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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: CDC42-IT1 (CAeditome ID:100874292)

Gene summary for CDC42-IT1

check button Gene summary
Gene informationGene symbol

CDC42-IT1

Gene ID

100874292

Gene nameCDC42 intronic transcript 1
Synonyms-
Cytomap

1p36.12

Type of genencRNA
DescriptionCDC42 intronic transcript 1 (non-protein coding)
Modification date20190324
UniProtAcc

.

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for CDC42-IT1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000230068.2

check button RNA A-to-I editing events in Cancer.
CAediting_24605(22059206, +), CAediting_24606(22059252, +), CAediting_24607(22059265, +), CAediting_24608(22059569, +), CAediting_24609(22059606, +), CAediting_24610(22059661, +), CAediting_24611(22059673, +), CAediting_24612(22059683, +), CAediting_24613(22060086, +), CAediting_24614(22060087, +), CAediting_24615(22060095, +), CAediting_24616(22060117, +), CAediting_24617(22060127, +), CAediting_24618(22060140, +), CAediting_24619(22060141, +), CAediting_24620(22060147, +), CAediting_24621(22060156, +), CAediting_24622(22060165, +), CAediting_24623(22060166, +), CAediting_24624(22060182, +), CAediting_24625(22060188, +), CAediting_24626(22060189, +), CAediting_24627(22060192, +), CAediting_24628(22060195, +), CAediting_24629(22060217, +), CAediting_24630(22060218, +), CAediting_24631(22060223, +), CAediting_24632(22060227, +), CAediting_24633(22060234, +), CAediting_24634(22060240, +), CAediting_24635(22060249, +), CAediting_24636(22060250, +), CAediting_24637(22060258, +), CAediting_24638(22060259, +), CAediting_24639(22060279, +), CAediting_24640(22060283, +), CAediting_24641(22060294, +), CAediting_24642(22061151, +), CAediting_24643(22061287, +), CAediting_24644(22061288, +), CAediting_24645(22061349, +), CAediting_24646(22061353, +), CAediting_24647(22061358, +), CAediting_24648(22061398, +), CAediting_24649(22061423, +), CAediting_24650(22061647, +), CAediting_24651(22061683, +), CAediting_24652(22061783, +), CAediting_24653(22061796, +), CAediting_24654(22061835, +), CAediting_24655(22061970, +), CAediting_24656(22062018, +), CAediting_24657(22062053, +), CAediting_24658(22062062, +), CAediting_24659(22062075, +), CAediting_24660(22062097, +), CAediting_24661(22062116, +), CAediting_24662(22062119, +), CAediting_24663(22062133, +), CAediting_24664(22062136, +), CAediting_24665(22062145, +), CAediting_24666(22062170, +), CAediting_24667(22062171, +), CAediting_24668(22062172, +), CAediting_24669(22062197, +), CAediting_24670(22062198, +), CAediting_24671(22062219, +), CAediting_24672(22062610, +), CAediting_24673(22062620, +), CAediting_24674(22062628, +), CAediting_24675(22062629, +), CAediting_24676(22062634, +), CAediting_24677(22062637, +), CAediting_24678(22062645, +), CAediting_24679(22062647, +), CAediting_24680(22062651, +), CAediting_24681(22062658, +), CAediting_24682(22062674, +), CAediting_24683(22062710, +), CAediting_24684(22063743, +), CAediting_24685(22063745, +), CAediting_24686(22063772, +), CAediting_24687(22063780, +), CAediting_24688(22063795, +), CAediting_24689(22063820, +), CAediting_24690(22063838, +), CAediting_24691(22063850, +), CAediting_24692(22063860, +), CAediting_24693(22063900, +), CAediting_24694(22063905, +), CAediting_24695(22063981, +), CAediting_24696(22063982, +), CAediting_24697(22063994, +),

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RNA editing positional annotations for CDC42-IT1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_24605chr1_22059206_+ncRNA_exonic
CAediting_24606chr1_22059252_+ncRNA_exonic
CAediting_24607chr1_22059265_+ncRNA_exonic
CAediting_24608chr1_22059569_+ncRNA_exonic
CAediting_24609chr1_22059606_+ncRNA_exonic
CAediting_24610chr1_22059661_+ncRNA_exonic
CAediting_24611chr1_22059673_+ncRNA_exonic
CAediting_24612chr1_22059683_+ncRNA_exonic
CAediting_24613chr1_22060086_+ncRNA_intronic
CAediting_24614chr1_22060087_+ncRNA_intronic
CAediting_24615chr1_22060095_+ncRNA_intronic
CAediting_24616chr1_22060117_+ncRNA_intronic
CAediting_24617chr1_22060127_+ncRNA_intronic
CAediting_24618chr1_22060140_+ncRNA_intronic
CAediting_24619chr1_22060141_+ncRNA_intronic
CAediting_24620chr1_22060147_+ncRNA_intronic
CAediting_24621chr1_22060156_+ncRNA_intronic
CAediting_24622chr1_22060165_+ncRNA_intronic
CAediting_24623chr1_22060166_+ncRNA_intronic
CAediting_24624chr1_22060182_+ncRNA_intronic
CAediting_24625chr1_22060188_+ncRNA_intronic
CAediting_24626chr1_22060189_+ncRNA_intronic
CAediting_24627chr1_22060192_+ncRNA_intronic
CAediting_24628chr1_22060195_+ncRNA_intronic
CAediting_24629chr1_22060217_+ncRNA_intronic
CAediting_24630chr1_22060218_+ncRNA_intronic
CAediting_24631chr1_22060223_+ncRNA_intronic
CAediting_24632chr1_22060227_+ncRNA_intronic
CAediting_24633chr1_22060234_+ncRNA_intronic
CAediting_24634chr1_22060240_+ncRNA_intronic
CAediting_24635chr1_22060249_+ncRNA_intronic
CAediting_24636chr1_22060250_+ncRNA_intronic
CAediting_24637chr1_22060258_+ncRNA_intronic
CAediting_24638chr1_22060259_+ncRNA_intronic
CAediting_24639chr1_22060279_+ncRNA_intronic
CAediting_24640chr1_22060283_+ncRNA_intronic
CAediting_24641chr1_22060294_+ncRNA_intronic
CAediting_24642chr1_22061151_+ncRNA_intronic
CAediting_24643chr1_22061287_+ncRNA_intronic
CAediting_24644chr1_22061288_+ncRNA_intronic
CAediting_24645chr1_22061349_+ncRNA_intronic
CAediting_24646chr1_22061353_+ncRNA_intronic
CAediting_24647chr1_22061358_+ncRNA_intronic
CAediting_24648chr1_22061398_+ncRNA_intronic
CAediting_24649chr1_22061423_+ncRNA_intronic
CAediting_24650chr1_22061647_+ncRNA_intronic
CAediting_24651chr1_22061683_+ncRNA_intronic
CAediting_24652chr1_22061783_+ncRNA_intronic
CAediting_24653chr1_22061796_+ncRNA_intronic
CAediting_24654chr1_22061835_+ncRNA_intronic
CAediting_24655chr1_22061970_+ncRNA_intronic
CAediting_24656chr1_22062018_+ncRNA_intronic
CAediting_24657chr1_22062053_+ncRNA_intronic
CAediting_24658chr1_22062062_+ncRNA_intronic
CAediting_24659chr1_22062075_+ncRNA_intronic
CAediting_24660chr1_22062097_+ncRNA_intronic
CAediting_24661chr1_22062116_+ncRNA_intronic
CAediting_24662chr1_22062119_+ncRNA_intronic
CAediting_24663chr1_22062133_+ncRNA_intronic
CAediting_24664chr1_22062136_+ncRNA_intronic
CAediting_24665chr1_22062145_+ncRNA_intronic
CAediting_24666chr1_22062170_+ncRNA_intronic
CAediting_24667chr1_22062171_+ncRNA_intronic
CAediting_24668chr1_22062172_+ncRNA_intronic
CAediting_24669chr1_22062197_+ncRNA_intronic
CAediting_24670chr1_22062198_+ncRNA_intronic
CAediting_24671chr1_22062219_+ncRNA_intronic
CAediting_24672chr1_22062610_+ncRNA_intronic
CAediting_24673chr1_22062620_+ncRNA_intronic
CAediting_24674chr1_22062628_+ncRNA_intronic
CAediting_24675chr1_22062629_+ncRNA_intronic
CAediting_24676chr1_22062634_+ncRNA_intronic
CAediting_24677chr1_22062637_+ncRNA_intronic
CAediting_24678chr1_22062645_+ncRNA_intronic
CAediting_24679chr1_22062647_+ncRNA_intronic
CAediting_24680chr1_22062651_+ncRNA_intronic
CAediting_24681chr1_22062658_+ncRNA_intronic
CAediting_24682chr1_22062674_+ncRNA_intronic
CAediting_24683chr1_22062710_+ncRNA_intronic
CAediting_24684chr1_22063743_+ncRNA_intronic
CAediting_24685chr1_22063745_+ncRNA_intronic
CAediting_24686chr1_22063772_+ncRNA_intronic
CAediting_24687chr1_22063780_+ncRNA_intronic
CAediting_24688chr1_22063795_+ncRNA_intronic
CAediting_24689chr1_22063820_+ncRNA_intronic
CAediting_24690chr1_22063838_+ncRNA_intronic
CAediting_24691chr1_22063850_+ncRNA_intronic
CAediting_24692chr1_22063860_+ncRNA_intronic
CAediting_24693chr1_22063900_+ncRNA_intronic
CAediting_24694chr1_22063905_+ncRNA_intronic
CAediting_24695chr1_22063981_+ncRNA_intronic
CAediting_24696chr1_22063982_+ncRNA_intronic
CAediting_24697chr1_22063994_+ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_24605chr1_22059206_+SINEAluAluSp
CAediting_24606chr1_22059252_+SINEAluAluSp
CAediting_24607chr1_22059265_+SINEAluAluSp
CAediting_24608chr1_22059569_+SINEAluAluSx
CAediting_24609chr1_22059606_+SINEAluAluSx
CAediting_24610chr1_22059661_+SINEAluAluSx
CAediting_24611chr1_22059673_+SINEAluAluSx
CAediting_24612chr1_22059683_+SINEAluAluSx
CAediting_24613chr1_22060086_+SINEAluAluSx
CAediting_24614chr1_22060087_+SINEAluAluSx
CAediting_24615chr1_22060095_+SINEAluAluSx
CAediting_24616chr1_22060117_+SINEAluAluSx
CAediting_24617chr1_22060127_+SINEAluAluSx
CAediting_24618chr1_22060140_+SINEAluAluSx
CAediting_24619chr1_22060141_+SINEAluAluSx
CAediting_24620chr1_22060147_+SINEAluAluSx
CAediting_24621chr1_22060156_+SINEAluAluSx
CAediting_24622chr1_22060165_+SINEAluAluSx
CAediting_24623chr1_22060166_+SINEAluAluSx
CAediting_24624chr1_22060182_+SINEAluAluSx
CAediting_24625chr1_22060188_+SINEAluAluSx
CAediting_24626chr1_22060189_+SINEAluAluSx
CAediting_24627chr1_22060192_+SINEAluAluSx
CAediting_24628chr1_22060195_+SINEAluAluSx
CAediting_24629chr1_22060217_+SINEAluAluSx
CAediting_24630chr1_22060218_+SINEAluAluSx
CAediting_24631chr1_22060223_+SINEAluAluSx
CAediting_24632chr1_22060227_+SINEAluAluSx
CAediting_24633chr1_22060234_+SINEAluAluSx
CAediting_24634chr1_22060240_+SINEAluAluSx
CAediting_24635chr1_22060249_+SINEAluAluSx
CAediting_24636chr1_22060250_+SINEAluAluSx
CAediting_24637chr1_22060258_+SINEAluAluSx
CAediting_24638chr1_22060259_+SINEAluAluSx
CAediting_24639chr1_22060279_+SINEAluAluSx
CAediting_24640chr1_22060283_+SINEAluAluSx
CAediting_24641chr1_22060294_+SINEAluAluSx
CAediting_24642chr1_22061151_+SINEAluAluSq
CAediting_24643chr1_22061287_+SINEAluAluSq
CAediting_24644chr1_22061288_+SINEAluAluSq
CAediting_24645chr1_22061349_+SINEAluAluSq
CAediting_24646chr1_22061353_+SINEAluAluSq
CAediting_24647chr1_22061358_+SINEAluAluSq
CAediting_24648chr1_22061398_+SINEAluAluSq
CAediting_24649chr1_22061423_+SINEAluAluSq
CAediting_24650chr1_22061647_+SINEAluAluSx1
CAediting_24651chr1_22061683_+SINEAluAluSx1
CAediting_24652chr1_22061783_+SINEAluAluSx1
CAediting_24653chr1_22061796_+SINEAluAluSx1
CAediting_24654chr1_22061835_+SINEAluAluSx1
CAediting_24655chr1_22061970_+SINEAluAluSz
CAediting_24656chr1_22062018_+SINEAluAluSz
CAediting_24657chr1_22062053_+SINEAluAluSz
CAediting_24658chr1_22062062_+SINEAluAluSz
CAediting_24659chr1_22062075_+SINEAluAluSz
CAediting_24660chr1_22062097_+SINEAluAluSz
CAediting_24661chr1_22062116_+SINEAluAluSz
CAediting_24662chr1_22062119_+SINEAluAluSz
CAediting_24663chr1_22062133_+SINEAluAluSz
CAediting_24664chr1_22062136_+SINEAluAluSz
CAediting_24665chr1_22062145_+SINEAluAluSz
CAediting_24666chr1_22062170_+SINEAluAluSz
CAediting_24667chr1_22062171_+SINEAluAluSz
CAediting_24668chr1_22062172_+SINEAluAluSz
CAediting_24669chr1_22062197_+SINEAluAluSz
CAediting_24670chr1_22062198_+SINEAluAluSz
CAediting_24671chr1_22062219_+SINEAluAluSz
CAediting_24672chr1_22062610_+SINEAluFLAM_C
CAediting_24673chr1_22062620_+SINEAluFLAM_C
CAediting_24674chr1_22062628_+SINEAluFLAM_C
CAediting_24675chr1_22062629_+SINEAluFLAM_C
CAediting_24676chr1_22062634_+SINEAluFLAM_C
CAediting_24677chr1_22062637_+SINEAluFLAM_C
CAediting_24678chr1_22062645_+SINEAluFLAM_C
CAediting_24679chr1_22062647_+SINEAluFLAM_C
CAediting_24680chr1_22062651_+SINEAluFLAM_C
CAediting_24681chr1_22062658_+SINEAluFLAM_C
CAediting_24682chr1_22062674_+SINEAluFLAM_C
CAediting_24683chr1_22062710_+SINEAluFLAM_C
CAediting_24684chr1_22063743_+SINEAluAluSz6
CAediting_24685chr1_22063745_+SINEAluAluSz6
CAediting_24686chr1_22063772_+SINEAluAluSz6
CAediting_24687chr1_22063780_+SINEAluAluSz6
CAediting_24688chr1_22063795_+SINEAluAluSz6
CAediting_24689chr1_22063820_+SINEAluAluSz6
CAediting_24690chr1_22063838_+SINEAluAluSz6
CAediting_24691chr1_22063850_+SINEAluAluSz6
CAediting_24692chr1_22063860_+SINEAluAluSz6
CAediting_24693chr1_22063900_+SINEAluAluSz6
CAediting_24694chr1_22063905_+SINEAluAluSz6
CAediting_24695chr1_22063981_+SINEAluAluSz6
CAediting_24696chr1_22063982_+SINEAluAluSz6
CAediting_24697chr1_22063994_+SINEAluAluSz6

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RNA A-to-I editing events in the alternative splicing sites for CDC42-IT1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000230068.2.CDC42-IT1.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000230068.2.CDC42-IT1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CDC42-IT1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CDC42-IT1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for CDC42-IT1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_24606chr1_22059252_+ENSG00000230068.2ENST00000431803.2hsa-miR-427022059246220592527mer-m82205923322059253153-26.82
CAediting_24606chr1_22059252_+ENSG00000230068.2ENST00000431803.2hsa-miR-444122059246220592527mer-m82205923722059253147-17.92
CAediting_24606chr1_22059252_+ENSG00000230068.2ENST00000431803.2hsa-miR-6753-5p22059248220592558mer-1a2205923422059255153-22.89
CAediting_24606chr1_22059252_+ENSG00000230068.2ENST00000431803.2hsa-miR-6754-5p22059246220592527mer-m82205923122059253155-33.87
CAediting_24606chr1_22059252_+ENSG00000230068.2ENST00000431803.2hsa-miR-7113-5p22059247220592537mer-m82205923422059254145-22.73
CAediting_24611chr1_22059673_+ENSG00000230068.2ENST00000431803.2hsa-miR-3614-5p22059667220596737mer-m82205965122059674150-24.23
CAediting_24611chr1_22059673_+ENSG00000230068.2ENST00000431803.2hsa-miR-4691-3p22059671220596777mer-m82205965122059678150-26.36

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_24611chr1_22059673_+ENSG00000230068.2ENST00000431803.2hsa-miR-569022059671220596777mer-m82205965822059678145-16.74

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CDC42-IT1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000431803.2sense_intronicSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_24605ENST00000431803.2chr1_22059206_+-167.50-165.20-178.10
CAediting_24606ENST00000431803.2chr1_22059252_+-168.50-165.20-178.10
CAediting_24607ENST00000431803.2chr1_22059265_+-166.80-165.20-178.10
CAediting_24608ENST00000431803.2chr1_22059569_+-164.70-165.20-178.10
CAediting_24609ENST00000431803.2chr1_22059606_+-168.00-165.20-178.10
CAediting_24610ENST00000431803.2chr1_22059661_+-166.00-165.20-178.10
CAediting_24611ENST00000431803.2chr1_22059673_+-169.50-165.20-178.10
CAediting_24612ENST00000431803.2chr1_22059683_+-166.50-165.20-178.10

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Relation with ADAR for CDC42-IT1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
STADCAediting_24675chr1_22062629_+0.02072114323406290.284244746062854....

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Relation with cancer stages for CDC42-IT1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for CDC42-IT1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
STADCAediting_24675chr1_22062629_+0.01928198591163090.0266869116.482

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RelatedDrugs for CDC42-IT1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CDC42-IT1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource