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lncRNA: ENSG00000235823

Summary for OLMALINC

Gene summary

Gene information	Ensembl ID	ENSG00000235823
	Gene symbol	OLMALINC
	Gene name	oligodendrocyte maturation-associated long intergenic non-coding RNA
	HGNC	28060
	Entrez ID	90271
	Gene type	lincRNA
	Synonyms	10q24.31\|OLMALINC
	UniProtAcc

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Structure and expression level for OLMALINC

AS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.

Differentially expressed gene analysis between cancer and normal samples.

Ensembl ID	Base mean	log2FC(AD/control)	lfcSE	Stat	P-value	Adjc.p-value	DEG direction	Cancer type
ENSG00000235823	3.753397e+02	-1.221723e+00	2.617893e-01	-4.666816e+00	3.060000e-06	2.230000e-05	DOWN	GBM
ENSG00000235823	3.061651e+02	-1.704723e+00	2.650627e-01	-6.431396e+00	1.260000e-10	1.630000e-09	DOWN	CHOL
ENSG00000235823	1.468682e+03	2.802259e+00	2.057480e-01	1.361986e+01	3.050000e-42	2.700000e-40	UP	KICH
ENSG00000235823	3.554456e+02	1.017594e+00	1.423277e-01	7.149654e+00	8.700000e-13	7.350000e-12	UP	UCEC

Correlation between lncRNAs and cancer stages.

LncRNA Ensembl ID	Correlation	P-value	Cancer Type	Adjc.p-value
ENSG00000235823	6.753892e-01	3.882058e-13	KICH	1.724316e-11

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lncRNA-Protein interaction for OLMALINC

lncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID

LncRNA ENST ID

LncRNA Name

Protein Ensembl ID

Protein Name

CatRAPID Score

Lncpro Score

UniPortID

Gene Subtype

Public source

lncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID

LncRNA ENST ID

LncRNA Name

Protein Ensembl ID

Protein Name

CatRAPID Score

Lncpro Score

UniPortID

Gene Subtype

Public source

lncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID

LncRNA ENST ID

LncRNA Name

Protein Ensembl ID

Protein Name

CatRAPID Score

Lncpro Score

UniPortID

Gene Subtype

Public source

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lncRNA-DNA interaction for OLMALINC

lncRNA targets the enhancer region and positively regulates the gene expression.

Only predicted by TDF

MECP2,ZBED5,DEAF1,TTC14,HSF4,CIRBP,ETV5,ZFP62,MZF1,SGSM2,NRF1,ZNF84,RBM4B,DMTF1,CXXC5,DDX51,PCBP4,ZNF74,MBD6,ARNT2,SP4,ZMAT1,RNPC3,ZNF3,THAP6,PATZ1,DDX17,NR2C2,ZNF10

Exist in public source

lncRNA targets the promoter region and positively regulates the gene expression.

lncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for OLMALINC

lncRNA targets the 3'UTR region and negatively regulates the mRNA.

lncRNA targets the skipped exon region.

-lncRNA and exonskipping events are positively correlated.

lncRNA and exonskipping events positive correlated

LncRNA Ensembl ID	LncRNA ENST ID	Exon ID	Skipped Exon	dG	ndG	Gene name with skipped exon	TransID with skipped exon	ORF mutation
ENSG00000235823	ENST00000454935	exon_skip_482403	chr8:27445793-27445919	-13.86	-0.1283	PTK2B	ENST00000346049,ENST00000397501	In-frame

-lncRNA and exonskipping events are negatively correlated.

lncRNA and exonskipping events negative correlated

LncRNA Ensembl ID	LncRNA ENST ID	Exon ID	Skipped Exon	dG	ndG	Gene name with skipped exon	TransID with skipped exon	LOF
ENSG00000235823	ENST00000454935	exon_skip_30360	chr1:150842423-150842468	-9.63	-0.2349	ARNT	ENST00000358595	In-frame
ENSG00000235823	ENST00000454935	exon_skip_361434	chr21:25997359-25997416	-11.99	-0.3074	APP	ENST00000346798	In-frame

lncRNA targets by miRNA.

LncRNA Ensembl ID	miRNA ID	LncRNA ENST ID	Binding site in lncRNA	Score	Energy	Align Len	Public source
ENSG00000235823	hsa-mir-127	ENST00000454935	chr10:100375528-100375628	215.00	-77.17	99	NA
ENSG00000235823	hsa-mir-127	ENST00000454935	chr10:100374386-100374502	209.00	-88.41	109	NA
ENSG00000235823	hsa-mir-127	ENST00000454935	chr10:100375092-100375178	201.00	-65.32	90	NA
ENSG00000235823	hsa-mir-127	ENST00000454935	chr10:100373785-100373884	198.00	-78.76	94	NA
ENSG00000235823	hsa-mir-127	ENST00000454935	chr10:100373645-100373731	195.00	-86.45	94	NA
ENSG00000235823	hsa-mir-127	ENST00000454935	chr10:100374091-100374197	193.00	-90.90	107	NA
ENSG00000235823	hsa-mir-127	ENST00000454935	chr10:100375722-100375825	181.00	-83.93	103	NA
ENSG00000235823	hsa-mir-127	ENST00000454935	chr10:100376008-100376114	179.00	-73.09	103	NA
ENSG00000235823	hsa-mir-127	ENST00000454935	chr10:100374854-100374958	176.00	-79.12	99	NA
ENSG00000235823	hsa-mir-127	ENST00000454935	chr10:100375381-100375476	171.00	-81.14	95	NA
ENSG00000235823	hsa-mir-127	ENST00000454935	chr10:100374749-100374836	167.00	-60.54	87	NA
ENSG00000235823	hsa-mir-127	ENST00000454935	chr10:100375238-100375332	165.00	-80.63	91	NA
ENSG00000235823	hsa-mir-127	ENST00000454935	chr10:100373952-100374061	160.00	-79.56	106	NA
ENSG00000235823	hsa-mir-127	ENST00000454935	chr10:100374985-100375086	148.00	-63.64	93	NA
ENSG00000235823	hsa-mir-127	ENST00000454935	chr10:100374502-100374610	146.00	-88.93	108	NA
ENSG00000235823	hsa-mir-127	ENST00000454935	chr10:100375831-100375924	144.00	-79.78	96	NA
ENSG00000235823	hsa-mir-199a-1	ENST00000454935	chr10:100375632-100375705	212.00	-67.91	69	NA
ENSG00000235823	hsa-mir-199a-1	ENST00000454935	chr10:100374440-100374513	184.00	-60.60	73	NA
ENSG00000235823	hsa-mir-199a-1	ENST00000454935	chr10:100375253-100375329	151.00	-59.06	73	NA
ENSG00000235823	hsa-mir-199a-1	ENST00000454935	chr10:100373983-100374057	148.00	-58.51	72	NA
ENSG00000235823	hsa-mir-199a-1	ENST00000454935	chr10:100373646-100373725	147.00	-63.05	71	NA
ENSG00000235823	hsa-mir-199a-1	ENST00000454935	chr10:100375814-100375880	146.00	-59.75	68	NA
ENSG00000235823	hsa-mir-199a-1	ENST00000454935	chr10:100376018-100376091	142.00	-51.24	68	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100374426-100374539	210.00	-102.70	114	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100375618-100375719	207.00	-97.48	100	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100373616-100373713	203.00	-100.07	108	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100375208-100375312	199.00	-97.21	113	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100374325-100374434	186.00	-90.01	112	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100375445-100375545	186.00	-99.61	104	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100374190-100374300	183.00	-90.67	110	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100374883-100375000	179.00	-92.29	114	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100374577-100374694	177.00	-92.60	118	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100375998-100376116	176.00	-77.84	115	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100374044-100374150	175.00	-95.15	105	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100374753-100374861	174.00	-75.05	110	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100375325-100375445	172.00	-105.59	120	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100375784-100375894	170.00	-111.17	114	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100373806-100373911	168.00	-95.20	110	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100375009-100375122	168.00	-91.74	112	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100373894-100373996	157.00	-81.26	97	NA
ENSG00000235823	hsa-mir-199a-2	ENST00000454935	chr10:100375891-100376000	145.00	-75.83	115	NA

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Variants for OLMALINC

RNA A-to-I editing events in lncRNA.

LncRNAediting ID	LncRNA Ensembl ID	Chromosome	Editing Position	Strand	Gene Type	Gene Name	Transcript ID	Transcript Type	Transcript Name
LncEditing_237328	ENSG00000235823.1	chr10	100380738	+	lincRNA	OLMALINC	ENST00000454935.1	lincRNA	OLMALINC-001

Edited-associated DElncRNAs in cancer.

LncRNA Ensembl ID	LncRNA Index	Cancer Type	Chr_Postion_Strand	AVE1	AVE2	log2FC	W-value	P-value	Adjc.p-value	Change
ENSG00000235823	LncEditing_237328	STAD	chr10_100380738_+	4.790043e+00	2.339827e+00	9.674576e-01	6.772958e+00	1.261757e-11	2.272749e-11	UP
ENSG00000235823	LncEditing_237328	ESCA	chr10_100380738_+	5.363472e+00	2.271085e+00	8.065911e-01	6.921233e+00	4.477300e-12	1.934932e-11	UP

Correlation between RNA A-to-I editing events's frequecy and lncRNA expression.

LncRNA Ensembl ID

LncRNA Index

Correlation

P-value

Adjc.p-value

Cis-expression quantitative trait loci(cis-eQTL) of lncRNA.

LncRNA Ensembl ID

LncRNA Name

SNP info

Number of Positive corelated Cancer

Positive corelated Cancer

Number of Negative corelated Cancer

Negative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncRNA regulates differentially expressed genes by function as enhancer.

LncRNA Ensembl ID

PC Gene ID

PC Gene Name

Positive correlated cancers

Cancer with PC gene up-regulation

Cancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

LncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).

lncRNA ID

TF ID

TF Name

PCgene ID

PCgene Name

Number of Cancer

Canaer Types

LncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).

lncRNA ID

TF ID

TF Name

PCgene ID

PCgene Name

Number of Cancer

Canaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

LncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.

LncRNA Ensembl ID

RBP ID

RBP Gene Name

Exon Skipping ID

Skipped Exon

EX Gene Name

EX Affected TransID

ORF_anno

Cancer Type

LncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.

LncRNA Ensembl ID

RBP ID

RBP Gene Name

Exon Skipping ID

Skipped Exon

EX Gene Name

EX Affected TransID

ORF_anno

Cancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.

LncRNA Ensembl ID

LncRNA ENST ID

PC Gene Name

PC Gene ID

PC ENST ID

nDG

Cancer with PC gene up-regulation

Cancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncRNA regulates mRNA by competing the miRNA binding site with mRNA.

LncRNA Ensembl ID

lncRNA-miRNA-mRNA

Cancer Types

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lncRNA coding potential

ORFfinder result for the gencode.v22.lncRNA.transcript.fa.

lncRNA Ensembl ID	lncRNA ENST ID	length(AA)	start at transcript	end at transcript
ENSG00000235823.1	ENST00000454935.1	125	428	51

	lncRNA summary
	lncRNA structure and expression level
	lncRNA-Protein interaction
	lncRNA-DNA interaction
	lncRNA-RNA interaction
	Variants in lncRNA
	lncRNAs regulate the target genes through functioning as enhancers
	lncRNAs regulate the target genes through recruiting transcript factors
	lncRNAs regulate the alternative splicing events through interacting with splicing factor
	lncRNAs regulate mRNA through targeting the 3'-UTR region
	lncRNAs regulate mRNA by competing with miRNA
	lncRNA coding potential