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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000246067

Summary for RAB30-DT

check button Gene summary

Gene informationEnsembl ID

ENSG00000246067

Gene symbol

RAB30-DT

Gene nameRAB30 divergent transcript
HGNC

48672

Entrez ID
Gene typelincRNA
SynonymsRAB30-AS1|11q14.1|RAB30-DT
UniProtAcc

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Structure and expression level for RAB30-DT

check buttonDifferentially expressed gene analysis between cancer and normal samples.
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002460674.839529e-017.566021e-04CHOL1.365456e-03
ENSG00000246067-4.698847e-013.388952e-06KICH8.252251e-06
ENSG000002460673.121696e-011.724248e-10LIHC6.114599e-10

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lncRNA-Protein interaction for RAB30-DT

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000067066SP10077.2694.3291P23497TF,EpiNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000116539ASH1L71.7895.133Q9NR48TF,EpiNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000134046MBD216.3491.5729Q9UBB5TF,EpiNA

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000167967E4F183.9494.296Q66K89TFNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000067066SP10077.2693.8643P23497TF,EpiNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000116539ASH1L71.7894.6941Q9NR48TF,EpiNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000005889ZFX61.3391.1081P17010TFChIP-seq
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000196670ZFP6251.5893.3075Q8NB50TFNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000168795ZBTB537.094.3887O15062TFNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000198815FOXJ331.9690.0473Q9UPW0TFNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000062194GPBP127.1390.3815Q86WP2TFNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000065029ZNF7617.9892.2086P36508TFNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000134046MBD216.3490.9515Q9UBB5TF,EpiNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000167766ZNF8310.3791.203P51522TFChIP-seq

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000178105DDX10102.5791.2145Q13206RBPNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000106344RBM2871.0993.2664Q9NW13RBPNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000135870RC3H149.1694.7673Q5TC82RBPNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000140319SRP1437.9691.753P37108RBPNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000265241RBM8A33.5391.8368Q9Y5S9RBPNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000084072PPIE29.6492.8912Q9UNP9RBPNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000117133RPF121.2393.2032Q9H9Y2RBPNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000110060PUS318.391.3128Q9BZE2RBPNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000089280FUS15.3694.0473P35637RBPHITS-CLIP,PAR-CLIP,High-throughput data
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000108349CASC315.1892.3578O15234RBPNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000134597RBMX214.5291.7418Q9Y388RBPNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000111605CPSF614.2593.7665Q16630RBPENCODE;High-throughput data,eCLIP,PAR-CLIP
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000121390PSPC110.4693.6179Q8WXF1RBPNA
ENSG00000246067ENST00000533708RAB30-AS1ENSG00000149532CPSF77.2193.9064Q8N684RBPHigh-throughput data,PAR-CLIP

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lncRNA-DNA interaction for RAB30-DT

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
SLIRP,GLI4,PBX2,KLF12,IRF3,CIRBP,RBM7,NRF1,PHF19,RFX5,SUGP2,DMTF1,RBM28,TBP,GABPA,DDX55,ZBTB5,RNPC3,ZFP69,SAFB2,THOC1,LSM3,TRNT1,CHTOP,LSM5,ZBED5,CENPT,TTC14,RBM4,RC3H1,SP100,SUGP1,ZNF44,RBMX,AGO2,RBM4B,CSTF3,PUS3,RBM26,RNPS1,RBM14,PURB,ZBTB3,CWC15,ASH1L,DHX34,CASC3,PPIE,CPSF7,MBD2,SF3B6,NELFE,LIN54,THAP9,DDX6,USF1,E2F5,CSTF1,E2F6,ZNF22,PHF1,FOXJ3,THYN1,ZC3H8,TGIF2,HSF4,NOL9,THOC6,DZIP3,ILF2,ZFP62,ZNF48,CELF1,PSPC1,RTCA,ELK4,TIGD1,RBM45,MBD4,AGO3,THAP3,UNC50,SRSF2,MYNN,ZNF83,NXF1,ZFX,EIF2D,PUS10,GPBP1,C1D,RBM6,HMGN3,CPSF3,KHDC1,E2F1,NOL3,PUM2,XPO1,RBM5,ELF2,LSM2,NFYB,ZNF84,PIN1,RXRB,TRA2A,RBM8A,SMYD3,ZNF69,HINFP,XPA,NR2C1,THOC7,TFDP2,PCGF6,SFPQ,RBM33,SRSF7
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.
Only predicted by TDF
RBM5,CNOT6,GMEB1,MYNN,CELF1,LSM2,TBP,DDX10,RBM6,CIRBP,EIF2D,SRP14
Exist in public source
NA

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for RAB30-DT

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000246067ENST00000534499exon_skip_303345chr19:17227839-17228005-16.98-0.1196OCEL1ENST00000215061Frame-shift
ENSG00000246067ENST00000530270exon_skip_370518chr22:50247691-50247776-9.15-0.1726HDAC10ENST00000216271Frame-shift
ENSG00000246067ENST00000534499exon_skip_5818chr1:45568484-45568684-17.20-0.1211AKR1A1ENST00000351829,ENST00000372070Frame-shift
ENSG00000246067ENST00000530270exon_skip_11029chr1:154989559-154989707-19.92-0.1633FLAD1ENST00000292180Frame-shift
ENSG00000246067ENST00000530270exon_skip_11532chr1:155137560-155137722-19.26-0.1211SLC50A1ENST00000368404In-frame
ENSG00000246067ENST00000530270exon_skip_123726chr15:75339701-75339878-14.76-0.1210COMMD4ENST00000267935In-frame
ENSG00000246067ENST00000530270exon_skip_140232chr16:634888-634956-9.10-0.2333METTL26ENST00000301686Frame-shift
ENSG00000246067ENST00000530270exon_skip_140339chr16:635611-635774-22.39-0.1503METTL26ENST00000301686Frame-shift
ENSG00000246067ENST00000530270exon_skip_145647chr16:69121052-69121170-11.97-0.1088CHTF8ENST00000398235,ENST00000448552Frame-shift
ENSG00000246067ENST00000530270exon_skip_382458chr3:38131595-38131638-6.03-0.3174ACAA1ENST00000333167Frame-shift
ENSG00000246067ENST00000530270exon_skip_436498chr5:96729152-96729209-8.60-0.2687CASTENST00000341926,ENST00000395813In-frame
ENSG00000246067ENST00000530270exon_skip_446770chr5:178215275-178215430-15.76-0.1185PHYKPLENST00000308158Frame-shift
ENSG00000246067ENST00000530270exon_skip_462160chr6:127316449-127316502-7.57-0.1802ECHDC1ENST00000531967Frame-shift
ENSG00000246067ENST00000530270exon_skip_114365chr14:74290026-74290118-10.20-0.1186ABCD4ENST00000356924Frame-shift
ENSG00000246067ENST00000530270exon_skip_353131chr20:58669290-58669453-19.46-0.1306STX16ENST00000371141Frame-shift
ENSG00000246067ENST00000530270exon_skip_360685chr21:44973196-44973265-10.21-0.1926FAM207AENST00000291634In-frame
ENSG00000246067ENST00000533528exon_skip_370501chr22:50220250-50221874-30.30-0.1086TUBGCP6ENST00000248846Frame-shift
ENSG00000246067ENST00000526795exon_skip_123601chr15:74897010-74897219-16.40-0.1242MPIENST00000352410Frame-shift

check buttonlncRNA targets by miRNA.
lncRNA targets by miRNA
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source
ENSG00000246067hsa-mir-22ENST00000527627chr11:83072406-83072491181.00-77.6685NA
ENSG00000246067hsa-mir-22ENST00000526795chr11:83072085-83072176183.00-89.9086NA
ENSG00000246067hsa-mir-22ENST00000526795chr11:83072536-83072620154.00-74.1272NA
ENSG00000246067hsa-mir-22ENST00000533528chr11:83072132-83072205157.00-84.0982NA
ENSG00000246067hsa-mir-22ENST00000533528chr11:83072228-83072314152.00-67.3987NA
ENSG00000246067hsa-mir-22ENST00000533528chr11:83072321-83072403147.00-66.1676NA
ENSG00000246067hsa-mir-22ENST00000533708chr11:83072284-83072381177.00-72.9293NA
ENSG00000246067hsa-mir-22ENST00000533708chr11:83072532-83072624173.00-89.5385NA
ENSG00000246067hsa-mir-22ENST00000533708chr11:83072119-83072176167.00-68.5652NA
ENSG00000246067hsa-mir-22ENST00000533708chr11:83072708-83072799157.00-67.3187NA
ENSG00000246067hsa-mir-22ENST00000534499chr11:83072249-83072346177.00-72.9293NA
ENSG00000246067hsa-mir-22ENST00000534499chr11:83072497-83072589173.00-89.5385NA
ENSG00000246067hsa-mir-22ENST00000528156chr11:83072347-83072437152.00-69.6781NA
ENSG00000246067hsa-mir-22ENST00000528156chr11:83072421-83072513141.00-83.1180NA
ENSG00000246067hsa-mir-22ENST00000528156chr11:83072598-83072702140.00-76.51103NA
ENSG00000246067hsa-mir-22ENST00000530270chr11:83073274-83073359170.00-61.1284NA
ENSG00000246067hsa-mir-22ENST00000530270chr11:83073143-83073221160.00-66.1570NA
ENSG00000246067hsa-mir-22ENST00000530270chr11:83072356-83072437152.00-68.1881NA
ENSG00000246067hsa-mir-22ENST00000530270chr11:83072421-83072513141.00-83.1180NA
ENSG00000246067hsa-mir-22ENST00000530270chr11:83072598-83072702140.00-76.51103NA

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Variants for RAB30-DT

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types
ENSG00000246067ENSG00000065029ZNF76ENSG00000003756RBM55CHOL,KICH,KIRC,LGG,THCA
ENSG00000246067ENSG00000167766ZNF83ENSG00000003756RBM55CHOL,COAD,KICH,KIRC,LUAD
ENSG00000246067ENSG00000065029ZNF76ENSG00000112592TBP6CHOL,KICH,KIRC,KIRP,LIHC,THCA
ENSG00000246067ENSG00000167766ZNF83ENSG00000112592TBP5CHOL,KICH,KIRC,KIRP,LIHC
ENSG00000246067ENSG00000065029ZNF76ENSG00000004534RBM69CHOL,KICH,KIRC,KIRP,LGG,LIHC,PRAD,THCA,THYM
ENSG00000246067ENSG00000167766ZNF83ENSG00000004534RBM68CHOL,COAD,KICH,KIRC,KIRP,LIHC,LUAD,PRAD
ENSG00000246067ENSG00000065029ZNF76ENSG00000099622CIRBP5CHOL,KIRP,LGG,PRAD,THCA
ENSG00000246067ENSG00000167967E4F1ENSG00000099622CIRBP5CHOL,HNSC,KIRP,LGG,PRAD
ENSG00000246067ENSG00000065029ZNF76ENSG00000143486EIF2D6KICH,KIRP,LGG,LIHC,PAAD,THCA

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types
ENSG00000246067RAB30-DT,hsa-mir-22,C1orf35KICH,CHOL,ACC,SARC,THYM
ENSG00000246067RAB30-DT,hsa-mir-22,PTMAKICH,CHOL,ACC,SARC,THYM
ENSG00000246067RAB30-DT,hsa-mir-22,FBXO46KICH,CHOL,ACC,SARC,THYM
ENSG00000246067RAB30-DT,hsa-mir-22,RBM14KICH,CHOL,ACC,SARC,THYM
ENSG00000246067RAB30-DT,hsa-mir-22,FAF1KICH,CHOL,ACC,SARC,THYM
ENSG00000246067RAB30-DT,hsa-mir-22,BUD13KICH,CHOL,ACC,SARC,THYM
ENSG00000246067RAB30-DT,hsa-mir-22,SRRTKICH,CHOL,ACC,SARC,THYM
ENSG00000246067RAB30-DT,hsa-mir-22,SKA2KICH,CHOL,ACC,SARC,THYM
ENSG00000246067RAB30-DT,hsa-mir-22,CCHCR1KICH,CHOL,ACC,SARC,THYM

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000246067.6ENST00000501011.571169384
ENSG00000246067.6ENST00000527627.47024634
ENSG00000246067.6ENST00000526795.1531602
ENSG00000246067.6ENST00000533528.15317918
ENSG00000246067.6ENST00000533708.125196273
ENSG00000246067.6ENST00000534499.169518309
ENSG00000246067.6ENST00000528156.169479270
ENSG00000246067.6ENST00000530270.287111374