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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000213963

Summary for AC074286.1

check button Gene summary

Gene informationEnsembl ID

ENSG00000213963

Gene symbol

AC074286.1

Gene name
HGNC
Entrez ID

100130691

Gene typesense_overlapping
Synonyms
UniProtAcc

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Structure and expression level for AC074286.1

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002139634.957895e+02-3.594713e+001.062433e-01-3.383473e+016.090000e-2514.720000e-247DOWNKIRC
ENSG000002139635.494551e+02-3.252262e+002.813864e-01-1.155800e+016.730000e-312.720000e-29DOWNKICH
ENSG000002139634.620644e+02-3.425007e+001.867001e-01-1.834497e+013.620000e-755.240000e-72DOWNKIRP
ENSG000002139636.560339e+022.364706e+002.198282e-011.075706e+015.490000e-275.080000e-26UPLUSC

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG00000213963-4.090978e-016.876326e-05KICH1.212761e-04

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lncRNA-Protein interaction for AC074286.1

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

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lncRNA-DNA interaction for AC074286.1

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for AC074286.1

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
CD63
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for AC074286.1

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name
LncEditing_97623ENSG00000213963.5chr2177296689-sense_overlappingAC074286.1ENST00000627798.1sense_overlappingAC074286.1-007
LncEditing_97943ENSG00000213963.5chr2177305502-sense_overlappingAC074286.1ENST00000627798.1sense_overlappingAC074286.1-007
LncEditing_98134ENSG00000213963.5chr2177319964-sense_overlappingAC074286.1ENST00000456746.4sense_overlappingAC074286.1-002

check buttonEdited-associated DElncRNAs in cancer.
Differentially expressed gene
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange
ENSG00000213963LncEditing_97623LAMLchr2_177296689_-3.527672e+002.527783e+002.079677e+003.135447e+001.715927e-032.134109e-03UP
ENSG00000213963LncEditing_97943LAMLchr2_177305502_-3.649831e+002.511250e+001.853830e+004.082972e+004.446346e-057.481250e-05UP
ENSG00000213963LncEditing_98134LAMLchr2_177319964_-3.299509e+002.553049e+002.702484e+002.715504e+006.617500e-037.449966e-03UP

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation
ENSG00000213963ENST00000397057CD63ENSG00000135404ENST00000420846-0.11604295KICH,KIRP-
ENSG00000213963ENST00000397057CD63ENSG00000135404ENST00000552067-0.11604300KICH,KIRP-
ENSG00000213963ENST00000397057CD63ENSG00000135404ENST00000548160-0.2384984KICH,KIRP-
ENSG00000213963ENST00000397057CD63ENSG00000135404ENST00000546939-0.2384984KICH,KIRP-
ENSG00000213963ENST00000397057CD63ENSG00000135404ENST00000552692-0.2384984KICH,KIRP-
ENSG00000213963ENST00000397057CD63ENSG00000135404ENST00000549117-0.22263165KICH,KIRP-
ENSG00000213963ENST00000397057CD63ENSG00000135404ENST00000257857-0.22263170KICH,KIRP-
ENSG00000213963ENST00000397057CD63ENSG00000135404ENST00000552754-0.53121040KICH,KIRP-
ENSG00000213963ENST00000397057CD63ENSG00000135404ENST00000550776-0.87754628KICH,KIRP-
ENSG00000213963ENST00000456746CD63ENSG00000135404ENST00000420846-0.1623649KICH,KIRP-
ENSG00000213963ENST00000456746CD63ENSG00000135404ENST00000552067-0.1623654KICH,KIRP-
ENSG00000213963ENST00000456746CD63ENSG00000135404ENST00000548160-0.1787676KICH,KIRP-
ENSG00000213963ENST00000456746CD63ENSG00000135404ENST00000546939-0.1787676KICH,KIRP-
ENSG00000213963ENST00000456746CD63ENSG00000135404ENST00000552692-0.1787676KICH,KIRP-
ENSG00000213963ENST00000456746CD63ENSG00000135404ENST00000549117-0.2547688KICH,KIRP-
ENSG00000213963ENST00000456746CD63ENSG00000135404ENST00000257857-0.2547693KICH,KIRP-
ENSG00000213963ENST00000456746CD63ENSG00000135404ENST00000552754-0.5584706KICH,KIRP-
ENSG00000213963ENST00000456746CD63ENSG00000135404ENST00000550776-0.87754577KICH,KIRP-
ENSG00000213963ENST00000430416CD63ENSG00000135404ENST00000420846-0.1083330KICH,KIRP-
ENSG00000213963ENST00000430416CD63ENSG00000135404ENST00000552067-0.1097335KICH,KIRP-
ENSG00000213963ENST00000430416CD63ENSG00000135404ENST00000548160-0.2384357KICH,KIRP-
ENSG00000213963ENST00000430416CD63ENSG00000135404ENST00000546939-0.2384357KICH,KIRP-
ENSG00000213963ENST00000430416CD63ENSG00000135404ENST00000552692-0.2384357KICH,KIRP-
ENSG00000213963ENST00000430416CD63ENSG00000135404ENST00000549117-0.2384369KICH,KIRP-
ENSG00000213963ENST00000430416CD63ENSG00000135404ENST00000257857-0.2384374KICH,KIRP-
ENSG00000213963ENST00000430416CD63ENSG00000135404ENST00000552754-0.5312413KICH,KIRP-
ENSG00000213963ENST00000430416CD63ENSG00000135404ENST00000550776-0.6960413KICH,KIRP-
ENSG00000213963ENST00000627798CD63ENSG00000135404ENST00000420846-0.1083350KICH,KIRP-
ENSG00000213963ENST00000627798CD63ENSG00000135404ENST00000552067-0.1097355KICH,KIRP-
ENSG00000213963ENST00000627798CD63ENSG00000135404ENST00000548160-0.2384377KICH,KIRP-
ENSG00000213963ENST00000627798CD63ENSG00000135404ENST00000546939-0.2384377KICH,KIRP-
ENSG00000213963ENST00000627798CD63ENSG00000135404ENST00000552692-0.2384377KICH,KIRP-
ENSG00000213963ENST00000627798CD63ENSG00000135404ENST00000549117-0.2384389KICH,KIRP-
ENSG00000213963ENST00000627798CD63ENSG00000135404ENST00000257857-0.2384394KICH,KIRP-
ENSG00000213963ENST00000627798CD63ENSG00000135404ENST00000552754-0.5312433KICH,KIRP-
ENSG00000213963ENST00000627798CD63ENSG00000135404ENST00000550776-0.6960433KICH,KIRP-
ENSG00000213963ENST00000625449CD63ENSG00000135404ENST00000420846-0.1083347KICH,KIRP-
ENSG00000213963ENST00000625449CD63ENSG00000135404ENST00000552067-0.1097352KICH,KIRP-
ENSG00000213963ENST00000625449CD63ENSG00000135404ENST00000548160-0.2384374KICH,KIRP-
ENSG00000213963ENST00000625449CD63ENSG00000135404ENST00000546939-0.2384374KICH,KIRP-
ENSG00000213963ENST00000625449CD63ENSG00000135404ENST00000552692-0.2384374KICH,KIRP-
ENSG00000213963ENST00000625449CD63ENSG00000135404ENST00000549117-0.2384386KICH,KIRP-
ENSG00000213963ENST00000625449CD63ENSG00000135404ENST00000257857-0.192846KICH,KIRP-
ENSG00000213963ENST00000625449CD63ENSG00000135404ENST00000552754-0.5312430KICH,KIRP-
ENSG00000213963ENST00000625449CD63ENSG00000135404ENST00000550776-0.6960430KICH,KIRP-
ENSG00000213963ENST00000443132CD63ENSG00000135404ENST00000420846-0.20491KICH,KIRP-
ENSG00000213963ENST00000443132CD63ENSG00000135404ENST00000552067-0.20491KICH,KIRP-
ENSG00000213963ENST00000443132CD63ENSG00000135404ENST00000548160-0.20491KICH,KIRP-
ENSG00000213963ENST00000443132CD63ENSG00000135404ENST00000546939-0.20491KICH,KIRP-
ENSG00000213963ENST00000443132CD63ENSG00000135404ENST00000552692-0.20491KICH,KIRP-
ENSG00000213963ENST00000443132CD63ENSG00000135404ENST00000549117-0.20491KICH,KIRP-
ENSG00000213963ENST00000443132CD63ENSG00000135404ENST00000257857-0.20491KICH,KIRP-
ENSG00000213963ENST00000443132CD63ENSG00000135404ENST00000552754-0.421134KICH,KIRP-
ENSG00000213963ENST00000443132CD63ENSG00000135404ENST00000550776-0.5000276KICH,KIRP-
ENSG00000213963ENST00000447413CD63ENSG00000135404ENST00000420846-0.1203484KICH,KIRP-
ENSG00000213963ENST00000447413CD63ENSG00000135404ENST00000552067-0.1203489KICH,KIRP-
ENSG00000213963ENST00000447413CD63ENSG00000135404ENST00000548160-0.2222511KICH,KIRP-
ENSG00000213963ENST00000447413CD63ENSG00000135404ENST00000546939-0.2222511KICH,KIRP-
ENSG00000213963ENST00000447413CD63ENSG00000135404ENST00000552692-0.2222511KICH,KIRP-
ENSG00000213963ENST00000447413CD63ENSG00000135404ENST00000549117-0.2222523KICH,KIRP-
ENSG00000213963ENST00000447413CD63ENSG00000135404ENST00000257857-0.2222528KICH,KIRP-
ENSG00000213963ENST00000447413CD63ENSG00000135404ENST00000552754-0.3961327KICH,KIRP-
ENSG00000213963ENST00000447413CD63ENSG00000135404ENST00000550776-0.6433371KICH,KIRP-
ENSG00000213963ENST00000611493CD63ENSG00000135404ENST00000548160-0.1192217KICH,KIRP-
ENSG00000213963ENST00000611493CD63ENSG00000135404ENST00000546939-0.1192217KICH,KIRP-
ENSG00000213963ENST00000611493CD63ENSG00000135404ENST00000552692-0.1192217KICH,KIRP-
ENSG00000213963ENST00000611493CD63ENSG00000135404ENST00000549117-0.1059161KICH,KIRP-
ENSG00000213963ENST00000611493CD63ENSG00000135404ENST00000257857-0.1147166KICH,KIRP-
ENSG00000213963ENST00000611493CD63ENSG00000135404ENST00000552754-0.3479285KICH,KIRP-
ENSG00000213963ENST00000611493CD63ENSG00000135404ENST00000550776-0.3177479KICH,KIRP-

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000213963.5ENST00000397057.516212497
ENSG00000213963.5ENST00000456746.418030403582
ENSG00000213963.5ENST00000430416.418029893531
ENSG00000213963.5ENST00000627798.1175657130
ENSG00000213963.5ENST00000625449.1150602150
ENSG00000213963.5ENST00000443132.1111599264
ENSG00000213963.5ENST00000447413.181113358
ENSG00000213963.5ENST00000611493.1100467769