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| Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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| The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: HCN4 (CAeditome ID:10021) |
Gene summary for HCN4 |
 Gene summary |
| Gene information | Gene symbol | HCN4 | Gene ID | 10021 |
| Gene name | hyperpolarization activated cyclic nucleotide gated potassium channel 4 | |
| Synonyms | SSS2 | |
| Cytomap | 15q24.1 | |
| Type of gene | protein-coding | |
| Description | potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4hyperpolarization activated cyclic nucleotide-gated cation channel 4 | |
| Modification date | 20210518 | |
| UniProtAcc | Q9Y3Q4 | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| HCN4 | GO:0005222 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 10228147 |
| HCN4 | GO:0005222 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 12750403 |
| HCN4 | GO:0005222 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 16407510 |
| HCN4 | GO:0005249 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 16407510 |
| HCN4 | GO:0003254 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 12750403 |
| HCN4 | GO:0006812 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 12750403 |
| HCN4 | GO:0071320 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 12750403 |
| HCN4 | GO:0071320 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 16407510 |
| HCN4 | GO:0071320 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 22748890 |
| HCN4 | GO:0071321 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 22748890 |
| HCN4 | GO:0071805 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 16407510 |
| HCN4 | GO:0098719 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 10228147 |
| HCN4 | GO:1990573 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 10228147 |
| HCN4 | GO:0005886 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 12750403 |
| HCN4 | GO:0005886 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 22748890 |
| HCN4 | GO:0031226 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 16407510 |
| HCN4 | GO:0048471 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 12750403 |
| HCN4 | GO:0098855 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 10228147 |
| HCN4 | GO:0098855 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 16407510 |
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RNA A-to-I events for HCN4 |
| RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure. |
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| RNA editing frequencies across 33 cancers of gene: ENSG00000138622.3 |
| RNA A-to-I editing events in Cancer. |
| CAediting_1059749(73321385, -), CAediting_1059750(73321396, -), CAediting_1059751(73321512, -), |
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RNA editing positional annotations for HCN4 using Annovar |
| Protein coding RNA editing(s). |
| CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
| Gene structure information of RNA editing(s). |
| CAeditome ID | Position | Variant type |
| CAediting_1059749 | chr15_73321385_- | UTR3 |
| CAediting_1059750 | chr15_73321396_- | UTR3 |
| CAediting_1059751 | chr15_73321512_- | UTR3 |
| Repat-regional RNA editing(s). |
| CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
| CAediting_1059749 | chr15_73321385_- | SINE | MIR | MIRb |
| CAediting_1059750 | chr15_73321396_- | SINE | MIR | MIRb |
| CAediting_1059751 | chr15_73321512_- | SINE | MIR | MIRb |
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RNA A-to-I editing events in the alternative splicing sites for HCN4 |
| RNA A-to-I editing(s) in the alternative splicing sites. |
| AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
| Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000138622.3.HCN4. |
| Correlation between RNA A-to-I editing and PSI for ENSG00000138622.3.HCN4. |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for HCN4 |
| Differential gene expressions between RNA A-to-I edited and non-edited tumor samples. * The grey color means N/A. |
| Correlation between RNA A-to-I editing and gene expression. |
| - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples. * Click on the image to enlarge it in a new window. |
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Protein coding region RNA A-to-I editings for HCN4 |
| - Lollipop plot for RNA A-to-I editings across protein structure. * Click on the image to enlarge it in a new window. |
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The effects of the RNA editing to the miRNA binding sites for HCN4 |
| **If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
| RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| CAediting_1059749 | chr15_73321385_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-221-3p | 73321384 | 73321390 | 7mer-m8 | 73321383 | 73321403 | 151.00 | -18.70 |
| CAediting_1059749 | chr15_73321385_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-222-3p | 73321384 | 73321390 | 7mer-m8 | 73321383 | 73321400 | 147.00 | -17.64 |
| CAediting_1059751 | chr15_73321512_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-1271-3p | 73321508 | 73321514 | 7mer-m8 | 73321507 | 73321528 | 156.00 | -23.41 |
| CAediting_1059751 | chr15_73321512_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-221-5p | 73321511 | 73321517 | 7mer-m8 | 73321510 | 73321529 | 157.00 | -23.73 |
| CAediting_1059751 | chr15_73321512_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-3116 | 73321509 | 73321515 | 7mer-1a | 73321509 | 73321530 | 142.00 | -26.17 |
| CAediting_1059751 | chr15_73321512_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-3116 | 73321509 | 73321515 | 7mer-1a | 73321509 | 73321530 | 142.00 | -26.17 |
| CAediting_1059751 | chr15_73321512_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-33b-3p | 73321507 | 73321513 | 7mer-m8 | 73321506 | 73321528 | 166.00 | -28.43 |
| CAediting_1059751 | chr15_73321512_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-515-3p | 73321507 | 73321513 | 7mer-m8 | 73321506 | 73321526 | 146.00 | -17.49 |
| CAediting_1059751 | chr15_73321512_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-515-3p | 73321507 | 73321513 | 7mer-m8 | 73321506 | 73321526 | 146.00 | -17.49 |
| CAediting_1059751 | chr15_73321512_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-519e-3p | 73321507 | 73321513 | 7mer-m8 | 73321506 | 73321526 | 146.00 | -17.75 |
| CAediting_1059751 | chr15_73321512_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-550a-3-5p | 73321508 | 73321514 | 7mer-m8 | 73321507 | 73321528 | 151.00 | -21.64 |
| CAediting_1059751 | chr15_73321512_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-550a-5p | 73321508 | 73321514 | 7mer-m8 | 73321507 | 73321530 | 152.00 | -22.62 |
| CAediting_1059751 | chr15_73321512_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-550a-5p | 73321508 | 73321514 | 7mer-m8 | 73321507 | 73321530 | 152.00 | -22.62 |
| CAediting_1059751 | chr15_73321512_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-5588-5p | 73321512 | 73321517 | 6mer | 73321511 | 73321531 | 140.00 | -19.15 |
| CAediting_1059751 | chr15_73321512_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-8073 | 73321511 | 73321517 | 7mer-m8 | 73321510 | 73321531 | 157.00 | -24.46 |
| RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| CAediting_1059751 | chr15_73321512_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-12133 | 73321512 | 73321518 | 7mer-m8 | 73321511 | 73321539 | 142 | -15.99 |
| CAediting_1059750 | chr15_73321396_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-1299 | 73321393 | 73321400 | 8mer-1a | 73321393 | 73321414 | 140 | -11.83 |
| CAediting_1059751 | chr15_73321512_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-520f-3p | 73321507 | 73321513 | 7mer-m8 | 73321506 | 73321526 | 144 | -15.36 |
| CAediting_1059751 | chr15_73321512_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-636 | 73321508 | 73321514 | 7mer-m8 | 73321507 | 73321529 | 140 | -12.68 |
| CAediting_1059750 | chr15_73321396_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-875-3p | 73321394 | 73321401 | 8mer-1a | 73321394 | 73321418 | 146 | -16.42 |
| RNA A-to-I editing in lncRNA gained miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in lncRNA lost miRNA binding sites. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to lncRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs lost binding to lncRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| CAediting_688081 | chr9_63819627_+ | ENSG00000138622.3 | ENST00000261917 | hsa-miR-4477b | 73320891 | 73320897 | 7mer-m8 | 73320890 | 73320911 | 140 | -11.31 |
| CAediting_1054808 | chr15_66496985_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-4512 | 73321692 | 73321698 | 7mer-m8 | 73321691 | 73321711 | 144 | -20.44 |
| CAediting_1229413 | chr17_67471544_+ | ENSG00000138622.3 | ENST00000261917 | hsa-miR-548aa | 73321501 | 73321507 | 7mer-m8 | 73321500 | 73321520 | 145 | -12.57 |
| CAediting_396018 | chr5_1062918_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-4635 | 73321603 | 73321609 | 7mer-m8 | 73321602 | 73321622 | 146 | -15.51 |
| CAediting_524911 | chr7_5495852_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-589-3p | 73321518 | 73321524 | 7mer-m8 | 73321517 | 73321540 | 145 | -18.14 |
| CAediting_573001 | chr7_92204086_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-1285-5p | 73320385 | 73320392 | 8mer-1a | 73320385 | 73320405 | 143 | -24.66 |
| RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA. |
| CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
| CAediting_1306324 | chr19_13836464_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-27a-3p | 73322412 | 73322418 | 7mer-m8 | 73322411 | 73322428 | 141 | -10.42 |
| CAediting_468389 | chr6_31355314_- | ENSG00000138622.3 | ENST00000261917 | hsa-miR-6891-5p | 73321334 | 73321340 | 7mer-m8 | 73321333 | 73321353 | 143 | -23.01 |
| Differentially expressed gene-miRNA network |
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The effects of the RNA editing to the stability of the RNA structures for HCN4 |
| - RNA A-to-I editing in mRNA. * Click on the image to enlarge it in a new window. |
| ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
| RNA A-to-I editing in RNA structures for Minimum free energy (MFE). |
| CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for HCN4 |
| Correlation between ADAR gene expression and RNA editing frequency |
| Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
| PCPG | CAediting_1059750 | chr15_73321396_- | 0.0414429595726195 | 0.253684222087258 | . | . | . | . |
| TGCT | CAediting_1059750 | chr15_73321396_- | 0.00241666240315361 | 0.362022687556815 | . | . | . | . |
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Relation with cancer stages for HCN4 |
| Correlation between Cancer stages and RNA editing frequency |
| Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for HCN4 |
| Correlation between RNA editing and survival |
| Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for HCN4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.8 2021-01-03) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HCN4 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| HCN4 | C1834144 | Sick Sinus Syndrome 2, Autosomal Dominant | 7 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| HCN4 | C0264893 | Nodal rhythm disorder | 4 | CLINGEN |
| HCN4 | C0348626 | Other specified cardiac arrhythmias | 4 | CLINGEN |
| HCN4 | C0428908 | Sinus Node Dysfunction (disorder) | 4 | CLINGEN |
| HCN4 | C1142166 | Brugada Syndrome (disorder) | 4 | CLINGEN |
| HCN4 | C1399226 | Ectopic rhythm | 4 | CLINGEN |
| HCN4 | C2748542 | CARDIAC CONDUCTION DEFECT, NONSPECIFIC (disorder) | 4 | CLINGEN |
| HCN4 | C4551804 | Brugada Syndrome 1 | 4 | CLINGEN |
| HCN4 | C2751083 | Brugada Syndrome 8 | 3 | CTD_human;GENOMICS_ENGLAND |
| HCN4 | C0004238 | Atrial Fibrillation | 2 | CTD_human |
| HCN4 | C0235480 | Paroxysmal atrial fibrillation | 2 | CTD_human |
| HCN4 | C2585653 | Persistent atrial fibrillation | 2 | CTD_human |
| HCN4 | C3468561 | familial atrial fibrillation | 2 | CTD_human |
| HCN4 | C4707243 | Familial thoracic aortic aneurysm and aortic dissection | 2 | CLINGEN;GENOMICS_ENGLAND |
| HCN4 | C0525045 | Mood Disorders | 1 | PSYGENET |
