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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000229589

Summary for ACVR2B-AS1

check button Gene summary

Gene informationEnsembl ID

ENSG00000229589

Gene symbol

ACVR2B-AS1

Gene nameACVR2B antisense RNA 1
HGNC

44161

Entrez ID

100128640

Gene typeantisense
Synonyms03p22.2|ACVR2B-AS1
UniProtAcc

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Structure and expression level for ACVR2B-AS1

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value

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lncRNA-Protein interaction for ACVR2B-AS1

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000229589ENST00000441531ACVR2B-AS1ENSG00000163930BAP162.5291.031Q92560EpiNA

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000229589ENST00000441531ACVR2B-AS1ENSG00000070476ZXDC44.4292.1903Q2QGD7TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000229589ENST00000441531ACVR2B-AS1ENSG00000132153DHX3038.3293.0928Q7L2E3RBPENCODE

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lncRNA-DNA interaction for ACVR2B-AS1

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
ACVR2B,SLC35A5,SLC41A3,KIAA1143,OXNAD1,TAMM41,RAF1,PDCD6IP,EIF2A,FYCO1,TXNRD3,NICN1,WDR6,RNF123,CRBN,ZXDC,BAP1,RAB5A,EIF1B,MKRN2,MRPS25,TCAIM,PHF7,SMARCC1,TFDP2,XPC,HEMK1,APPL1,TBC1D5,DCAF1,LZTFL1,TRNT1,SEC22C
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for ACVR2B-AS1

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for ACVR2B-AS1

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name
LncEditing_104013ENSG00000229589.1chr338451297-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104021ENSG00000229589.1chr338451411-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104022ENSG00000229589.1chr338451412-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104028ENSG00000229589.1chr338451457-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104029ENSG00000229589.1chr338451460-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104030ENSG00000229589.1chr338451466-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104031ENSG00000229589.1chr338451474-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104032ENSG00000229589.1chr338451475-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104042ENSG00000229589.1chr338451538-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104043ENSG00000229589.1chr338451539-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104044ENSG00000229589.1chr338451544-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104045ENSG00000229589.1chr338451552-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104046ENSG00000229589.1chr338451564-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104048ENSG00000229589.1chr338451577-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104059ENSG00000229589.1chr338452496-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104061ENSG00000229589.1chr338452503-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104062ENSG00000229589.1chr338452507-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104069ENSG00000229589.1chr338452559-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104093ENSG00000229589.1chr338452666-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001
LncEditing_104094ENSG00000229589.1chr338452671-antisenseACVR2B-AS1ENST00000441531.1antisenseACVR2B-AS1-001

check buttonEdited-associated DElncRNAs in cancer.
Differentially expressed gene
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange
ENSG00000229589LncEditing_104029UCSchr3_38451460_-1.773718e+001.077609e+001.390930e+002.755027e+005.868724e-038.497187e-03UP
ENSG00000229589LncEditing_104022KIRPchr3_38451412_-2.092880e+001.059170e+001.017755e+001.020661e+011.852293e-245.544531e-23UP
ENSG00000229589LncEditing_104028KIRPchr3_38451457_-2.220732e+001.139953e+001.039436e+009.235767e+002.564413e-202.396060e-19UP
ENSG00000229589LncEditing_104030KIRPchr3_38451466_-2.281715e+001.139923e+009.988187e-019.733524e+002.169451e-223.478869e-21UP
ENSG00000229589LncEditing_104042KIRPchr3_38451538_-2.288412e+001.220981e+001.103381e+008.317346e+008.995518e-174.696497e-16UP
ENSG00000229589LncEditing_104043KIRPchr3_38451539_-2.371667e+001.216596e+001.038366e+008.576375e+009.790974e-185.709282e-17UP
ENSG00000229589LncEditing_104048KIRPchr3_38451577_-2.336628e+001.205087e+001.046801e+008.502838e+001.850111e-171.008271e-16UP
ENSG00000229589LncEditing_104013OVchr3_38451297_-2.861440e+002.219219e+002.727107e+004.767138e+001.868615e-062.394692e-06UP
ENSG00000229589LncEditing_104021OVchr3_38451411_-3.686622e+002.204432e+001.347904e+006.585587e+004.530904e-118.537226e-11UP
ENSG00000229589LncEditing_104029OVchr3_38451460_-3.670686e+001.748387e+009.345576e-011.088692e+011.330684e-271.223564e-26UP
ENSG00000229589LncEditing_104031OVchr3_38451474_-3.920911e+002.123928e+001.130641e+007.615505e+002.626615e-146.890648e-14UP
ENSG00000229589LncEditing_104032OVchr3_38451475_-3.955163e+001.912708e+009.540888e-011.001576e+011.299656e-238.264163e-23UP
ENSG00000229589LncEditing_104044OVchr3_38451544_-3.452930e+002.178523e+001.504957e+006.970238e+003.164044e-126.719027e-12UP
ENSG00000229589LncEditing_104045OVchr3_38451552_-4.321236e+002.164807e+001.002802e+007.711081e+001.247563e-143.359105e-14UP
ENSG00000229589LncEditing_104046OVchr3_38451564_-3.585098e+002.224427e+001.452266e+005.938594e+002.874774e-094.553582e-09UP
ENSG00000229589LncEditing_104059OVchr3_38452496_-4.186009e+001.814726e+008.293085e-011.118237e+014.974464e-295.477868e-28UP
ENSG00000229589LncEditing_104061OVchr3_38452503_-3.880745e+001.674995e+008.249624e-011.193353e+017.914903e-331.565108e-31UP
ENSG00000229589LncEditing_104069OVchr3_38452559_-4.153919e+001.757852e+008.060230e-011.109086e+011.389532e-281.411795e-27UP
ENSG00000229589LncEditing_104093OVchr3_38452666_-3.998061e+001.690014e+008.049812e-011.162087e+013.228338e-314.989003e-30UP
ENSG00000229589LncEditing_104094OVchr3_38452671_-3.923407e+001.706492e+008.325889e-011.141720e+013.431142e-304.438833e-29UP
ENSG00000229589LncEditing_104022PRADchr3_38451412_-2.248855e+001.375170e+001.409283e+001.212706e+017.592240e-349.347946e-33UP
ENSG00000229589LncEditing_104028PRADchr3_38451457_-2.318185e+001.425663e+001.425797e+001.202095e+012.757765e-333.134306e-32UP
ENSG00000229589LncEditing_104029PRADchr3_38451460_-2.560449e+001.648409e+001.574003e+007.740077e+009.935675e-152.575432e-14UP
ENSG00000229589LncEditing_104030PRADchr3_38451466_-2.335741e+001.405470e+001.364577e+001.255011e+013.969747e-366.340866e-35UP
ENSG00000229589LncEditing_104042PRADchr3_38451538_-2.464950e+001.500194e+001.395850e+001.119739e+014.199466e-293.026688e-28UP
ENSG00000229589LncEditing_104043PRADchr3_38451539_-2.489750e+001.512304e+001.390332e+001.109774e+011.286507e-288.545043e-28UP
ENSG00000229589LncEditing_104048PRADchr3_38451577_-2.561640e+001.474599e+001.255107e+001.214454e+016.132504e-347.711298e-33UP
ENSG00000229589LncEditing_104093PRADchr3_38452666_-2.704084e+001.645731e+001.395846e+008.297821e+001.060381e-163.165077e-16UP
ENSG00000229589LncEditing_104094PRADchr3_38452671_-2.652667e+001.602504e+001.375298e+009.097936e+009.206483e-203.510343e-19UP

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value
ENSG00000229589LncEditing_104013-3.016855e-011.432615e-032.668475e-03
ENSG00000229589LncEditing_104021-4.208197e-012.105630e-033.653115e-03
ENSG00000229589LncEditing_104031-4.499096e-013.500990e-049.996247e-04
ENSG00000229589LncEditing_104032-3.428423e-018.787242e-041.860323e-03
ENSG00000229589LncEditing_104044-4.190500e-014.164130e-041.136624e-03
ENSG00000229589LncEditing_104045-4.344616e-014.040803e-036.005852e-03
ENSG00000229589LncEditing_104046-5.882786e-017.031647e-066.634206e-05
ENSG00000229589LncEditing_104062-3.403638e-011.876893e-033.338407e-03
ENSG00000229589LncEditing_104029-3.606037e-012.720439e-033.324981e-03
ENSG00000229589LncEditing_104061-8.234795e-012.280796e-024.535387e-02

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000229589.1ENST00000441531.159571392