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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000257815

Summary for PRANCR

check button Gene summary

Gene informationEnsembl ID

ENSG00000257815

Gene symbol

PRANCR

Gene nameprogenitor renewal associated non-coding RNA
HGNC

51126

Entrez ID

101928062

Gene typeantisense
SynonymsPRANCR|RP11-611E13.2|12q15
UniProtAcc

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Structure and expression level for PRANCR

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002578151.294837e+021.212707e+002.335051e-015.193490e+002.060000e-072.160000e-06UPBLCA
ENSG000002578151.084851e+021.055814e+002.940588e-013.590486e+003.300620e-043.311469e-03UPESCA

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002578155.113882e-013.305280e-04CHOL7.238908e-04
ENSG000002578153.308719e-012.948955e-05ESCA1.253306e-03
ENSG00000257815-4.504932e-019.431147e-06KICH2.021677e-05

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lncRNA-Protein interaction for PRANCR

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000257815ENST00000549651RP11-611E13.2ENSG00000132780NASP78.8790.4589P49321EpiNA

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000257815ENST00000549651RP11-611E13.2ENSG00000102878HSF45.1290.4347Q9ULV5TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000257815ENST00000549651RP11-611E13.2ENSG00000135314KHDC118.7690.2287Q4VXA5RBPNA

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lncRNA-DNA interaction for PRANCR

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for PRANCR

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
TBC1D14,CNOT1,IDH3A,VPS4B,MYH9,SNX12,RNF123,RDX,SNX6,UBR1,PI4KA,TRIP11,KAT5,MID2,ITGB1,PLEKHB2,FLVCR2,XPC,EIF4G1,SUCLG2,VPS26A,PSMC1,SEC24B,CLTC,IPO11,ACSL3,CTNNB1,CCDC47,BCL2L13,RAB31,HSPA8,APAF1,TMEM127,RNF111,PCNX1,TPP1,COPS4,SEC24D,LRP10,IQGAP1,IQGAP2,SEC23A,STK24,UBE3C,ABHD2,COPB2,PRKAR2A,TM9SF1,RAB11FIP1,NIPA2,USP9X,MYOF,HSPG2,ZFYVE1,KIF13B,DYNC1LI2,KBTBD4,ATG7,DCTN1,DNAJC13,FOXN3,ADAM9,AZI2,PPARA,TRIP12,ITGA6,TFIP11,SEC23B,GTF2I,CSNK1A1,SPTLC1,DYNC1H1,SMG8,CAB39,POLK,ACTN4,ERAP1,YME1L1,CYFIP1,ARL2BP,CAST,PLAA,SNX18,BTD,CCNK,PSMD1,AHNAK,MCFD2,SDAD1,PGM2
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000257815ENST00000553135exon_skip_436035chr5:79656957-79657001-6.51-0.3100TENT2ENST00000296783,ENST00000428308,ENST00000453514Frame-shift
ENSG00000257815ENST00000553135exon_skip_111863chr14:23565815-23565892-15.55-0.2549AP1G2ENST00000308724,ENST00000397120Frame-shift
ENSG00000257815ENST00000553135exon_skip_382458chr3:38131595-38131638-6.48-0.1662ACAA1ENST00000333167Frame-shift
ENSG00000257815ENST00000549651exon_skip_16568chr1:201989382-201989531-16.13-0.1333RNPEPENST00000295640Frame-shift
ENSG00000257815ENST00000553135exon_skip_41813chr10:68337857-68337996-14.75-0.1432HNRNPH3ENST00000265866Frame-shift
ENSG00000257815ENST00000553135exon_skip_41841chr10:68756272-68756483-19.88-0.1169CCAR1ENST00000265872Frame-shift
ENSG00000257815ENST00000553135exon_skip_53559chr10:101793912-101793998-8.70-0.1012OGAENST00000361464Frame-shift
ENSG00000257815ENST00000553135exon_skip_66482chr11:126274926-126275021-10.25-0.1152FOXRED1ENST00000263578Frame-shift
ENSG00000257815ENST00000553135exon_skip_74009chr11:64773429-64773505-9.58-0.2129SF1ENST00000377390Frame-shift
ENSG00000257815ENST00000553135exon_skip_87733chr12:120571190-120571291-14.14-0.2049RNF10ENST00000325954Frame-shift
ENSG00000257815ENST00000553135exon_skip_114365chr14:74290026-74290118-14.50-0.1812ABCD4ENST00000356924Frame-shift
ENSG00000257815ENST00000553135exon_skip_127618chr15:58890280-58890461-15.96-0.1071SLTMENST00000380516Frame-shift
ENSG00000257815ENST00000553135exon_skip_309204chr19:49181348-49181461-13.73-0.2112TRPM4ENST00000252826Frame-shift
ENSG00000257815ENST00000553135exon_skip_319223chr19:43526200-43526349-19.10-0.1447ETHE1ENST00000292147Frame-shift
ENSG00000257815ENST00000553135exon_skip_324294chr2:27774423-27774530-12.80-0.2977MRPL33ENST00000296102Frame-shift
ENSG00000257815ENST00000553135exon_skip_350725chr20:35500048-35500169-10.10-0.1041CEP250ENST00000397527Frame-shift
ENSG00000257815ENST00000553135exon_skip_353131chr20:58669290-58669453-19.80-0.1752STX16ENST00000371141Frame-shift
ENSG00000257815ENST00000553135exon_skip_358821chr20:63943652-63943669-6.26-1.2520UCKL1ENST00000354216Frame-shift
ENSG00000257815ENST00000553135exon_skip_370518chr22:50247691-50247776-9.61-0.1264HDAC10ENST00000216271Frame-shift
ENSG00000257815ENST00000553135exon_skip_377198chr3:123130479-123130616-18.05-0.1492PDIA5ENST00000316218Frame-shift
ENSG00000257815ENST00000553135exon_skip_380242chr3:186784961-186785101-12.58-0.1048EIF4A2ENST00000323963Frame-shift
ENSG00000257815ENST00000553135exon_skip_433210chr4:177436275-177436351-7.16-0.1461AGAENST00000264595Frame-shift
ENSG00000257815ENST00000549651exon_skip_442657chr5:74730259-74730398-13.89-0.1077GFM2ENST00000296805,ENST00000509430Frame-shift
ENSG00000257815ENST00000549651exon_skip_445390chr5:150403120-150403312-28.29-0.1664CD74ENST00000009530In-frame
ENSG00000257815ENST00000553135exon_skip_470226chr7:103307595-103307708-13.99-0.1283PMPCBENST00000249269Frame-shift
ENSG00000257815ENST00000553135exon_skip_476549chr7:76013741-76013887-18.60-0.1691STYXL1ENST00000248600,ENST00000359697,ENST00000431581Frame-shift
ENSG00000257815ENST00000549651exon_skip_511212chrX:71555189-71555385-22.47-0.1183OGTENST00000373719Frame-shift
ENSG00000257815ENST00000553135exon_skip_11029chr1:154989559-154989707-13.29-0.1278FLAD1ENST00000292180Frame-shift
ENSG00000257815ENST00000553135exon_skip_52701chr10:97468965-97469104-15.76-0.1487MMS19ENST00000370782,ENST00000438925Frame-shift
ENSG00000257815ENST00000553135exon_skip_140339chr16:635611-635774-19.59-0.1315METTL26ENST00000301686Frame-shift
ENSG00000257815ENST00000553135exon_skip_153767chr17:48057031-48057121-11.92-0.1419NFE2L1ENST00000362042In-frame
ENSG00000257815ENST00000553135exon_skip_5818chr1:45568484-45568684-15.44-0.1816AKR1A1ENST00000351829,ENST00000372070Frame-shift
ENSG00000257815ENST00000553135exon_skip_125857chr15:34361399-34361532-15.55-0.1851LPCAT4ENST00000314891Frame-shift
ENSG00000257815ENST00000553135exon_skip_439146chr5:154950820-154950938-13.48-0.1498MRPL22ENST00000523037Frame-shift

check buttonlncRNA targets by miRNA.
lncRNA targets by miRNA
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source
ENSG00000257815hsa-mir-22ENST00000549419chr12:69904191-69904279169.00-81.2184NA
ENSG00000257815hsa-mir-22ENST00000549419chr12:69904356-69904440154.00-68.1784NA
ENSG00000257815hsa-mir-22ENST00000549419chr12:69904471-69904564144.00-76.8494NA
ENSG00000257815hsa-mir-22ENST00000550216chr12:70225059-70225160189.00-106.4598NA
ENSG00000257815hsa-mir-22ENST00000550216chr12:70225279-70225367161.00-70.0387NA
ENSG00000257815hsa-mir-22ENST00000550216chr12:70225372-70225466146.00-64.8393NA
ENSG00000257815hsa-mir-22ENST00000549651chr12:70242490-70242591189.00-106.4598NA
ENSG00000257815hsa-mir-22ENST00000549651chr12:70242352-70242441168.00-89.2591NA
ENSG00000257815hsa-mir-22ENST00000549651chr12:70242844-70242922164.00-73.1467NA
ENSG00000257815hsa-mir-22ENST00000549651chr12:70242742-70242826156.00-74.4084NA
ENSG00000257815hsa-mir-22ENST00000549651chr12:70243007-70243090153.00-58.8472NA
ENSG00000257815hsa-mir-22ENST00000549651chr12:70242633-70242710149.00-68.7483NA
ENSG00000257815hsa-mir-22ENST00000553135chr12:70242779-70242857164.00-73.1467NA
ENSG00000257815hsa-mir-22ENST00000553135chr12:70242677-70242761156.00-74.4084NA
ENSG00000257815hsa-mir-22ENST00000553135chr12:70242568-70242645149.00-68.7483NA

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Variants for PRANCR

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name
LncEditing_254581ENSG00000257815.4chr1270215977-antisenseRP11-611E13.2ENST00000549419.4antisenseRP11-611E13.2-001

check buttonEdited-associated DElncRNAs in cancer.
Differentially expressed gene
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange
ENSG00000257815LncEditing_254581LAMLchr12_70215977_-3.907979e+003.235203e+003.668829e+002.058493e+003.954281e-024.006183e-02UP

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types
ENSG00000257815PRANCR,hsa-mir-22,C1orf35KICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,FUZKICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,PRR14KICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,ILKAPKICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,RETREG3KICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,BOLA1KICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,POLR2HKICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,DYNC2I2KICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,MRPL53KICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,TSEN54KICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,TEPSINKICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,FBXO46KICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,CCDC57KICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,SNRPAKICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,INTS11KICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,SUGP1KICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,CDK5RAP3KICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,UBXN11KICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,WDR83KICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,SSBP4KICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,NT5CKICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,SRRTKICH,CHOL,PAAD,THYM,KIRP
ENSG00000257815PRANCR,hsa-mir-22,PMF1KICH,CHOL,PAAD,THYM,KIRP

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000257815.4ENST00000549419.41303890
ENSG00000257815.4ENST00000550216.11454340
ENSG00000257815.4ENST00000549651.166259459
ENSG00000257815.4ENST00000553135.18728291