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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000268388

Summary for FENDRR

check button Gene summary

Gene informationEnsembl ID

ENSG00000268388

Gene symbol

FENDRR

Gene nameFOXF1 adjacent non-coding developmental regulatory RNA
HGNC

43894

Entrez ID

400550

Gene typelincRNA
Synonyms16q24.1|FENDRR
UniProtAcc

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Structure and expression level for FENDRR

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002683886.428400e+02-3.739193e+004.491841e-01-8.324411e+008.470000e-175.360000e-15DOWNBLCA
ENSG000002683887.833162e+02-2.163179e+004.742199e-01-4.561552e+005.080000e-061.097410e-04DOWNESCA
ENSG000002683887.537050e+02-1.326670e+001.772308e-01-7.485549e+007.120000e-148.110000e-13DOWNPRAD
ENSG000002683884.615550e+02-4.083992e+002.304298e-01-1.772337e+012.770000e-701.320000e-68DOWNLUSC
ENSG000002683884.782973e+02-3.882976e+002.126305e-01-1.826162e+011.670000e-742.660000e-72DOWNLUAD
ENSG000002683884.453220e+02-1.978439e+001.827720e-01-1.082463e+012.630000e-275.880000e-26DOWNCOAD
ENSG000002683881.386844e+03-1.601465e+002.709752e-01-5.910005e+003.420000e-093.670000e-08DOWNSTAD
ENSG000002683885.402549e+02-2.342837e+003.144248e-01-7.451184e+009.250000e-145.530000e-12DOWNREAD

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG00000268388-3.612509e-011.668500e-19LUAD6.618384e-18
ENSG00000268388-3.123827e-017.590737e-14LUSC2.260656e-12

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lncRNA-Protein interaction for FENDRR

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000268388ENST00000598996FENDRRENSG00000182568SATB136.3893.2618Q01826TF,EpiRNA-seq,Microarray
ENSG00000268388ENST00000598996FENDRRENSG00000114861FOXP157.7793.7846Q9H334TF,EpiChIP-seq
ENSG00000268388ENST00000598996FENDRRENSG00000131759RARA24.1992.231P10276TF,EpiNA

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000268388ENST00000595886FENDRRENSG00000174282ZBTB491.3196.0855Q9P1Z0TFRNA-seq,Microarray
ENSG00000268388ENST00000595886FENDRRENSG00000177374HIC165.3695.0579Q14526TFRNA-seq,Microarray
ENSG00000268388ENST00000595886FENDRRENSG00000187098MITF42.8692.378O75030TFChIP-seq
ENSG00000268388ENST00000595886FENDRRENSG00000148516ZEB142.2593.3487P37275TFPredict
ENSG00000268388ENST00000595886FENDRRENSG00000148411NACC242.0690.2761Q96BF6TFRNA-seq,Microarray
ENSG00000268388ENST00000595886FENDRRENSG00000126705AHDC136.6295.2831Q5TGY3TFNA
ENSG00000268388ENST00000595886FENDRRENSG00000185630PBX133.9892.5115P40424TFNA
ENSG00000268388ENST00000595886FENDRRENSG00000108924HLF33.1490.6106Q16534TFNA
ENSG00000268388ENST00000595886FENDRRENSG00000120738EGR128.6994.818P18146TFChIP-seq
ENSG00000268388ENST00000595886FENDRRENSG00000143995MEIS128.6494.0672O00470TFRNA-seq,Microarray
ENSG00000268388ENST00000595886FENDRRENSG00000164107HAND223.991.7881P61296TFNA
ENSG00000268388ENST00000595886FENDRRENSG00000008441NFIX22.0992.1754Q14938TFRNA-seq,Microarray
ENSG00000268388ENST00000595886FENDRRENSG00000137273FOXF217.9493.1973Q12947TFNA
ENSG00000268388ENST00000595886FENDRRENSG00000134138MEIS216.3590.9985O14770TFNA
ENSG00000268388ENST00000595886FENDRRENSG00000164736SOX1715.3392.9734Q9H6I2TFNA
ENSG00000268388ENST00000595886FENDRRENSG00000119138KLF914.0590.0997Q13886TFRNA-seq,ChIP-seq,Microarray
ENSG00000268388ENST00000595886FENDRRENSG00000141905NFIC13.593.3704P08651TFNA
ENSG00000268388ENST00000595886FENDRRENSG00000162599NFIA13.2492.8778Q12857TFNA
ENSG00000268388ENST00000595886FENDRRENSG00000175395ZNF2511.7594.6109P17030TFNA
ENSG00000268388ENST00000595886FENDRRENSG00000151702FLI110.694.0388Q01543TFNA
ENSG00000268388ENST00000595886FENDRRENSG00000157554ERG9.4993.8814P11308TFChIP-seq
ENSG00000268388ENST00000598996FENDRRENSG00000174282ZBTB485.9294.2493Q9P1Z0TFRNA-seq,Microarray
ENSG00000268388ENST00000598996FENDRRENSG00000157933SKI74.0593.7303P12755TFRNA-seq,Microarray
ENSG00000268388ENST00000598996FENDRRENSG00000174306ZHX371.2593.3227Q9H4I2TFNA
ENSG00000268388ENST00000598996FENDRRENSG00000177374HIC162.0394.2585Q14526TFRNA-seq,Microarray
ENSG00000268388ENST00000598996FENDRRENSG00000114861FOXP157.7794.0811Q9H334TF,EpiChIP-seq
ENSG00000268388ENST00000598996FENDRRENSG00000169554ZEB255.596.3649O60315TFNA
ENSG00000268388ENST00000598996FENDRRENSG00000148516ZEB150.6395.1701P37275TFPredict
ENSG00000268388ENST00000598996FENDRRENSG00000182568SATB136.3893.4016Q01826TF,EpiRNA-seq,Microarray
ENSG00000268388ENST00000598996FENDRRENSG00000126705AHDC133.5395.3147Q5TGY3TFNA
ENSG00000268388ENST00000598996FENDRRENSG00000081189MEF2C27.1492.8315Q06413TFNA
ENSG00000268388ENST00000598996FENDRRENSG00000118526TCF2126.9890.2491O43680TFNA
ENSG00000268388ENST00000598996FENDRRENSG00000116604MEF2D24.491.925Q14814TFNA
ENSG00000268388ENST00000598996FENDRRENSG00000131759RARA24.1992.2766P10276TF,EpiNA
ENSG00000268388ENST00000598996FENDRRENSG00000148411NACC221.5892.8816Q96BF6TFRNA-seq,Microarray
ENSG00000268388ENST00000598996FENDRRENSG00000185630PBX113.6592.3047P40424TFNA
ENSG00000268388ENST00000598996FENDRRENSG00000175395ZNF256.7295.3771P17030TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000268388ENST00000593604FENDRRENSG00000137449CPEB215.4892.6652Q7Z5Q1RBPRNA-seq,Microarray
ENSG00000268388ENST00000593604FENDRRENSG00000184898RBM4315.0990.691Q6ZSC3RBPNA
ENSG00000268388ENST00000595886FENDRRENSG00000009307CSDE185.3494.6689O75534RBPRNA-seq,Microarray
ENSG00000268388ENST00000595886FENDRRENSG00000137449CPEB240.2794.9661Q7Z5Q1RBPRNA-seq,Microarray
ENSG00000268388ENST00000595886FENDRRENSG00000144642RBMS319.1292.1123Q6XE24RBPRNA-seq,Microarray,Scan,pipeline,widely,used,MATCH,algorithm
ENSG00000268388ENST00000595886FENDRRENSG00000076067RBMS211.7893.914Q15434RBPNA

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lncRNA-DNA interaction for FENDRR

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
JUN,FOXN3,ZHX3,KLF9,JDP2,CPEB2,ZBTB4,HIC1,SMAD9,TEAD3,JAZF1,KLF10,GATA6,CSDE1,FOXF2,RBPMS,RBMS3,AHDC1,ZEB2,NACC2,FOXP1,MEIS1,NR4A3,NFIA,MEIS2,RARA,HAND2,MEF2C,RBM43,MEF2D,FLI1,KLF11,NFIC,QKI,ERG,ZNF25
Exist in public source
FOXF1

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for FENDRR

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
ILF2,RNPS1,TFAP4,SRSF1,NOP2,PA2G4,LSM4,DDX41,PREB,PTBP1,SNRPA
Exist in public source
DKC1,EIF3B,DDX56,CPSF3

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
lncRNA and exonskipping events positive correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation
ENSG00000268388ENST00000593604exon_skip_7558chr1:81952986-81953025-8.37-0.2790ADGRL2ENST00000370717,ENST00000370728In-frame
ENSG00000268388ENST00000593604exon_skip_42594chr10:74111908-74112112-25.86-0.2330VCLENST00000211998In-frame
ENSG00000268388ENST00000593604exon_skip_97739chr12:121244572-121244615-8.64-0.3757CAMKK2ENST00000324774,ENST00000402834,ENST00000404169Frame-shift
ENSG00000268388ENST00000593604exon_skip_287874chr17:29085603-29085648-9.05-0.3771MYO18AENST00000527372In-frame
ENSG00000268388ENST00000593604exon_skip_335378chr2:237751199-237751271-9.71-0.2624LRRFIP1ENST00000392000In-frame
ENSG00000268388ENST00000593604exon_skip_436488chr5:96726793-96726859-8.21-0.2219CASTENST00000341926,ENST00000395813In-frame
ENSG00000268388ENST00000593604exon_skip_21628chr1:9756480-9756510-6.79-0.3086CLSTN1ENST00000377298In-frame
ENSG00000268388ENST00000593604exon_skip_33516chr1:156938417-156938513-16.38-0.1998ARHGEF11ENST00000361409In-frame
ENSG00000268388ENST00000593604exon_skip_43507chr10:84499874-84499959-23.77-0.3212CCSER2ENST00000224756Frame-shift

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000268388ENST00000593604exon_skip_149413chr17:17175292-17175412-21.70-0.2411MPRIPENST00000341712In-frame
ENSG00000268388ENST00000593604exon_skip_48713chr10:34336198-34336243-8.12-0.2388PARD3ENST00000374789In-frame
ENSG00000268388ENST00000593604exon_skip_456460chr6:17771113-17771218-18.49-0.2341KIF13AENST00000259711In-frame

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for FENDRR

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000268388.4ENST00000595886.179134373
ENSG00000268388.4ENST00000600553.497501208
ENSG00000268388.4ENST00000598996.26626161
ENSG00000268388.4ENST00000599749.414728292386
ENSG00000268388.4ENST00000597578.1156636166
ENSG00000268388.4ENST00000594398.19031303
ENSG00000268388.4ENST00000593604.166331131