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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000278126

Summary for RP11-454E5.4

check button Gene summary

Gene informationEnsembl ID

ENSG00000278126

Gene symbol

RP11-454E5.4

Gene name
HGNC
Entrez ID
Gene typesense_intronic
Synonyms
UniProtAcc

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Structure and expression level for RP11-454E5.4

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002781264.773175e+01-2.015516e+004.697086e-01-4.290992e+001.780000e-052.892380e-04DOWNCESC

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002781265.708198e-014.231636e-05CHOL1.651923e-04

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lncRNA-Protein interaction for RP11-454E5.4

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

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lncRNA-DNA interaction for RP11-454E5.4

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
TSPYL2,FKBP8,EPOR,ATG13,ARFIP2,THAP4,PRPSAP2,MCRS1,ABHD17A,DNAJC27,CIRBP,PET100,WDR83OS,LYSMD4,KLF2,CACFD1,PPP2R3B,N4BP2L2,BCS1L,ACD,XAB2,MRPL46,ISCU,BCCIP,ACSS1,NDUFA11,SMUG1,MSANTD2,TUBGCP6,FAM200A,LIMS2,OSER1,C6orf136,EIF2B5,SLC2A11,SUGP1,SPG7,NAA80,C19orf44,BAHD1,SIAH1,PPIP5K1,CCNB1IP1,BNIP1,RAB4B,TARBP2,ILKAP,LYRM4,SSU72,CHKB,RIC8B,FANCE,CBY1,WDR83,C3orf18,ANKRD39,PDZD4,BABAM1,ACYP1,CFAP298,TSSC4,DDX49,NAPB,C3orf62,YJU2,CBX7,ZFP62,ALKBH2,ANAPC5,ZBED8,BORCS6,ORMDL1,COQ7,C22orf39,C12orf73,DDX51,AGER,ESS2,FBXW4,TFCP2,TSEN54,LRRC37B,ATG4B,MRPL57,DCUN1D2,PAN2,C2orf76,TEAD2,PFDN5,TIMM10B,FAM193B,SLC25A28,ARFGAP2,CZIB,DMAC2L,HDAC5,N4BP2L1,ELOF1,LNP1,HEXD,SDHAF2,TMEM50B,CCDC24,MRPS25,CCDC12,KAT14,FAM204A,TDRP,ALKBH3,KIF12,RSL24D1,ZNF30,ADO,TRMO,GLI4,SH2B1,FAM98C,NICN1,IP6K2,ZC3H10,IFTAP,MLLT6,PIGH,C9orf78,CAPN10,LARP6,APBB1,CTDSP1,CCDC59,SURF1,TMEM175,PTGES2,C11orf68,TNK2,SEPTIN4,TAMM41,IMP4,ZNF44,TMEM116,MTURN,RIMKLB,ANAPC13,TCTA,CCDC106,MED27,FBXO44,NELFE,GLT8D1,PATZ1,PCED1A,TUSC2,SPRYD3,TARS3,LMF1,UBOX5,DNAJC19,LENG1,DENND6B,ATF4,INPP5E,TOMM22,PPM1K,SGF29,NEK8,ZSWIM1,FIZ1,VPS4A,SERP2,MED19,HEMK1,POMGNT2,TMEM199,PTOV1,PYURF,NDUFA12,C18orf32,NDUFAF5,RBM6,AP5S1,PISD,TMEM134,POP5,CRMP1,NTHL1,GDI1,UBXN6,CUEDC2,MKKS,UBAC1,GGT7,UCKL1,GSTA4,UBXN11,PPCDC,CERS5,RSAD1,PPP1R26,RP9,ARHGEF25,EMC10,ENKD1,ZNF10,NISCH,MORN2,POMT1,YTHDF1,CDPF1,DPY19L2,KATNBL1,MKS1,CDK5RAP1,NME5,IFT88,NPRL2,LARGE2,CLK3,C14orf28,ANKRD10,UQCRB,SGSM3,COQ4,CCDC32,PBXIP1,ARMC5,ST6GALNAC6,SNU13,LRRC23,RBPMS,ZBTB3,BLCAP,BSG,RAMP2,POLI,ELP6,ZNF34,ERMARD,RNF114,PHF1,SAP30L,SNX21,TMEM128,HEXIM2,TGIF2,ARGLU1,NEPRO,UCK1,SMDT1,ANKRD54,RNF25,ZFYVE21,HSPBAP1,YAE1,CENPS,RPS6,PBX4,TMUB2,ZNF3,CIAO2B,TBC1D20,MYL6B,C19orf25,SMARCD1,MYG1,ABHD10,DDX5,DTX3,MTG2,RNF215,GIN1,TLE5,LIPT1,ABHD14A,CRAMP1,LUC7L,COA5,MROH1,C14orf93,LRSAM1,DPH7,MAPKAPK5,FUNDC2,MRPL43,POLR3F,XPA,GPS1,STX2,RWDD2A,ADAL,IMMP1L,C15orf61,RPS29,SLC25A27,TXN2,MRPS26,SERGEF,C7orf31,SNAI3,RRNAD1,CCDC92,ZSWIM7,TRIM39,NEK3,CSAD,KIAA0895L,ZNF77,MYL9,BANF1,TMEM259,FRA10AC1,FBXO10,VPS37B,LIN37,OGA,IFT27,RECQL5,PMF1,NIPSNAP3B,ASB6,LRRC75B,SS18L2,TBC1D17,DCAF16,ARL3,NT5C3B,RNH1,UBE2D4,TM2D3,OSGEPL1,SHC2,SPPL3,DTNB,YAF2,DNAJB2,MRPS31,BEND5,C20orf27,EZH1,TTLL1,TMEM9B,ARVCF,LIAS,IFT46,C12orf76,POLL,FAM228B,WASHC1,WDR61,TIGD1,KLC1,AP3S2,GPS2,TRIM52,NDUFC1,COA8,NOL12,CRYZL1,SUPT3H,CLASRP,TTC32,COMMD6,SS18,RPS24,TAPT1,SETD4,SORBS3,TYSND1,GMEB2,RBM5,BOLA1,RPS19BP1,YPEL3,BCDIN3D,TMEM11,GNG7,ATP5MC2,RXRB,PARP6,DGCR6L,PRPF40B,SIRT6,DXO,USP20,MRFAP1L1
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.
Only predicted by TDF
ANKRD39,SGSM3,DPH7,C22orf39,RP9,APITD1,VPS4A,TTLL1,TEAD2,OSGEPL1,LYSMD4,FAM204A,PISD,ZNF3,EID2B,ZNF30,C3orf18,ATG13,CFAP36,SORBS3,STX16,SNTA1,CUEDC2,HEMK1,ELOF1,MRPS31,RBM5,E4F1,DYNLRB1,DGCR14,NICN1,SS18,UBXN6,C19orf44,FAM73B,THAP7,IL3RA,PRPF40B,KLF2,VPS37D,BEND5,CRYZL1,MCRS1,TUSC2,RIMKLB,SRP14,CLASRP,LUC7L,C14orf79,TMEM134,C3orf62,ZSWIM1,BANF1,TRMO,PTDSS2,ZFP2,SRSF5,MANBAL,SETD4,NEK3,CRTC1,CIRBP,PPCDC,ZSWIM7,ELAC1,PBX4,GGA1,CCDC130,C19orf25,MAGEF1,ARIH2,C21orf59,COMMD3,ING5,ST6GALNAC6,SLC25A35,TFCP2,POMT1,BABAM1,GMPR,SLC25A38,SGF29,ARIH2OS,RBM6,TMEM50B,ALKBH2,FKBP8
Exist in public source
NA

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for RP11-454E5.4

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
PNPO,ECT2,LDHA,SPATS2L,FAH,FCGR2A,MYOF,TMOD3,TNFRSF1A,PLIN3,CDCP1,AP2A1,UGGT1,RTCA,IQGAP1,TPM3,RIN3,ERO1A,TUBA1C,SEC23A,GALNT7,DPP3,FNDC3B,ACTR2,ITGB4,BAZ1A,NRDC
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
lncRNA and exonskipping events positive correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation
ENSG00000278126ENST00000620274exon_skip_150854chr17:32366664-32366757-12.59-0.1517ZNF207ENST00000321233In-frame
ENSG00000278126ENST00000620274exon_skip_83395chr12:53464759-53464852-12.30-0.1430PCBP2ENST00000439930In-frame

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000278126ENST00000620274exon_skip_7523chr1:78660553-78660654-11.12-0.1135IFI44ENST00000370747Frame-shift
ENSG00000278126ENST00000620274exon_skip_81515chr12:42351884-42352049-11.78-0.1081PPHLN1ENST00000395568In-frame
ENSG00000278126ENST00000620274exon_skip_131398chr15:101286213-101286293-11.30-0.2825SNRPA1ENST00000254193Frame-shift
ENSG00000278126ENST00000620274exon_skip_324294chr2:27774423-27774530-11.22-0.1476MRPL33ENST00000296102Frame-shift
ENSG00000278126ENST00000620274exon_skip_361485chr21:29008239-29008307-10.51-0.2502RWDD2BENST00000493196Frame-shift

check buttonlncRNA targets by miRNA.
lncRNA targets by miRNA
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source
ENSG00000278126hsa-mir-3677ENST00000620274chr12:51202297-51202354194.00-59.2652NA
ENSG00000278126hsa-mir-3677ENST00000620274chr12:51201832-51201889165.00-53.5355NA
ENSG00000278126hsa-mir-3677ENST00000620274chr12:51202168-51202225144.00-60.6158NA
ENSG00000278126hsa-mir-378aENST00000620274chr12:51202117-51202186197.00-70.1367NA
ENSG00000278126hsa-mir-378aENST00000620274chr12:51202446-51202510165.00-62.3561NA
ENSG00000278126hsa-mir-378aENST00000620274chr12:51201685-51201716155.00-52.8332NA
ENSG00000278126hsa-mir-378aENST00000620274chr12:51201753-51201825149.00-68.6438NA
ENSG00000278126hsa-mir-744ENST00000620274chr12:51202084-51202173181.00-77.4797NA
ENSG00000278126hsa-mir-744ENST00000620274chr12:51202300-51202389169.00-83.8292NA
ENSG00000278126hsa-mir-744ENST00000620274chr12:51201767-51201868168.00-89.8186NA
ENSG00000278126hsa-mir-744ENST00000620274chr12:51202404-51202495166.00-68.7385NA
ENSG00000278126hsa-mir-744ENST00000620274chr12:51201977-51202063149.00-61.4595NA
ENSG00000278126hsa-mir-744ENST00000620274chr12:51202168-51202267142.00-78.51104NA
ENSG00000278126hsa-mir-940ENST00000620274chr12:51202300-51202390168.00-97.4588NA
ENSG00000278126hsa-mir-940ENST00000620274chr12:51201835-51201925163.00-91.0290NA
ENSG00000278126hsa-mir-940ENST00000620274chr12:51202095-51202179150.00-90.9389NA

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Variants for RP11-454E5.4

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation
ENSG00000278126ENSG00000032742IFT88ACC,CESC,LUSC,PAAD,THCACESC
ENSG00000278126ENSG00000100307CBX7ACC,BRCA,CESC,CHOL,DLBC,KICH,KIRC,LUAD,LUSC,PAAD,THYMCESC
ENSG00000278126ENSG00000111450STX2ACC,CESC,KIRP,LUSC,PAAD,TGCT,THCACESC
ENSG00000278126ENSG00000163644PPM1KACC,CESC,CHOL,LUSC,PAADCESC
ENSG00000278126ENSG00000179476C14orf28ACC,CESC,CHOL,LGG,THCA,THYM,UVMCESC
ENSG00000278126ENSG00000214941ZSWIM7ACC,CESC,CHOL,LGG,LUSCCESC
ENSG00000278126ENSG00000072163LIMS2BRCA,CESC,CHOL,DLBC,KIRP,LGG,LUAD,LUSCCESC
ENSG00000278126ENSG00000101335MYL9BRCA,CESC,DLBC,SARC,THYMCESC
ENSG00000278126ENSG00000120896SORBS3BRCA,CESC,LGG,PAAD,THCA,THYM,UCECCESC
ENSG00000278126ENSG00000131477RAMP2BRCA,CESC,CHOL,LGG,LUAD,LUSC,PAAD,THYMCESC
ENSG00000278126ENSG00000136003ISCUBRCA,CESC,CHOL,KIRC,LUSC,PAAD,UCEC,UCSCESC
ENSG00000278126ENSG00000139597N4BP2L1BRCA,CESC,KIRP,LUSC,PAAD,UCECCESC
ENSG00000278126ENSG00000160408ST6GALNAC6BRCA,CESC,DLBC,PAAD,THYMCESC
ENSG00000278126ENSG00000162384CZIBBRCA,CESC,CHOL,PAAD,THCA,UCEC,UCSCESC
ENSG00000278126ENSG00000166313APBB1BRCA,CESC,CHOL,KIRP,PAAD,UCECCESC
ENSG00000278126ENSG00000184205TSPYL2BRCA,CESC,LUAD,LUSC,PAAD,UCECCESC
ENSG00000278126ENSG00000240771ARHGEF25BRCA,CESC,CHOL,PAAD,UCEC,UCSCESC
ENSG00000278126ENSG00000119242CCDC92CESC,CHOL,KIRP,LUSC,PAADCESC
ENSG00000278126ENSG00000129158SERGEFCESC,CHOL,DLBC,KIRP,PAADCESC
ENSG00000278126ENSG00000144182LIPT1CESC,CHOL,KIRP,TGCT,THCA,THYMCESC
ENSG00000278126ENSG00000169762TAPT1CESC,KICH,LUAD,LUSC,PAAD,THCA,UCSCESC
ENSG00000278126ENSG00000175573C11orf68CESC,CHOL,DLBC,KICH,KIRP,LGGCESC
ENSG00000278126ENSG00000178498DTX3CESC,CHOL,KICH,KIRC,KIRP,PAAD,THCA,UCEC,UCSCESC
ENSG00000278126ENSG00000180354MTURNCESC,CHOL,KICH,KIRC,PAAD,TGCT,THCACESC

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation
ENSG00000278126ENST00000620274CDCP1ENSG00000163814ENST00000296129-0.14321CESC-
ENSG00000278126ENST00000620274TUBA1CENSG00000167553ENST00000549818-0.457352CESC-

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types
ENSG00000278126RP11-454E5.4,hsa-mir-378a,SCAMP4KICH,CHOL,GBM,PAAD,KIRP
ENSG00000278126RP11-454E5.4,hsa-mir-744,SELENOSKICH,TGCT,LGG,GBM,THYM
ENSG00000278126RP11-454E5.4,hsa-mir-744,PLEKHH1KICH,TGCT,ACC,GBM,THYM
ENSG00000278126RP11-454E5.4,hsa-mir-744,FBXO8KICH,TGCT,LGG,ACC,GBM
ENSG00000278126RP11-454E5.4,hsa-mir-744,TMEM259KICH,TGCT,LGG,ACC,GBM
ENSG00000278126RP11-454E5.4,hsa-mir-744,TMEM9BKICH,TGCT,LGG,GBM,THYM

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000278126.1ENST00000620274.152405247