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Editing gene: IL18BP (CAeditome ID:10068)

Gene summary for IL18BP

Gene summary

Gene information	Gene symbol	IL18BP
	Gene ID	10068
	Gene name	interleukin 18 binding protein
	Synonyms	FVH\|IL18BPa
	Cytomap	11q13.4
	Type of gene	protein-coding
	Description	interleukin-18-binding proteinMC51L-53L-54L homolog gene producttadekinig-alfa
	Modification date	20210531
	UniProtAcc	O95998
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
IL18BP	GO:0042007	Interleukin-18-binding protein	10023777
IL18BP	GO:0042088	Interleukin-18-binding protein	10023777

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RNA A-to-I events for IL18BP

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000137496.16

RNA A-to-I editing events in Cancer.

CAediting_836951(72001440, +), CAediting_836952(72001782, +), CAediting_836953(72002108, +), CAediting_836954(72002150, +),

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RNA editing positional annotations for IL18BP using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_836951	chr11_72001440_+	exonic
CAediting_836952	chr11_72001782_+	splicing
CAediting_836953	chr11_72002108_+	UTR3
CAediting_836954	chr11_72002150_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID

Position

Repeat family

Repeat sub family

Repeat name

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RNA A-to-I editing events in the alternative splicing sites for IL18BP

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_836952	chr11_72001782_+	72001763:72001785	3SS	0+1i	TGTCTGCCTTCACTTCCCTAGGC	-6.29	TGTCTGCCTTCACTTCCCTGGGC	2.46
IR	CAediting_836952	chr11_72001782_+	72001763:72001785	3SS	0+1i	TGTCTGCCTTCACTTCCCTAGGC	-6.29	TGTCTGCCTTCACTTCCCTGGGC	2.46

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000137496.16.IL18BP.

Correlation between RNA A-to-I editing and PSI for ENSG00000137496.16.IL18BP.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for IL18BP

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for IL18BP

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for IL18BP

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_836952	chr11_72001782_+	ENSG00000137496.16	ENST00000497194	hsa-miR-1915-3p	72001777	72001783	7mer-m8	72001764	72001784	141.00	-23.17
CAediting_836952	chr11_72001782_+	ENSG00000137496.16	ENST00000497194	hsa-miR-4270	72001776	72001781	6mer	72001762	72001782	141.00	-24.27
CAediting_836952	chr11_72001782_+	ENSG00000137496.16	ENST00000497194	hsa-miR-4685-5p	72001777	72001782	6mer	72001757	72001783	143.00	-35.17
CAediting_836952	chr11_72001782_+	ENSG00000137496.16	ENST00000497194	hsa-miR-6764-5p	72001777	72001783	7mer-m8	72001760	72001784	145.00	-22.78
CAediting_836952	chr11_72001782_+	ENSG00000137496.16	ENST00000497194	hsa-miR-7113-5p	72001776	72001782	7mer-m8	72001766	72001783	143.00	-19.65

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_836953	chr11_72002108_+	ENSG00000137496.16	ENST00000497194	hsa-miR-1258	72002103	72002109	7mer-m8	72002091	72002110	151	-18.52
CAediting_836952	chr11_72001782_+	ENSG00000137496.16	ENST00000497194	hsa-miR-3135a	72001778	72001784	7mer-m8	72001763	72001785	151	-20.26
CAediting_836952	chr11_72001782_+	ENSG00000137496.16	ENST00000497194	hsa-miR-3162-5p	72001776	72001781	6mer	72001760	72001782	143	-24.09
CAediting_836953	chr11_72002108_+	ENSG00000137496.16	ENST00000393705	hsa-miR-1258	72002103	72002109	7mer-m8	72002091	72002110	151	-18.52
CAediting_836953	chr11_72002108_+	ENSG00000137496.16	ENST00000337131	hsa-miR-1258	72002103	72002109	7mer-m8	72002091	72002110	151	-18.52
CAediting_836953	chr11_72002108_+	ENSG00000137496.16	ENST00000620017	hsa-miR-1258	72002103	72002109	7mer-m8	72002091	72002110	151	-18.52
CAediting_836953	chr11_72002108_+	ENSG00000137496.16	ENST00000343898	hsa-miR-1258	72002103	72002109	7mer-m8	72002091	72002110	151	-18.52
CAediting_836953	chr11_72002108_+	ENSG00000137496.16	ENST00000404792	hsa-miR-1258	72002103	72002109	7mer-m8	72002091	72002110	151	-18.52
CAediting_836953	chr11_72002108_+	ENSG00000137496.16	ENST00000260049	hsa-miR-1258	72002103	72002109	7mer-m8	72002091	72002110	151	-18.52
CAediting_836953	chr11_72002108_+	ENSG00000137496.16	ENST00000393707	hsa-miR-1258	72002103	72002109	7mer-m8	72002091	72002110	151	-18.52

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_748296	chr10_51299626_+	ENSG00000137496.16	ENST00000497194	hsa-miR-605-3p	72001823	72001829	7mer-m8	72001809	72001830	140	-12.18
CAediting_688080	chr9_63819626_+	ENSG00000137496.16	ENST00000497194	hsa-miR-4477b	72001660	72001666	7mer-m8	72001645	72001667	152	-11.45
CAediting_688080	chr9_63819626_+	ENSG00000137496.16	ENST00000531053	hsa-miR-4477b	72001660	72001666	7mer-m8	72001645	72001667	152	-11.45
CAediting_1054808	chr15_66496985_-	ENSG00000137496.16	ENST00000497194	hsa-miR-4512	72003325	72003331	7mer-m8	72003312	72003332	142	-16.36
CAediting_1351755	chr19_40282625_-	ENSG00000137496.16	ENST00000497194	hsa-miR-641	72002259	72002265	7mer-m8	72002243	72002266	153	-18.66
CAediting_1368054	chr19_46709310_-	ENSG00000137496.16	ENST00000497194	hsa-miR-320e	72003337	72003343	7mer-m8	72003327	72003344	142	-18.37
CAediting_396018	chr5_1062918_-	ENSG00000137496.16	ENST00000497194	hsa-miR-4635	72001661	72001667	7mer-m8	72001648	72001668	140	-14.62
CAediting_1351755	chr19_40282625_-	ENSG00000137496.16	ENST00000393705	hsa-miR-641	72002259	72002265	7mer-m8	72002243	72002266	153	-18.66
CAediting_1351755	chr19_40282625_-	ENSG00000137496.16	ENST00000337131	hsa-miR-641	72002259	72002265	7mer-m8	72002243	72002266	153	-18.66
CAediting_1351755	chr19_40282625_-	ENSG00000137496.16	ENST00000620017	hsa-miR-641	72002259	72002265	7mer-m8	72002243	72002266	153	-18.66
CAediting_396018	chr5_1062918_-	ENSG00000137496.16	ENST00000531053	hsa-miR-4635	72001661	72001667	7mer-m8	72001648	72001668	140	-14.62
CAediting_1351755	chr19_40282625_-	ENSG00000137496.16	ENST00000343898	hsa-miR-641	72002259	72002265	7mer-m8	72002243	72002266	153	-18.66
CAediting_77128	chr1_85133844_+	ENSG00000137496.16	ENST00000343898	hsa-miR-4423-3p	72005691	72005698	8mer-1a	72005678	72005698	156	-22.8
CAediting_1351755	chr19_40282625_-	ENSG00000137496.16	ENST00000404792	hsa-miR-641	72002259	72002265	7mer-m8	72002243	72002266	153	-18.66
CAediting_1351755	chr19_40282625_-	ENSG00000137496.16	ENST00000260049	hsa-miR-641	72002259	72002265	7mer-m8	72002243	72002266	153	-18.66
CAediting_1351755	chr19_40282625_-	ENSG00000137496.16	ENST00000393707	hsa-miR-641	72002259	72002265	7mer-m8	72002243	72002266	153	-18.66

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_748296	chr10_51299626_+	ENSG00000137496.16	ENST00000497194	hsa-miR-605-3p	72001766	72001773	8mer-1a	72001753	72001773	150	-14.71
CAediting_580943	chr7_100356700_+	ENSG00000137496.16	ENST00000497194	hsa-miR-6840-3p	72003044	72003051	8mer-1a	72003029	72003051	147	-22.31
CAediting_468389	chr6_31355314_-	ENSG00000137496.16	ENST00000497194	hsa-miR-6891-5p	72001739	72001745	7mer-m8	72001728	72001746	153	-18.75

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for IL18BP

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for IL18BP

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for IL18BP

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for IL18BP

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for IL18BP

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for IL18BP

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
IL18BP	C0023893	Liver Cirrhosis, Experimental	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene