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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000204261

Summary for PSMB8-AS1

check button Gene summary

Gene informationEnsembl ID

ENSG00000204261

Gene symbol

PSMB8-AS1

Gene namePSMB8 antisense RNA 1 (head to head)
HGNC

39758

Entrez ID

100507463

Gene typelincRNA
Synonyms06p21.32|PSMB8-AS1
UniProtAcc

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Structure and expression level for PSMB8-AS1

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002042615.212944e+022.350771e+003.662933e-016.417729e+001.380000e-102.680000e-09UPGBM
ENSG000002042619.398605e+021.478263e+007.352651e-022.010517e+016.650000e-906.770000e-88UPKIRC
ENSG000002042616.149651e+021.002257e+002.779839e-013.605449e+003.116140e-043.163344e-03UPESCA

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002042614.199603e-014.078782e-03CHOL5.470902e-03
ENSG000002042613.684146e-015.554456e-21KIRC5.101031e-20

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lncRNA-Protein interaction for PSMB8-AS1

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000204261ENST00000413039PSMB8-AS1ENSG00000067066SP10038.490.721P23497TF,EpiNA
ENSG00000204261ENST00000415067PSMB8-AS1ENSG00000067066SP10036.5590.4025P23497TF,EpiNA

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000204261ENST00000429600PSMB8-AS1ENSG00000135899SP11032.0290.2239Q9HB58TFNA
ENSG00000204261ENST00000429600PSMB8-AS1ENSG00000065029ZNF7615.6190.0218P36508TFNA
ENSG00000204261ENST00000429600PSMB8-AS1ENSG00000136630HLX10.2392.2956Q14774TFNA
ENSG00000204261ENST00000413039PSMB8-AS1ENSG00000115415STAT139.691.6173P42224TFChIP-seq
ENSG00000204261ENST00000413039PSMB8-AS1ENSG00000067066SP10038.490.4582P23497TF,EpiNA
ENSG00000204261ENST00000413039PSMB8-AS1ENSG00000138378STAT435.4890.04899999999998Q14765TFChIP-seq
ENSG00000204261ENST00000413039PSMB8-AS1ENSG00000135899SP11027.8591.896Q9HB58TFNA
ENSG00000204261ENST00000413039PSMB8-AS1ENSG00000102034ELF423.0692.464Q99607TFNA
ENSG00000204261ENST00000415067PSMB8-AS1ENSG00000065029ZNF7616.7292.7685P36508TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000204261ENST00000413039PSMB8-AS1ENSG00000137628DDX6048.1894.3517Q8IY21RBPNA
ENSG00000204261ENST00000413039PSMB8-AS1ENSG00000004534RBM639.5491.2829P78332RBPNA
ENSG00000204261ENST00000415067PSMB8-AS1ENSG00000174720LARP711.8491.7617Q4G0J3RBPNA

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lncRNA-DNA interaction for PSMB8-AS1

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for PSMB8-AS1

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
MEX3D,GTF2I
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
lncRNA and exonskipping events positive correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation
ENSG00000204261ENST00000415067exon_skip_75398chr11:72692752-72692785-13.26-0.4911ARAP1ENST00000393605In-frame
ENSG00000204261ENST00000415067exon_skip_81540chr12:42384939-42384996-7.53-0.1537PPHLN1ENST00000395568In-frame
ENSG00000204261ENST00000415067exon_skip_368285chr22:29329711-29329720-2.93-0.4883AP1B1ENST00000357586,ENST00000405198In-frame
ENSG00000204261ENST00000415067exon_skip_372419chr3:32449453-32449552-13.02-0.1514CMTM7ENST00000334983In-frame
ENSG00000204261ENST00000415067exon_skip_482144chr8:22539468-22539498-8.71-0.5124PPP3CCENST00000240139In-frame
ENSG00000204261ENST00000415067exon_skip_285471chr17:3723287-3723383-12.19-0.1741ITGAEENST00000263087In-frame
ENSG00000204261ENST00000415067exon_skip_497057chr9:90867130-90867199-14.35-0.2432SYKENST00000375746,ENST00000375754In-frame

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000204261ENST00000415067exon_skip_95025chr12:79805591-79805768-20.88-0.1273PPP1R12AENST00000261207,ENST00000450142In-frame
ENSG00000204261ENST00000415067exon_skip_150854chr17:32366664-32366757-12.37-0.1455ZNF207ENST00000321233In-frame
ENSG00000204261ENST00000415067exon_skip_335781chr2:241153475-241153604-18.24-0.1495PPP1R7ENST00000234038,ENST00000407025In-frame
ENSG00000204261ENST00000415067exon_skip_378912chr3:152446703-152446757-10.08-0.2585MBNL1ENST00000282486,ENST00000463374In-frame
ENSG00000204261ENST00000415067exon_skip_379903chr3:184180644-184180650-2.18-0.4360AP2M1ENST00000292807In-frame
ENSG00000204261ENST00000415067exon_skip_454626chr6:144827347-144827386-6.56-0.3453UTRNENST00000367545In-frame
ENSG00000204261ENST00000415067exon_skip_482403chr8:27445793-27445919-15.29-0.1529PTK2BENST00000346049,ENST00000397501In-frame
ENSG00000204261ENST00000415067exon_skip_484062chr8:73030335-73030395-8.63-0.1488TERF1ENST00000276603In-frame
ENSG00000204261ENST00000415067exon_skip_499791chr9:128627924-128627942-6.94-0.8675SPTAN1ENST00000372731In-frame
ENSG00000204261ENST00000415067exon_skip_353131chr20:58669290-58669453-23.17-0.1439STX16ENST00000371141Frame-shift
ENSG00000204261ENST00000415067exon_skip_53559chr10:101793912-101793998-12.16-0.1483OGAENST00000361464Frame-shift
ENSG00000204261ENST00000415067exon_skip_143275chr16:24939363-24939597-30.17-0.1509ARHGAP17ENST00000289968In-frame
ENSG00000204261ENST00000415067exon_skip_343108chr2:127051153-127051243-17.69-0.2211BIN1ENST00000316724In-frame

check buttonlncRNA targets by miRNA.
lncRNA targets by miRNA
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source
ENSG00000204261hsa-mir-1296ENST00000453426chr6:32844486-32844583203.00-97.8991NA
ENSG00000204261hsa-mir-1296ENST00000453426chr6:32844605-32844698174.00-92.2492NA
ENSG00000204261hsa-mir-1296ENST00000453426chr6:32844135-32844230168.00-96.5895NA
ENSG00000204261hsa-mir-1296ENST00000453426chr6:32844244-32844357164.00-93.79110NA
ENSG00000204261hsa-mir-1296ENST00000453426chr6:32844390-32844485159.00-91.5381NA
ENSG00000204261hsa-mir-1296ENST00000453426chr6:32845186-32845282153.00-101.6689NA
ENSG00000204261hsa-mir-1296ENST00000453426chr6:32844760-32844850152.00-77.4796NA
ENSG00000204261hsa-mir-1296ENST00000453426chr6:32845083-32845175151.00-77.7089NA
ENSG00000204261hsa-mir-1296ENST00000458296chr6:32844875-32844972203.00-97.8991NA
ENSG00000204261hsa-mir-1296ENST00000458296chr6:32844475-32844561187.00-92.2279NA
ENSG00000204261hsa-mir-1296ENST00000458296chr6:32844135-32844230168.00-96.5895NA
ENSG00000204261hsa-mir-1296ENST00000458296chr6:32844779-32844874159.00-91.5381NA
ENSG00000204261hsa-mir-1296ENST00000458296chr6:32844639-32844746149.00-87.37102NA
ENSG00000204261hsa-mir-1296ENST00000413039chr6:32844712-32844809203.00-97.8991NA
ENSG00000204261hsa-mir-1296ENST00000413039chr6:32844400-32844486187.00-92.2279NA
ENSG00000204261hsa-mir-1296ENST00000413039chr6:32844831-32844924174.00-92.2492NA
ENSG00000204261hsa-mir-1296ENST00000413039chr6:32844135-32844230168.00-96.5895NA
ENSG00000204261hsa-mir-1296ENST00000413039chr6:32844482-32844583165.00-85.44104NA
ENSG00000204261hsa-mir-1296ENST00000413039chr6:32844616-32844711159.00-91.5381NA
ENSG00000204261hsa-mir-1296ENST00000429600chr6:32844244-32844339205.00-94.6594NA
ENSG00000204261hsa-mir-1296ENST00000429600chr6:32844547-32844644203.00-97.8991NA
ENSG00000204261hsa-mir-1296ENST00000429600chr6:32844666-32844759174.00-92.2492NA
ENSG00000204261hsa-mir-1296ENST00000429600chr6:32844135-32844230168.00-96.5895NA
ENSG00000204261hsa-mir-1296ENST00000429600chr6:32844451-32844546159.00-91.5381NA
ENSG00000204261hsa-mir-1296ENST00000429600chr6:32844821-32844911152.00-77.4796NA
ENSG00000204261hsa-mir-1296ENST00000429600chr6:32844345-32844437140.00-84.3789NA
ENSG00000204261hsa-mir-1296ENST00000412095chr6:32844221-32844320189.00-98.5482NA
ENSG00000204261hsa-mir-1296ENST00000412095chr6:32844770-32844856187.00-92.2279NA
ENSG00000204261hsa-mir-1296ENST00000412095chr6:32844380-32844475176.00-88.0696NA
ENSG00000204261hsa-mir-1296ENST00000412095chr6:32844135-32844230168.00-96.5895NA
ENSG00000204261hsa-mir-1296ENST00000412095chr6:32844852-32844953165.00-85.44104NA
ENSG00000204261hsa-mir-1296ENST00000412095chr6:32844986-32845081159.00-91.5381NA
ENSG00000204261hsa-mir-1296ENST00000412095chr6:32844515-32844611156.00-100.0088NA
ENSG00000204261hsa-mir-1296ENST00000415067chr6:32844574-32844671203.00-97.8991NA
ENSG00000204261hsa-mir-1296ENST00000415067chr6:32844244-32844336186.00-88.3795NA
ENSG00000204261hsa-mir-1296ENST00000415067chr6:32844693-32844786174.00-92.2492NA
ENSG00000204261hsa-mir-1296ENST00000415067chr6:32844140-32844230168.00-93.5494NA
ENSG00000204261hsa-mir-1296ENST00000415067chr6:32844478-32844573159.00-91.5381NA
ENSG00000204261hsa-mir-1296ENST00000415067chr6:32844848-32844938152.00-77.4796NA
ENSG00000204261hsa-mir-1296ENST00000415067chr6:32844338-32844445149.00-87.37102NA

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Variants for PSMB8-AS1

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types
ENSG00000204261PSMB8-AS1,hsa-mir-1296,TAPBPLLGG,UVM,MESO,SARC,THYM
ENSG00000204261PSMB8-AS1,hsa-mir-1296,DTX3LLGG,UVM,MESO,SARC,THYM
ENSG00000204261PSMB8-AS1,hsa-mir-1296,RAB29LGG,UVM,MESO,SARC,THYM

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000204261.7ENST00000453426.16243231
ENSG00000204261.7ENST00000458296.116711514
ENSG00000204261.7ENST00000413039.4159402881
ENSG00000204261.7ENST00000429600.1175166693
ENSG00000204261.7ENST00000412095.1132614216
ENSG00000204261.7ENST00000415067.11605351014