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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000230630

Summary for DNM3OS

check button Gene summary

Gene informationEnsembl ID

ENSG00000230630

Gene symbol

DNM3OS

Gene nameDNM3 opposite strand/antisense RNA
HGNC

41228

Entrez ID
Gene typeantisense
SynonymsDNM3OS|01q24.3
UniProtAcc

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Structure and expression level for DNM3OS

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002306301.227421e+02-2.111800e+002.878403e-01-7.336708e+002.190000e-131.970000e-12DOWNUCEC

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value

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lncRNA-Protein interaction for DNM3OS

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000230630ENST00000417354DNM3OSENSG00000177200CHD943.2495.1933Q3L8U1EpiNA

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000230630ENST00000417354DNM3OSENSG00000148516ZEB132.4893.8193P37275TFNA
ENSG00000230630ENST00000417354DNM3OSENSG00000106571GLI331.198.2145P10071TFChIP-seq
ENSG00000230630ENST00000417354DNM3OSENSG00000184517ZFP122.494.4532Q6P2D0TFNA
ENSG00000230630ENST00000417354DNM3OSENSG00000116132PRRX112.4796.0569P54821TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

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lncRNA-DNA interaction for DNM3OS

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
TMEM119,SENP7,ADGRA2,FSTL1,CDON,KLF12,P3H4,FKBP10,SEPTIN7,CNRIP1,DACT3,ARHGAP31,ADAMTS7,LDB2,DSE,NREP,CCDC88A,CHD9,CDH11,FKBP7,GLT8D2,OLFML1,LIX1L,ZFP1,GLI3,COL6A3,RNF144A,FMNL3,TIA1,NRIP2,SH3PXD2A,EFS,NID1,PLXDC1,DCHS1,PCDH18
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for DNM3OS

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
lncRNA and exonskipping events positive correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation
ENSG00000230630ENST00000417354exon_skip_21610chr1:9737497-9737554-11.68-0.2716CLSTN1ENST00000377298In-frame
ENSG00000230630ENST00000417354exon_skip_287874chr17:29085603-29085648-8.68-0.2411MYO18AENST00000527372In-frame
ENSG00000230630ENST00000417354exon_skip_361434chr21:25997359-25997416-9.01-0.2435APPENST00000346798In-frame
ENSG00000230630ENST00000417354exon_skip_451515chr6:41080810-41080897-13.78-0.1701NFYAENST00000341376In-frame

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000230630ENST00000417354exon_skip_44853chr10:104010815-104010908-10.84-0.1902SLKENST00000369755In-frame
ENSG00000230630ENST00000417354exon_skip_44998chr10:110132304-110132400-13.68-0.1900ADD3ENST00000356080In-frame
ENSG00000230630ENST00000417354exon_skip_48713chr10:34336198-34336243-8.86-0.2161PARD3ENST00000374789In-frame
ENSG00000230630ENST00000417354exon_skip_302276chr19:10808568-10808580-7.06-1.4120DNM2ENST00000355667In-frame
ENSG00000230630ENST00000417354exon_skip_423795chr4:55888887-55888932-8.11-0.3119EXOC1ENST00000346134,ENST00000381295In-frame
ENSG00000230630ENST00000417354exon_skip_434332chr5:34813573-34813660-11.83-0.1536RAI14ENST00000265109,ENST00000428746,ENST00000503673In-frame
ENSG00000230630ENST00000417354exon_skip_456460chr6:17771113-17771218-18.14-0.2016KIF13AENST00000259711In-frame

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for DNM3OS

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation
ENSG00000230630ENSG00000053702NRIP2BRCA,MESO,PAAD,TGCT,UCECUCEC
ENSG00000230630ENSG00000107957SH3PXD2ABRCA,PAAD,TGCT,UCEC,UCSUCEC
ENSG00000230630ENSG00000140937CDH11BRCA,OV,PAAD,TGCT,UCEC,UCSUCEC
ENSG00000230630ENSG00000151692RNF144ABRCA,PAAD,TGCT,UCEC,UCSUCEC
ENSG00000230630ENSG00000163359COL6A3BRCA,MESO,PAAD,TGCT,UCECUCEC
ENSG00000230630ENSG00000177200CHD9BRCA,PAAD,SARC,TGCT,UCEC,UCSUCEC
ENSG00000230630ENSG00000189184PCDH18BRCA,MESO,OV,PAAD,TGCT,UCECUCEC
ENSG00000230630ENSG00000079150FKBP7MESO,OV,PAAD,TGCT,UCECUCEC
ENSG00000230630ENSG00000116962NID1MESO,OV,PAAD,TGCT,UCECUCEC
ENSG00000230630ENSG00000119865CNRIP1MESO,OV,PAAD,TGCT,UCECUCEC
ENSG00000230630ENSG00000120820GLT8D2MESO,OV,PAAD,TGCT,UCEC,UCSUCEC
ENSG00000230630ENSG00000161381PLXDC1MESO,OV,PAAD,TGCT,UCECUCEC
ENSG00000230630ENSG00000169744LDB2MESO,OV,PAAD,TGCT,UCECUCEC
ENSG00000230630ENSG00000271601LIX1LMESO,OV,PAAD,TGCT,UCEC,UCSUCEC
ENSG00000230630ENSG00000020181ADGRA2OV,PAAD,TGCT,UCEC,UCSUCEC
ENSG00000230630ENSG00000031081ARHGAP31OV,PAAD,TGCT,UCEC,UCSUCEC
ENSG00000230630ENSG00000122545SEPTIN7OV,PAAD,TGCT,UCEC,UCSUCEC
ENSG00000230630ENSG00000166341DCHS1OV,PAAD,TGCT,UCEC,UCSUCEC
ENSG00000230630ENSG00000064309CDONPAAD,SARC,TGCT,UCEC,UCSUCEC

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000230630.2ENST00000417354.244343209