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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000269958

Summary for RP11-73M18.8

check button Gene summary

Gene informationEnsembl ID

ENSG00000269958

Gene symbol

RP11-73M18.8

Gene name
HGNC
Entrez ID
Gene typesense_intronic
Synonyms
UniProtAcc

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Structure and expression level for RP11-73M18.8

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002699583.001055e+021.102883e+008.895243e-021.239857e+012.660000e-353.500000e-34UPKIRC

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002699586.494630e-011.387987e-06CHOL2.288818e-05
ENSG000002699583.601337e-011.078339e-13LIHC9.067851e-13

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lncRNA-Protein interaction for RP11-73M18.8

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000132780NASP70.395.4382P49321EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000104885DOT1L50.6297.2191Q8TEK3TF,EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000001497LAS1L50.694.3741Q9Y4W2EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000154832CXXC142.2693.8962Q9P0U4TF,EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000078487ZCWPW135.3793.9943Q9H0M4EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000161036LRWD125.1593.4876Q9UFC0EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000083544TDRD322.895.5414Q9H7E2RBP,EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000101945SUV39H114.8292.8472O43463EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000105619TFPT13.4996.0658P0C1Z6EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000275023MLLT663.0295.9495P55198EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000108799EZH148.896.6379Q92800EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000197114ZGPAT28.8891.3386Q8N5A5TF,EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000115241PPM1G15.7993.978O15355EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000134046MBD214.6391.2911Q9UBB5TF,EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000156858PRR1411.893.0563Q9BWN1EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000172530BANP6.6895.2154Q8N9N5EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000132275RRP85.7291.8034O43159EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000156860FBRS5.1890.0271Q9HAH7EpiNA

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000167967E4F166.392.4945Q66K89TFNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000130254SAFB264.3991.5055Q14151TF,RBPENCODE
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000099326MZF152.4595.0001P28698TFNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000104885DOT1L50.6297.2375Q8TEK3TF,EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000141258SGSM247.1893.0075O43147TFNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000154832CXXC142.2693.7282Q9P0U4TF,EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000197114ZGPAT28.8893.1435Q8N5A5TF,EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000256223ZNF1014.7693.5563P21506TFNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000134046MBD214.6390.1563Q9UBB5TF,EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000167766ZNF838.3994.3391P51522TFNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000105717PBX47.9193.2834Q9BYU1TFNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000187815ZFP696.9292.2368Q49AA0TFNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000221944TIGD16.6192.7988Q96MW7TFNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000102878HSF46.293.6786Q9ULV5TFNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000154957ZNF186.0991.4764P17022TFNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000138073PREB4.9993.8213Q9HCU5TFNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000126456IRF32.892.5484Q14653TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000130254SAFB264.3991.5041Q14151TF,RBPENCODE
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000004534RBM663.8295.8655P78332RBPNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000122965RBM1961.4295.8793Q9Y4C8RBPNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000162775RBM1547.8890.8822Q96T37RBPENCODE
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000079134THOC142.8493.3531Q96FV9RBPNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000135870RC3H138.7594.2354Q5TC82RBPNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000084072PPIE36.892.414Q9UNP9RBPNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000177971IMP333.5292.8775Q9NV31RBPNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000160917CPSF428.3492.1172O95639RBPNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000099622CIRBP23.5390.6311Q14011RBPNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000083544TDRD322.895.4308Q9H7E2RBP,EpiNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000179151EDC316.5594.4261Q96F86RBPNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000150316CWC1515.6790.3058Q9P013RBPNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000278619MRM114.7790.2024Q6IN84RBPNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000125970RALY7.0392.8789Q9UKM9RBPNA
ENSG00000269958ENST00000602422RP11-73M18.8ENSG00000172795DCP23.3293.0655Q8IU60RBPNA

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lncRNA-DNA interaction for RP11-73M18.8

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for RP11-73M18.8

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
CNOT1,NEK4,RBBP4,SINHCAF,VPS26C,TRAP1,CES2,PNPO,GET3,UHRF1BP1L,RNF123,HACD3,PFKM,SENP2,RNF40,EPB41,PCDHGC3,GNL3L,DHX40,EHBP1,CEP104,TSR1,HPS3,EIF4G1,RAB7A,SERP1,ATP6V0C,PUM1,OS9,C1orf43,RABL3,L2HGDH,RAB3IP,VGLL4,LZIC,THTPA,EXOC7,M6PR,ATP2C1,MFSD6,ANAPC1,PMS2,APAF1,FBXO21,ILK,FLT1,NMNAT3,TUBGCP4,GOLIM4,PC,KIDINS220,DOCK7,WBP11,RFFL,ARNT,ABAT,BRD3,BCKDHA,GANAB,PCCA,ZFPL1,DCAF11,WLS,SLC25A15,MTMR12,PSME3,AP2B1,SMAD1,COPB2,WIPF2,PRKAR2A,RAB11FIP1,FBXL14,RAB5C,PRPS1,ZFAND3,COPG1,HSPG2,C1orf109,MCCC1,KBTBD4,SSX2IP,APP,CHTF8,STT3A,CFL2,ARF3,ATPAF1,NCOA4,SMG6,SF3A1,SNX3,TMLHE,KLHL5,PKP2,ABHD5,AZI2,RSRC1,PEX19,PIGS,TBC1D23,TM9SF4,ALDH5A1,MRPL49,NEO1,SEC23B,PLS1,EIF3L,SNX4,IPO9,LDHD,LARS2,IQCK,CS,PRKAR1A,BRF2,SUFU,MIEF1,ARL2BP,HCCS,SLC25A30,PLAA,CPD,EVC,BTD,AMBRA1,RUSF1,USP10,GABARAPL1,AGBL5,UBFD1,ADAT1,CTDSP2,BCKDHB,CRADD,MCFD2,NOMO2,BSCL2,ZDHHC4
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
lncRNA and exonskipping events positive correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation
ENSG00000269958ENST00000602422exon_skip_470077chr7:102397619-102397698-11.74-0.1525PRKRIP1ENST00000397912,ENST00000496391Frame-shift
ENSG00000269958ENST00000602422exon_skip_372419chr3:32449453-32449552-11.29-0.1241CMTM7ENST00000334983In-frame
ENSG00000269958ENST00000602422exon_skip_340124chr2:74142271-74142360-10.79-0.1332BOLA3ENST00000327428Frame-shift

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000269958ENST00000602422exon_skip_349646chr20:25207075-25207397-34.88-0.1282ENTPD6ENST00000376652Frame-shift
ENSG00000269958ENST00000602422exon_skip_41813chr10:68337857-68337996-15.13-0.1164HNRNPH3ENST00000265866Frame-shift
ENSG00000269958ENST00000602422exon_skip_370518chr22:50247691-50247776-15.06-0.1883HDAC10ENST00000216271Frame-shift
ENSG00000269958ENST00000602422exon_skip_382458chr3:38131595-38131638-8.89-0.2615ACAA1ENST00000333167Frame-shift
ENSG00000269958ENST00000602422exon_skip_387016chr3:121788283-121788432-13.93-0.1114IQCB1ENST00000310864Frame-shift
ENSG00000269958ENST00000602422exon_skip_53559chr10:101793912-101793998-11.22-0.1352OGAENST00000361464Frame-shift
ENSG00000269958ENST00000602422exon_skip_114365chr14:74290026-74290118-14.01-0.1819ABCD4ENST00000356924Frame-shift
ENSG00000269958ENST00000602422exon_skip_127618chr15:58890280-58890461-19.28-0.1518SLTMENST00000380516Frame-shift
ENSG00000269958ENST00000602422exon_skip_353131chr20:58669290-58669453-24.80-0.1771STX16ENST00000371141Frame-shift
ENSG00000269958ENST00000602422exon_skip_363747chr22:23877720-23877869-24.67-0.1737SLC2A11ENST00000345044Frame-shift
ENSG00000269958ENST00000602422exon_skip_377198chr3:123130479-123130616-20.55-0.1605PDIA5ENST00000316218Frame-shift
ENSG00000269958ENST00000602422exon_skip_442657chr5:74730259-74730398-15.37-0.1240GFM2ENST00000296805,ENST00000509430Frame-shift
ENSG00000269958ENST00000602422exon_skip_444499chr5:138164086-138164133-6.33-0.4220BRD8ENST00000254900Frame-shift
ENSG00000269958ENST00000602422exon_skip_445390chr5:150403120-150403312-21.95-0.1347CD74ENST00000009530In-frame
ENSG00000269958ENST00000602422exon_skip_446758chr5:178212972-178213103-19.15-0.1637PHYKPLENST00000308158Frame-shift
ENSG00000269958ENST00000602422exon_skip_470226chr7:103307595-103307708-12.56-0.1380PMPCBENST00000249269Frame-shift
ENSG00000269958ENST00000602422exon_skip_511212chrX:71555189-71555385-22.01-0.1171OGTENST00000373719Frame-shift
ENSG00000269958ENST00000602422exon_skip_382439chr3:38126161-38126341-21.54-0.1517ACAA1ENST00000333167In-frame

check buttonlncRNA targets by miRNA.
lncRNA targets by miRNA
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source
ENSG00000269958hsa-let-7cENST00000602422chr14:103696508-103696597182.00-58.4090NA
ENSG00000269958hsa-let-7cENST00000602422chr14:103696755-103696840180.00-82.2881NA
ENSG00000269958hsa-let-7cENST00000602422chr14:103696999-103697083161.00-63.2285NA
ENSG00000269958hsa-let-7cENST00000602422chr14:103696853-103696931156.00-69.9672NA

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Variants for RP11-73M18.8

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA-RBP complex negative regulation
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type
ENSG00000269958ENSG00000004534RBM6exon_skip_370518ENSG00000100429:chr22:50247691-50247776HDAC10ENST00000216271Frame-shiftSTAD,UVM,PRAD,THYM,PAAD
ENSG00000269958ENSG00000004534RBM6exon_skip_382458ENSG00000060971:chr3:38131595-38131638ACAA1ENST00000333167Frame-shiftSTAD,PRAD,THYM,PAAD,THCA
ENSG00000269958ENSG00000079134THOC1exon_skip_382458ENSG00000060971:chr3:38131595-38131638ACAA1ENST00000333167Frame-shiftSTAD,PRAD,THYM,PAAD,THCA

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation
ENSG00000269958ENST00000602422ABATENSG00000183044ENST00000567812-0.1096384-KIRC
ENSG00000269958ENST00000602422ABATENSG00000183044ENST00000425191-0.1133464-KIRC
ENSG00000269958ENST00000602422ABATENSG00000183044ENST00000569156-0.1052456-KIRC
ENSG00000269958ENST00000602422ABATENSG00000183044ENST00000562115-0.1267612-KIRC
ENSG00000269958ENST00000602422WLSENSG00000116729ENST00000527864-0.1159522-KIRC
ENSG00000269958ENST00000602422WLSENSG00000116729ENST00000370971-0.1460593-KIRC
ENSG00000269958ENST00000602422ALDH5A1ENSG00000112294ENST00000491546-0.1386660-KIRC
ENSG00000269958ENST00000602422ACADMENSG00000117054ENST00000420607-0.5462518-KIRC
ENSG00000269958ENST00000602422ACADMENSG00000117054ENST00000528016-0.1531345-KIRC
ENSG00000269958ENST00000602422LDHDENSG00000166816ENST00000569876-0.1030213-KIRC
ENSG00000269958ENST00000602422PCENSG00000173599ENST00000524491-0.6331409-KIRC
ENSG00000269958ENST00000602422NDUFS1ENSG00000023228ENST00000449699-0.2690435-KIRC
ENSG00000269958ENST00000602422NDUFS1ENSG00000023228ENST00000432169-0.2690435-KIRC
ENSG00000269958ENST00000602422NDUFS1ENSG00000023228ENST00000456284-0.1209459-KIRC
ENSG00000269958ENST00000602422HACD3ENSG00000074696ENST00000565299-0.1236366-KIRC
ENSG00000269958ENST00000602422MCCC1ENSG00000078070ENST00000466650-0.1085368-KIRC
ENSG00000269958ENST00000602422MCCC1ENSG00000078070ENST00000486226-0.1042253-KIRC

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types
ENSG00000269958RP11-73M18.8,hsa-let-7c,SLC52A2HNSC,TGCT,UVM,GBM,LIHC

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000269958.1ENST00000602422.1119507148