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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000269918

Summary for AF131215.9

check button Gene summary

Gene informationEnsembl ID

ENSG00000269918

Gene symbol

AF131215.9

Gene name
HGNC
Entrez ID
Gene typesense_intronic
Synonyms
UniProtAcc

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Structure and expression level for AF131215.9

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002699181.757319e+022.953016e+004.496432e-016.567465e+005.120000e-117.000000e-10UPCHOL

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002699185.831899e-012.620585e-05CHOL1.224396e-04

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lncRNA-Protein interaction for AF131215.9

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000269918ENST00000602575AF131215.9ENSG00000108773KAT2A101.8890.9293Q92830EpiNA
ENSG00000269918ENST00000602575AF131215.9ENSG00000166987MBD671.7590.4234Q96DN6TF,EpiNA
ENSG00000269918ENST00000602575AF131215.9ENSG00000182979MTA140.6191.674Q13330EpiNA
ENSG00000269918ENST00000602575AF131215.9ENSG00000147162OGT116.3793.2415O15294EpiNA
ENSG00000269918ENST00000602575AF131215.9ENSG00000136807CDK928.7791.6738P50750EpiNA
ENSG00000269918ENST00000602575AF131215.9ENSG00000277258PCGF219.493.295P35227TF,EpiNA
ENSG00000269918ENST00000602575AF131215.9ENSG00000115274INO80B16.3793.8749Q9C086EpiNA

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000269918ENST00000602575AF131215.9ENSG00000100105PATZ174.1891.8447Q9HBE1TFNA
ENSG00000269918ENST00000602575AF131215.9ENSG00000166987MBD671.7590.3911Q96DN6TF,EpiNA
ENSG00000269918ENST00000602575AF131215.9ENSG00000198040ZNF8452.3492.1046P51523TFNA
ENSG00000269918ENST00000602575AF131215.9ENSG00000166432ZMAT136.8391.5056Q5H9K5TFNA
ENSG00000269918ENST00000602575AF131215.9ENSG00000277258PCGF219.493.2279P35227TF,EpiNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000269918ENST00000602575AF131215.9ENSG00000163728TTC14110.5493.9915Q96N46RBPNA
ENSG00000269918ENST00000602575AF131215.9ENSG00000003756RBM5104.4991.2896P52756RBPNA
ENSG00000269918ENST00000602575AF131215.9ENSG00000071894CPSF193.5493.2912Q10570RBPNA
ENSG00000269918ENST00000602575AF131215.9ENSG00000134815DHX3492.3593.7658Q14147RBPNA
ENSG00000269918ENST00000602575AF131215.9ENSG00000100201DDX1768.994.0941Q92841RBPNA
ENSG00000269918ENST00000602575AF131215.9ENSG00000105705SUGP132.1492.0037Q8IWZ8RBPNA
ENSG00000269918ENST00000602575AF131215.9ENSG00000157110RBPMS24.9491.5979Q93062RBPNA

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lncRNA-DNA interaction for AF131215.9

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for AF131215.9

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
IQGAP1,CPSF2,YIPF5,PLIN3,CRAT,TUBA1B,OGDH,MCFD2,G3BP2,ALAS1,MYOF
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000269918ENST00000602575exon_skip_41813chr10:68337857-68337996-15.78-0.1360HNRNPH3ENST00000265866Frame-shift
ENSG00000269918ENST00000602575exon_skip_290158chr17:42953723-42953778-9.40-0.2611AARSD1ENST00000427569Frame-shift
ENSG00000269918ENST00000602575exon_skip_377198chr3:123130479-123130616-18.49-0.1411PDIA5ENST00000316218Frame-shift
ENSG00000269918ENST00000602575exon_skip_382458chr3:38131595-38131638-12.77-0.3547ACAA1ENST00000333167Frame-shift
ENSG00000269918ENST00000602575exon_skip_470226chr7:103307595-103307708-13.54-0.1341PMPCBENST00000249269Frame-shift
ENSG00000269918ENST00000602575exon_skip_445390chr5:150403120-150403312-21.79-0.1165CD74ENST00000009530In-frame

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for AF131215.9

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name
LncEditing_199980ENSG00000269918.1chr811106493-sense_intronicAF131215.9ENST00000602575.1sense_intronicAF131215.9-001
LncEditing_199983ENSG00000269918.1chr811106592-sense_intronicAF131215.9ENST00000602575.1sense_intronicAF131215.9-001
LncEditing_199984ENSG00000269918.1chr811106604-sense_intronicAF131215.9ENST00000602575.1sense_intronicAF131215.9-001
LncEditing_199985ENSG00000269918.1chr811106605-sense_intronicAF131215.9ENST00000602575.1sense_intronicAF131215.9-001
LncEditing_199987ENSG00000269918.1chr811106614-sense_intronicAF131215.9ENST00000602575.1sense_intronicAF131215.9-001
LncEditing_199988ENSG00000269918.1chr811106619-sense_intronicAF131215.9ENST00000602575.1sense_intronicAF131215.9-001
LncEditing_199999ENSG00000269918.1chr811106701-sense_intronicAF131215.9ENST00000602575.1sense_intronicAF131215.9-001
LncEditing_200000ENSG00000269918.1chr811106702-sense_intronicAF131215.9ENST00000602575.1sense_intronicAF131215.9-001

check buttonEdited-associated DElncRNAs in cancer.
Differentially expressed gene
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange
ENSG00000269918LncEditing_199983GBMchr8_11106592_-3.354374e+002.210507e+001.662051e+005.219332e+001.795692e-073.969167e-07UP
ENSG00000269918LncEditing_199984GBMchr8_11106604_-3.313339e+002.304572e+001.909173e+004.334709e+001.459534e-052.371010e-05UP
ENSG00000269918LncEditing_199985GBMchr8_11106605_-3.307929e+002.172279e+001.648210e+005.616432e+001.949408e-085.054715e-08UP
ENSG00000269918LncEditing_199987GBMchr8_11106614_-3.327013e+001.704883e+001.036747e+008.292549e+001.108474e-162.637517e-15UP
ENSG00000269918LncEditing_199988GBMchr8_11106619_-3.492922e+002.337461e+001.725648e+003.909275e+009.257338e-051.300831e-04UP
ENSG00000269918LncEditing_199999GBMchr8_11106701_-4.270078e+002.290732e+001.113024e+004.408162e+001.042516e-051.735381e-05UP
ENSG00000269918LncEditing_200000GBMchr8_11106702_-3.801633e+001.985815e+001.067364e+007.268736e+003.628658e-133.433840e-12UP
ENSG00000269918LncEditing_199983LGGchr8_11106592_-5.043683e+003.918642e+002.746318e+005.760637e+008.379732e-091.157748e-08UP
ENSG00000269918LncEditing_199980PCPGchr8_11106493_-5.330632e+003.894440e+002.208037e+002.628853e+008.567332e-039.615989e-03UP
ENSG00000269918LncEditing_199983PCPGchr8_11106592_-5.374941e+003.793778e+001.989600e+003.810574e+001.386447e-041.930697e-04UP
ENSG00000269918LncEditing_199983THCAchr8_11106592_-5.790977e+004.524272e+002.808034e+006.866081e+006.598952e-121.357562e-11UP
ENSG00000269918LncEditing_199983PRADchr8_11106592_-3.153133e+002.522698e+003.107344e+004.475586e+007.620216e-061.023534e-05UP

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value
ENSG00000269918LncEditing_199983-3.571735e-011.363633e-078.103879e-07
ENSG00000269918LncEditing_199983-3.281472e-013.169161e-024.629798e-02
ENSG00000269918LncEditing_199983-3.483880e-013.967186e-058.331090e-05

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation
ENSG00000269918ENST00000602575ALAS1ENSG00000023330ENST00000394965-0.15621147-CHOL
ENSG00000269918ENST00000602575ALAS1ENSG00000023330ENST00000310271-0.15621147-CHOL
ENSG00000269918ENST00000602575ALAS1ENSG00000023330ENST00000484952-0.15621147-CHOL
ENSG00000269918ENST00000602575ALAS1ENSG00000023330ENST00000493402-0.4575927-CHOL
ENSG00000269918ENST00000602575CRATENSG00000095321ENST00000455396-0.1487168-CHOL

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000269918.1ENST00000602575.193256537