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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000266904

Summary for LINC00663

check button Gene summary

Gene informationEnsembl ID

ENSG00000266904

Gene symbol

LINC00663

Gene namelong intergenic non-protein coding RNA 663
HGNC

28609

Entrez ID
Gene typelincRNA
SynonymsCTC-559E9.1|LINC00663|19p13.11
UniProtAcc

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Structure and expression level for LINC00663

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value

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lncRNA-Protein interaction for LINC00663

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000169057MECP217.3991.6912P51608TF,EpiNA

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000266904ENST00000589508CTC-559E9.1ENSG00000167232ZNF9140.5891.7836Q05481TFNA
ENSG00000266904ENST00000588223CTC-559E9.1ENSG00000070476ZXDC31.0990.6503Q2QGD7TFNA
ENSG00000266904ENST00000588223CTC-559E9.1ENSG00000166432ZMAT117.7691.5789Q5H9K5TFNA
ENSG00000266904ENST00000589910CTC-559E9.1ENSG00000257923CUX138.0791.151P39880TFChIP-seq
ENSG00000266904ENST00000589910CTC-559E9.1ENSG00000167232ZNF9126.992.4568Q05481TFNA
ENSG00000266904ENST00000589910CTC-559E9.1ENSG00000196670ZFP6223.3791.7528Q8NB50TFNA
ENSG00000266904ENST00000589910CTC-559E9.1ENSG00000170448NFXL121.2791.2598Q6ZNB6TFNA
ENSG00000266904ENST00000589910CTC-559E9.1ENSG00000146587RBAK19.7390.0261Q9NYW8TFNA
ENSG00000266904ENST00000589910CTC-559E9.1ENSG00000124459ZNF4519.1791.2213Q02386TFNA
ENSG00000266904ENST00000589910CTC-559E9.1ENSG00000168795ZBTB515.791.8936O15062TFNA
ENSG00000266904ENST00000589910CTC-559E9.1ENSG00000166432ZMAT114.6890.2544Q5H9K5TFNA
ENSG00000266904ENST00000589910CTC-559E9.1ENSG00000184939ZFP908.2790.0036Q8TF47TFNA
ENSG00000266904ENST00000586885CTC-559E9.1ENSG00000168152THAP9147.6892.5296Q9H5L6TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000174282ZBTB458.6492.9409Q9P1Z0TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000257923CUX147.293.4511P39880TFChIP-seq
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000105127AKAP842.4393.2601O43823TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000196867ZFP2840.9293.9696Q8NHY6TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000070476ZXDC35.0291.8246Q2QGD7TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000167232ZNF9134.2395.7256Q05481TFNA
ENSG00000266904ENST00000586885CTC-559E9.1ENSG00000186272ZNF1733.3593.3107P17021TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000196670ZFP6230.2995.2901Q8NB50TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000124459ZNF4527.7294.9801Q02386TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000165821SALL226.6393.6202Q9Y467TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000146587RBAK26.4293.4969Q9NYW8TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000170448NFXL125.8193.4189Q6ZNB6TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000168795ZBTB522.3795.2874O15062TFNA
ENSG00000266904ENST00000586885CTC-559E9.1ENSG00000197857ZNF4422.1991.8951P15621TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000166432ZMAT119.5691.9833Q5H9K5TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000186272ZNF1719.3594.3494P17021TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000164631ZNF1218.9392.5902P17014TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000169057MECP217.3991.8963P51608TF,EpiNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000105708ZNF1414.8292.8371P17017TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000184939ZFP9011.3494.1936Q8TF47TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000197857ZNF4411.0193.3283P15621TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000120784ZFP3010.5893.55Q9Y2G7TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000180787ZFP39.7693.1138Q96NJ6TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000142065ZFP149.6993.0741Q9HCL3TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000187792ZNF709.2993.1652Q9UC06TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000175395ZNF252.4494.2972P17030TFNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000198939ZFP21.1393.3079Q6ZN57TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000266904ENST00000586885CTC-559E9.1ENSG00000106344RBM28101.3293.9762Q9NW13RBPNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000163728TTC1443.990.7886Q96N46RBPNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000106344RBM2841.2795.4348Q9NW13RBPNA
ENSG00000266904ENST00000589508CTC-559E9.1ENSG00000100201DDX1736.0590.0906Q92841RBPNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000085872CHERP34.392.7976Q8IWX8RBPNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000100650SRSF523.3191.6387Q13243RBPNA
ENSG00000266904ENST00000586885CTC-559E9.1ENSG00000100461RBM2319.3194.4598Q86U06RBPNA
ENSG00000266904ENST00000590092CTC-559E9.1ENSG00000107164FUBP32.4493.0743Q96I24RBPNA
ENSG00000266904ENST00000589910CTC-559E9.1ENSG00000106344RBM2833.2793.5054Q9NW13RBPNA
ENSG00000266904ENST00000588223CTC-559E9.1ENSG00000198231DDX4243.7791.8756Q86XP3RBPNA
ENSG00000266904ENST00000588223CTC-559E9.1ENSG00000085872CHERP31.6790.8715Q8IWX8RBPNA

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lncRNA-DNA interaction for LINC00663

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
MECP2,ZNF14,RFX1,TTC14,ZBTB4,DZIP3,RBM5,ZFP62,ZNF44,ZFP28,NRF1,RBM23,AKAP8,ZNF17,ZNF91,KAT7,ZXDC,ZNF45,SUGP2,DDX42,DMTF1,RXRB,NFXL1,ZNF70,RBM28,DDX31,ZFP30,SALL2,ZFP3,ZMAT1,ZBTB5,THAP9,ZFP14,THAP6,ZNF25,DDX17,SIX5
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.
Only predicted by TDF
ZNF70,ZBTB4,MECP2,ZMAT1,DDX17,ZFP2,ZNF14,DDX31,ZNF45
Exist in public source
NA

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for LINC00663

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for LINC00663

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name
LncEditing_347137ENSG00000266904.4chr1919757382-lincRNACTC-559E9.1ENST00000586645.4lincRNACTC-559E9.1-001
LncEditing_347180ENSG00000266904.4chr1919759021-lincRNACTC-559E9.1ENST00000590092.4lincRNACTC-559E9.1-007
LncEditing_347184ENSG00000266904.4chr1919759031-lincRNACTC-559E9.1ENST00000590092.4lincRNACTC-559E9.1-007
LncEditing_347188ENSG00000266904.4chr1919759057-lincRNACTC-559E9.1ENST00000590092.4lincRNACTC-559E9.1-007
LncEditing_347204ENSG00000266904.4chr1919759066-lincRNACTC-559E9.1ENST00000590092.4lincRNACTC-559E9.1-007

check buttonEdited-associated DElncRNAs in cancer.
Differentially expressed gene
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange
ENSG00000266904LncEditing_347137GBMchr19_19757382_-1.810978e+001.290624e+002.046242e+003.297989e+009.737978e-041.204591e-03UP
ENSG00000266904LncEditing_347184GBMchr19_19759031_-1.935012e+001.244973e+001.571764e+004.967662e+006.776489e-071.340386e-06UP
ENSG00000266904LncEditing_347188GBMchr19_19759057_-1.674776e+001.229731e+002.244037e+004.472167e+007.743108e-061.302323e-05UP
ENSG00000266904LncEditing_347204GBMchr19_19759066_-1.930287e+001.236182e+001.555393e+005.228688e+001.707173e-073.804692e-07UP
ENSG00000266904LncEditing_347180LGGchr19_19759021_-2.104283e+001.641679e+002.792073e+007.790783e+006.659519e-151.343320e-14UP
ENSG00000266904LncEditing_347184LGGchr19_19759031_-2.080934e+001.641940e+002.925431e+007.599681e+002.968617e-145.726348e-14UP
ENSG00000266904LncEditing_347188LGGchr19_19759057_-2.099531e+001.690194e+003.196127e+006.008447e+001.873090e-092.687807e-09UP
ENSG00000266904LncEditing_347180THCAchr19_19759021_-1.645063e+001.184239e+002.108894e+006.609135e+003.865716e-117.594703e-11UP

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value
ENSG00000266904LncEditing_347180-4.870475e-012.506444e-044.017797e-04
ENSG00000266904LncEditing_347188-3.439724e-018.425862e-041.059540e-03

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types
ENSG00000266904ENSG00000168152THAP9ENSG00000166432ZMAT15ACC,GBM,KIRP,LGG,THCA

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000266904.4ENST00000586645.4106619936
ENSG00000266904.4ENST00000590092.4124241615
ENSG00000266904.4ENST00000589910.4124324698
ENSG00000266904.4ENST00000588223.4113393731
ENSG00000266904.4ENST00000589508.191223498
ENSG00000266904.4ENST00000586816.180430188
ENSG00000266904.4ENST00000586885.135201305