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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000272913

Summary for RP11-440D17.3

check button Gene summary

Gene informationEnsembl ID

ENSG00000272913

Gene symbol

RP11-440D17.3

Gene name
HGNC
Entrez ID
Gene typelincRNA
Synonyms
UniProtAcc

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Structure and expression level for RP11-440D17.3

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002729131.710026e+021.335597e+004.164197e-013.207334e+001.339713e-034.881402e-03UPGBM
ENSG000002729132.626363e+02-1.019522e+002.799265e-01-3.642108e+002.704150e-047.197570e-04DOWNKICH
ENSG000002729131.864211e+021.280375e+002.775700e-014.612801e+003.970000e-063.050000e-05UPBLCA
ENSG000002729132.968818e+021.255456e+001.044827e-011.201592e+012.930000e-336.950000e-32UPLUAD

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002729134.046878e-015.826606e-03CHOL7.357621e-03
ENSG00000272913-5.577602e-011.361943e-08KICH7.128093e-08

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lncRNA-Protein interaction for RP11-440D17.3

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000117139KDM5B64.0495.6871Q9UGL1TF,EpiNA

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000117139KDM5B64.0491.9022Q9UGL1TF,EpiNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000166888STAT661.8993.7718P42226TFNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000115816CEBPZ53.3493.1048Q03701TFNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000198521ZNF4340.6291.993P17038TFNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000186416NKRF37.6690.432O15226TFNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000236287ZBED530.1993.4552Q49AG3TFNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000204231RXRB27.0191.4982P28702TFNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000213676ATF6B25.8891.9966Q99941TFNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000198538ZNF2825.8591.2438P17035TFNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000135457TFCP220.2894.0901Q12800TFNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000140632GLYR119.2693.2802Q49A26TF,EpiNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000197857ZNF4418.691.8952P15621TFNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000104221BRF26.3891.3201Q9HAW0TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000009307CSDE174.9391.5335O75534RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000134698AGO465.0592.0467Q9HCK5RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000213079SCAF860.5191.1134Q9UPN6RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000068784SRBD159.3794.7418Q8N5C6RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000079785DDX157.294.4087Q92499RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000165934CPSF255.3295.4998Q9P2I0RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000121057AKAP154.6391.7145Q92667RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000091009RBM2753.5196.3262Q9P2N5RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000136381IREB252.9794.632P48200RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000021776AQR46.6796.0895O60306RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000092847AGO144.4990.8677Q9UL18RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000135870RC3H139.1893.9343Q5TC82RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000119203CPSF330.692.2054Q9UKF6RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000244462RBM1228.8894.5992Q9NTZ6RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000184898RBM4324.9390.6247Q6ZSC3RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000088205DDX1820.8791.9915Q9NVP1RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000140694PARN17.6991.6643O95453RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000111364DDX5515.9892.877Q8NHQ9RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000080802CNOT415.0793.7621O95628RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000118197DDX5911.4292.2305Q5T1V6RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000065457ADAT19.6491.7344Q9BUB4RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000278053DDX527.4492.11Q9Y2R4RBPNA
ENSG00000272913ENST00000609975RP11-440D17.3ENSG00000101138CSTF12.8292.4898Q05048RBPNA

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lncRNA-DNA interaction for RP11-440D17.3

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
ZNF30,CEBPZ,PUM1,ILF3,PBX2,RBM39,THAP4,GLYR1,MZF1,MYSM1,NRF1,CSDE1,AKAP8,ZNF2,KAT7,ARID2,ZXDC,SUGP2,TRUB2,DMTF1,VEZF1,RBM27,DDX52,RBM28,ATF6B,TBP,GABPA,DDX55,TET3,ZBTB5,SRP68,ZFP14,RNPC3,KDM5B,ATMIN,LARP7,PNPT1,CNOT4,SON,CHTOP,TFAP4,DDX59,CWC22,ZBED5,ZZZ3,PNO1,MLX,ZBED3,RBM4,CREB1,RC3H1,PCBP2,MRM1,SP100,ZNF44,RBM4B,U2AF2,CSTF3,TIGD6,ZFP1,TCFL5,ERAL1,GZF1,ADNP,NCBP1,TERF2,MBD1,ASH1L,NFYC,DHX34,ASCC1,FUBP1,RBM43,SF3B6,AGFG1,DDX6,TSN,ZBTB6,THAP6,PATZ1,ZBTB2,CSTF1,PUS7,E2F6,BRF2,AQR,ZNF22,SP2,FOXJ3,SRSF9,ZC3H8,TTF1,SART3,THAP1,SRBD1,ILF2,IRF2,NIP7,ZFP62,MEX3D,ZNF48,PARN,PAIP1,ZNF28,CPSF2,ZNF45,CELF1,ELK4,RTCA,RBM45,TIGD1,NFXL1,RBM18,UNC50,MBD6,DDX31,MYNN,TFCP2,ZFR,ZNF3,STAU1,ZNF18,NKRF,EIF2D,SIX5,STAT6,C1D,CPSF3,ZNF14,RFX1,KHDC1,RBM48,PUM2,XPO1,ELF2,SMAD4,NFYB,ZNF43,MTF1,SP3,ZNF84,DDX42,RXRB,TRA2A,CSTF2,NAIF1,AKAP1,HINFP,TFDP2,ZFP3,ADAT1,SFPQ,XPO5,ETV3,TDRKH,NOL8,ATF2
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for RP11-440D17.3

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
lncRNA and exonskipping events positive correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation
ENSG00000272913ENST00000609975exon_skip_84780chr12:57720098-57720263-23.52-0.1452OS9ENST00000315970In-frame

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000272913ENST00000609975exon_skip_462160chr6:127316449-127316502-11.78-0.2945ECHDC1ENST00000531967Frame-shift

check buttonlncRNA targets by miRNA.
lncRNA targets by miRNA
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source
ENSG00000272913hsa-mir-1258ENST00000609975chr2:95526361-95526437185.00-105.7373NA
ENSG00000272913hsa-mir-1258ENST00000609975chr2:95526100-95526168177.00-92.6372NA
ENSG00000272913hsa-mir-1258ENST00000609975chr2:95525171-95525241170.00-107.1473NA
ENSG00000272913hsa-mir-1258ENST00000609975chr2:95525829-95525909164.00-95.6676NA
ENSG00000272913hsa-mir-1258ENST00000609975chr2:95525314-95525394161.00-96.2378NA
ENSG00000272913hsa-mir-1258ENST00000609975chr2:95525529-95525608157.00-92.0377NA
ENSG00000272913hsa-mir-1258ENST00000609975chr2:95525920-95525989155.00-87.7171NA
ENSG00000272913hsa-mir-1258ENST00000609975chr2:95525698-95525772152.00-90.0176NA
ENSG00000272913hsa-mir-1258ENST00000609975chr2:95526169-95526233147.00-82.8466NA
ENSG00000272913hsa-mir-1258ENST00000609975chr2:95526253-95526328141.00-99.0771NA
ENSG00000272913hsa-mir-1258ENST00000609975chr2:95525110-95525167140.00-90.2856NA
ENSG00000272913hsa-mir-378aENST00000609975chr2:95525293-95525364183.00-75.0162NA
ENSG00000272913hsa-mir-378aENST00000609975chr2:95525841-95525907179.00-68.0564NA
ENSG00000272913hsa-mir-378aENST00000609975chr2:95526276-95526345167.00-67.8869NA
ENSG00000272913hsa-mir-378aENST00000609975chr2:95525638-95525702165.00-56.1562NA
ENSG00000272913hsa-mir-378aENST00000609975chr2:95525191-95525275162.00-81.2682NA
ENSG00000272913hsa-mir-378aENST00000609975chr2:95526160-95526231160.00-62.3771NA
ENSG00000272913hsa-mir-378aENST00000609975chr2:95525360-95525423156.00-70.8567NA
ENSG00000272913hsa-mir-378aENST00000609975chr2:95525113-95525191154.00-80.5972NA
ENSG00000272913hsa-mir-378aENST00000609975chr2:95526436-95526504153.00-85.3361NA
ENSG00000272913hsa-mir-378aENST00000609975chr2:95525966-95526027149.00-65.5758NA

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Variants for RP11-440D17.3

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types
ENSG00000272913RP11-440D17.3,hsa-mir-1258,NCSTNKICH,CHOL,GBM,DLBC,LIHC
ENSG00000272913RP11-440D17.3,hsa-mir-1258,VPS54KICH,CHOL,GBM,DLBC,LIHC
ENSG00000272913RP11-440D17.3,hsa-mir-378a,TMEM9BCHOL,BRCA,UVM,GBM,DLBC

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000272913.1ENST00000609975.157299126