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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000197291

Summary for RAMP2-AS1

check button Gene summary

Gene informationEnsembl ID

ENSG00000197291

Gene symbol

RAMP2-AS1

Gene nameRAMP2 antisense RNA 1
HGNC

44358

Entrez ID

100190938

Gene typelincRNA
SynonymsRAMP2-AS1|17q21.2
UniProtAcc

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Structure and expression level for RAMP2-AS1

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value

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lncRNA-Protein interaction for RAMP2-AS1

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000197291ENST00000592195RAMP2-AS1ENSG00000171634BPTF40.5795.7714Q12830TF,EpiPredict

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000197291ENST00000592195RAMP2-AS1ENSG00000171634BPTF40.5795.6007Q12830TF,EpiPredict

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000197291ENST00000592670RAMP2-AS1ENSG00000100201DDX1743.4693.5829Q92841RBPPredict

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lncRNA-DNA interaction for RAMP2-AS1

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
RBM5,DDX17
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for RAMP2-AS1

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for RAMP2-AS1

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name
LncEditing_323103ENSG00000197291.7chr1742754396-lincRNARAMP2-AS1ENST00000592670.4lincRNARAMP2-AS1-001
LncEditing_323136ENSG00000197291.7chr1742754495-lincRNARAMP2-AS1ENST00000592670.4lincRNARAMP2-AS1-001
LncEditing_323142ENSG00000197291.7chr1742754499-lincRNARAMP2-AS1ENST00000592670.4lincRNARAMP2-AS1-001
LncEditing_323148ENSG00000197291.7chr1742754504-lincRNARAMP2-AS1ENST00000592670.4lincRNARAMP2-AS1-001
LncEditing_323154ENSG00000197291.7chr1742754528-lincRNARAMP2-AS1ENST00000592670.4lincRNARAMP2-AS1-001
LncEditing_323157ENSG00000197291.7chr1742754529-lincRNARAMP2-AS1ENST00000592670.4lincRNARAMP2-AS1-001
LncEditing_323172ENSG00000197291.7chr1742754594-lincRNARAMP2-AS1ENST00000592670.4lincRNARAMP2-AS1-001

check buttonEdited-associated DElncRNAs in cancer.
Differentially expressed gene
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange
ENSG00000197291LncEditing_323136GBMchr17_42754495_-2.175362e+009.390722e-018.251182e-015.512875e+003.530185e-088.841858e-08UP
ENSG00000197291LncEditing_323148GBMchr17_42754504_-2.040131e+008.971055e-018.436596e-016.451255e+001.109278e-104.930803e-10UP
ENSG00000197291LncEditing_323103LGGchr17_42754396_-2.663591e+001.579628e+001.326633e+008.897343e+005.719932e-191.615309e-18UP
ENSG00000197291LncEditing_323136LGGchr17_42754495_-2.741963e+001.448320e+001.085979e+001.102064e+013.038960e-281.510919e-27UP
ENSG00000197291LncEditing_323142LGGchr17_42754499_-2.585804e+001.640593e+001.523471e+007.997553e+001.269160e-152.723486e-15UP
ENSG00000197291LncEditing_323148LGGchr17_42754504_-2.767853e+001.374530e+009.902661e-011.247712e+019.952076e-368.465260e-35UP
ENSG00000197291LncEditing_323154LGGchr17_42754528_-2.665673e+001.691210e+001.523359e+006.106922e+001.015710e-091.484660e-09UP
ENSG00000197291LncEditing_323157LGGchr17_42754529_-2.526384e+001.705317e+001.763561e+005.303600e+001.135410e-071.484443e-07UP
ENSG00000197291LncEditing_323172LGGchr17_42754594_-3.021883e+001.639070e+001.133054e+007.655483e+001.925872e-143.776849e-14UP

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value
ENSG00000197291LncEditing_323148-5.170530e-016.834238e-031.046493e-02
ENSG00000197291LncEditing_323103-4.384030e-013.626822e-061.301616e-05
ENSG00000197291LncEditing_323136-3.343236e-015.411610e-051.052257e-04
ENSG00000197291LncEditing_323142-3.612954e-017.340602e-049.342584e-04
ENSG00000197291LncEditing_323148-4.634441e-018.678840e-101.822556e-08
ENSG00000197291LncEditing_323154-3.700744e-015.880312e-036.332643e-03
ENSG00000197291LncEditing_323157-5.532983e-011.180643e-052.990339e-05
ENSG00000197291LncEditing_323172-3.738417e-013.843498e-034.270553e-03

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000197291.7ENST00000592670.455163330
ENSG00000197291.7ENST00000589716.41103301
ENSG00000197291.7ENST00000587694.421229667
ENSG00000197291.7ENST00000591082.416018500
ENSG00000197291.7ENST00000592195.11153462