489 | hsa-miR-515-3p | 12721152 | 12721158 | 7mer-m8 | 12721139 | 12721159 | 143.00 | -15.13 |
| CAediting_869453 | chr12_12721154_+ | ENSG00000111276.9 | ENST00000442489 | hsa-miR-515-3p | 12721152 | 12721158 | 7mer-m8 | 12721139 | 12721159 | 143.00 | -15.13 |
| CAediting_869453 | chr12_12721154_+ | ENSG00000111276.9 | ENST00000442489 | hsa-miR-519e-3p | 12721152 | 12721158 | 7mer-m8 | 12721140 | 12721159 | 145.00 | -15.99 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| CAediting_869453 | chr12_12721154_+ | ENSG00000111276.9 | ENST00000442489 | hsa-miR-520f-3p | 12721152 | 12721158 | 7mer-m8 | 12721138 | 12721159 | 140 | -14.72 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for CDKN1B |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in RNA structures for Minimum free energy (MFE). |
| CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for CDKN1B |
| Correlation between ADAR gene expression and RNA editing frequency |
| Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for CDKN1B |
| Correlation between Cancer stages and RNA editing frequency |
| Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for CDKN1B |
| Correlation between RNA editing and survival |
| Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for CDKN1B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.8 2021-01-03) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDKN1B |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| CDKN1B | C1970712 | Multiple Endocrine Neoplasia, Type IV | 11 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET |
| CDKN1B | C4274947 | Multiple endocrine neoplasia type 4 | 9 | CLINGEN |
| CDKN1B | C0009405 | Hereditary Nonpolyposis Colorectal Neoplasms | 8 | CLINGEN |
| CDKN1B | C1112155 | Hereditary non-polyposis colorectal cancer syndrome | 8 | CLINGEN |
| CDKN1B | C1333990 | Hereditary Nonpolyposis Colorectal Cancer | 8 | CLINGEN |
| CDKN1B | C1333991 | Hereditary Non-Polyposis Colon Cancer Type 2 | 8 | CLINGEN |
| CDKN1B | C2936783 | Colorectal cancer, hereditary nonpolyposis, type 1 | 8 | CLINGEN |
| CDKN1B | C0024121 | Lung Neoplasms | 3 | CTD_human |
| CDKN1B | C0033578 | Prostatic Neoplasms | 3 | CTD_human |
| CDKN1B | C0242379 | Malignant neoplasm of lung | 3 | CTD_human |
| CDKN1B | C0376358 | Malignant neoplasm of prostate | 3 | CTD_human |
| CDKN1B | C0025267 | Multiple Endocrine Neoplasia Type 1 | 2 | ORPHANET |
| CDKN1B | C0032000 | Pituitary Adenoma | 2 | CGI;CTD_human;GENOMICS_ENGLAND |
| CDKN1B | C0006142 | Malignant neoplasm of breast | 1 | CGI;CTD_human |
| CDKN1B | C0007113 | Rectal Carcinoma | 1 | CTD_human |
| CDKN1B | C0021841 | Intestinal Neoplasms | 1 | CTD_human |
| CDKN1B | C0022665 | Kidney Neoplasm | 1 | CTD_human |
| CDKN1B | C0023903 | Liver neoplasms | 1 | CTD_human |
| CDKN1B | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
| CDKN1B | C0025500 | Mesothelioma | 1 | CTD_human |
| CDKN1B | C0032019 | Pituitary Neoplasms | 1 | CTD_human |
| CDKN1B | C0034885 | Rectal Neoplasms | 1 | CTD_human |
| CDKN1B | C0036920 | Sezary Syndrome | 1 | CTD_human |
| CDKN1B | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| CDKN1B | C0042138 | Uterine Neoplasms | 1 | CTD_human |
| CDKN1B | C0079487 | Helicobacter Infections | 1 | CTD_human |
| CDKN1B | C0153567 | Uterine Cancer | 1 | CTD_human |
| CDKN1B | C0206669 | Hepatocellular Adenoma | 1 | CTD_human |
| CDKN1B | C0206754 | Neuroendocrine Tumors | 1 | CTD_human |
| CDKN1B | C0263454 | Chloracne | 1 | CTD_human |
| CDKN1B | C0282612 | Prostatic Intraepithelial Neoplasias | 1 | CTD_human |
| CDKN1B | C0345904 | Malignant neoplasm of liver | 1 | CTD_human |
| CDKN1B | C0346300 | Pituitary carcinoma | 1 | CTD_human |
| CDKN1B | C0346627 | Intestinal Cancer | 1 | CTD_human |
| CDKN1B | C0549473 | Thyroid carcinoma | 1 | GENOMICS_ENGLAND |
| CDKN1B | C0678222 | Breast Carcinoma | 1 | CGI;CTD_human |
| CDKN1B | C0740457 | Malignant neoplasm of kidney | 1 | CTD_human |
| CDKN1B | C0919267 | ovarian neoplasm | 1 | CTD_human |
| CDKN1B | C1140680 | Malignant neoplasm of ovary | 1 | CTD_human |
| CDKN1B | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| CDKN1B | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| CDKN1B | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
| CDKN1B | C2239176 | Liver carcinoma | 1 | CTD_human |
| CDKN1B | C2931456 | Prostate cancer, familial | 1 | CTD_human |
| CDKN1B | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
| CDKN1B | C4722327 | PROSTATE CANCER, HEREDITARY, 1 | 1 | CTD_human |
