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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000271646

Summary for IRF2-DT

check button Gene summary

Gene informationEnsembl ID

ENSG00000271646

Gene symbol

IRF2-DT

Gene nameIRF2 divergent transcript
HGNC

54871

Entrez ID
Gene typelincRNA
SynonymsIRF2-DT|04q35.1|RP11-326I11.3
UniProtAcc

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Structure and expression level for IRF2-DT

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002716461.536772e+02-1.307221e+003.516809e-01-3.717067e+002.015490e-043.224354e-03DOWNPCPG

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG00000271646-5.524915e-011.984938e-08KICH9.875679e-08

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lncRNA-Protein interaction for IRF2-DT

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000167967E4F178.6593.3714Q66K89TFNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000130254SAFB275.6497.3116Q14151TF,RBPNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000067066SP10072.9795.4791P23497TF,EpiNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000116731PRDM268.5595.8193Q13029TF,EpiNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000135899SP11066.7895.0793Q9HB58TFNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000099326MZF162.7991.953P28698TFNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000204231RXRB58.0590.8787P28702TFNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000070476ZXDC55.6493.5586Q2QGD7TFNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000154832CXXC152.5495.441Q9P0U4TF,EpiNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000172273HINFP46.8392.1709Q9BQA5TF,EpiNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000197857ZNF4442.995.8316P15621TFNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000065029ZNF7637.9192.4004P36508TFNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000184939ZFP9037.0794.584Q8TF47TFNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000185507IRF737.0490.835Q92985TFNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000112592TBP36.9391.4836P20226TFNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000186272ZNF1734.795.0099P17021TFNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000166432ZMAT130.4792.7525Q5H9K5TFNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000256223ZNF1029.8494.2678P21506TFNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000154957ZNF1827.5791.1229P17022TFNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000275111ZNF28.3793.1757Q9BSG1TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000130254SAFB275.6497.1876Q14151TF,RBPNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000004534RBM675.4996.6771P78332RBPNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000100650SRSF564.4994.0279Q13243RBPNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000108771DHX5860.492.194Q96C10RBPNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000100201DDX1748.9395.1936Q92841RBPNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000116560SFPQ41.1993.1486P23246RBP,EpiNA
ENSG00000271646ENST00000605834RP11-326I11.3ENSG00000150316CWC1522.894.1852Q9P013RBPNA

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lncRNA-DNA interaction for IRF2-DT

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
CHTOP,PHF1,RBM6,ZBED5,HMGN3,KHDC1,PBX2,CENPT,TTC14,DDX60,DZIP3,RBM5,CIRBP,ELF2,SP100,IRF2,SUGP1,ZNF44,MZF1,NRF1,RFX5,ZNF17,ZNF2,ZXDC,SUGP2,RBM4B,RBPMS,CSTF3,RXRB,TIGD6,TIGD1,PRDM2,RBM14,ZBTB3,RBM8A,MBD4,CWC15,NFYC,NFIA,HINFP,TBP,XPA,SALL2,PPIE,RBM43,CPSF7,MBD2,ZMAT1,DHX58,SFPQ,IRF7,GATA3,CXXC1,NSUN6,SP110,NXF1,SAFB2,THAP6,THOC1,ZNF18,DDX17,MOV10,LARP7,ZNF10
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.
Only predicted by TDF
GMEB1,TBP,DDX17,MZF1,THAP6,SP110,ZNF18,E4F1,IRF5,CXXC1,ZMAT1,MBNL1,TIGD6,SRSF5,KHDC1,CPSF7,RBM6,DHX30,PBX2,DDX60,NFIA,RXRB,CIRBP,ELF2
Exist in public source
NA

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for IRF2-DT

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for IRF2-DT

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name
LncEditing_146038ENSG00000271646.1chr4184476145+lincRNARP11-326I11.3ENST00000605834.1lincRNARP11-326I11.3-001

check buttonEdited-associated DElncRNAs in cancer.
Differentially expressed gene
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange
ENSG00000271646LncEditing_146038OVchr4_184476145_+3.849742e+001.885791e+009.712587e-011.012586e+014.242297e-242.836940e-23UP

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value
ENSG00000271646LncEditing_146038-5.737914e-011.020518e-022.009555e-02

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types
ENSG00000271646ENSG00000070476ZXDCENSG00000100201DDX175DLBC,KICH,KIRP,PAAD,THCA
ENSG00000271646ENSG00000067066SP100ENSG00000174796THAP65DLBC,GBM,KICH,MESO,SKCM
ENSG00000271646ENSG00000070476ZXDCENSG00000174796THAP65DLBC,KICH,KIRP,PAAD,THCA
ENSG00000271646ENSG00000065029ZNF76ENSG00000166432ZMAT15CESC,KIRP,PAAD,PRAD,THCA
ENSG00000271646ENSG00000065029ZNF76ENSG00000100650SRSF56CESC,KIRP,LUAD,PAAD,SARC,THCA
ENSG00000271646ENSG00000070476ZXDCENSG00000004534RBM65DLBC,KICH,KIRP,PAAD,THCA
ENSG00000271646ENSG00000065029ZNF76ENSG00000204304PBX25ESCA,KICH,KIRP,PAAD,THCA
ENSG00000271646ENSG00000065029ZNF76ENSG00000204231RXRB5CESC,KICH,KIRC,PAAD,THCA
ENSG00000271646ENSG00000166432ZMAT1ENSG00000109381ELF25CESC,DLBC,KIRP,PAAD,THCA

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000271646.1ENST00000605834.15165220