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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000244300

Summary for GATA2-AS1

check button Gene summary

Gene informationEnsembl ID

ENSG00000244300

Gene symbol

GATA2-AS1

Gene nameGATA2 antisense RNA 1
HGNC

51108

Entrez ID
Gene typeantisense
SynonymsGATA2-AS1|03q21.3
UniProtAcc

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Structure and expression level for GATA2-AS1

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002443001.093066e+022.653501e+005.835588e-014.547101e+005.440000e-063.110000e-05UPCHOL
ENSG000002443007.099983e+021.574061e+002.240450e-017.025646e+002.130000e-121.600000e-11UPKICH
ENSG000002443002.792938e+023.114966e+004.974982e-016.261262e+003.820000e-102.990000e-08UPPCPG
ENSG000002443001.335347e+022.833631e+002.354337e-011.203579e+012.300000e-337.580000e-32UPCOAD
ENSG000002443001.590039e+021.297080e+002.898083e-014.475647e+007.620000e-064.170000e-05UPSTAD
ENSG000002443001.780066e+022.295771e+004.353226e-015.273725e+001.340000e-072.080000e-06UPREAD

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002443004.694406e-011.141121e-03CHOL1.896607e-03
ENSG000002443003.945980e-011.299774e-04KICH2.142367e-04
ENSG00000244300-3.113661e-013.905527e-15KIRC1.642511e-14

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lncRNA-Protein interaction for GATA2-AS1

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000244300ENST00000464242GATA2-AS1ENSG00000140836ZFHX322.9793.2645Q15911TFNA
ENSG00000244300ENST00000464242GATA2-AS1ENSG00000196670ZFP6219.3290.9234Q8NB50TFNA
ENSG00000244300ENST00000464242GATA2-AS1ENSG00000114439BBX18.8191.2068Q8WY36TFPredict
ENSG00000244300ENST00000473958GATA2-AS1ENSG00000140836ZFHX325.9392.7608Q15911TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

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lncRNA-DNA interaction for GATA2-AS1

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
PCDH1,GATA2,GK5,TLE1,ALG12,CEP70,ZNF41,TP53BP1,ZFHX3,ARHGAP12,SLC37A1,MINDY1,ARFGEF1,RGL3,ZFP62,MAP4K3,WDR6,ILDR1,FBXO34,RALGAPA2,ZDHHC23,CRB3,RNF31,SVIP,ATP6AP1,PIGO,AP1M2,WDR5B,P4HTM,EXD2,JMY,GORASP1,SUSD1,MTMR12
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for GATA2-AS1

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for GATA2-AS1

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation
ENSG00000244300ENSG00000011566MAP4K3BLCA,CHOL,KIRC,LAML,PRADCHOL
ENSG00000244300ENSG00000071553ATP6AP1BLCA,CHOL,KICH,KIRC,UCSKICH
ENSG00000244300ENSG00000129354AP1M2BLCA,CHOL,KIRC,READ,UCSCHOL
ENSG00000244300ENSG00000143409MINDY1BLCA,CHOL,KICH,KIRC,LAMLKICH
ENSG00000244300ENSG00000145103ILDR1BLCA,CESC,CHOL,KICH,KIRC,UCSCHOL
ENSG00000244300ENSG00000156453PCDH1BLCA,CHOL,KICH,KIRC,UCSKICH
ENSG00000244300ENSG00000160190SLC37A1BLCA,CHOL,LAML,PRAD,UCSCHOL
ENSG00000244300ENSG00000184307ZDHHC23BLCA,CESC,KICH,KIRC,UCSKICH
ENSG00000244300ENSG00000188559RALGAPA2BLCA,CESC,CHOL,KICH,KIRCKICH
ENSG00000244300ENSG00000198168SVIPBLCA,CESC,KICH,KIRC,LAMLKICH
ENSG00000244300ENSG00000205517RGL3BLCA,CESC,CHOL,KICH,KIRCCHOL,KICH
ENSG00000244300ENSG00000067369TP53BP1CESC,CHOL,KICH,LAML,PCPGCHOL,PCPG
ENSG00000244300ENSG00000196781TLE1CESC,CHOL,COAD,KICH,KIRC,UCEC,UCSKICH
ENSG00000244300ENSG00000092098RNF31CHOL,KICH,KIRC,READ,UCSKICH

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000244300.2ENST00000464242.114917941345
ENSG00000244300.2ENST00000468377.1107334657
ENSG00000244300.2ENST00000473958.1153159620