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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000259658

Summary for RP11-89K11.1

check button Gene summary

Gene informationEnsembl ID

ENSG00000259658

Gene symbol

RP11-89K11.1

Gene name
HGNC
Entrez ID

100128108

Gene typelincRNA
Synonyms
UniProtAcc

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Structure and expression level for RP11-89K11.1

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002596586.843487e+011.771458e+001.243714e-011.424329e+014.930000e-461.010000e-44UPKIRC
ENSG000002596585.531772e+011.348180e+002.227049e-016.053660e+001.420000e-099.630000e-09UPKIRP

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG00000259658-3.195285e-016.692524e-15THCA9.852882e-14

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lncRNA-Protein interaction for RP11-89K11.1

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

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lncRNA-DNA interaction for RP11-89K11.1

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
ZNF30,PHF1,RBM6,ZBED5,KHDC1,GLI4,RBM39,EDC3,CENPT,TTC14,NOL3,HSF4,RBM5,SUGP1,ZFP82,MZF1,ZFP28,RBM4B,DMTF1,TIGD1,RBM26,RBM45,TRA2A,PCBP4,CWC15,CPEB1,DHX34,HINFP,NR2C1,ZMAT1,ZNF83,NSUN6,RNPC3,SAFB2,THOC1,DDX17,EIF2D,ZNF10
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for RP11-89K11.1

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000259658ENST00000560292exon_skip_370518chr22:50247691-50247776-14.75-0.2201HDAC10ENST00000216271Frame-shift
ENSG00000259658ENST00000560292exon_skip_41813chr10:68337857-68337996-18.02-0.1453HNRNPH3ENST00000265866Frame-shift
ENSG00000259658ENST00000560292exon_skip_382458chr3:38131595-38131638-7.37-0.1939ACAA1ENST00000333167Frame-shift
ENSG00000259658ENST00000560292exon_skip_470226chr7:103307595-103307708-10.19-0.1757PMPCBENST00000249269Frame-shift

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for RP11-89K11.1

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name
LncEditing_303149ENSG00000259658.3chr15101744987-lincRNARP11-89K11.1ENST00000558592.1lincRNARP11-89K11.1-001
LncEditing_303151ENSG00000259658.3chr15101745011-lincRNARP11-89K11.1ENST00000558592.1lincRNARP11-89K11.1-001
LncEditing_303156ENSG00000259658.3chr15101745036-lincRNARP11-89K11.1ENST00000558592.1lincRNARP11-89K11.1-001
LncEditing_303159ENSG00000259658.3chr15101745066-lincRNARP11-89K11.1ENST00000558592.1lincRNARP11-89K11.1-001
LncEditing_303163ENSG00000259658.3chr15101745125-lincRNARP11-89K11.1ENST00000558592.1lincRNARP11-89K11.1-001

check buttonEdited-associated DElncRNAs in cancer.
Differentially expressed gene
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange
ENSG00000259658LncEditing_303149KIRCchr15_101744987_-3.312523e+001.530681e+008.978622e-011.027577e+019.062206e-253.131730e-24UP
ENSG00000259658LncEditing_303151KIRCchr15_101745011_-3.214582e+001.571954e+009.689243e-019.742909e+001.978094e-225.423335e-22UP
ENSG00000259658LncEditing_303159KIRCchr15_101745066_-3.187614e+001.475486e+008.998581e-011.131042e+011.165327e-295.696304e-29UP
ENSG00000259658LncEditing_303159DLBCchr15_101745066_-3.123211e+001.621266e+001.057185e+002.088932e+003.671386e-023.912697e-02UP
ENSG00000259658LncEditing_303159THCAchr15_101745066_-2.645010e+001.352862e+001.033849e+008.266373e+001.380960e-163.961347e-16UP
ENSG00000259658LncEditing_303149THYMchr15_101744987_-4.785270e+003.682207e+002.645295e+003.221328e+001.275980e-031.746416e-03UP
ENSG00000259658LncEditing_303151THYMchr15_101745011_-4.496261e+003.796871e+004.099793e+002.046340e+004.072292e-024.156652e-02UP
ENSG00000259658LncEditing_303156THYMchr15_101745036_-4.727357e+003.929774e+003.751117e+002.452889e+001.417139e-021.606283e-02UP
ENSG00000259658LncEditing_303159THYMchr15_101745066_-4.630920e+003.757452e+003.316261e+002.955243e+003.124228e-033.965648e-03UP
ENSG00000259658LncEditing_303163THYMchr15_101745125_-4.738441e+003.935796e+003.734731e+002.142171e+003.217974e-023.360582e-02UP

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value
ENSG00000259658LncEditing_303151-6.623988e-015.175380e-031.211796e-02
ENSG00000259658LncEditing_303149-4.428703e-011.113633e-021.537127e-02
ENSG00000259658LncEditing_3031593.655094e-012.403303e-022.676405e-02

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000259658.3ENST00000558592.110547364
ENSG00000259658.3ENST00000560292.297100393