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Editing gene: MIR4775 (CAeditome ID:100616361)

Gene summary for MIR4775

Gene summary

Gene information	Gene symbol	MIR4775
	Gene ID	100616361
	Gene name	microRNA 4775
	Synonyms	-
	Cytomap	2q33.3
	Type of gene	ncRNA
	Description	hsa-mir-4775
	Modification date	20210518
	UniProtAcc	.
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for MIR4775

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000264900.1

RNA A-to-I editing events in Cancer.

CAediting_240705(207754810, +), CAediting_240706(207754811, +), CAediting_240707(207754847, +), CAediting_240708(207754851, +), CAediting_240709(207754855, +), CAediting_240710(207754859, +), CAediting_240711(207754860, +), CAediting_240712(207754861, +), CAediting_240713(207754863, +), CAediting_240714(207754864, +), CAediting_240715(207754865, +), CAediting_240716(207754866, +), CAediting_240717(207754867, +), CAediting_240718(207754868, +), CAediting_240719(207754871, +), CAediting_240720(207754874, +), CAediting_240721(207754880, +),

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RNA editing positional annotations for MIR4775 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_240705	chr2_207754810_+	ncRNA_exonic
CAediting_240706	chr2_207754811_+	ncRNA_exonic
CAediting_240707	chr2_207754847_+	ncRNA_exonic
CAediting_240708	chr2_207754851_+	ncRNA_exonic
CAediting_240709	chr2_207754855_+	ncRNA_exonic
CAediting_240710	chr2_207754859_+	ncRNA_exonic
CAediting_240711	chr2_207754860_+	ncRNA_exonic
CAediting_240712	chr2_207754861_+	ncRNA_exonic
CAediting_240713	chr2_207754863_+	ncRNA_exonic
CAediting_240714	chr2_207754864_+	ncRNA_exonic
CAediting_240715	chr2_207754865_+	ncRNA_exonic
CAediting_240716	chr2_207754866_+	ncRNA_exonic
CAediting_240717	chr2_207754867_+	ncRNA_exonic
CAediting_240718	chr2_207754868_+	ncRNA_exonic
CAediting_240719	chr2_207754871_+	ncRNA_exonic
CAediting_240720	chr2_207754874_+	ncRNA_exonic
CAediting_240721	chr2_207754880_+	ncRNA_exonic

Repat-regional RNA editing(s).

CAeditome ID

Position

Repeat family

Repeat sub family

Repeat name

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RNA A-to-I editing events in the alternative splicing sites for MIR4775

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000264900.1.MIR4775.

Correlation between RNA A-to-I editing and PSI for ENSG00000264900.1.MIR4775.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MIR4775

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for MIR4775

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for MIR4775

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for MIR4775

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000581168.1	miRNA

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_240705	ENST00000581168.1	chr2_207754810_+	-33.00	-32.60	-28.00
CAediting_240706	ENST00000581168.1	chr2_207754811_+	-32.30	-32.60	-28.00
CAediting_240707	ENST00000581168.1	chr2_207754847_+	-32.60	-32.60	-28.00
CAediting_240708	ENST00000581168.1	chr2_207754851_+	-33.00	-32.60	-28.00
CAediting_240709	ENST00000581168.1	chr2_207754855_+	-32.00	-32.60	-28.00
CAediting_240710	ENST00000581168.1	chr2_207754859_+	-32.10	-32.60	-28.00
CAediting_240711	ENST00000581168.1	chr2_207754860_+	-32.70	-32.60	-28.00
CAediting_240712	ENST00000581168.1	chr2_207754861_+	-32.60	-32.60	-28.00
CAediting_240713	ENST00000581168.1	chr2_207754863_+	-32.30	-32.60	-28.00
CAediting_240714	ENST00000581168.1	chr2_207754864_+	-32.70	-32.60	-28.00
CAediting_240715	ENST00000581168.1	chr2_207754865_+	-32.70	-32.60	-28.00
CAediting_240716	ENST00000581168.1	chr2_207754866_+	-32.70	-32.60	-28.00
CAediting_240717	ENST00000581168.1	chr2_207754867_+	-32.70	-32.60	-28.00
CAediting_240718	ENST00000581168.1	chr2_207754868_+	-32.60	-32.60	-28.00
CAediting_240719	ENST00000581168.1	chr2_207754871_+	-32.70	-32.60	-28.00
CAediting_240720	ENST00000581168.1	chr2_207754874_+	-32.30	-32.60	-28.00
CAediting_240721	ENST00000581168.1	chr2_207754880_+	-32.60	-32.60	-28.00

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Relation with ADAR for MIR4775

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BLCA	CAediting_240711	chr2_207754860_+	0.0298726944435353	0.29581361614669	.	.	0.000587939909464852	0.45270539792871
STAD	CAediting_240711	chr2_207754860_+	.	.	.	.	0.0287880380549673	0.280101764958407
BLCA	CAediting_240712	chr2_207754861_+	1.67623902960733e-06	0.325708617731738	.	.	.	.
LGG	CAediting_240712	chr2_207754861_+	2.76816894998801e-07	0.309908066274012	.	.	.	.
BRCA	CAediting_240712	chr2_207754861_+	6.89015702127885e-41	0.439944477272777	.	.	.	.
LIHC	CAediting_240712	chr2_207754861_+	0.0154374133628313	0.174133030997975	.	.	.	.
CESC	CAediting_240712	chr2_207754861_+	7.50691078433801e-10	0.415870293645045	.	.	.	.
LUAD	CAediting_240712	chr2_207754861_+	3.94684919005264e-15	0.37279958969662	.	.	.	.
COAD	CAediting_240712	chr2_207754861_+	0.00410773406337399	0.198673497767088	.	.	.	.
LUSC	CAediting_240712	chr2_207754861_+	8.39404988317861e-12	0.326325348005801	.	.	0.0198192054387866	0.114058327562297
GBM	CAediting_240712	chr2_207754861_+	0.000185031395429113	0.299710934397622	.	.	.	.
PRAD	CAediting_240712	chr2_207754861_+	0.000213660053771801	0.267578982177879	.	.	.	.
HNSC	CAediting_240712	chr2_207754861_+	1.91413984228404e-14	0.371148083793129	0.021017852473349	0.115648101049488	.	.
STAD	CAediting_240712	chr2_207754861_+	2.43236281000397e-08	0.323481083505678	.	.	.	.
THCA	CAediting_240712	chr2_207754861_+	1.41461474126534e-11	0.32667507624452	.	.	.	.
KIRC	CAediting_240712	chr2_207754861_+	7.34198670997248e-05	0.185186235009948	.	.	.	.
UCEC	CAediting_240712	chr2_207754861_+	0.00528059866086422	0.26074832499882	.	.	.	.
KIRP	CAediting_240712	chr2_207754861_+	0.0163821469182487	0.204768822229076	.	.	.	.
ESCA	CAediting_240712	chr2_207754861_+	0.00131509126362293	0.254204757704857	.	.	.	.
OV	CAediting_240712	chr2_207754861_+	1.30021240145684e-06	0.280181371567814	.	.	.	.
PAAD	CAediting_240712	chr2_207754861_+	8.41676977962783e-05	0.355406447074372	.	.	.	.
SKCM	CAediting_240712	chr2_207754861_+	1.06298381894428e-20	0.500748310100662	.	.	.	.
MESO	CAediting_240712	chr2_207754861_+	1.86995964171169e-09	0.636453799763374	.	.	.	.
READ	CAediting_240712	chr2_207754861_+	0.00192269450484844	0.361984812551355	0.00674050825617603	0.318770002264271	.	.
SARC	CAediting_240712	chr2_207754861_+	1.51256153768316e-07	0.434909009719361	.	.	.	.
TGCT	CAediting_240712	chr2_207754861_+	2.54214966885997e-09	0.516331496255052	.	.	.	.
KIRC	CAediting_240716	chr2_207754866_+	.	.	.	.	0.0235897938778164	0.272325106517431

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Relation with cancer stages for MIR4775

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BRCA	pathologic_stage	CAediting_240712	chr2_207754861_+	0.00402157323819346	0.100349920850522
KIRP	clinical_stage	CAediting_240712	chr2_207754861_+	4.30594907690467e-05	0.415022996055506
KIRP	pathologic_stage	CAediting_240712	chr2_207754861_+	0.000171860014685584	0.336446297790727
LUAD	pathologic_stage	CAediting_240712	chr2_207754861_+	0.00431363379467914	0.141033014899487
READ	pathologic_stage	CAediting_240712	chr2_207754861_+	0.00338825906230736	0.366540278148523

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Relation with survival for MIR4775

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
KIRP	CAediting_240712	chr2_207754861_+	0.000432869750602749	0.00025453	2758.1

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RelatedDrugs for MIR4775

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MIR4775

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene