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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: USPL1 (CAeditome ID:10208)

Gene summary for USPL1

check button Gene summary
Gene informationGene symbol

USPL1

Gene ID

10208

Gene nameubiquitin specific peptidase like 1
SynonymsC13orf22|D13S106E|bA121O19.1
Cytomap

13q12.3

Type of geneprotein-coding
DescriptionSUMO-specific isopeptidase USPL1USP-like 1highly charged proteinubiquitin-specific peptidase-like protein 1
Modification date20210522
UniProtAcc

Q5W0Q7

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
USPL1

GO:0043130

SUMO-specific isopeptidase USPL1

22878415

USPL1

GO:0032183

SUMO-specific isopeptidase USPL1

22878415

USPL1

GO:0070140

SUMO-specific isopeptidase USPL1

22878415

USPL1

GO:0016926

SUMO-specific isopeptidase USPL1

22878415

USPL1

GO:0015030

SUMO-specific isopeptidase USPL1

22878415

USPL1

GO:0015030

SUMO-specific isopeptidase USPL1

24413172


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RNA A-to-I events for USPL1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000132952.10

check button RNA A-to-I editing events in Cancer.
CAediting_956338(30624360, +), CAediting_956339(30624366, +), CAediting_956340(30625575, +), CAediting_956341(30625580, +), CAediting_956342(30625585, +), CAediting_956343(30625607, +), CAediting_956344(30625652, +), CAediting_956345(30625677, +), CAediting_956346(30625739, +), CAediting_956347(30626298, +), CAediting_956348(30628006, +), CAediting_956349(30629271, +), CAediting_956350(30629991, +), CAediting_956351(30629993, +), CAediting_956352(30629995, +), CAediting_956353(30629997, +), CAediting_956354(30630077, +), CAediting_956355(30630094, +), CAediting_956356(30631600, +), CAediting_956357(30631626, +), CAediting_956358(30632507, +), CAediting_956359(30632531, +), CAediting_956360(30633493, +), CAediting_956361(30633499, +), CAediting_956362(30633507, +), CAediting_956363(30633515, +), CAediting_956364(30633516, +), CAediting_956365(30633524, +), CAediting_956366(30633529, +), CAediting_956367(30633533, +), CAediting_956368(30633539, +), CAediting_956369(30633556, +), CAediting_956370(30633561, +), CAediting_956371(30633606, +), CAediting_956372(30633609, +), CAediting_956373(30633620, +), CAediting_956374(30633622, +), CAediting_956375(30633651, +), CAediting_956376(30633679, +), CAediting_956377(30633684, +), CAediting_956378(30633685, +), CAediting_956379(30633698, +), CAediting_956380(30633708, +), CAediting_956381(30633770, +), CAediting_956382(30636763, +), CAediting_956383(30636989, +), CAediting_956384(30637056, +), CAediting_956385(30637057, +), CAediting_956386(30642046, +), CAediting_956387(30642115, +), CAediting_956388(30643668, +), CAediting_956389(30643714, +), CAediting_956390(30644162, +), CAediting_956391(30644168, +), CAediting_956392(30644233, +), CAediting_956393(30650041, +), CAediting_956394(30650770, +), CAediting_956395(30650774, +), CAediting_956396(30650775, +), CAediting_956397(30650780, +), CAediting_956398(30651706, +), CAediting_956399(30651711, +), CAediting_956400(30651836, +),

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RNA editing positional annotations for USPL1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_956338chr13_30624360_+ncRNA_intronic
CAediting_956339chr13_30624366_+ncRNA_intronic
CAediting_956340chr13_30625575_+ncRNA_intronic
CAediting_956341chr13_30625580_+ncRNA_intronic
CAediting_956342chr13_30625585_+ncRNA_intronic
CAediting_956343chr13_30625607_+ncRNA_intronic
CAediting_956344chr13_30625652_+ncRNA_intronic
CAediting_956345chr13_30625677_+ncRNA_intronic
CAediting_956346chr13_30625739_+ncRNA_intronic
CAediting_956347chr13_30626298_+ncRNA_intronic
CAediting_956348chr13_30628006_+ncRNA_intronic
CAediting_956349chr13_30629271_+ncRNA_intronic
CAediting_956350chr13_30629991_+ncRNA_intronic
CAediting_956351chr13_30629993_+ncRNA_intronic
CAediting_956352chr13_30629995_+ncRNA_intronic
CAediting_956353chr13_30629997_+ncRNA_intronic
CAediting_956354chr13_30630077_+ncRNA_intronic
CAediting_956355chr13_30630094_+ncRNA_intronic
CAediting_956356chr13_30631600_+intronic
CAediting_956357chr13_30631626_+intronic
CAediting_956358chr13_30632507_+intronic
CAediting_956359chr13_30632531_+intronic
CAediting_956360chr13_30633493_+intronic
CAediting_956361chr13_30633499_+intronic
CAediting_956362chr13_30633507_+intronic
CAediting_956363chr13_30633515_+intronic
CAediting_956364chr13_30633516_+intronic
CAediting_956365chr13_30633524_+intronic
CAediting_956366chr13_30633529_+intronic
CAediting_956367chr13_30633533_+intronic
CAediting_956368chr13_30633539_+intronic
CAediting_956369chr13_30633556_+intronic
CAediting_956370chr13_30633561_+intronic
CAediting_956371chr13_30633606_+intronic
CAediting_956372chr13_30633609_+intronic
CAediting_956373chr13_30633620_+intronic
CAediting_956374chr13_30633622_+intronic
CAediting_956375chr13_30633651_+intronic
CAediting_956376chr13_30633679_+intronic
CAediting_956377chr13_30633684_+intronic
CAediting_956378chr13_30633685_+intronic
CAediting_956379chr13_30633698_+intronic
CAediting_956380chr13_30633708_+intronic
CAediting_956381chr13_30633770_+intronic
CAediting_956382chr13_30636763_+intronic
CAediting_956383chr13_30636989_+intronic
CAediting_956384chr13_30637056_+intronic
CAediting_956385chr13_30637057_+intronic
CAediting_956386chr13_30642046_+intronic
CAediting_956387chr13_30642115_+intronic
CAediting_956388chr13_30643668_+intronic
CAediting_956389chr13_30643714_+intronic
CAediting_956390chr13_30644162_+intronic
CAediting_956391chr13_30644168_+intronic
CAediting_956392chr13_30644233_+intronic
CAediting_956393chr13_30650041_+intronic
CAediting_956394chr13_30650770_+intronic
CAediting_956395chr13_30650774_+intronic
CAediting_956396chr13_30650775_+intronic
CAediting_956397chr13_30650780_+intronic
CAediting_956398chr13_30651706_+intronic
CAediting_956399chr13_30651711_+intronic
CAediting_956400chr13_30651836_+intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_956338chr13_30624360_+SINEAluAluJo
CAediting_956339chr13_30624366_+SINEAluAluJo
CAediting_956340chr13_30625575_+SINEAluAluSc5
CAediting_956341chr13_30625580_+SINEAluAluSc5
CAediting_956342chr13_30625585_+SINEAluAluSc5
CAediting_956343chr13_30625607_+SINEAluAluSc5
CAediting_956344chr13_30625652_+SINEAluAluSc5
CAediting_956345chr13_30625677_+SINEAluAluSc5
CAediting_956346chr13_30625739_+SINEAluAluSc5
CAediting_956347chr13_30626298_+SINEAluAluSz
CAediting_956348chr13_30628006_+SINEAluAluSx
CAediting_956349chr13_30629271_+SINEAluAluJb
CAediting_956351chr13_30629993_+SINEAluAluJr
CAediting_956352chr13_30629995_+SINEAluAluJr
CAediting_956353chr13_30629997_+SINEAluAluJr
CAediting_956354chr13_30630077_+SINEAluAluJr
CAediting_956355chr13_30630094_+SINEAluAluJr
CAediting_956356chr13_30631600_+SINEAluAluJb
CAediting_956357chr13_30631626_+SINEAluAluJb
CAediting_956358chr13_30632507_+SINEAluAluSx4
CAediting_956359chr13_30632531_+SINEAluAluSx4
CAediting_956360chr13_30633493_+SINEAluAluSx
CAediting_956361chr13_30633499_+SINEAluAluSx
CAediting_956362chr13_30633507_+SINEAluAluSx
CAediting_956363chr13_30633515_+SINEAluAluSx
CAediting_956364chr13_30633516_+SINEAluAluSx
CAediting_956365chr13_30633524_+SINEAluAluSx
CAediting_956366chr13_30633529_+SINEAluAluSx
CAediting_956367chr13_30633533_+SINEAluAluSx
CAediting_956368chr13_30633539_+SINEAluAluSx
CAediting_956369chr13_30633556_+SINEAluAluSx
CAediting_956370chr13_30633561_+SINEAluAluSx
CAediting_956371chr13_30633606_+SINEAluAluSx
CAediting_956372chr13_30633609_+SINEAluAluSx
CAediting_956373chr13_30633620_+SINEAluAluSx
CAediting_956374chr13_30633622_+SINEAluAluSx
CAediting_956375chr13_30633651_+SINEAluAluSx
CAediting_956376chr13_30633679_+SINEAluAluSx
CAediting_956377chr13_30633684_+SINEAluAluSx
CAediting_956378chr13_30633685_+SINEAluAluSx
CAediting_956379chr13_30633698_+SINEAluAluSx
CAediting_956380chr13_30633708_+SINEAluAluSx
CAediting_956381chr13_30633770_+SINEAluAluSx
CAediting_956383chr13_30636989_+SINEAluAluJr
CAediting_956384chr13_30637056_+SINEAluAluJr
CAediting_956385chr13_30637057_+SINEAluAluJr
CAediting_956386chr13_30642046_+SINEAluAluJo
CAediting_956387chr13_30642115_+SINEAluAluJo
CAediting_956388chr13_30643668_+SINEAluAluSx
CAediting_956389chr13_30643714_+SINEAluAluSx
CAediting_956390chr13_30644162_+SINEAluAluSq4
CAediting_956391chr13_30644168_+SINEAluAluSq4
CAediting_956392chr13_30644233_+SINEAluAluSq4
CAediting_956393chr13_30650041_+SINEAluAluSx
CAediting_956394chr13_30650770_+SINEAluAluSx
CAediting_956395chr13_30650774_+SINEAluAluSx
CAediting_956396chr13_30650775_+SINEAluAluSx
CAediting_956397chr13_30650780_+SINEAluAluSx
CAediting_956398chr13_30651706_+SINEAluAluSz
CAediting_956399chr13_30651711_+SINEAluAluSz
CAediting_956400chr13_30651836_+SINEAluAluSz

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RNA A-to-I editing events in the alternative splicing sites for USPL1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000132952.10.USPL1.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000132952.10.USPL1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for USPL1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for USPL1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for USPL1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1054808chr15_66496985_-ENSG00000132952.10ENST00000614860hsa-miR-451230660390306603967mer-m83066037630660397140-18.43
CAediting_1229413chr17_67471544_+ENSG00000132952.10ENST00000614860hsa-miR-548aa30659558306595658mer-1a3065954130659565147-10.24
CAediting_396018chr5_1062918_-ENSG00000132952.10ENST00000614860hsa-miR-463530659896306599027mer-m83065988430659903149-18.27

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1054808chr15_66496985_-ENSG00000132952.10ENST00000614860hsa-miR-451230659925306599317mer-m83065990830659932141-21.55
CAediting_1054808chr15_66496985_-ENSG00000132952.10ENST00000614860hsa-miR-451230660261306602666mer3066025930660282145-18.65
CAediting_1054808chr15_66496985_-ENSG00000132952.10ENST00000614860hsa-miR-451230660275306602817mer-m83066025930660282145-18.65
CAediting_1229413chr17_67471544_+ENSG00000132952.10ENST00000614860hsa-miR-548aa30659709306597157mer-m83065969230659716155-14.43
CAediting_228905chr2_188297554_+ENSG00000132952.10ENST00000614860hsa-miR-561-3p30660641306606477mer-m83066062730660648155-10.91
CAediting_980496chr14_31014685_-ENSG00000132952.10ENST00000614860hsa-miR-624-3p30660697306607037mer-m83066068330660704146-14.23

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for USPL1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for USPL1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
STADCAediting_956381chr13_30633770_+0.03624933824196390.273265308531884....

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Relation with cancer stages for USPL1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
STADpathologic_stageCAediting_956381chr13_30633770_+0.02604798283980720.289689561755031

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Relation with survival for USPL1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for USPL1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USPL1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource