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Editing gene: MSANTD3-TMEFF1 (CAeditome ID:100526694)

Gene summary for MSANTD3-TMEFF1

Gene summary

Gene information	Gene symbol	MSANTD3-TMEFF1
	Gene ID	100526694
	Gene name	MSANTD3-TMEFF1 readthrough
	Synonyms	C9orf2\|C9orf3-TMEFF1\|C9orf30-TMEFF1\|H7365\|TMEFF1\|TR-1
	Cytomap	9q31.1
	Type of gene	protein-coding
	Description	MSANTD3-TMEFF1 fusion proteinC9orf30-TMEFF1 readthroughTomoregulin-1Transmembrane protein with EGF-like and one follistatin-like domain
	Modification date	20210518
	UniProtAcc	.
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for MSANTD3-TMEFF1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000251349.3

RNA A-to-I editing events in Cancer.

CAediting_699614(100442624, +), CAediting_699615(100442658, +), CAediting_699616(100446571, +), CAediting_699617(100446616, +), CAediting_699618(100446729, +), CAediting_699619(100447992, +), CAediting_699620(100448045, +), CAediting_699621(100448094, +), CAediting_699622(100452412, +), CAediting_699623(100452464, +), CAediting_699624(100452477, +), CAediting_699625(100452513, +), CAediting_699626(100452523, +), CAediting_699627(100452549, +), CAediting_699628(100452591, +), CAediting_699629(100452604, +), CAediting_699630(100452645, +), CAediting_699631(100452646, +), CAediting_699632(100452657, +), CAediting_699633(100452659, +), CAediting_699634(100452666, +), CAediting_699635(100454583, +), CAediting_699636(100454590, +), CAediting_699637(100454592, +), CAediting_699638(100454596, +), CAediting_699639(100454624, +), CAediting_699640(100454625, +), CAediting_699641(100454630, +), CAediting_699642(100454635, +), CAediting_699643(100454641, +), CAediting_699644(100454646, +), CAediting_699645(100454665, +), CAediting_699646(100454670, +), CAediting_699647(100454681, +), CAediting_699648(100454693, +), CAediting_699649(100454694, +), CAediting_699650(100454696, +), CAediting_699651(100454704, +), CAediting_699652(100454718, +), CAediting_699653(100454719, +), CAediting_699654(100454720, +), CAediting_699655(100454721, +), CAediting_699656(100454722, +), CAediting_699657(100454724, +), CAediting_699658(100454728, +), CAediting_699659(100454729, +), CAediting_699660(100454730, +), CAediting_699661(100454734, +), CAediting_699662(100454738, +), CAediting_699663(100454750, +), CAediting_699664(100454760, +), CAediting_699665(100454761, +), CAediting_699666(100454787, +), CAediting_699667(100454793, +), CAediting_699668(100454801, +), CAediting_699669(100454802, +), CAediting_699670(100454806, +), CAediting_699671(100454830, +), CAediting_699672(100454831, +), CAediting_699673(100454838, +), CAediting_699674(100454846, +), CAediting_699675(100454864, +), CAediting_699676(100454866, +), CAediting_699677(100454871, +), CAediting_699678(100454884, +), CAediting_699679(100470540, +), CAediting_699680(100470541, +), CAediting_699681(100510737, +), CAediting_699682(100527022, +), CAediting_699683(100527023, +), CAediting_699684(100539115, +),

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RNA editing positional annotations for MSANTD3-TMEFF1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_699614	chr9_100442624_+	ncRNA_intronic
CAediting_699615	chr9_100442658_+	ncRNA_intronic
CAediting_699616	chr9_100446571_+	ncRNA_intronic
CAediting_699617	chr9_100446616_+	ncRNA_intronic
CAediting_699618	chr9_100446729_+	ncRNA_intronic
CAediting_699619	chr9_100447992_+	ncRNA_intronic
CAediting_699620	chr9_100448045_+	ncRNA_intronic
CAediting_699621	chr9_100448094_+	ncRNA_intronic
CAediting_699622	chr9_100452412_+	intronic
CAediting_699623	chr9_100452464_+	intronic
CAediting_699624	chr9_100452477_+	intronic
CAediting_699625	chr9_100452513_+	intronic
CAediting_699626	chr9_100452523_+	intronic
CAediting_699627	chr9_100452549_+	intronic
CAediting_699628	chr9_100452591_+	intronic
CAediting_699629	chr9_100452604_+	intronic
CAediting_699630	chr9_100452645_+	intronic
CAediting_699631	chr9_100452646_+	intronic
CAediting_699632	chr9_100452657_+	intronic
CAediting_699633	chr9_100452659_+	intronic
CAediting_699634	chr9_100452666_+	intronic
CAediting_699635	chr9_100454583_+	intronic
CAediting_699636	chr9_100454590_+	intronic
CAediting_699637	chr9_100454592_+	intronic
CAediting_699638	chr9_100454596_+	intronic
CAediting_699639	chr9_100454624_+	intronic
CAediting_699640	chr9_100454625_+	intronic
CAediting_699641	chr9_100454630_+	intronic
CAediting_699642	chr9_100454635_+	intronic
CAediting_699643	chr9_100454641_+	intronic
CAediting_699644	chr9_100454646_+	intronic
CAediting_699645	chr9_100454665_+	intronic
CAediting_699646	chr9_100454670_+	intronic
CAediting_699647	chr9_100454681_+	intronic
CAediting_699648	chr9_100454693_+	intronic
CAediting_699649	chr9_100454694_+	intronic
CAediting_699650	chr9_100454696_+	intronic
CAediting_699651	chr9_100454704_+	intronic
CAediting_699652	chr9_100454718_+	intronic
CAediting_699653	chr9_100454719_+	intronic
CAediting_699654	chr9_100454720_+	intronic
CAediting_699655	chr9_100454721_+	intronic
CAediting_699656	chr9_100454722_+	intronic
CAediting_699657	chr9_100454724_+	intronic
CAediting_699658	chr9_100454728_+	intronic
CAediting_699659	chr9_100454729_+	intronic
CAediting_699660	chr9_100454730_+	intronic
CAediting_699661	chr9_100454734_+	intronic
CAediting_699662	chr9_100454738_+	intronic
CAediting_699663	chr9_100454750_+	intronic
CAediting_699664	chr9_100454760_+	intronic
CAediting_699665	chr9_100454761_+	intronic
CAediting_699666	chr9_100454787_+	intronic
CAediting_699667	chr9_100454793_+	intronic
CAediting_699668	chr9_100454801_+	intronic
CAediting_699669	chr9_100454802_+	intronic
CAediting_699670	chr9_100454806_+	intronic
CAediting_699671	chr9_100454830_+	intronic
CAediting_699672	chr9_100454831_+	intronic
CAediting_699673	chr9_100454838_+	intronic
CAediting_699674	chr9_100454846_+	intronic
CAediting_699675	chr9_100454864_+	intronic
CAediting_699676	chr9_100454866_+	intronic
CAediting_699677	chr9_100454871_+	intronic
CAediting_699678	chr9_100454884_+	intronic
CAediting_699679	chr9_100470540_+	intronic
CAediting_699680	chr9_100470541_+	intronic
CAediting_699681	chr9_100510737_+	intronic
CAediting_699682	chr9_100527022_+	intronic
CAediting_699683	chr9_100527023_+	intronic
CAediting_699684	chr9_100539115_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_699614	chr9_100442624_+	SINE	Alu	AluJo
CAediting_699615	chr9_100442658_+	SINE	Alu	AluJo
CAediting_699616	chr9_100446571_+	SINE	Alu	AluSx
CAediting_699617	chr9_100446616_+	SINE	Alu	AluSx
CAediting_699618	chr9_100446729_+	SINE	Alu	AluSx
CAediting_699619	chr9_100447992_+	SINE	Alu	AluSz
CAediting_699620	chr9_100448045_+	SINE	Alu	AluSz
CAediting_699621	chr9_100448094_+	SINE	Alu	AluSz
CAediting_699622	chr9_100452412_+	SINE	Alu	AluY
CAediting_699623	chr9_100452464_+	SINE	Alu	AluY
CAediting_699624	chr9_100452477_+	SINE	Alu	AluY
CAediting_699625	chr9_100452513_+	SINE	Alu	AluY
CAediting_699626	chr9_100452523_+	SINE	Alu	AluY
CAediting_699627	chr9_100452549_+	SINE	Alu	AluY
CAediting_699628	chr9_100452591_+	SINE	Alu	AluY
CAediting_699629	chr9_100452604_+	SINE	Alu	AluY
CAediting_699630	chr9_100452645_+	SINE	Alu	AluY
CAediting_699631	chr9_100452646_+	SINE	Alu	AluY
CAediting_699632	chr9_100452657_+	SINE	Alu	AluY
CAediting_699633	chr9_100452659_+	SINE	Alu	AluY
CAediting_699634	chr9_100452666_+	SINE	Alu	AluY
CAediting_699639	chr9_100454624_+	SINE	Alu	AluSq2
CAediting_699640	chr9_100454625_+	SINE	Alu	AluSq2
CAediting_699641	chr9_100454630_+	SINE	Alu	AluSq2
CAediting_699642	chr9_100454635_+	SINE	Alu	AluSq2
CAediting_699643	chr9_100454641_+	SINE	Alu	AluSq2
CAediting_699644	chr9_100454646_+	SINE	Alu	AluSq2
CAediting_699645	chr9_100454665_+	SINE	Alu	AluSq2
CAediting_699646	chr9_100454670_+	SINE	Alu	AluSq2
CAediting_699647	chr9_100454681_+	SINE	Alu	AluSq2
CAediting_699648	chr9_100454693_+	SINE	Alu	AluSq2
CAediting_699649	chr9_100454694_+	SINE	Alu	AluSq2
CAediting_699650	chr9_100454696_+	SINE	Alu	AluSq2
CAediting_699651	chr9_100454704_+	SINE	Alu	AluSq2
CAediting_699652	chr9_100454718_+	SINE	Alu	AluSq2
CAediting_699653	chr9_100454719_+	SINE	Alu	AluSq2
CAediting_699654	chr9_100454720_+	SINE	Alu	AluSq2
CAediting_699655	chr9_100454721_+	SINE	Alu	AluSq2
CAediting_699656	chr9_100454722_+	SINE	Alu	AluSq2
CAediting_699657	chr9_100454724_+	SINE	Alu	AluSq2
CAediting_699658	chr9_100454728_+	SINE	Alu	AluSq2
CAediting_699659	chr9_100454729_+	SINE	Alu	AluSq2
CAediting_699660	chr9_100454730_+	SINE	Alu	AluSq2
CAediting_699661	chr9_100454734_+	SINE	Alu	AluSq2
CAediting_699662	chr9_100454738_+	SINE	Alu	AluSq2
CAediting_699663	chr9_100454750_+	SINE	Alu	AluSq2
CAediting_699664	chr9_100454760_+	SINE	Alu	AluSq2
CAediting_699665	chr9_100454761_+	SINE	Alu	AluSq2
CAediting_699666	chr9_100454787_+	SINE	Alu	AluSq2
CAediting_699667	chr9_100454793_+	SINE	Alu	AluSq2
CAediting_699668	chr9_100454801_+	SINE	Alu	AluSq2
CAediting_699669	chr9_100454802_+	SINE	Alu	AluSq2
CAediting_699670	chr9_100454806_+	SINE	Alu	AluSq2
CAediting_699671	chr9_100454830_+	SINE	Alu	AluSq2
CAediting_699672	chr9_100454831_+	SINE	Alu	AluSq2
CAediting_699673	chr9_100454838_+	SINE	Alu	AluSq2
CAediting_699674	chr9_100454846_+	SINE	Alu	AluSq2
CAediting_699675	chr9_100454864_+	SINE	Alu	AluSq2
CAediting_699676	chr9_100454866_+	SINE	Alu	AluSq2
CAediting_699677	chr9_100454871_+	SINE	Alu	AluSq2
CAediting_699678	chr9_100454884_+	SINE	Alu	AluSq2
CAediting_699679	chr9_100470540_+	SINE	Alu	AluJr4
CAediting_699680	chr9_100470541_+	SINE	Alu	AluJr4
CAediting_699681	chr9_100510737_+	SINE	Alu	AluJb
CAediting_699682	chr9_100527022_+	SINE	Alu	AluSx
CAediting_699683	chr9_100527023_+	SINE	Alu	AluSx
CAediting_699684	chr9_100539115_+	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for MSANTD3-TMEFF1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000251349.3.MSANTD3-TMEFF1.

Correlation between RNA A-to-I editing and PSI for ENSG00000251349.3.MSANTD3-TMEFF1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MSANTD3-TMEFF1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for MSANTD3-TMEFF1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for MSANTD3-TMEFF1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for MSANTD3-TMEFF1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for MSANTD3-TMEFF1

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
GBM	CAediting_699665	chr9_100454761_+	.	.	0.0163031692908208	0.308974597680152	.	.
LGG	CAediting_699670	chr9_100454806_+	0.0355419865525266	0.261259135705384	.	.	0.0388824769797293	0.256853360450124
BRCA	CAediting_699670	chr9_100454806_+	4.73199038358326e-05	0.51995446915008	.	.	.	.
SKCM	CAediting_699670	chr9_100454806_+	0.00600121227540557	0.334796883605986	.	.	.	.
SARC	CAediting_699670	chr9_100454806_+	0.000733348939561502	0.396931971827051	.	.	.	.

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Relation with cancer stages for MSANTD3-TMEFF1

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
KIRC	pathologic_stage	CAediting_699670	chr9_100454806_+	0.020188721012154	0.301774975999328
SKCM	pathologic_stage	CAediting_699670	chr9_100454806_+	0.0198452539398979	-0.310526363948151

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Relation with survival for MSANTD3-TMEFF1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for MSANTD3-TMEFF1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for MSANTD3-TMEFF1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene