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Editing gene: RASA4 (CAeditome ID:10156)

Gene summary for RASA4

Gene summary

Gene information	Gene symbol	RASA4
	Gene ID	10156
	Gene name	RAS p21 protein activator 4
	Synonyms	CAPRI\|GAPL
	Cytomap	7q22.1
	Type of gene	protein-coding
	Description	ras GTPase-activating protein 4Ca2+-promoted Ras inactivatorcalcium-promoted Ras inactivatorrasGAP-activating-like protein 2
	Modification date	20210518
	UniProtAcc	O43374
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
RASA4	GO:0005886	Ras GTPase-activating protein 4	16009725
RASA4	GO:0005096	Ras GTPase-activating protein 4	11448776
RASA4	GO:0005096	Ras GTPase-activating protein 4	16009725
RASA4	GO:0034260	Ras GTPase-activating protein 4	12845332
RASA4	GO:0005829	Ras GTPase-activating protein 4	16009725

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RNA A-to-I events for RASA4

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000105808.16

RNA A-to-I editing events in Cancer.

CAediting_588462(102576244, -), CAediting_588463(102577168, -), CAediting_588464(102577240, -), CAediting_588465(102578353, -), CAediting_588466(102578358, -), CAediting_588467(102578426, -), CAediting_588468(102578427, -), CAediting_588469(102578478, -), CAediting_588470(102580046, -), CAediting_588471(102580055, -), CAediting_588472(102580056, -), CAediting_588473(102580072, -), CAediting_588474(102580091, -), CAediting_588475(102580416, -), CAediting_588476(102580431, -), CAediting_588477(102580434, -), CAediting_588478(102580482, -), CAediting_588479(102580486, -), CAediting_588480(102580487, -), CAediting_588481(102580509, -), CAediting_588482(102580515, -), CAediting_588483(102580837, -), CAediting_588484(102580839, -), CAediting_588485(102580841, -), CAediting_588486(102585268, -), CAediting_588487(102585280, -), CAediting_588488(102585307, -), CAediting_588489(102585331, -), CAediting_588490(102585333, -), CAediting_588491(102585359, -), CAediting_588492(102585369, -), CAediting_588493(102585389, -), CAediting_588494(102585394, -), CAediting_588495(102585405, -), CAediting_588496(102585410, -), CAediting_588497(102585416, -), CAediting_588498(102585429, -), CAediting_588499(102585442, -), CAediting_588500(102585446, -), CAediting_588501(102585447, -), CAediting_588502(102585472, -), CAediting_588503(102585477, -), CAediting_588504(102585515, -), CAediting_588505(102585924, -), CAediting_588506(102585925, -), CAediting_588507(102585948, -), CAediting_588508(102603915, -), CAediting_588509(102606321, -), CAediting_588510(102606505, -), CAediting_588511(102606513, -), CAediting_588512(102606777, -), CAediting_588513(102606778, -), CAediting_588514(102606780, -), CAediting_588515(102608007, -), CAediting_588516(102608107, -),

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RNA editing positional annotations for RASA4 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_588462	chr7_102576244_-	intronic
CAediting_588463	chr7_102577168_-	intronic
CAediting_588464	chr7_102577240_-	intronic
CAediting_588465	chr7_102578353_-	intronic
CAediting_588466	chr7_102578358_-	intronic
CAediting_588467	chr7_102578426_-	intronic
CAediting_588468	chr7_102578427_-	intronic
CAediting_588469	chr7_102578478_-	intronic
CAediting_588470	chr7_102580046_-	UTR3
CAediting_588471	chr7_102580055_-	UTR3
CAediting_588472	chr7_102580056_-	UTR3
CAediting_588473	chr7_102580072_-	UTR3
CAediting_588474	chr7_102580091_-	UTR3
CAediting_588475	chr7_102580416_-	UTR3
CAediting_588476	chr7_102580431_-	UTR3
CAediting_588477	chr7_102580434_-	UTR3
CAediting_588478	chr7_102580482_-	UTR3
CAediting_588479	chr7_102580486_-	UTR3
CAediting_588480	chr7_102580487_-	UTR3
CAediting_588481	chr7_102580509_-	UTR3
CAediting_588482	chr7_102580515_-	UTR3
CAediting_588483	chr7_102580837_-	UTR3
CAediting_588484	chr7_102580839_-	UTR3
CAediting_588485	chr7_102580841_-	UTR3
CAediting_588486	chr7_102585268_-	ncRNA_intronic
CAediting_588487	chr7_102585280_-	ncRNA_intronic
CAediting_588488	chr7_102585307_-	ncRNA_intronic
CAediting_588489	chr7_102585331_-	ncRNA_intronic
CAediting_588490	chr7_102585333_-	ncRNA_intronic
CAediting_588491	chr7_102585359_-	ncRNA_intronic
CAediting_588492	chr7_102585369_-	ncRNA_intronic
CAediting_588493	chr7_102585389_-	ncRNA_intronic
CAediting_588494	chr7_102585394_-	ncRNA_intronic
CAediting_588495	chr7_102585405_-	ncRNA_intronic
CAediting_588496	chr7_102585410_-	ncRNA_intronic
CAediting_588497	chr7_102585416_-	ncRNA_intronic
CAediting_588498	chr7_102585429_-	ncRNA_intronic
CAediting_588499	chr7_102585442_-	ncRNA_intronic
CAediting_588500	chr7_102585446_-	ncRNA_intronic
CAediting_588501	chr7_102585447_-	ncRNA_intronic
CAediting_588502	chr7_102585472_-	ncRNA_intronic
CAediting_588503	chr7_102585477_-	ncRNA_intronic
CAediting_588504	chr7_102585515_-	ncRNA_intronic
CAediting_588505	chr7_102585924_-	ncRNA_intronic
CAediting_588506	chr7_102585925_-	ncRNA_intronic
CAediting_588507	chr7_102585948_-	ncRNA_intronic
CAediting_588508	chr7_102603915_-	ncRNA_intronic
CAediting_588509	chr7_102606321_-	ncRNA_intronic
CAediting_588510	chr7_102606505_-	ncRNA_intronic
CAediting_588511	chr7_102606513_-	ncRNA_intronic
CAediting_588512	chr7_102606777_-	ncRNA_intronic
CAediting_588513	chr7_102606778_-	ncRNA_intronic
CAediting_588514	chr7_102606780_-	ncRNA_intronic
CAediting_588515	chr7_102608007_-	ncRNA_intronic
CAediting_588516	chr7_102608107_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_588462	chr7_102576244_-	SINE	Alu	AluJo
CAediting_588463	chr7_102577168_-	SINE	Alu	AluSx
CAediting_588464	chr7_102577240_-	SINE	Alu	AluSx
CAediting_588465	chr7_102578353_-	SINE	Alu	AluSx1
CAediting_588466	chr7_102578358_-	SINE	Alu	AluSx1
CAediting_588467	chr7_102578426_-	SINE	Alu	AluSx1
CAediting_588468	chr7_102578427_-	SINE	Alu	AluSx1
CAediting_588469	chr7_102578478_-	SINE	Alu	AluSx1
CAediting_588470	chr7_102580046_-	SINE	Alu	FLAM_A
CAediting_588471	chr7_102580055_-	SINE	Alu	FLAM_A
CAediting_588472	chr7_102580056_-	SINE	Alu	FLAM_A
CAediting_588473	chr7_102580072_-	SINE	Alu	FLAM_A
CAediting_588474	chr7_102580091_-	LINE	L1	L1MC5a
CAediting_588475	chr7_102580416_-	SINE	Alu	FLAM_A
CAediting_588476	chr7_102580431_-	SINE	Alu	FLAM_A
CAediting_588477	chr7_102580434_-	SINE	Alu	FLAM_A
CAediting_588478	chr7_102580482_-	SINE	Alu	FLAM_A
CAediting_588479	chr7_102580486_-	SINE	Alu	FLAM_A
CAediting_588480	chr7_102580487_-	SINE	Alu	FLAM_A
CAediting_588481	chr7_102580509_-	SINE	Alu	FLAM_A
CAediting_588482	chr7_102580515_-	SINE	Alu	FLAM_A
CAediting_588483	chr7_102580837_-	SINE	Alu	AluSx
CAediting_588484	chr7_102580839_-	SINE	Alu	AluSx
CAediting_588485	chr7_102580841_-	SINE	Alu	AluSx
CAediting_588486	chr7_102585268_-	SINE	Alu	AluJr
CAediting_588487	chr7_102585280_-	SINE	Alu	AluJr
CAediting_588488	chr7_102585307_-	SINE	Alu	AluJr
CAediting_588489	chr7_102585331_-	SINE	Alu	AluJr
CAediting_588490	chr7_102585333_-	SINE	Alu	AluJr
CAediting_588491	chr7_102585359_-	SINE	Alu	AluJr
CAediting_588492	chr7_102585369_-	SINE	Alu	AluJr
CAediting_588493	chr7_102585389_-	SINE	Alu	AluJr
CAediting_588494	chr7_102585394_-	SINE	Alu	AluJr
CAediting_588495	chr7_102585405_-	SINE	Alu	AluJr
CAediting_588496	chr7_102585410_-	SINE	Alu	AluJr
CAediting_588497	chr7_102585416_-	SINE	Alu	AluJr
CAediting_588498	chr7_102585429_-	SINE	Alu	AluJr
CAediting_588499	chr7_102585442_-	SINE	Alu	AluJr
CAediting_588500	chr7_102585446_-	SINE	Alu	AluJr
CAediting_588501	chr7_102585447_-	SINE	Alu	AluJr
CAediting_588502	chr7_102585472_-	SINE	Alu	AluJr
CAediting_588503	chr7_102585477_-	SINE	Alu	AluJr
CAediting_588504	chr7_102585515_-	SINE	Alu	AluJr
CAediting_588505	chr7_102585924_-	SINE	Alu	AluSx
CAediting_588506	chr7_102585925_-	SINE	Alu	AluSx
CAediting_588507	chr7_102585948_-	SINE	Alu	AluSx
CAediting_588508	chr7_102603915_-	SINE	Alu	AluSx
CAediting_588509	chr7_102606321_-	SINE	Alu	AluSx
CAediting_588510	chr7_102606505_-	SINE	Alu	AluJr
CAediting_588511	chr7_102606513_-	SINE	Alu	AluJr
CAediting_588512	chr7_102606777_-	SINE	Alu	AluJr
CAediting_588513	chr7_102606778_-	SINE	Alu	AluJr
CAediting_588514	chr7_102606780_-	SINE	Alu	AluJr
CAediting_588515	chr7_102608007_-	SINE	Alu	AluY
CAediting_588516	chr7_102608107_-	SINE	Alu	AluY

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RNA A-to-I editing events in the alternative splicing sites for RASA4

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000105808.16.RASA4.

Correlation between RNA A-to-I editing and PSI for ENSG00000105808.16.RASA4.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RASA4

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for RASA4

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for RASA4

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_588474	chr7_102580091_-	ENSG00000105808.16	ENST00000262940	hsa-miR-103a-3p	102580086	102580093	8mer-1a	102580086	102580109	156.00	-14.87
CAediting_588474	chr7_102580091_-	ENSG00000105808.16	ENST00000262940	hsa-miR-103a-3p	102580086	102580093	8mer-1a	102580086	102580109	156.00	-14.87
CAediting_588474	chr7_102580091_-	ENSG00000105808.16	ENST00000262940	hsa-miR-107	102580086	102580093	8mer-1a	102580086	102580109	156.00	-14.87
CAediting_588470	chr7_102580046_-	ENSG00000105808.16	ENST00000262940	hsa-miR-1207-3p	102580046	102580052	7mer-m8	102580045	102580062	140.00	-12.56
CAediting_588470	chr7_102580046_-	ENSG00000105808.16	ENST00000262940	hsa-miR-646	102580044	102580050	7mer-m8	102580043	102580061	145.00	-16.24
CAediting_588471	chr7_102580055_-	ENSG00000105808.16	ENST00000262940	hsa-miR-8052	102580050	102580056	7mer-1a	102580050	102580068	143.00	-23.77
CAediting_588472	chr7_102580056_-	ENSG00000105808.16	ENST00000262940	hsa-miR-513a-5p	102580055	102580061	7mer-m8	102580054	102580071	160.00	-21.48
CAediting_588472	chr7_102580056_-	ENSG00000105808.16	ENST00000262940	hsa-miR-513a-5p	102580055	102580061	7mer-m8	102580054	102580071	160.00	-21.48
CAediting_588472	chr7_102580056_-	ENSG00000105808.16	ENST00000262940	hsa-miR-638	102580050	102580056	7mer-1a	102580050	102580074	161.00	-34.25
CAediting_588477	chr7_102580434_-	ENSG00000105808.16	ENST00000262940	hsa-miR-4659a-5p	102580430	102580437	8mer-1a	102580430	102580451	145.00	-14.78
CAediting_588477	chr7_102580434_-	ENSG00000105808.16	ENST00000262940	hsa-miR-4659b-5p	102580430	102580437	8mer-1a	102580430	102580448	145.00	-14.91
CAediting_588477	chr7_102580434_-	ENSG00000105808.16	ENST00000262940	hsa-miR-4716-5p	102580433	102580439	7mer-m8	102580432	102580453	148.00	-14.66
CAediting_588477	chr7_102580434_-	ENSG00000105808.16	ENST00000262940	hsa-miR-4776-3p	102580429	102580436	8mer-1a	102580429	102580452	153.00	-18.04
CAediting_588477	chr7_102580434_-	ENSG00000105808.16	ENST00000262940	hsa-miR-4776-3p	102580429	102580436	8mer-1a	102580429	102580452	153.00	-18.04
CAediting_588479	chr7_102580486_-	ENSG00000105808.16	ENST00000262940	hsa-miR-3176	102580486	102580492	7mer-m8	102580485	102580504	144.00	-17.65
CAediting_588479	chr7_102580486_-	ENSG00000105808.16	ENST00000262940	hsa-miR-3922-3p	102580486	102580492	7mer-m8	102580485	102580507	143.00	-18.40
CAediting_588483	chr7_102580837_-	ENSG00000105808.16	ENST00000262940	hsa-miR-340-3p	102580835	102580842	8mer-1a	102580835	102580856	146.00	-18.22
CAediting_588483	chr7_102580837_-	ENSG00000105808.16	ENST00000262940	hsa-miR-6827-3p	102580835	102580842	8mer-1a	102580835	102580855	140.00	-14.67
CAediting_588484	chr7_102580839_-	ENSG00000105808.16	ENST00000262940	hsa-miR-5001-3p	102580835	102580841	7mer-m8	102580834	102580855	145.00	-15.37
CAediting_588485	chr7_102580841_-	ENSG00000105808.16	ENST00000262940	hsa-miR-4433b-5p	102580837	102580843	7mer-m8	102580836	102580856	140.00	-10.81

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_588471	chr7_102580055_-	ENSG00000105808.16	ENST00000262940	hsa-miR-10399-5p	102580054	102580060	7mer-m8	102580053	102580074	152	-12.02
CAediting_588472	chr7_102580056_-	ENSG00000105808.16	ENST00000262940	hsa-miR-10399-5p	102580054	102580060	7mer-m8	102580053	102580074	152	-12.02
CAediting_588476	chr7_102580431_-	ENSG00000105808.16	ENST00000262940	hsa-miR-19b-1-5p	102580427	102580433	7mer-m8	102580426	102580446	154	-16.4
CAediting_588476	chr7_102580431_-	ENSG00000105808.16	ENST00000262940	hsa-miR-19b-2-5p	102580427	102580433	7mer-m8	102580426	102580447	152	-11.4
CAediting_588478	chr7_102580482_-	ENSG00000105808.16	ENST00000262940	hsa-miR-3182	102580478	102580484	7mer-m8	102580477	102580493	144	-13.15
CAediting_588483	chr7_102580837_-	ENSG00000105808.16	ENST00000262940	hsa-miR-3664-5p	102580833	102580839	7mer-m8	102580832	102580853	153	-15.28
CAediting_588485	chr7_102580841_-	ENSG00000105808.16	ENST00000262940	hsa-miR-371b-5p	102580839	102580846	8mer-1a	102580839	102580860	146	-7.79
CAediting_588485	chr7_102580841_-	ENSG00000105808.16	ENST00000262940	hsa-miR-373-5p	102580839	102580846	8mer-1a	102580839	102580860	142	-8.35
CAediting_588473	chr7_102580072_-	ENSG00000105808.16	ENST00000262940	hsa-miR-4252	102580066	102580073	8mer-1a	102580066	102580085	154	-21.45
CAediting_588483	chr7_102580837_-	ENSG00000105808.16	ENST00000262940	hsa-miR-4522	102580832	102580838	7mer-m8	102580831	102580851	148	-12.83
CAediting_588478	chr7_102580482_-	ENSG00000105808.16	ENST00000262940	hsa-miR-4743-3p	102580479	102580485	7mer-m8	102580478	102580496	152	-18.78
CAediting_588475	chr7_102580416_-	ENSG00000105808.16	ENST00000262940	hsa-miR-4775	102580410	102580417	8mer-1a	102580410	102580432	145	-8.22
CAediting_588471	chr7_102580055_-	ENSG00000105808.16	ENST00000262940	hsa-miR-5089-5p	102580050	102580056	7mer-m8	102580049	102580068	146	-12.33
CAediting_588484	chr7_102580839_-	ENSG00000105808.16	ENST00000262940	hsa-miR-514b-5p	102580839	102580844	6mer	102580838	102580859	146	-12.74
CAediting_588485	chr7_102580841_-	ENSG00000105808.16	ENST00000262940	hsa-miR-514b-5p	102580839	102580844	6mer	102580838	102580859	146	-12.74
CAediting_588481	chr7_102580509_-	ENSG00000105808.16	ENST00000262940	hsa-miR-520g-5p	102580508	102580514	7mer-m8	102580507	102580530	153	-19.25
CAediting_588470	chr7_102580046_-	ENSG00000105808.16	ENST00000262940	hsa-miR-562	102580043	102580049	7mer-m8	102580042	102580061	150	-12.74
CAediting_588470	chr7_102580046_-	ENSG00000105808.16	ENST00000262940	hsa-miR-5697	102580042	102580048	7mer-m8	102580041	102580063	149	-18.32
CAediting_588475	chr7_102580416_-	ENSG00000105808.16	ENST00000262940	hsa-miR-590-3p	102580411	102580418	8mer-1a	102580411	102580431	154	-7.05
CAediting_588485	chr7_102580841_-	ENSG00000105808.16	ENST00000262940	hsa-miR-616-5p	102580839	102580846	8mer-1a	102580839	102580860	140	-5.71
CAediting_588481	chr7_102580509_-	ENSG00000105808.16	ENST00000262940	hsa-miR-6503-3p	102580505	102580511	7mer-m8	102580504	102580525	149	-20.95
CAediting_588471	chr7_102580055_-	ENSG00000105808.16	ENST00000262940	hsa-miR-6504-3p	102580054	102580060	7mer-m8	102580053	102580074	152	-14.83
CAediting_588472	chr7_102580056_-	ENSG00000105808.16	ENST00000262940	hsa-miR-6504-3p	102580054	102580060	7mer-m8	102580053	102580074	152	-14.83
CAediting_588473	chr7_102580072_-	ENSG00000105808.16	ENST00000262940	hsa-miR-6529-3p	102580071	102580077	7mer-m8	102580070	102580091	141	-12.75
CAediting_588480	chr7_102580487_-	ENSG00000105808.16	ENST00000262940	hsa-miR-6878-3p	102580486	102580493	8mer-1a	102580486	102580506	142	-13.4
CAediting_588483	chr7_102580837_-	ENSG00000105808.16	ENST00000262940	hsa-miR-6888-3p	102580835	102580841	7mer-m8	102580834	102580854	151	-14.42
CAediting_588484	chr7_102580839_-	ENSG00000105808.16	ENST00000262940	hsa-miR-6888-3p	102580835	102580841	7mer-m8	102580834	102580854	151	-14.42
CAediting_588478	chr7_102580482_-	ENSG00000105808.16	ENST00000262940	hsa-miR-6888-3p	102580479	102580486	8mer-1a	102580479	102580496	147	-16.36
CAediting_588473	chr7_102580072_-	ENSG00000105808.16	ENST00000262940	hsa-miR-6889-3p	102580071	102580077	7mer-m8	102580070	102580089	145	-18.25
CAediting_588472	chr7_102580056_-	ENSG00000105808.16	ENST00000262940	hsa-miR-7151-3p	102580055	102580062	8mer-1a	102580055	102580079	144	-19.54

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_688080	chr9_63819626_+	ENSG00000105808.16	ENST00000262940	hsa-miR-4477b	102582069	102582076	8mer-1a	102582069	102582090	142	-11.37
CAediting_688081	chr9_63819627_+	ENSG00000105808.16	ENST00000262940	hsa-miR-4477b	102580415	102580422	8mer-1a	102580415	102580440	152	-15.26
CAediting_1054808	chr15_66496985_-	ENSG00000105808.16	ENST00000262940	hsa-miR-4512	102581252	102581258	7mer-m8	102581251	102581272	150	-21.08
CAediting_1054808	chr15_66496985_-	ENSG00000105808.16	ENST00000262940	hsa-miR-4512	102582406	102582412	7mer-1a	102582406	102582427	140	-25.09
CAediting_1368054	chr19_46709310_-	ENSG00000105808.16	ENST00000262940	hsa-miR-320e	102581561	102581567	7mer-m8	102581560	102581577	143	-13.44
CAediting_1368054	chr19_46709310_-	ENSG00000105808.16	ENST00000262940	hsa-miR-320e	102582553	102582559	7mer-m8	102582552	102582569	145	-15.82
CAediting_1054808	chr15_66496985_-	ENSG00000105808.16	ENST00000461209	hsa-miR-4512	102582406	102582412	7mer-1a	102582406	102582427	140	-25.09
CAediting_1368054	chr19_46709310_-	ENSG00000105808.16	ENST00000461209	hsa-miR-320e	102582553	102582559	7mer-m8	102582552	102582569	145	-15.82
CAediting_1054808	chr15_66496985_-	ENSG00000105808.16	ENST00000449970	hsa-miR-4512	102582406	102582412	7mer-1a	102582406	102582427	140	-25.09
CAediting_1368054	chr19_46709310_-	ENSG00000105808.16	ENST00000449970	hsa-miR-320e	102582553	102582559	7mer-m8	102582552	102582569	145	-15.82
CAediting_468389	chr6_31355314_-	ENSG00000105808.16	ENST00000262940	hsa-miR-6891-5p	102581192	102581198	7mer-m8	102581191	102581209	140	-22.13
CAediting_468389	chr6_31355314_-	ENSG00000105808.16	ENST00000262940	hsa-miR-6891-5p	102582508	102582514	7mer-m8	102582507	102582529	146	-27.95
CAediting_468389	chr6_31355314_-	ENSG00000105808.16	ENST00000461209	hsa-miR-6891-5p	102582508	102582514	7mer-m8	102582507	102582529	146	-27.95
CAediting_468389	chr6_31355314_-	ENSG00000105808.16	ENST00000449970	hsa-miR-6891-5p	102582508	102582514	7mer-m8	102582507	102582529	146	-27.95

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1524209	chrX_134546392_-	ENSG00000105808.16	ENST00000262940	hsa-miR-503-5p	102581324	102581331	8mer-1a	102581324	102581346	145	-22.68
CAediting_748296	chr10_51299626_+	ENSG00000105808.16	ENST00000262940	hsa-miR-605-3p	102581701	102581708	8mer-1a	102581701	102581721	154	-15.52
CAediting_580943	chr7_100356700_+	ENSG00000105808.16	ENST00000262940	hsa-miR-6840-3p	102581608	102581615	8mer-1a	102581608	102581627	148	-29.95
CAediting_580943	chr7_100356700_+	ENSG00000105808.16	ENST00000262940	hsa-miR-6840-3p	102581449	102581455	7mer-m8	102581448	102581469	150	-27.22
CAediting_468389	chr6_31355314_-	ENSG00000105808.16	ENST00000262940	hsa-miR-6891-5p	102581227	102581233	7mer-m8	102581226	102581245	155	-20.14
CAediting_468389	chr6_31355314_-	ENSG00000105808.16	ENST00000262940	hsa-miR-6891-5p	102581827	102581833	7mer-m8	102581826	102581844	145	-16.35
CAediting_468389	chr6_31355314_-	ENSG00000105808.16	ENST00000262940	hsa-miR-6891-5p	102581781	102581787	7mer-m8	102581780	102581798	150	-17.68

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for RASA4

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000262940.10	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_588470	ENST00000262940.10	chr7_102580046_-	-2399.58	-2399.58	-2429.90
CAediting_588471	ENST00000262940.10	chr7_102580055_-	-2405.78	-2399.58	-2429.90
CAediting_588472	ENST00000262940.10	chr7_102580056_-	-2399.38	-2399.58	-2429.90
CAediting_588473	ENST00000262940.10	chr7_102580072_-	-2403.38	-2399.58	-2429.90
CAediting_588474	ENST00000262940.10	chr7_102580091_-	-2399.58	-2399.58	-2429.90
CAediting_588475	ENST00000262940.10	chr7_102580416_-	-2399.58	-2399.58	-2429.90
CAediting_588476	ENST00000262940.10	chr7_102580431_-	-2403.20	-2399.58	-2429.90
CAediting_588477	ENST00000262940.10	chr7_102580434_-	-2405.90	-2399.58	-2429.90
CAediting_588478	ENST00000262940.10	chr7_102580482_-	-2405.78	-2399.58	-2429.90
CAediting_588479	ENST00000262940.10	chr7_102580486_-	-2399.28	-2399.58	-2429.90
CAediting_588480	ENST00000262940.10	chr7_102580487_-	-2399.28	-2399.58	-2429.90
CAediting_588481	ENST00000262940.10	chr7_102580509_-	-2399.18	-2399.58	-2429.90
CAediting_588482	ENST00000262940.10	chr7_102580515_-	-2401.18	-2399.58	-2429.90
CAediting_588483	ENST00000262940.10	chr7_102580837_-	-2399.78	-2399.58	-2429.90
CAediting_588484	ENST00000262940.10	chr7_102580839_-	-2399.28	-2399.58	-2429.90
CAediting_588485	ENST00000262940.10	chr7_102580841_-	-2402.28	-2399.58	-2429.90

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Relation with ADAR for RASA4

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BRCA	CAediting_588474	chr7_102580091_-	.	.	0.0119911162961427	0.307595323512923	.	.
THCA	CAediting_588474	chr7_102580091_-	.	.	.	.	0.00549952289306217	0.351319029537514

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Relation with cancer stages for RASA4

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for RASA4

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
KIRC	CAediting_588490	chr7_102585333_-	0.00285125266658459	0.0244857	0.00052881

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RelatedDrugs for RASA4

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for RASA4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene