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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000264575

Summary for LINC00526

check button Gene summary

Gene informationEnsembl ID

ENSG00000264575

Gene symbol

LINC00526

Gene namelong intergenic non-protein coding RNA 526
HGNC

28278

Entrez ID
Gene typelincRNA
SynonymsLINC00526|18p11.31
UniProtAcc

Q96FQ7


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Structure and expression level for LINC00526

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002645752.004574e+02-2.324242e+002.452000e-01-9.478963e+002.570000e-211.520000e-19DOWNCHOL
ENSG000002645752.986786e+021.275481e+003.413677e-013.736385e+001.866850e-043.028911e-03UPPCPG

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG00000264575-4.673674e-011.208356e-03CHOL1.988703e-03
ENSG00000264575-5.339328e-017.112787e-08KICH2.880857e-07
ENSG00000264575-3.016974e-017.809516e-05READ2.947453e-03

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lncRNA-Protein interaction for LINC00526

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000264575ENST00000581067LINC00526ENSG00000154832CXXC145.0394.6933Q9P0U4TF,EpiNA
ENSG00000264575ENST00000581067LINC00526ENSG00000141644MBD132.6992.9654Q9UIS9TF,EpiNA
ENSG00000264575ENST00000581067LINC00526ENSG00000116560SFPQ38.3490.3307P23246RBP,EpiNA
ENSG00000264575ENST00000581067LINC00526ENSG00000198176TFDP19.9692.6906Q14186TF,EpiChIP-seq

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000264575ENST00000581067LINC00526ENSG00000025156HSF251.3692.6883Q03933TFNA
ENSG00000264575ENST00000581067LINC00526ENSG00000154832CXXC145.0394.6615Q9P0U4TF,EpiNA
ENSG00000264575ENST00000581067LINC00526ENSG00000142065ZFP1440.2893.7462Q9HCL3TFNA
ENSG00000264575ENST00000581067LINC00526ENSG00000198040ZNF8438.3694.4195P51523TFNA
ENSG00000264575ENST00000581067LINC00526ENSG00000124459ZNF4537.995.4381Q02386TFNA
ENSG00000264575ENST00000581067LINC00526ENSG00000120784ZFP3034.4594.2807Q9Y2G7TFNA
ENSG00000264575ENST00000581067LINC00526ENSG00000065029ZNF7633.6693.5746P36508TFNA
ENSG00000264575ENST00000581067LINC00526ENSG00000141644MBD132.6993.0102Q9UIS9TF,EpiNA
ENSG00000264575ENST00000581067LINC00526ENSG00000168795ZBTB530.4992.4272O15062TFNA
ENSG00000264575ENST00000581067LINC00526ENSG00000126705AHDC124.9693.207Q5TGY3TFPredict
ENSG00000264575ENST00000581067LINC00526ENSG00000175691ZNF7723.7895.1593Q15935TFNA
ENSG00000264575ENST00000581067LINC00526ENSG00000095574IKZF518.0190.1822Q9H5V7TFNA
ENSG00000264575ENST00000581067LINC00526ENSG00000196378ZNF3417.1794.0643Q8IZ26TFPredict
ENSG00000264575ENST00000581067LINC00526ENSG00000101076HNF4A16.1392.1109P41235TFChIP-seq
ENSG00000264575ENST00000581067LINC00526ENSG00000175395ZNF2510.294.8672P17030TFNA
ENSG00000264575ENST00000581067LINC00526ENSG00000198176TFDP19.9691.42Q14186TF,EpiChIP-seq
ENSG00000264575ENST00000581067LINC00526ENSG00000275111ZNF26.5193.9155Q9BSG1TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000264575ENST00000581067LINC00526ENSG00000116560SFPQ38.3490.2469P23246RBP,EpiNA
ENSG00000264575ENST00000581067LINC00526ENSG00000135314KHDC127.6694.3379Q4VXA5RBPNA
ENSG00000264575ENST00000581067LINC00526ENSG00000100461RBM238.2996.5881Q86U06RBPNA

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lncRNA-DNA interaction for LINC00526

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for LINC00526

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
TEAD4,NFKB2,KLF16
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
lncRNA and exonskipping events positive correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation
ENSG00000264575ENST00000581067exon_skip_322579chr19:55455635-55455845-34.68-0.1708ISOC2ENST00000425675In-frame
ENSG00000264575ENST00000581067exon_skip_331103chr2:171712766-171712826-11.73-0.2213DYNC1I2ENST00000397119,ENST00000409773In-frame
ENSG00000264575ENST00000581067exon_skip_150854chr17:32366664-32366757-10.21-0.1134ZNF207ENST00000321233In-frame
ENSG00000264575ENST00000581067exon_skip_4279chr1:36174897-36175008-17.07-0.2276MAP7D1ENST00000373151In-frame

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000264575ENST00000581067exon_skip_287763chr17:28884224-28884315-23.56-0.2873FLOT2ENST00000394908Frame-shift

check buttonlncRNA targets by miRNA.
lncRNA targets by miRNA
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source
ENSG00000264575hsa-mir-21ENST00000581067chr18:5237697-5237772167.00-67.4777NA
ENSG00000264575hsa-mir-21ENST00000581067chr18:5237298-5237366164.00-76.6869NA
ENSG00000264575hsa-mir-21ENST00000581067chr18:5237366-5237444163.00-68.2369NA
ENSG00000264575hsa-mir-21ENST00000581067chr18:5236725-5236789160.00-75.3265NA
ENSG00000264575hsa-mir-21ENST00000581067chr18:5238109-5238180159.00-63.8162NA
ENSG00000264575hsa-mir-21ENST00000581067chr18:5236974-5237049152.00-73.0374NA
ENSG00000264575hsa-mir-21ENST00000581067chr18:5237942-5238012148.00-69.5669NA
ENSG00000264575hsa-mir-21ENST00000581067chr18:5237859-5237935147.00-71.5475NA
ENSG00000264575hsa-mir-21ENST00000581067chr18:5238230-5238306146.00-59.2568NA
ENSG00000264575hsa-mir-21ENST00000581067chr18:5237041-5237112144.00-72.6172NA
ENSG00000264575hsa-mir-21ENST00000581067chr18:5237120-5237188144.00-64.0863NA
ENSG00000264575hsa-mir-21ENST00000581067chr18:5236883-5236964142.00-71.5878NA
ENSG00000264575hsa-mir-221ENST00000581067chr18:5236767-5236879204.00-99.92109NA
ENSG00000264575hsa-mir-221ENST00000581067chr18:5237873-5238000201.00-103.27119NA
ENSG00000264575hsa-mir-221ENST00000581067chr18:5237251-5237363191.00-120.08114NA
ENSG00000264575hsa-mir-221ENST00000581067chr18:5238245-5238357188.00-81.27109NA
ENSG00000264575hsa-mir-221ENST00000581067chr18:5238448-5238549187.00-65.90105NA
ENSG00000264575hsa-mir-221ENST00000581067chr18:5237031-5237129185.00-101.02110NA
ENSG00000264575hsa-mir-221ENST00000581067chr18:5237775-5237877185.00-92.00109NA
ENSG00000264575hsa-mir-221ENST00000581067chr18:5237997-5238120184.00-92.36123NA
ENSG00000264575hsa-mir-221ENST00000581067chr18:5238116-5238237182.00-90.80121NA
ENSG00000264575hsa-mir-221ENST00000581067chr18:5237532-5237635170.00-90.92100NA
ENSG00000264575hsa-mir-221ENST00000581067chr18:5237137-5237257168.00-104.12121NA
ENSG00000264575hsa-mir-221ENST00000581067chr18:5237411-5237510152.00-104.61106NA
ENSG00000264575hsa-mir-221ENST00000581067chr18:5236934-5237042141.00-90.46107NA
ENSG00000264575hsa-mir-221ENST00000581067chr18:5237654-5237766141.00-87.85109NA
ENSG00000264575hsa-mir-222ENST00000581067chr18:5236972-5237077229.00-117.54110NA
ENSG00000264575hsa-mir-222ENST00000581067chr18:5238047-5238155214.00-99.61107NA
ENSG00000264575hsa-mir-222ENST00000581067chr18:5237084-5237208211.00-107.71124NA
ENSG00000264575hsa-mir-222ENST00000581067chr18:5237254-5237368211.00-128.93111NA
ENSG00000264575hsa-mir-222ENST00000581067chr18:5237801-5237904210.00-105.06109NA
ENSG00000264575hsa-mir-222ENST00000581067chr18:5236804-5236905197.00-104.30110NA
ENSG00000264575hsa-mir-222ENST00000581067chr18:5237417-5237521196.00-118.98110NA
ENSG00000264575hsa-mir-222ENST00000581067chr18:5237656-5237759184.00-92.12102NA
ENSG00000264575hsa-mir-222ENST00000581067chr18:5237892-5237998177.00-98.80104NA
ENSG00000264575hsa-mir-222ENST00000581067chr18:5238169-5238287176.00-100.95118NA
ENSG00000264575hsa-mir-222ENST00000581067chr18:5238333-5238446160.00-84.90111NA
ENSG00000264575hsa-mir-222ENST00000581067chr18:5237535-5237656153.00-98.71118NA

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Variants for LINC00526

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types
ENSG00000264575LINC00526,hsa-mir-221,TCAIMPCPG,KICH,CHOL,LGG,GBM
ENSG00000264575LINC00526,hsa-mir-222,TCAIMPCPG,KICH,CHOL,LGG,GBM

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000264575.1ENST00000581067.1153976515