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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000227039

Summary for ITGB2-AS1

check button Gene summary

Gene informationEnsembl ID

ENSG00000227039

Gene symbol

ITGB2-AS1

Gene nameITGB2 antisense RNA 1
HGNC

44304

Entrez ID

100505746

Gene typeantisense
Synonyms21q22.3|ITGB2-AS1
UniProtAcc

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Structure and expression level for ITGB2-AS1

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002270392.076072e+022.886427e+001.794503e-011.608482e+013.260000e-581.070000e-56UPKIRC
ENSG000002270391.288123e+022.170796e+002.531674e-018.574548e+009.950000e-181.890000e-16UPKIRP
ENSG000002270392.526937e+021.718810e+001.917106e-018.965650e+003.080000e-192.950000e-18UPLUAD

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002270393.688846e-014.912681e-21KIRC4.558158e-20

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lncRNA-Protein interaction for ITGB2-AS1

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000227039ENST00000441379ITGB2-AS1ENSG00000275023MLLT649.7492.4732P55198EpiNA
ENSG00000227039ENST00000441379ITGB2-AS1ENSG00000005302MSL343.294.9017Q8N5Y2EpiNA
ENSG00000227039ENST00000441379ITGB2-AS1ENSG00000156858PRR1414.8792.2633Q9BWN1EpiNA
ENSG00000227039ENST00000441379ITGB2-AS1ENSG00000079263SP14047.5194.3057Q13342TF,EpiNA
ENSG00000227039ENST00000441379ITGB2-AS1ENSG00000135655USP1545.2395.3182Q9Y4E8EpiNA
ENSG00000227039ENST00000441379ITGB2-AS1ENSG00000112511PHF17.6890.9793O43189TF,EpiNA

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000227039ENST00000441379ITGB2-AS1ENSG00000135899SP11074.8293.9242Q9HB58TFNA
ENSG00000227039ENST00000441379ITGB2-AS1ENSG00000236287ZBED559.5494.1746Q49AG3TFNA
ENSG00000227039ENST00000441379ITGB2-AS1ENSG00000138378STAT451.293.8541Q14765TFNA
ENSG00000227039ENST00000441379ITGB2-AS1ENSG00000079263SP14047.5194.3176Q13342TF,EpiNA
ENSG00000227039ENST00000441379ITGB2-AS1ENSG00000168310IRF234.690.8592P14316TFNA
ENSG00000227039ENST00000441379ITGB2-AS1ENSG00000128604IRF530.5492.6122Q13568TFChIP-seq
ENSG00000227039ENST00000441379ITGB2-AS1ENSG00000125347IRF117.4990.4624P10914TFChIP-seq
ENSG00000227039ENST00000441379ITGB2-AS1ENSG00000112511PHF17.6891.0779O43189TF,EpiNA
ENSG00000227039ENST00000441379ITGB2-AS1ENSG00000126456IRF34.1492.818Q14653TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000227039ENST00000441379ITGB2-AS1ENSG00000129566TEP151.0491.6844Q99973RBPNA
ENSG00000227039ENST00000441379ITGB2-AS1ENSG00000100650SRSF551.0392.0529Q13243RBPNA

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lncRNA-DNA interaction for ITGB2-AS1

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for ITGB2-AS1

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
TOM1L1,APOOL,L2HGDH,MAIP1
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
lncRNA and exonskipping events positive correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation
ENSG00000227039ENST00000429132exon_skip_75398chr11:72692752-72692785-11.49-0.4419ARAP1ENST00000393605In-frame
ENSG00000227039ENST00000429132exon_skip_285471chr17:3723287-3723383-10.19-0.1199ITGAEENST00000263087In-frame

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000227039ENST00000429132exon_skip_482403chr8:27445793-27445919-17.87-0.1670PTK2BENST00000346049,ENST00000397501In-frame
ENSG00000227039ENST00000429132exon_skip_511212chrX:71555189-71555385-22.34-0.1732OGTENST00000373719Frame-shift
ENSG00000227039ENST00000429132exon_skip_53559chr10:101793912-101793998-10.71-0.1727OGAENST00000361464Frame-shift
ENSG00000227039ENST00000429132exon_skip_95025chr12:79805591-79805768-19.45-0.1271PPP1R12AENST00000261207,ENST00000450142In-frame
ENSG00000227039ENST00000429132exon_skip_143275chr16:24939363-24939597-31.86-0.1517ARHGAP17ENST00000289968In-frame
ENSG00000227039ENST00000429132exon_skip_454626chr6:144827347-144827386-5.05-0.5050UTRNENST00000367545In-frame
ENSG00000227039ENST00000429132exon_skip_499791chr9:128627924-128627942-6.68-0.8350SPTAN1ENST00000372731In-frame
ENSG00000227039ENST00000429132exon_skip_64939chr11:112230207-112230230-4.69-0.3350PTSENST00000280362Frame-shift

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for ITGB2-AS1

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation
ENSG00000227039ENST00000441379L2HGDHENSG00000087299ENST00000261699-0.2807643-KIRC,KIRP
ENSG00000227039ENST00000441379L2HGDHENSG00000087299ENST00000555423-0.20381363-KIRC,KIRP
ENSG00000227039ENST00000441379L2HGDHENSG00000087299ENST00000555610-0.1034396-KIRC,KIRP
ENSG00000227039ENST00000609694L2HGDHENSG00000087299ENST00000261699-0.6786444-KIRC,KIRP
ENSG00000227039ENST00000609694L2HGDHENSG00000087299ENST00000555423-0.2479293-KIRC,KIRP
ENSG00000227039ENST00000609694L2HGDHENSG00000087299ENST00000555610-0.1378404-KIRC,KIRP
ENSG00000227039ENST00000609592L2HGDHENSG00000087299ENST00000261699-0.627132-KIRC,KIRP
ENSG00000227039ENST00000609592L2HGDHENSG00000087299ENST00000555423-0.3856374-KIRC,KIRP
ENSG00000227039ENST00000609592L2HGDHENSG00000087299ENST00000555610-0.1136330-KIRC,KIRP
ENSG00000227039ENST00000610063L2HGDHENSG00000087299ENST00000261699-0.627129-KIRC,KIRP
ENSG00000227039ENST00000610063L2HGDHENSG00000087299ENST00000555423-0.3856398-KIRC,KIRP
ENSG00000227039ENST00000610063L2HGDHENSG00000087299ENST00000555610-0.1657330-KIRC,KIRP
ENSG00000227039ENST00000610063L2HGDHENSG00000087299ENST00000554191-0.1061204-KIRC,KIRP
ENSG00000227039ENST00000608043L2HGDHENSG00000087299ENST00000261699-0.627129-KIRC,KIRP
ENSG00000227039ENST00000608043L2HGDHENSG00000087299ENST00000555423-0.2479290-KIRC,KIRP
ENSG00000227039ENST00000608043L2HGDHENSG00000087299ENST00000555610-0.1559401-KIRC,KIRP
ENSG00000227039ENST00000429132L2HGDHENSG00000087299ENST00000261699-0.205421-KIRC,KIRP
ENSG00000227039ENST00000429132L2HGDHENSG00000087299ENST00000555423-0.3856172-KIRC,KIRP
ENSG00000227039ENST00000429132L2HGDHENSG00000087299ENST00000555610-0.1324104-KIRC,KIRP

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000227039.5ENST00000441379.472666448
ENSG00000227039.5ENST00000609694.419913551954
ENSG00000227039.5ENST00000609592.154543379
ENSG00000227039.5ENST00000610063.479410171
ENSG00000227039.5ENST00000608043.413545043
ENSG00000227039.5ENST00000429132.175325549