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| Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: CDKN1A (CAeditome ID:1026) |
Gene summary for CDKN1A |
 Gene summary |
| Gene information | Gene symbol | CDKN1A | Gene ID | 1026 |
| Gene name | cyclin dependent kinase inhibitor 1A | |
| Synonyms | CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1 | |
| Cytomap | 6p21.2 | |
| Type of gene | protein-coding | |
| Description | cyclin-dependent kinase inhibitor 1CDK-interacting protein 1CDK-interaction protein 1DNA synthesis inhibitorcyclin-dependent kinase inhibitor 1A (p21, Cip1)melanoma differentiation associated protein 6wild-type p53-activated fragment 1 | |
| Modification date | 20210531 | |
| UniProtAcc | P38936 | |
| Context | - 31438587(The Multifaceted p21 (Cip1/Waf1/�CDKN1A) in Cell Differentiation, Migration and Cancer Therapy) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CDKN1A | GO:0045860 | Cyclin-dependent kinase inhibitor 1 | 22869755 |
| CDKN1A | GO:0019912 | Cyclin-dependent kinase inhibitor 1 | 9106657 |
| CDKN1A | GO:0000082 | Cyclin-dependent kinase inhibitor 1 | 10208428 |
| CDKN1A | GO:0006977 | Cyclin-dependent kinase inhibitor 1 | 15149599 |
| CDKN1A | GO:0008285 | Cyclin-dependent kinase inhibitor 1 | 10208428 |
| CDKN1A | GO:0008285 | Cyclin-dependent kinase inhibitor 1 | 15149599 |
| CDKN1A | GO:0030308 | Cyclin-dependent kinase inhibitor 1 | 10208428 |
| CDKN1A | GO:0042326 | Cyclin-dependent kinase inhibitor 1 | 10208428 |
| CDKN1A | GO:0051726 | Cyclin-dependent kinase inhibitor 1 | 15149599 |
| CDKN1A | GO:0005634 | Cyclin-dependent kinase inhibitor 1 | 11343236 |
| CDKN1A | GO:0005634 | Cyclin-dependent kinase inhibitor 1 | 23213251 |
| CDKN1A | GO:0005654 | Cyclin-dependent kinase inhibitor 1 | 0000052 |
| CDKN1A | GO:0005654 | Cyclin-dependent kinase inhibitor 1 | 22869755 |
| CDKN1A | GO:0005730 | Cyclin-dependent kinase inhibitor 1 | 22869755 |
| CDKN1A | GO:0016604 | Cyclin-dependent kinase inhibitor 1 | 0000052 |
| CDKN1A | GO:0000307 | Cyclin-dependent kinase inhibitor 1 | 17420273 |
| CDKN1A | GO:0032991 | Cyclin-dependent kinase inhibitor 1 | 22869755 |
| CDKN1A | GO:0070557 | Cyclin-dependent kinase inhibitor 1 | 18794347 |
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RNA A-to-I events for CDKN1A |
| RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure. |
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| RNA editing frequencies across 33 cancers of gene: ENSG00000124762.12 |
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| RNA A-to-I editing events in Cancer. |
| CAediting_475104(36680105, +), CAediting_475105(36681518, +), CAediting_475106(36681532, +), CAediting_475107(36681540, +), CAediting_475108(36682189, +), CAediting_475109(36682194, +), CAediting_475110(36682198, +), CAediting_475111(36682202, +), CAediting_475112(36682207, +), CAediting_475113(36683240, +), CAediting_475114(36683257, +), CAediting_475115(36683262, +), CAediting_475116(36683266, +), CAediting_475117(36683267, +), CAediting_475118(36683271, +), CAediting_475119(36684893, +), CAediting_475120(36684969, +), CAediting_475121(36684987, +), CAediting_475122(36685023, +), CAediting_475123(36685030, +), CAediting_475124(36685040, +), CAediting_475125(36685069, +), |
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RNA editing positional annotations for CDKN1A using Annovar |
| Protein coding RNA editing(s). |
| CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| CAeditome ID | Position | Variant type |
| CAediting_475104 | chr6_36680105_+ | ncRNA_intronic |
| CAediting_475105 | chr6_36681518_+ | ncRNA_intronic |
| CAediting_475106 | chr6_36681532_+ | ncRNA_intronic |
| CAediting_475107 | chr6_36681540_+ | ncRNA_intronic |
| CAediting_475108 | chr6_36682189_+ | ncRNA_intronic |
| CAediting_475109 | chr6_36682194_+ | ncRNA_intronic |
| CAediting_475110 | chr6_36682198_+ | ncRNA_intronic |
| CAediting_475111 | chr6_36682202_+ | ncRNA_intronic |
| CAediting_475112 | chr6_36682207_+ | ncRNA_intronic |
| CAediting_475113 | chr6_36683240_+ | ncRNA_intronic |
| CAediting_475114 | chr6_36683257_+ | ncRNA_intronic |
| CAediting_475115 | chr6_36683262_+ | ncRNA_intronic |
| CAediting_475116 | chr6_36683266_+ | ncRNA_intronic |
| CAediting_475117 | chr6_36683267_+ | ncRNA_intronic |
| CAediting_475118 | chr6_36683271_+ | ncRNA_intronic |
| CAediting_475119 | chr6_36684893_+ | intronic |
| CAediting_475120 | chr6_36684969_+ | intronic |
| CAediting_475121 | chr6_36684987_+ | intronic |
| CAediting_475122 | chr6_36685023_+ | intronic |
| CAediting_475123 | chr6_36685030_+ | intronic |
| CAediting_475124 | chr6_36685040_+ | intronic |
| CAediting_475125 | chr6_36685069_+ | intronic |
| Repat-regional RNA editing(s). |
| CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| CAediting_475105 | chr6_36681518_+ | SINE | Alu | AluJo |
| CAediting_475106 | chr6_36681532_+ | SINE | Alu | AluJo |
| CAediting_475107 | chr6_36681540_+ | SINE | Alu | AluJo |
| CAediting_475108 | chr6_36682189_+ | SINE | MIR | MIRb |
| CAediting_475109 | chr6_36682194_+ | SINE | MIR | MIRb |
| CAediting_475110 | chr6_36682198_+ | SINE | MIR | MIRb |
| CAediting_475111 | chr6_36682202_+ | SINE | MIR | MIRb |
| CAediting_475112 | chr6_36682207_+ | SINE | MIR | MIRb |
| CAediting_475113 | chr6_36683240_+ | SINE | MIR | MIR |
| CAediting_475114 | chr6_36683257_+ | SINE | MIR | MIR |
| CAediting_475115 | chr6_36683262_+ | SINE | MIR | MIR |
| CAediting_475116 | chr6_36683266_+ | SINE | MIR | MIR |
| CAediting_475117 | chr6_36683267_+ | SINE | MIR | MIR |
| CAediting_475118 | chr6_36683271_+ | SINE | MIR | MIR |
| CAediting_475119 | chr6_36684893_+ | SINE | Alu | AluJo |
| CAediting_475120 | chr6_36684969_+ | SINE | Alu | AluJo |
| CAediting_475121 | chr6_36684987_+ | SINE | Alu | AluJo |
| CAediting_475122 | chr6_36685023_+ | SINE | Alu | AluJo |
| CAediting_475123 | chr6_36685030_+ | SINE | Alu | AluJo |
| CAediting_475124 | chr6_36685040_+ | SINE | Alu | AluJo |
| CAediting_475125 | chr6_36685069_+ | SINE | Alu | AluJo |
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RNA A-to-I editing events in the alternative splicing sites for CDKN1A |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000124762.12.CDKN1A. |
| Correlation between RNA A-to-I editing and PSI for ENSG00000124762.12.CDKN1A. |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CDKN1A |
| Differential gene expressions between RNA A-to-I edited and non-edited tumor samples. * The grey color means N/A. |
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| Correlation between RNA A-to-I editing and gene expression. |
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| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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Protein coding region RNA A-to-I editings for CDKN1A |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for CDKN1A |
| **If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| CAediting_748296 | chr10_51299626_+ | ENSG00000124762.12 | ENST00000615513 | hsa-miR-605-3p | 36686470 | 36686477 | 8mer-1a | 36686456 | 36686477 | 140 | -12.39 |
| CAediting_980496 | chr14_31014685_- | ENSG00000124762.12 | ENST00000615513 | hsa-miR-624-3p | 36687245 | 36687252 | 8mer-1a | 36687233 | 36687252 | 148 | -19.62 |
| CAediting_748296 | chr10_51299626_+ | ENSG00000124762.12 | ENST00000448526 | hsa-miR-605-3p | 36686470 | 36686477 | 8mer-1a | 36686456 | 36686477 | 140 | -12.39 |
| CAediting_980496 | chr14_31014685_- | ENSG00000124762.12 | ENST00000448526 | hsa-miR-624-3p | 36687245 | 36687252 | 8mer-1a | 36687233 | 36687252 | 148 | -19.62 |
| CAediting_748296 | chr10_51299626_+ | ENSG00000124762.12 | ENST00000405375 | hsa-miR-605-3p | 36686470 | 36686477 | 8mer-1a | 36686456 | 36686477 | 140 | -12.39 |
| CAediting_980496 | chr14_31014685_- | ENSG00000124762.12 | ENST00000405375 | hsa-miR-624-3p | 36687245 | 36687252 | 8mer-1a | 36687233 | 36687252 | 148 | -19.62 |
| CAediting_1054808 | chr15_66496985_- | ENSG00000124762.12 | ENST00000615513 | hsa-miR-4512 | 36686814 | 36686820 | 7mer-m8 | 36686796 | 36686821 | 149 | -23.98 |
| CAediting_1368054 | chr19_46709310_- | ENSG00000124762.12 | ENST00000615513 | hsa-miR-320e | 36687139 | 36687145 | 7mer-m8 | 36687129 | 36687146 | 142 | -16.45 |
| CAediting_1368054 | chr19_46709310_- | ENSG00000124762.12 | ENST00000615513 | hsa-miR-320e | 36686687 | 36686694 | 8mer-1a | 36686677 | 36686694 | 145 | -17.4 |
| CAediting_86358 | chr1_109598906_+ | ENSG00000124762.12 | ENST00000615513 | hsa-miR-197-5p | 36686921 | 36686927 | 7mer-m8 | 36686905 | 36686928 | 158 | -26.5 |
| CAediting_1054808 | chr15_66496985_- | ENSG00000124762.12 | ENST00000448526 | hsa-miR-4512 | 36686814 | 36686820 | 7mer-m8 | 36686796 | 36686821 | 149 | -23.98 |
| CAediting_1368054 | chr19_46709310_- | ENSG00000124762.12 | ENST00000448526 | hsa-miR-320e | 36687139 | 36687145 | 7mer-m8 | 36687129 | 36687146 | 142 | -16.45 |
| CAediting_1368054 | chr19_46709310_- | ENSG00000124762.12 | ENST00000448526 | hsa-miR-320e | 36686687 | 36686694 | 8mer-1a | 36686677 | 36686694 | 145 | -17.4 |
| CAediting_86358 | chr1_109598906_+ | ENSG00000124762.12 | ENST00000448526 | hsa-miR-197-5p | 36686921 | 36686927 | 7mer-m8 | 36686905 | 36686928 | 158 | -26.5 |
| CAediting_1054808 | chr15_66496985_- | ENSG00000124762.12 | ENST00000405375 | hsa-miR-4512 | 36686814 | 36686820 | 7mer-m8 | 36686796 | 36686821 | 149 | -23.98 |
| CAediting_1368054 | chr19_46709310_- | ENSG00000124762.12 | ENST00000405375 | hsa-miR-320e | 36687139 | 36687145 | 7mer-m8 | 36687129 | 36687146 | 142 | -16.45 |
| CAediting_1368054 | chr19_46709310_- | ENSG00000124762.12 | ENST00000405375 | hsa-miR-320e | 36686687 | 36686694 | 8mer-1a | 36686677 | 36686694 | 145 | -17.4 |
| CAediting_86358 | chr1_109598906_+ | ENSG00000124762.12 | ENST00000405375 | hsa-miR-197-5p | 36686921 | 36686927 | 7mer-m8 | 36686905 | 36686928 | 158 | -26.5 |
| CAediting_468389 | chr6_31355314_- | ENSG00000124762.12 | ENST00000615513 | hsa-miR-6891-5p | 36685918 | 36685925 | 8mer-1a | 36685907 | 36685925 | 148 | -17.8 |
| CAediting_468389 | chr6_31355314_- | ENSG00000124762.12 | ENST00000615513 | hsa-miR-6891-5p | 36686125 | 36686131 | 7mer-m8 | 36686114 | 36686132 | 147 | -22.84 |
| CAediting_468389 | chr6_31355314_- | ENSG00000124762.12 | ENST00000615513 | hsa-miR-6891-5p | 36686325 | 36686331 | 7mer-m8 | 36686313 | 36686332 | 146 | -29.4 |
| CAediting_468389 | chr6_31355314_- | ENSG00000124762.12 | ENST00000615513 | hsa-miR-6891-5p | 36686773 | 36686779 | 7mer-m8 | 36686762 | 36686780 | 155 | -27.51 |
| CAediting_468389 | chr6_31355314_- | ENSG00000124762.12 | ENST00000448526 | hsa-miR-6891-5p | 36685918 | 36685925 | 8mer-1a | 36685907 | 36685925 | 148 | -17.8 |
| CAediting_468389 | chr6_31355314_- | ENSG00000124762.12 | ENST00000448526 | hsa-miR-6891-5p | 36686125 | 36686131 | 7mer-m8 | 36686114 | 36686132 | 147 | -22.84 |
| CAediting_468389 | chr6_31355314_- | ENSG00000124762.12 | ENST00000448526 | hsa-miR-6891-5p | 36686325 | 36686331 | 7mer-m8 | 36686313 | 36686332 | 146 | -29.4 |
| CAediting_468389 | chr6_31355314_- | ENSG00000124762.12 | ENST00000448526 | hsa-miR-6891-5p | 36686773 | 36686779 | 7mer-m8 | 36686762 | 36686780 | 155 | -27.51 |
| CAediting_468389 | chr6_31355314_- | ENSG00000124762.12 | ENST00000405375 | hsa-miR-6891-5p | 36685918 | 36685925 | 8mer-1a | 36685907 | 36685925 | 148 | -17.8 |
| CAediting_468389 | chr6_31355314_- | ENSG00000124762.12 | ENST00000405375 | hsa-miR-6891-5p | 36686125 | 36686131 | 7mer-m8 | 36686114 | 36686132 | 147 | -22.84 |
| CAediting_468389 | chr6_31355314_- | ENSG00000124762.12 | ENST00000405375 | hsa-miR-6891-5p | 36686325 | 36686331 | 7mer-m8 | 36686313 | 36686332 | 146 | -29.4 |
| CAediting_468389 | chr6_31355314_- | ENSG00000124762.12 | ENST00000405375 | hsa-miR-6891-5p | 36686773 | 36686779 | 7mer-m8 | 36686762 | 36686780 | 155 | -27.51 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| CAediting_524911 | chr7_5495852_- | ENSG00000124762.12 | ENST00000615513 | hsa-miR-589-3p | 36687254 | 36687260 | 7mer-m8 | 36687239 | 36687261 | 148 | -12.81 |
| CAediting_524911 | chr7_5495852_- | ENSG00000124762.12 | ENST00000448526 | hsa-miR-589-3p | 36687254 | 36687260 | 7mer-m8 | 36687239 | 36687261 | 148 | -12.81 |
| CAediting_524911 | chr7_5495852_- | ENSG00000124762.12 | ENST00000405375 | hsa-miR-589-3p | 36687254 | 36687260 | 7mer-m8 | 36687239 | 36687261 | 148 | -12.81 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for CDKN1A |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in RNA structures for Minimum free energy (MFE). |
| CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for CDKN1A |
| Correlation between ADAR gene expression and RNA editing frequency |
| Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for CDKN1A |
| Correlation between Cancer stages and RNA editing frequency |
| Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for CDKN1A |
| Correlation between RNA editing and survival |
| Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for CDKN1A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.8 2021-01-03) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| CDKN1A | P38936 | DB01169 | Arsenic trioxide | Cyclin-dependent kinase inhibitor 1 | SmallMoleculeDrug | approved|investigational |
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RelatedDiseases for CDKN1A |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| CDKN1A | C0007138 | Carcinoma, Transitional Cell | 2 | CTD_human |
| CDKN1A | C0021841 | Intestinal Neoplasms | 2 | CTD_human |
| CDKN1A | C0024121 | Lung Neoplasms | 2 | CTD_human |
| CDKN1A | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| CDKN1A | C0242379 | Malignant neoplasm of lung | 2 | CTD_human |
| CDKN1A | C0346627 | Intestinal Cancer | 2 | CTD_human |
| CDKN1A | C0376358 | Malignant neoplasm of prostate | 2 | CTD_human |
| CDKN1A | C0004238 | Atrial Fibrillation | 1 | CTD_human |
| CDKN1A | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human |
| CDKN1A | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| CDKN1A | C0007102 | Malignant tumor of colon | 1 | CTD_human |
| CDKN1A | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| CDKN1A | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
| CDKN1A | C0017667 | Nodular glomerulosclerosis | 1 | CTD_human |
| CDKN1A | C0019693 | HIV Infections | 1 | CTD_human |
| CDKN1A | C0020564 | Hypertrophy | 1 | CTD_human |
| CDKN1A | C0022658 | Kidney Diseases | 1 | CTD_human |
| CDKN1A | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| CDKN1A | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
| CDKN1A | C0025267 | Multiple Endocrine Neoplasia Type 1 | 1 | ORPHANET |
| CDKN1A | C0030354 | Papilloma | 1 | CTD_human |
| CDKN1A | C0035126 | Reperfusion Injury | 1 | CTD_human |
| CDKN1A | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| CDKN1A | C0205874 | Papilloma, Squamous Cell | 1 | CTD_human |
| CDKN1A | C0205875 | Papillomatosis | 1 | CTD_human |
| CDKN1A | C0235480 | Paroxysmal atrial fibrillation | 1 | CTD_human |
| CDKN1A | C0238288 | Muscular Dystrophy, Facioscapulohumeral | 1 | CTD_human |
| CDKN1A | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| CDKN1A | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| CDKN1A | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
| CDKN1A | C2585653 | Persistent atrial fibrillation | 1 | CTD_human |
| CDKN1A | C3468561 | familial atrial fibrillation | 1 | CTD_human |
| CDKN1A | C4505456 | HIV Coinfection | 1 | CTD_human |
