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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: IGLL5 (CAeditome ID:100423062)

Gene summary for IGLL5

check button Gene summary
Gene informationGene symbol

IGLL5

Gene ID

100423062

Gene nameimmunoglobulin lambda like polypeptide 5
SynonymsIGL|IGLV|VL-MAR
Cytomap

22q11.22

Type of geneprotein-coding
Descriptionimmunoglobulin lambda-like polypeptide 5G lambda-1anti HBs antibody light-chain Fab fragmentgermline immunoglobulin lambda 1immunoglobin anti-granzymeB light chain variable regionimmunoglobulin lambda 1 light chainimmunoglobulin lambda 2 light chain
Modification date20210518
UniProtAcc

B9A064

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for IGLL5

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000254709.5
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_1464210(22734871, +), CAediting_1464211(22734887, +), CAediting_1464212(22734889, +), CAediting_1464213(22734931, +), CAediting_1464214(22734937, +), CAediting_1464215(22747689, +), CAediting_1464216(22747716, +), CAediting_1464217(22747720, +), CAediting_1464218(22747796, +), CAediting_1464219(22747807, +), CAediting_1464220(22747811, +), CAediting_1464221(22747824, +), CAediting_1464222(22747829, +), CAediting_1464223(22747833, +), CAediting_1464224(22747838, +), CAediting_1464225(22747848, +), CAediting_1464226(22747854, +), CAediting_1464227(22747859, +), CAediting_1464228(22747868, +), CAediting_1464229(22747876, +), CAediting_1464230(22747895, +), CAediting_1464231(22747898, +), CAediting_1464232(22747901, +), CAediting_1464233(22759036, +), CAediting_1464234(22759125, +), CAediting_1464235(22759165, +), CAediting_1464236(22759200, +), CAediting_1464237(22759206, +), CAediting_1464238(22772353, +), CAediting_1464239(22772365, +), CAediting_1464240(22772380, +), CAediting_1464241(22772403, +), CAediting_1464242(22792761, +), CAediting_1464243(22792845, +), CAediting_1464244(22792847, +), CAediting_1464245(22792861, +), CAediting_1464246(22792880, +), CAediting_1464247(22792917, +), CAediting_1464248(22812033, +), CAediting_1464249(22812063, +), CAediting_1464250(22812081, +), CAediting_1464251(22812089, +), CAediting_1464252(22812108, +), CAediting_1464253(22812137, +), CAediting_1464254(22812140, +), CAediting_1464255(22812150, +), CAediting_1464256(22812160, +), CAediting_1464257(22812167, +), CAediting_1464258(22812169, +), CAediting_1464259(22812202, +), CAediting_1464260(22812208, +), CAediting_1464261(22812214, +), CAediting_1464262(22812254, +), CAediting_1464263(22812258, +), CAediting_1464264(22812261, +), CAediting_1464265(22812263, +), CAediting_1464266(22812265, +), CAediting_1464267(22812268, +), CAediting_1464268(22812278, +), CAediting_1464269(22812280, +), CAediting_1464270(22819488, +), CAediting_1464271(22819514, +), CAediting_1464272(22819539, +), CAediting_1464273(22819540, +), CAediting_1464274(22819557, +), CAediting_1464275(22819579, +), CAediting_1464276(22819584, +), CAediting_1464277(22819589, +), CAediting_1464278(22819610, +), CAediting_1464279(22819621, +), CAediting_1464280(22819636, +), CAediting_1464281(22819660, +), CAediting_1464282(22819670, +), CAediting_1464283(22819684, +), CAediting_1464284(22819695, +), CAediting_1464285(22823039, +), CAediting_1464286(22823114, +), CAediting_1464287(22823131, +), CAediting_1464288(22823263, +), CAediting_1464289(22850448, +), CAediting_1464290(22850454, +), CAediting_1464291(22850470, +), CAediting_1464292(22850485, +), CAediting_1464293(22856857, +), CAediting_1464294(22856892, +), CAediting_1464295(22856985, +), CAediting_1464296(22871809, +), CAediting_1464297(22871818, +), CAediting_1464298(22881196, +), CAediting_1464299(22881224, +), CAediting_1464300(22881261, +), CAediting_1464301(22889657, +), CAediting_1464302(22889674, +), CAediting_1464303(22889731, +), CAediting_1464304(22889745, +), CAediting_1464305(22889753, +), CAediting_1464306(22889754, +), CAediting_1464307(22889797, +), CAediting_1464308(22894550, +), CAediting_1464309(22894571, +), CAediting_1464310(22894592, +), CAediting_1464311(22894599, +), CAediting_1464312(22895701, +), CAediting_1464313(22895738, +),

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RNA editing positional annotations for IGLL5 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1464210chr22_22734871_+exonic
CAediting_1464211chr22_22734887_+exonic
CAediting_1464212chr22_22734889_+exonic
CAediting_1464213chr22_22734931_+exonic
CAediting_1464214chr22_22734937_+exonic
CAediting_1464215chr22_22747689_+exonic
CAediting_1464216chr22_22747716_+exonic
CAediting_1464217chr22_22747720_+exonic
CAediting_1464218chr22_22747796_+exonic
CAediting_1464219chr22_22747807_+exonic
CAediting_1464220chr22_22747811_+exonic
CAediting_1464221chr22_22747824_+exonic
CAediting_1464222chr22_22747829_+exonic
CAediting_1464223chr22_22747833_+exonic
CAediting_1464224chr22_22747838_+exonic
CAediting_1464225chr22_22747848_+exonic
CAediting_1464226chr22_22747854_+exonic
CAediting_1464227chr22_22747859_+exonic
CAediting_1464228chr22_22747868_+exonic
CAediting_1464229chr22_22747876_+exonic
CAediting_1464230chr22_22747895_+exonic
CAediting_1464231chr22_22747898_+exonic
CAediting_1464232chr22_22747901_+exonic
CAediting_1464233chr22_22759036_+exonic
CAediting_1464234chr22_22759125_+exonic
CAediting_1464235chr22_22759165_+exonic
CAediting_1464236chr22_22759200_+exonic
CAediting_1464237chr22_22759206_+exonic
CAediting_1464238chr22_22772353_+exonic
CAediting_1464239chr22_22772365_+exonic
CAediting_1464240chr22_22772380_+exonic
CAediting_1464241chr22_22772403_+exonic
CAediting_1464242chr22_22792761_+exonic
CAediting_1464243chr22_22792845_+exonic
CAediting_1464244chr22_22792847_+exonic
CAediting_1464245chr22_22792861_+exonic
CAediting_1464246chr22_22792880_+exonic
CAediting_1464247chr22_22792917_+exonic
CAediting_1464248chr22_22812033_+exonic
CAediting_1464249chr22_22812063_+exonic
CAediting_1464250chr22_22812081_+exonic
CAediting_1464251chr22_22812089_+exonic
CAediting_1464252chr22_22812108_+exonic
CAediting_1464253chr22_22812137_+exonic
CAediting_1464254chr22_22812140_+exonic
CAediting_1464255chr22_22812150_+exonic
CAediting_1464256chr22_22812160_+exonic
CAediting_1464257chr22_22812167_+exonic
CAediting_1464258chr22_22812169_+exonic
CAediting_1464259chr22_22812202_+exonic
CAediting_1464260chr22_22812208_+exonic
CAediting_1464261chr22_22812214_+exonic
CAediting_1464262chr22_22812254_+exonic
CAediting_1464263chr22_22812258_+exonic
CAediting_1464264chr22_22812261_+exonic
CAediting_1464265chr22_22812263_+exonic
CAediting_1464266chr22_22812265_+exonic
CAediting_1464267chr22_22812268_+exonic
CAediting_1464268chr22_22812278_+exonic
CAediting_1464269chr22_22812280_+exonic
CAediting_1464270chr22_22819488_+exonic
CAediting_1464271chr22_22819514_+exonic
CAediting_1464272chr22_22819539_+exonic
CAediting_1464273chr22_22819540_+exonic
CAediting_1464274chr22_22819557_+exonic
CAediting_1464275chr22_22819579_+exonic
CAediting_1464276chr22_22819584_+exonic
CAediting_1464277chr22_22819589_+exonic
CAediting_1464278chr22_22819610_+exonic
CAediting_1464279chr22_22819621_+exonic
CAediting_1464280chr22_22819636_+exonic
CAediting_1464281chr22_22819660_+exonic
CAediting_1464282chr22_22819670_+exonic
CAediting_1464283chr22_22819684_+exonic
CAediting_1464284chr22_22819695_+exonic
CAediting_1464285chr22_22823039_+exonic
CAediting_1464286chr22_22823114_+exonic
CAediting_1464287chr22_22823131_+exonic
CAediting_1464288chr22_22823263_+exonic
CAediting_1464289chr22_22850448_+ncRNA_exonic
CAediting_1464290chr22_22850454_+ncRNA_exonic
CAediting_1464291chr22_22850470_+ncRNA_exonic
CAediting_1464292chr22_22850485_+ncRNA_exonic
CAediting_1464293chr22_22856857_+exonic
CAediting_1464294chr22_22856892_+exonic
CAediting_1464295chr22_22856985_+exonic
CAediting_1464296chr22_22871809_+exonic
CAediting_1464297chr22_22871818_+exonic
CAediting_1464298chr22_22881196_+exonic
CAediting_1464299chr22_22881224_+exonic
CAediting_1464300chr22_22881261_+exonic
CAediting_1464301chr22_22889657_+intronic
CAediting_1464302chr22_22889674_+intronic
CAediting_1464303chr22_22889731_+intronic
CAediting_1464304chr22_22889745_+intronic
CAediting_1464305chr22_22889753_+intronic
CAediting_1464306chr22_22889754_+intronic
CAediting_1464307chr22_22889797_+intronic
CAediting_1464308chr22_22894550_+intronic
CAediting_1464309chr22_22894571_+intronic
CAediting_1464310chr22_22894592_+intronic
CAediting_1464311chr22_22894599_+intronic
CAediting_1464312chr22_22895701_+UTR3
CAediting_1464313chr22_22895738_+UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1464301chr22_22889657_+SINEAluAluJo
CAediting_1464302chr22_22889674_+SINEAluAluJo
CAediting_1464303chr22_22889731_+SINEAluAluJo
CAediting_1464304chr22_22889745_+SINEAluAluJo
CAediting_1464305chr22_22889753_+SINEAluAluJo
CAediting_1464306chr22_22889754_+SINEAluAluJo
CAediting_1464307chr22_22889797_+SINEAluAluJo

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RNA A-to-I editing events in the alternative splicing sites for IGLL5

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
IRCAediting_1464313chr22_22895738_+22895716:228957383SS3+0iCACGGGAGCCTGGAGCTGCAGGA-35.16CACGGGAGCCTGGAGCTGCAGGG-33.66

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000254709.5.IGLL5.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000254709.5.IGLL5.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for IGLL5

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
BRCA.CAediting_1464279.ENSG00000254709.IGLL5.png
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COAD.CAediting_1464255.ENSG00000254709.IGLL5.png
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LUAD.CAediting_1464284.ENSG00000254709.IGLL5.png
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PAAD.CAediting_1464279.ENSG00000254709.IGLL5.png
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PAAD.CAediting_1464284.ENSG00000254709.IGLL5.png
Soverview

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Protein coding region RNA A-to-I editings for IGLL5

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for IGLL5

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1464312chr22_22895701_+ENSG00000254709.5ENST00000531372hsa-miR-425-3p22895695228957017mer-m82289568222895702145.00-16.53
CAediting_1464312chr22_22895701_+ENSG00000254709.5ENST00000531372hsa-miR-478522895698228957047mer-m82289568522895705148.00-20.42
CAediting_1464313chr22_22895738_+ENSG00000254709.5ENST00000532223hsa-miR-10a-5p22895733228957386mer2289571722895739148.00-24.92
CAediting_1464313chr22_22895738_+ENSG00000254709.5ENST00000532223hsa-miR-10b-5p22895733228957386mer2289571722895739140.00-23.86
CAediting_1464313chr22_22895738_+ENSG00000254709.5ENST00000532223hsa-miR-4725-5p22895733228957397mer-m82289572122895740162.00-25.65
CAediting_1464313chr22_22895738_+ENSG00000254709.5ENST00000532223hsa-miR-504-5p22895733228957397mer-m82289571822895740150.00-20.20
CAediting_1464313chr22_22895738_+ENSG00000254709.5ENST00000531372hsa-miR-10a-5p22895733228957386mer2289571722895739148.00-24.92
CAediting_1464313chr22_22895738_+ENSG00000254709.5ENST00000531372hsa-miR-10b-5p22895733228957386mer2289571722895739140.00-23.86
CAediting_1464313chr22_22895738_+ENSG00000254709.5ENST00000531372hsa-miR-4725-5p22895733228957397mer-m82289572122895740162.00-25.65
CAediting_1464313chr22_22895738_+ENSG00000254709.5ENST00000531372hsa-miR-504-5p22895733228957397mer-m82289571822895740150.00-20.20

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1464313chr22_22895738_+ENSG00000254709.5ENST00000532223hsa-miR-4713-3p22895735228957428mer-1a2289572222895742150-21.81
CAediting_1464313chr22_22895738_+ENSG00000254709.5ENST00000532223hsa-miR-769-3p22895736228957427mer-m82289572122895743153-25.07
CAediting_1464312chr22_22895701_+ENSG00000254709.5ENST00000531372hsa-miR-425922895697228957037mer-m82289568122895704148-15.87
CAediting_1464312chr22_22895701_+ENSG00000254709.5ENST00000531372hsa-miR-442522895696228957027mer-m82289568322895703145-14.74
CAediting_1464313chr22_22895738_+ENSG00000254709.5ENST00000531372hsa-miR-4713-3p22895735228957428mer-1a2289572222895742150-21.81
CAediting_1464312chr22_22895701_+ENSG00000254709.5ENST00000531372hsa-miR-57122895698228957047mer-m82289568522895705153-18.24
CAediting_1464313chr22_22895738_+ENSG00000254709.5ENST00000531372hsa-miR-769-3p22895736228957427mer-m82289572122895743153-25.07

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_442554chr5_154685830_+ENSG00000254709.5ENST00000532223hsa-miR-130322896001228960077mer-m82289598722896008162-21.41

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_86358chr1_109598906_+ENSG00000254709.5ENST00000531372hsa-miR-197-5p22895470228954767mer-m82289545722895477148-24.18

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for IGLL5

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for IGLL5

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
PAADCAediting_1464212chr22_22734889_+....0.02194906348344130.2755054376263
LUADCAediting_1464236chr22_22759200_+....0.006018838348303990.279861142164346
COADCAediting_1464236chr22_22759200_+0.0231089544681540.250687755970245....
KIRCCAediting_1464236chr22_22759200_+....0.04712859569538440.188860048699265
STADCAediting_1464241chr22_22772403_+....0.004342133225208630.372341739049713
KIRCCAediting_1464273chr22_22819540_+..0.04027735917222150.196783480027811..
COADCAediting_1464298chr22_22881196_+..0.001713282989948770.378748897051433..
KIRCCAediting_1464298chr22_22881196_+....0.02177961247402370.290949164767604

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Relation with cancer stages for IGLL5

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
HNSCclinical_stageCAediting_1464298chr22_22881196_+0.00217392326202406-0.397924809524275
LUADpathologic_stageCAediting_1464236chr22_22759200_+0.0466131612767548-0.204691712243036
LUADpathologic_stageCAediting_1464250chr22_22812081_+0.01013631187931810.275887505351741
LUSCpathologic_stageCAediting_1464227chr22_22747859_+0.04118858459554440.264423717088262

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Relation with survival for IGLL5

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for IGLL5

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IGLL5

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource