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Editing gene: SOS1-IT1 (CAeditome ID:100505911)

Gene summary for SOS1-IT1

Gene summary

Gene information	Gene symbol	SOS1-IT1
	Gene ID	100505911
	Gene name	SOS1 intronic transcript 1
	Synonyms	-
	Cytomap	2p21
	Type of gene	ncRNA
	Description	SOS1 intronic transcript 1 (non-protein coding)
	Modification date	20170408
	UniProtAcc	.
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for SOS1-IT1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000229692.3

RNA A-to-I editing events in Cancer.

CAediting_172189(38992972, -), CAediting_172190(38992991, -), CAediting_172191(38992992, -), CAediting_172192(38993000, -), CAediting_172193(38993001, -), CAediting_172194(38993014, -), CAediting_172195(38993017, -), CAediting_172196(38993018, -), CAediting_172197(38993032, -), CAediting_172198(38993033, -), CAediting_172199(38993038, -), CAediting_172200(38993044, -), CAediting_172201(38993045, -), CAediting_172202(38993064, -), CAediting_172203(38993175, -), CAediting_172204(38993222, -), CAediting_172205(38993249, -), CAediting_172206(38993274, -), CAediting_172207(38993360, -), CAediting_172208(38993362, -), CAediting_172209(38993364, -), CAediting_172210(38993365, -), CAediting_172211(38993374, -), CAediting_172212(38993379, -), CAediting_172213(38993388, -), CAediting_172214(38993393, -), CAediting_172215(38993398, -), CAediting_172216(38993411, -), CAediting_172217(38993412, -), CAediting_172218(38993417, -), CAediting_172219(38993427, -), CAediting_172220(38993433, -), CAediting_172221(38993434, -), CAediting_172222(38993442, -),

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RNA editing positional annotations for SOS1-IT1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_172189	chr2_38992972_-	ncRNA_exonic
CAediting_172190	chr2_38992991_-	ncRNA_exonic
CAediting_172191	chr2_38992992_-	ncRNA_exonic
CAediting_172192	chr2_38993000_-	ncRNA_exonic
CAediting_172193	chr2_38993001_-	ncRNA_exonic
CAediting_172194	chr2_38993014_-	ncRNA_exonic
CAediting_172195	chr2_38993017_-	ncRNA_exonic
CAediting_172196	chr2_38993018_-	ncRNA_exonic
CAediting_172197	chr2_38993032_-	ncRNA_exonic
CAediting_172198	chr2_38993033_-	ncRNA_exonic
CAediting_172199	chr2_38993038_-	ncRNA_exonic
CAediting_172200	chr2_38993044_-	ncRNA_exonic;splicing
CAediting_172201	chr2_38993045_-	ncRNA_exonic
CAediting_172202	chr2_38993064_-	ncRNA_exonic
CAediting_172203	chr2_38993175_-	ncRNA_intronic
CAediting_172204	chr2_38993222_-	ncRNA_intronic
CAediting_172205	chr2_38993249_-	ncRNA_intronic
CAediting_172206	chr2_38993274_-	ncRNA_intronic
CAediting_172207	chr2_38993360_-	ncRNA_intronic
CAediting_172208	chr2_38993362_-	ncRNA_intronic
CAediting_172209	chr2_38993364_-	ncRNA_intronic
CAediting_172210	chr2_38993365_-	ncRNA_intronic
CAediting_172211	chr2_38993374_-	ncRNA_intronic
CAediting_172212	chr2_38993379_-	ncRNA_intronic
CAediting_172213	chr2_38993388_-	ncRNA_intronic
CAediting_172214	chr2_38993393_-	ncRNA_exonic
CAediting_172215	chr2_38993398_-	ncRNA_exonic
CAediting_172216	chr2_38993411_-	ncRNA_exonic
CAediting_172217	chr2_38993412_-	ncRNA_exonic
CAediting_172218	chr2_38993417_-	ncRNA_exonic
CAediting_172219	chr2_38993427_-	ncRNA_exonic
CAediting_172220	chr2_38993433_-	ncRNA_exonic
CAediting_172221	chr2_38993434_-	ncRNA_exonic
CAediting_172222	chr2_38993442_-	ncRNA_exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_172189	chr2_38992972_-	SINE	Alu	AluJr
CAediting_172190	chr2_38992991_-	SINE	Alu	AluJr
CAediting_172191	chr2_38992992_-	SINE	Alu	AluJr
CAediting_172192	chr2_38993000_-	SINE	Alu	AluJr
CAediting_172193	chr2_38993001_-	SINE	Alu	AluJr
CAediting_172194	chr2_38993014_-	SINE	Alu	AluJr
CAediting_172195	chr2_38993017_-	SINE	Alu	AluJr
CAediting_172196	chr2_38993018_-	SINE	Alu	AluJr
CAediting_172197	chr2_38993032_-	SINE	Alu	AluJr
CAediting_172198	chr2_38993033_-	SINE	Alu	AluJr
CAediting_172199	chr2_38993038_-	SINE	Alu	AluJr
CAediting_172200	chr2_38993044_-	SINE	Alu	AluJr
CAediting_172201	chr2_38993045_-	SINE	Alu	AluJr
CAediting_172202	chr2_38993064_-	SINE	Alu	AluJr
CAediting_172203	chr2_38993175_-	SINE	Alu	AluJr
CAediting_172204	chr2_38993222_-	SINE	Alu	AluJr
CAediting_172205	chr2_38993249_-	SINE	Alu	AluJr
CAediting_172206	chr2_38993274_-	SINE	Alu	AluJr
CAediting_172207	chr2_38993360_-	SINE	Alu	AluJr
CAediting_172208	chr2_38993362_-	SINE	Alu	AluJr
CAediting_172209	chr2_38993364_-	SINE	Alu	AluJr
CAediting_172210	chr2_38993365_-	SINE	Alu	AluJr
CAediting_172211	chr2_38993374_-	SINE	Alu	AluJr
CAediting_172212	chr2_38993379_-	SINE	Alu	AluJr
CAediting_172213	chr2_38993388_-	SINE	Alu	AluJr
CAediting_172214	chr2_38993393_-	SINE	Alu	AluJr
CAediting_172215	chr2_38993398_-	SINE	Alu	AluJr
CAediting_172216	chr2_38993411_-	SINE	Alu	AluJr
CAediting_172217	chr2_38993412_-	SINE	Alu	AluJr
CAediting_172218	chr2_38993417_-	SINE	Alu	AluJr
CAediting_172219	chr2_38993427_-	SINE	Alu	AluJr
CAediting_172220	chr2_38993433_-	SINE	Alu	AluJr
CAediting_172221	chr2_38993434_-	SINE	Alu	AluJr
CAediting_172222	chr2_38993442_-	SINE	Alu	AluJr

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RNA A-to-I editing events in the alternative splicing sites for SOS1-IT1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000229692.3.SOS1-IT1.

Correlation between RNA A-to-I editing and PSI for ENSG00000229692.3.SOS1-IT1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SOS1-IT1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SOS1-IT1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for SOS1-IT1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_172193	chr2_38993001_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-3974	38992996	38993002	7mer-m8	38992995	38993019	157	-18.21
CAediting_172193	chr2_38993001_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-3974	38992996	38993002	7mer-m8	38992995	38993019	157	-18.21
CAediting_172193	chr2_38993001_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-3974	38992996	38993002	7mer-m8	38992995	38993019	157	-18.21
CAediting_172199	chr2_38993038_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-4786-5p	38993033	38993040	8mer-1a	38993033	38993054	156	-25.59
CAediting_172199	chr2_38993038_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-6849-3p	38993038	38993044	7mer-m8	38993037	38993057	150	-19.27
CAediting_172199	chr2_38993038_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-4786-5p	38993033	38993040	8mer-1a	38993033	38993421	151	-22.89
CAediting_172199	chr2_38993038_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-6849-3p	38993038	38993411	7mer-m8	38993037	38993425	149	-23.38
CAediting_172199	chr2_38993038_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-4786-5p	38993033	38993040	8mer-1a	38993033	38993403	147	-20.59
CAediting_172199	chr2_38993038_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-6849-3p	38993038	38993393	7mer-m8	38993037	38993415	144	-27.84
CAediting_172200	chr2_38993044_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-221-5p	38993043	38993049	7mer-m8	38993042	38993063	157	-23.68
CAediting_172200	chr2_38993044_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-3128	38993044	38993050	7mer-m8	38993043	38993410	146	-15.99
CAediting_172200	chr2_38993044_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-6779-3p	38993040	38993046	7mer-m8	38993039	38993059	143	-12.3
CAediting_172200	chr2_38993044_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-6868-5p	38993044	38993049	6mer	38993043	38993064	147	-18.65
CAediting_172200	chr2_38993044_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-8073	38993043	38993049	7mer-m8	38993042	38993063	160	-24.72
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-302a-3p	38993422	38993428	7mer-m8	38993421	38993442	147	-15.76
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-302b-3p	38993422	38993428	7mer-m8	38993421	38993441	145	-10.21
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-302c-3p	38993422	38993428	7mer-m8	38993421	38993441	149	-12.54
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-302d-3p	38993422	38993428	7mer-m8	38993421	38993448	151	-13.79
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-302e	38993422	38993428	7mer-m8	38993421	38993437	141	-8.62
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-372-3p	38993422	38993428	7mer-m8	38993421	38993441	153	-13.63
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-373-3p	38993422	38993428	7mer-m8	38993421	38993444	160	-20.02
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-512-3p	38993423	38993429	7mer-m8	38993422	38993446	151	-18.65
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-520a-3p	38993422	38993428	7mer-m8	38993421	38993442	140	-11.04
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-520b-3p	38993422	38993428	7mer-m8	38993421	38993440	141	-16.53
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-520c-3p	38993422	38993428	7mer-m8	38993421	38993441	146	-16.53
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-520d-3p	38993422	38993428	7mer-m8	38993421	38993444	142	-15.59
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-520e-3p	38993422	38993428	7mer-m8	38993421	38993441	140	-13.33
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-302a-3p	38993422	38993428	7mer-m8	38993421	38993442	147	-15.76
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-302b-3p	38993422	38993428	7mer-m8	38993421	38993441	145	-10.21
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-302c-3p	38993422	38993428	7mer-m8	38993421	38993441	149	-12.54
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-302d-3p	38993422	38993428	7mer-m8	38993421	38993448	151	-13.79
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-302e	38993422	38993428	7mer-m8	38993421	38993437	141	-8.62
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-372-3p	38993422	38993428	7mer-m8	38993421	38993441	153	-13.63
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-373-3p	38993422	38993428	7mer-m8	38993421	38993444	160	-20.02
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-512-3p	38993423	38993429	7mer-m8	38993422	38993446	151	-18.65
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-520a-3p	38993422	38993428	7mer-m8	38993421	38993442	140	-11.04
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-520b-3p	38993422	38993428	7mer-m8	38993421	38993440	141	-16.53
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-520c-3p	38993422	38993428	7mer-m8	38993421	38993441	146	-16.53
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-520d-3p	38993422	38993428	7mer-m8	38993421	38993444	142	-15.59
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-520e-3p	38993422	38993428	7mer-m8	38993421	38993441	140	-13.33
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-302a-3p	38993422	38993428	7mer-m8	38993421	38993442	147	-15.76
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-302b-3p	38993422	38993428	7mer-m8	38993421	38993441	145	-10.21
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-302c-3p	38993422	38993428	7mer-m8	38993421	38993441	149	-12.54
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-302d-3p	38993422	38993428	7mer-m8	38993421	38993448	151	-13.79
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-302e	38993422	38993428	7mer-m8	38993421	38993437	141	-8.62
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-372-3p	38993422	38993428	7mer-m8	38993421	38993441	153	-13.63
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-373-3p	38993422	38993428	7mer-m8	38993421	38993444	160	-20.02
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-512-3p	38993423	38993429	7mer-m8	38993422	38993446	151	-18.65
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-520a-3p	38993422	38993428	7mer-m8	38993421	38993442	140	-11.04
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-520b-3p	38993422	38993428	7mer-m8	38993421	38993440	141	-16.53
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-520c-3p	38993422	38993428	7mer-m8	38993421	38993441	146	-16.53
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-520d-3p	38993422	38993428	7mer-m8	38993421	38993444	142	-15.59
CAediting_172219	chr2_38993427_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-520e-3p	38993422	38993428	7mer-m8	38993421	38993441	140	-13.33
CAediting_172221	chr2_38993434_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-513a-5p	38993433	38993439	7mer-m8	38993432	38993452	147	-20.7
CAediting_172221	chr2_38993434_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-513a-5p	38993433	38993439	7mer-m8	38993432	38993452	147	-20.7
CAediting_172221	chr2_38993434_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-513a-5p	38993433	38993439	7mer-m8	38993432	38993452	147	-20.7
CAediting_172189	chr2_38992972_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-663b	38992967	38992973	7mer-m8	38992966	38992988	151	-26.14
CAediting_172189	chr2_38992972_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-663b	38992967	38992973	7mer-m8	38992966	38992988	151	-26.14
CAediting_172190	chr2_38992991_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-432-5p	38992991	38992996	6mer	38992990	38993015	140	-20.75
CAediting_172190	chr2_38992991_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-6813-3p	38992989	38992995	7mer-m8	38992988	38993008	140	-11.65
CAediting_172190	chr2_38992991_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-432-5p	38992991	38992996	6mer	38992990	38993015	140	-20.75
CAediting_172190	chr2_38992991_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-6813-3p	38992989	38992995	7mer-m8	38992988	38993008	140	-11.65
CAediting_172190	chr2_38992991_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-432-5p	38992991	38992996	6mer	38992990	38993015	140	-20.75
CAediting_172190	chr2_38992991_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-6813-3p	38992989	38992995	7mer-m8	38992988	38993008	140	-11.65
CAediting_172191	chr2_38992992_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-1299	38992991	38992997	7mer-m8	38992990	38993011	148	-16.6
CAediting_172191	chr2_38992992_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-514a-5p	38992989	38992995	7mer-m8	38992988	38993010	155	-18.4
CAediting_172191	chr2_38992992_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-518c-5p	38992990	38992996	7mer-m8	38992989	38993014	154	-20.42
CAediting_172191	chr2_38992992_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-1299	38992991	38992997	7mer-m8	38992990	38993011	148	-16.6
CAediting_172191	chr2_38992992_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-514a-5p	38992989	38992995	7mer-m8	38992988	38993010	155	-18.4
CAediting_172191	chr2_38992992_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-518c-5p	38992990	38992996	7mer-m8	38992989	38993014	154	-20.42
CAediting_172191	chr2_38992992_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-1299	38992991	38992997	7mer-m8	38992990	38993011	148	-16.6
CAediting_172191	chr2_38992992_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-514a-5p	38992989	38992995	7mer-m8	38992988	38993010	155	-18.4
CAediting_172191	chr2_38992992_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-518c-5p	38992990	38992996	7mer-m8	38992989	38993014	154	-20.42
CAediting_172194	chr2_38993014_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-6753-3p	38993011	38993017	7mer-m8	38993010	38993031	151	-15.3
CAediting_172194	chr2_38993014_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-7107-3p	38993011	38993017	7mer-m8	38993010	38993036	145	-16.3
CAediting_172194	chr2_38993014_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-6753-3p	38993011	38993017	7mer-m8	38993010	38993031	151	-15.3
CAediting_172194	chr2_38993014_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-7107-3p	38993011	38993017	7mer-m8	38993010	38993036	145	-16.3
CAediting_172194	chr2_38993014_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-6753-3p	38993011	38993017	7mer-m8	38993010	38993031	151	-15.3
CAediting_172194	chr2_38993014_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-7107-3p	38993011	38993017	7mer-m8	38993010	38993036	145	-16.3
CAediting_172195	chr2_38993017_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-6885-3p	38993013	38993019	7mer-m8	38993012	38993032	142	-7.25
CAediting_172195	chr2_38993017_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-6885-3p	38993013	38993019	7mer-m8	38993012	38993032	142	-7.25
CAediting_172195	chr2_38993017_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-6885-3p	38993013	38993019	7mer-m8	38993012	38993032	142	-7.25
CAediting_172214	chr2_38993393_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-4323	38993040	38993395	7mer-m8	38993039	38993404	141	-18.64
CAediting_172214	chr2_38993393_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-5699-5p	38993041	38993396	7mer-m8	38993040	38993410	140	-15.39
CAediting_172216	chr2_38993411_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-3176	38993411	38993417	7mer-m8	38993410	38993428	140	-15.24
CAediting_172216	chr2_38993411_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-3922-3p	38993411	38993417	7mer-m8	38993410	38993431	145	-15.95
CAediting_172216	chr2_38993411_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-3176	38993411	38993417	7mer-m8	38993410	38993428	140	-15.24
CAediting_172216	chr2_38993411_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-3922-3p	38993411	38993417	7mer-m8	38993410	38993431	145	-15.95
CAediting_172216	chr2_38993411_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-6779-3p	38993040	38993413	7mer-m8	38993039	38993425	152	-19.87
CAediting_172216	chr2_38993411_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-3176	38993411	38993417	7mer-m8	38993410	38993428	140	-15.24
CAediting_172216	chr2_38993411_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-3620-3p	38993407	38993413	7mer-m8	38993406	38993428	148	-19.9
CAediting_172216	chr2_38993411_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-3922-3p	38993411	38993417	7mer-m8	38993410	38993431	145	-15.95
CAediting_172218	chr2_38993417_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-328-3p	38993411	38993418	8mer-1a	38993411	38993432	146	-16.31
CAediting_172218	chr2_38993417_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-4290	38993414	38993420	7mer-m8	38993413	38993431	140	-13.66
CAediting_172218	chr2_38993417_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-519d-5p	38993417	38993423	7mer-m8	38993416	38993440	155	-19.82
CAediting_172218	chr2_38993417_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-328-3p	38993411	38993418	8mer-1a	38993411	38993432	146	-16.31
CAediting_172218	chr2_38993417_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-4290	38993414	38993420	7mer-m8	38993413	38993431	140	-13.66
CAediting_172218	chr2_38993417_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-519d-5p	38993417	38993423	7mer-m8	38993416	38993440	155	-19.82
CAediting_172218	chr2_38993417_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-328-3p	38993411	38993418	8mer-1a	38993411	38993432	146	-16.31
CAediting_172218	chr2_38993417_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-4290	38993414	38993420	7mer-m8	38993413	38993431	140	-13.66
CAediting_172218	chr2_38993417_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-519d-5p	38993417	38993423	7mer-m8	38993416	38993440	155	-19.82
CAediting_172196	chr2_38993018_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-12119	38993017	38993023	7mer-m8	38993016	38993037	154	-23.22
CAediting_172196	chr2_38993018_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-4649-3p	38993017	38993024	8mer-1a	38993017	38993037	147	-19.23
CAediting_172196	chr2_38993018_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-12119	38993017	38993023	7mer-m8	38993016	38993037	154	-23.22
CAediting_172196	chr2_38993018_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-4649-3p	38993017	38993024	8mer-1a	38993017	38993037	147	-19.23
CAediting_172196	chr2_38993018_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-12119	38993017	38993023	7mer-m8	38993016	38993037	154	-23.22
CAediting_172196	chr2_38993018_-	ENSG00000229692.3	ENST00000609942.1	hsa-miR-4649-3p	38993017	38993024	8mer-1a	38993017	38993037	147	-19.23

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_172200	chr2_38993044_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-212-5p	38993042	38993048	7mer-m8	38993041	38993063	145	-16.87
CAediting_172201	chr2_38993045_-	ENSG00000229692.3	ENST00000420644.1	hsa-miR-212-5p	38993042	38993048	7mer-m8	38993041	38993063	145	-16.87
CAediting_172221	chr2_38993434_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-10399-5p	38993432	38993438	7mer-m8	38993431	38993448	147	-11.76
CAediting_172220	chr2_38993433_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-10399-5p	38993432	38993438	7mer-m8	38993431	38993448	147	-11.76
CAediting_172221	chr2_38993434_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-6504-3p	38993432	38993438	7mer-m8	38993431	38993450	140	-7.92
CAediting_172220	chr2_38993433_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-6504-3p	38993432	38993438	7mer-m8	38993431	38993450	140	-7.92

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1160181	chr17_7017644_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-195-3p	38992436	38992442	7mer-m8	38992435	38992456	149	-15.14
CAediting_524911	chr7_5495852_-	ENSG00000229692.3	ENST00000594472.1	hsa-miR-589-3p	38992520	38992526	7mer-m8	38992519	38992539	146	-17.67

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SOS1-IT1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000594472.1	sense_intronic
ENST00000609942.1	sense_intronic
ENST00000420644.1	sense_intronic

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_172189	ENST00000594472.1	chr2_38992972_-	-295.60	-296.50	-316.20
CAediting_172190	ENST00000594472.1	chr2_38992991_-	-296.20	-296.50	-316.20
CAediting_172191	ENST00000594472.1	chr2_38992992_-	-296.60	-296.50	-316.20
CAediting_172192	ENST00000594472.1	chr2_38993000_-	-300.60	-296.50	-316.20
CAediting_172193	ENST00000594472.1	chr2_38993001_-	-300.00	-296.50	-316.20
CAediting_172194	ENST00000594472.1	chr2_38993014_-	-299.30	-296.50	-316.20
CAediting_172195	ENST00000594472.1	chr2_38993017_-	-296.70	-296.50	-316.20
CAediting_172196	ENST00000594472.1	chr2_38993018_-	-299.60	-296.50	-316.20
CAediting_172197	ENST00000594472.1	chr2_38993032_-	-299.40	-296.50	-316.20
CAediting_172198	ENST00000594472.1	chr2_38993033_-	-296.07	-296.50	-316.20
CAediting_172199	ENST00000594472.1	chr2_38993038_-	-298.70	-296.50	-316.20
CAediting_172216	ENST00000594472.1	chr2_38993411_-	-296.20	-296.50	-316.20
CAediting_172217	ENST00000594472.1	chr2_38993412_-	-296.90	-296.50	-316.20
CAediting_172218	ENST00000594472.1	chr2_38993417_-	-296.20	-296.50	-316.20
CAediting_172219	ENST00000594472.1	chr2_38993427_-	-303.20	-296.50	-316.20
CAediting_172220	ENST00000594472.1	chr2_38993433_-	-293.50	-296.50	-316.20
CAediting_172221	ENST00000594472.1	chr2_38993434_-	-296.60	-296.50	-316.20
CAediting_172222	ENST00000594472.1	chr2_38993442_-	-295.80	-296.50	-316.20
CAediting_172189	ENST00000609942.1	chr2_38992972_-	-189.70	-190.60	-208.80
CAediting_172190	ENST00000609942.1	chr2_38992991_-	-190.30	-190.60	-208.80
CAediting_172191	ENST00000609942.1	chr2_38992992_-	-190.70	-190.60	-208.80
CAediting_172192	ENST00000609942.1	chr2_38993000_-	-194.70	-190.60	-208.80
CAediting_172193	ENST00000609942.1	chr2_38993001_-	-194.10	-190.60	-208.80
CAediting_172194	ENST00000609942.1	chr2_38993014_-	-190.60	-190.60	-208.80
CAediting_172195	ENST00000609942.1	chr2_38993017_-	-193.60	-190.60	-208.80
CAediting_172196	ENST00000609942.1	chr2_38993018_-	-190.30	-190.60	-208.80
CAediting_172197	ENST00000609942.1	chr2_38993032_-	-190.60	-190.60	-208.80
CAediting_172198	ENST00000609942.1	chr2_38993033_-	-190.60	-190.60	-208.80
CAediting_172199	ENST00000609942.1	chr2_38993038_-	-192.70	-190.60	-208.80
CAediting_172214	ENST00000609942.1	chr2_38993393_-	-189.70	-190.60	-208.80
CAediting_172215	ENST00000609942.1	chr2_38993398_-	-190.60	-190.60	-208.80
CAediting_172216	ENST00000609942.1	chr2_38993411_-	-190.30	-190.60	-208.80
CAediting_172217	ENST00000609942.1	chr2_38993412_-	-191.00	-190.60	-208.80
CAediting_172218	ENST00000609942.1	chr2_38993417_-	-190.30	-190.60	-208.80
CAediting_172219	ENST00000609942.1	chr2_38993427_-	-197.30	-190.60	-208.80
CAediting_172220	ENST00000609942.1	chr2_38993433_-	-187.60	-190.60	-208.80
CAediting_172221	ENST00000609942.1	chr2_38993434_-	-190.70	-190.60	-208.80
CAediting_172222	ENST00000609942.1	chr2_38993442_-	-189.90	-190.60	-208.80
CAediting_172190	ENST00000420644.1	chr2_38992991_-	-145.70	-146.00	-170.80
CAediting_172191	ENST00000420644.1	chr2_38992992_-	-146.10	-146.00	-170.80
CAediting_172192	ENST00000420644.1	chr2_38993000_-	-150.10	-146.00	-170.80
CAediting_172193	ENST00000420644.1	chr2_38993001_-	-149.50	-146.00	-170.80
CAediting_172194	ENST00000420644.1	chr2_38993014_-	-147.90	-146.00	-170.80
CAediting_172195	ENST00000420644.1	chr2_38993017_-	-148.50	-146.00	-170.80
CAediting_172196	ENST00000420644.1	chr2_38993018_-	-146.20	-146.00	-170.80
CAediting_172197	ENST00000420644.1	chr2_38993032_-	-149.20	-146.00	-170.80
CAediting_172198	ENST00000420644.1	chr2_38993033_-	-144.90	-146.00	-170.80
CAediting_172199	ENST00000420644.1	chr2_38993038_-	-146.30	-146.00	-170.80
CAediting_172200	ENST00000420644.1	chr2_38993044_-	-148.10	-146.00	-170.80
CAediting_172201	ENST00000420644.1	chr2_38993045_-	-147.20	-146.00	-170.80
CAediting_172202	ENST00000420644.1	chr2_38993064_-	-144.70	-146.00	-170.80
CAediting_172216	ENST00000420644.1	chr2_38993411_-	-146.90	-146.00	-170.80
CAediting_172217	ENST00000420644.1	chr2_38993412_-	-146.40	-146.00	-170.80
CAediting_172218	ENST00000420644.1	chr2_38993417_-	-145.70	-146.00	-170.80
CAediting_172219	ENST00000420644.1	chr2_38993427_-	-152.70	-146.00	-170.80
CAediting_172220	ENST00000420644.1	chr2_38993433_-	-143.00	-146.00	-170.80
CAediting_172221	ENST00000420644.1	chr2_38993434_-	-146.10	-146.00	-170.80
CAediting_172222	ENST00000420644.1	chr2_38993442_-	-147.00	-146.00	-170.80

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Relation with ADAR for SOS1-IT1

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
STAD	CAediting_172193	chr2_38993001_-	0.0477629207371374	0.261073616587426	.	.	.	.
OV	CAediting_172193	chr2_38993001_-	4.15944808501532e-05	0.250823836766874	.	.	.	.
BRCA	CAediting_172201	chr2_38993045_-	0.0049975893882985	0.363799185668033	.	.	.	.
OV	CAediting_172201	chr2_38993045_-	0.00110956247378927	0.265489678910263	.	.	.	.

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Relation with cancer stages for SOS1-IT1

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BRCA	pathologic_stage	CAediting_172193	chr2_38993001_-	0.00498160259767901	0.249692102259459
KIRC	pathologic_stage	CAediting_172193	chr2_38993001_-	0.0164622228322379	0.325082181920589

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Relation with survival for SOS1-IT1

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
BRCA	CAediting_172201	chr2_38993045_-	0.00490551405188855	0.0400833	1.59278e-06

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RelatedDrugs for SOS1-IT1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SOS1-IT1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene