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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000267519

Summary for MIR23AHG

check button Gene summary

Gene informationEnsembl ID

ENSG00000267519

Gene symbol

MIR23AHG

Gene namemiR-23a/27a/24-2 cluster host gene
HGNC

27620

Entrez ID
Gene typelincRNA
SynonymsMIR23AHG|19p13.12|CTD-3252C9.4
UniProtAcc

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Structure and expression level for MIR23AHG

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002675199.394357e+021.976227e+003.375767e-015.854156e+004.790000e-094.770000e-08UPCHOL
ENSG000002675191.170509e+031.885307e+001.805313e-011.044310e+011.580000e-251.280000e-24UPKIRC
ENSG000002675193.418101e+02-1.644569e+002.480119e-01-6.631008e+003.330000e-112.190000e-10DOWNKICH
ENSG000002675191.242784e+03-1.977952e+002.699833e-01-7.326201e+002.370000e-138.020000e-12DOWNBLCA
ENSG000002675198.063097e+02-1.684056e+001.100165e-01-1.530731e+016.830000e-531.600000e-51DOWNBRCA
ENSG000002675198.318579e+021.203238e+001.641023e-017.332246e+002.260000e-131.760000e-12UPCOAD

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002675193.831330e-015.833911e-04ACC4.828064e-03
ENSG000002675195.045467e-014.090155e-04CHOL8.472464e-04
ENSG00000267519-5.623626e-019.747986e-09KICH5.533012e-08

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lncRNA-Protein interaction for MIR23AHG

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000267519ENST00000587762CTD-3252C9.4ENSG00000196378ZNF3412.5990.051Q8IZ26TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000267519ENST00000587762CTD-3252C9.4ENSG00000004534RBM661.7691.0614P78332RBPNA
ENSG00000267519ENST00000587762CTD-3252C9.4ENSG00000116350SRSF431.5591.0351Q08170RBPNA

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lncRNA-DNA interaction for MIR23AHG

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
JUN,ELF4,TGIF1,PHF1,KLF3,MYC,RBM6,ZBED5,JDP2,GLI4,PBX2,RBM39,HLX,TTC14,NOL3,HSF4,KLF6,RBM5,TEAD3,IRF3,JMJD6,RC3H1,CIRBP,EGR2,RBMS1,MZF1,KLF10,MYSM1,HES1,SGSM2,DOT1L,SRSF4,KLF2,TBX2,PITX1,DMTF1,FOSL2,TRA2A,ZNF69,NR4A3,RUNX1,FUBP1,MBD6,ZGPAT,NFKB1,NR4A2,NR2C1,DDX17,MYNN,MEF2C,RARG,PBX4,BCL6B,MBD2,ZNF83,IRF7,SOX7,EGR3,USF1,ATF3,NFIL3,RNPC3,IRF1,ZNF34,THOC1,RBM33,FOSL1,ZNF25,MOV10,PCGF2,TEAD2,SRRM2
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.
Only predicted by TDF
DOT1L,JUND,DDX17,HSF4,MZF1,TEAD2,EGR1,NOL3,GRB7,RBM5,FOSL1,IRF5,HES1,SOX7,FOS,NR4A3,RBMS2,JMJD6,SRSF5,FUBP1,KLF2,MYNN,ZNF69,ZNF83,MAFK,RBMS1,SYNJ2,USF1,RUNX1,RBM6,PRRX1,PBX2,ELF4,SRRM2,AGO4,PBX4,FOSL2,RBM39,TRA2A,IRF3,CIRBP,TGIF1
Exist in public source
NA

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for MIR23AHG

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000267519ENST00000587762exon_skip_309204chr19:49181348-49181461-20.68-0.2008TRPM4ENST00000252826Frame-shift
ENSG00000267519ENST00000587762exon_skip_2106chr1:17648553-17648675-23.19-0.2274ARHGEF10LENST00000361221Frame-shift
ENSG00000267519ENST00000587762exon_skip_41813chr10:68337857-68337996-17.10-0.1474HNRNPH3ENST00000265866Frame-shift
ENSG00000267519ENST00000587762exon_skip_53559chr10:101793912-101793998-13.63-0.4130OGAENST00000361464Frame-shift
ENSG00000267519ENST00000587762exon_skip_62623chr11:69079833-69079883-11.91-0.2647TPCN2ENST00000294309Frame-shift
ENSG00000267519ENST00000587762exon_skip_74009chr11:64773429-64773505-13.88-0.3155SF1ENST00000377390Frame-shift
ENSG00000267519ENST00000587762exon_skip_87733chr12:120571190-120571291-18.09-0.2349RNF10ENST00000325954Frame-shift
ENSG00000267519ENST00000587762exon_skip_92074chr12:50142052-50142110-8.39-0.1554CERS5ENST00000317551Frame-shift
ENSG00000267519ENST00000587762exon_skip_95407chr12:95040475-95040597-16.82-0.1515NR2C1ENST00000333003Frame-shift
ENSG00000267519ENST00000587762exon_skip_110959chr14:20372732-20372857-15.77-0.1447TEP1ENST00000262715Frame-shift
ENSG00000267519ENST00000587762exon_skip_114365chr14:74290026-74290118-16.08-0.2265ABCD4ENST00000356924Frame-shift
ENSG00000267519ENST00000587762exon_skip_133217chr16:8635038-8635079-12.40-0.3758METTL22ENST00000381920Frame-shift
ENSG00000267519ENST00000587762exon_skip_152655chr17:42514288-42514460-22.22-0.1415ATP6V0A1ENST00000393829Frame-shift
ENSG00000267519ENST00000587762exon_skip_290158chr17:42953723-42953778-9.72-0.2558AARSD1ENST00000427569Frame-shift
ENSG00000267519ENST00000587762exon_skip_302168chr19:10680345-10680443-15.27-0.1678ILF3ENST00000590261Frame-shift
ENSG00000267519ENST00000587762exon_skip_353131chr20:58669290-58669453-26.52-0.1829STX16ENST00000371141Frame-shift
ENSG00000267519ENST00000587762exon_skip_357254chr20:44622587-44622652-15.18-0.2919ADAENST00000372874Frame-shift
ENSG00000267519ENST00000587762exon_skip_370518chr22:50247691-50247776-22.58-0.2823HDAC10ENST00000216271Frame-shift
ENSG00000267519ENST00000587762exon_skip_374497chr3:49999439-49999513-14.34-0.2313RBM6ENST00000266022Frame-shift
ENSG00000267519ENST00000587762exon_skip_380242chr3:186784961-186785101-19.83-0.1983EIF4A2ENST00000323963Frame-shift
ENSG00000267519ENST00000587762exon_skip_382458chr3:38131595-38131638-9.60-0.5647ACAA1ENST00000333167Frame-shift
ENSG00000267519ENST00000587762exon_skip_442657chr5:74730259-74730398-15.34-0.1395GFM2ENST00000296805,ENST00000509430Frame-shift
ENSG00000267519ENST00000587762exon_skip_444499chr5:138164086-138164133-9.54-0.2726BRD8ENST00000254900Frame-shift
ENSG00000267519ENST00000587762exon_skip_446758chr5:178212972-178213103-19.19-0.2063PHYKPLENST00000308158Frame-shift
ENSG00000267519ENST00000587762exon_skip_466137chr7:48103296-48103411-15.15-0.1377UPP1ENST00000331803,ENST00000395564Frame-shift
ENSG00000267519ENST00000587762exon_skip_470226chr7:103307595-103307708-15.56-0.1511PMPCBENST00000249269Frame-shift
ENSG00000267519ENST00000587762exon_skip_11029chr1:154989559-154989707-24.30-0.1774FLAD1ENST00000292180Frame-shift
ENSG00000267519ENST00000587762exon_skip_13857chr1:168038370-168038488-14.37-0.1356DCAF6ENST00000312263Frame-shift
ENSG00000267519ENST00000587762exon_skip_127618chr15:58890280-58890461-15.72-0.1048SLTMENST00000380516Frame-shift
ENSG00000267519ENST00000587762exon_skip_364260chr22:29291561-29291599-11.70-0.4179EWSR1ENST00000397938Frame-shift
ENSG00000267519ENST00000587762exon_skip_466113chr7:48099669-48099787-12.30-0.1281UPP1ENST00000331803,ENST00000395564Frame-shift
ENSG00000267519ENST00000587762exon_skip_374552chr3:50104247-50104308-8.80-0.1600RBM5ENST00000347869Frame-shift

check buttonlncRNA targets by miRNA.
lncRNA targets by miRNA
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source
ENSG00000267519hsa-mir-616ENST00000587762chr19:13835429-13835509179.00-80.7191NA
ENSG00000267519hsa-mir-616ENST00000587762chr19:13835647-13835742167.00-90.3592NA
ENSG00000267519hsa-mir-616ENST00000587762chr19:13835211-13835306164.00-86.5094NA
ENSG00000267519hsa-mir-616ENST00000587762chr19:13836065-13836181164.00-106.48107NA
ENSG00000267519hsa-mir-616ENST00000587762chr19:13835888-13835979162.00-84.2391NA
ENSG00000267519hsa-mir-616ENST00000587762chr19:13834769-13834876156.00-109.84106NA
ENSG00000267519hsa-mir-616ENST00000587762chr19:13835977-13836075156.00-96.8386NA
ENSG00000267519hsa-mir-616ENST00000587762chr19:13834548-13834642153.00-91.0491NA
ENSG00000267519hsa-mir-616ENST00000587762chr19:13835503-13835596152.00-89.2899NA
ENSG00000267519hsa-mir-616ENST00000587762chr19:13835058-13835149151.00-109.6991NA
ENSG00000267519hsa-mir-616ENST00000587762chr19:13835294-13835396142.00-97.6299NA
ENSG00000267519hsa-mir-616ENST00000587762chr19:13834944-13835045141.00-97.97100NA
ENSG00000267519hsa-mir-616ENST00000587762chr19:13835778-13835877141.00-92.4598NA

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Variants for MIR23AHG

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types
ENSG00000267519MIR23AHG,hsa-mir-616,ZNF25KICH,TGCT,CHOL,DLBC,THYM
ENSG00000267519MIR23AHG,hsa-mir-616,DOCK1KICH,TGCT,CHOL,DLBC,THYM
ENSG00000267519MIR23AHG,hsa-mir-616,RYKKICH,TGCT,CHOL,DLBC,THYM
ENSG00000267519MIR23AHG,hsa-mir-616,ENTPD1KICH,TGCT,CHOL,DLBC,THYM
ENSG00000267519MIR23AHG,hsa-mir-616,BMPR2KICH,TGCT,CHOL,DLBC,THYM
ENSG00000267519MIR23AHG,hsa-mir-616,PLEKHG3KICH,TGCT,CHOL,DLBC,THYM
ENSG00000267519MIR23AHG,hsa-mir-616,F2RKICH,TGCT,CHOL,DLBC,THYM
ENSG00000267519MIR23AHG,hsa-mir-616,TMUB2KICH,TGCT,CHOL,DLBC,THYM
ENSG00000267519MIR23AHG,hsa-mir-616,RUSC2KICH,TGCT,CHOL,DLBC,THYM
ENSG00000267519MIR23AHG,hsa-mir-616,SKIKICH,TGCT,CHOL,DLBC,THYM
ENSG00000267519MIR23AHG,hsa-mir-616,KCTD3KICH,TGCT,CHOL,DLBC,THYM
ENSG00000267519MIR23AHG,hsa-mir-616,RARGKICH,TGCT,CHOL,DLBC,THYM
ENSG00000267519MIR23AHG,hsa-mir-616,VWA5AKICH,TGCT,CHOL,DLBC,THYM
ENSG00000267519MIR23AHG,hsa-mir-616,PDGFBKICH,TGCT,CHOL,DLBC,THYM

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000267519.3ENST00000587762.110311322