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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000170846

Summary for AC093323.3

check button Gene summary

Gene informationEnsembl ID

ENSG00000170846

Gene symbol

AC093323.3

Gene name
HGNC
Entrez ID

93622

Gene typelincRNA
Synonyms
UniProtAcc

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Structure and expression level for AC093323.3

check buttonDifferentially expressed gene analysis between cancer and normal samples.
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000001708464.068301e-015.547695e-03CHOL7.123071e-03

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lncRNA-Protein interaction for AC093323.3

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000170846ENST00000444232AC093323.3ENSG00000130254SAFB239.9793.11Q14151TF,RBPENCODE
ENSG00000170846ENST00000307533AC093323.3ENSG00000130254SAFB250.0393.8389Q14151TF,RBPENCODE
ENSG00000170846ENST00000307533AC093323.3ENSG00000158773USF139.4990.2218P22415TFChIP-seq

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000170846ENST00000307533AC093323.3ENSG00000130254SAFB250.0393.777Q14151TF,RBPENCODE
ENSG00000170846ENST00000444232AC093323.3ENSG00000130254SAFB239.9793.2663Q14151TF,RBPENCODE

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lncRNA-DNA interaction for AC093323.3

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
ZNF30,SLIRP,ILF3,GLI4,RBM39,MYPOP,GRSF1,IRF3,CIRBP,LCORL,IMP3,TIGD5,MZF1,NRF1,THOC3,SUGP2,TRUB2,CXXC5,ZNF77,ZNF74,TBP,SRP68,SAFB2,THOC1,LSM3,LARP7,CHTOP,TFAP4,LSM5,ZBED5,CENPT,PUF60,ZNF44,LSM4,RBMX,RBM4B,U2AF2,CSTF3,TCFL5,CPSF1,RNPS1,ERAL1,NR2F6,ZBTB3,CWC15,SURF6,DHX34,PPIE,SF3B6,NELFE,THAP9,USF1,CXXC1,ZNF34,PATZ1,CSTF1,HSF1,ZNF22,PHF1,THYN1,ZC3H8,DEAF1,TGIF2,HSF4,NOL9,THOC6,ZNF48,SGSM2,ATF4,REXO4,TIGD1,RBM45,DDX51,PCBP4,THAP3,APEX1,SRSF2,ZNF83,ZNF3,NXF1,ZNF18,GPBP1,RBM6,HMGN3,CPSF3,E2F1,RBM5,NFYB,ZNF84,PIN1,RXRB,RBM8A,NAIF1,DDX41,HINFP,XPA,THOC7,SFPQ,ZNF10
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.
Only predicted by TDF
RRP7BP,CWC15,NR2F6,ZNF48,MZF1,ZNF18,E4F1,RBM5,CXXC1,U2AF2,MSX1,TFAP4,TERF1,PATZ1,ZNF3,SRSF1,ZNF83,USF1,DHX30,RBM6,MYPOP,DHX34,TCFL5,ZNF30,RBM39,THAP3,HINFP,CIRBP,LCORL,SRP14
Exist in public source
NA

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for AC093323.3

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
ARNT
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000170846ENST00000444232exon_skip_361485chr21:29008239-29008307-12.55-0.2282RWDD2BENST00000493196Frame-shift
ENSG00000170846ENST00000444232exon_skip_133217chr16:8635038-8635079-16.05-0.8447METTL22ENST00000381920Frame-shift
ENSG00000170846ENST00000444232exon_skip_153767chr17:48057031-48057121-17.20-0.2293NFE2L1ENST00000362042In-frame
ENSG00000170846ENST00000444232exon_skip_462144chr6:125298713-125298816-17.79-0.2616HDDC2ENST00000398153Frame-shift

check buttonlncRNA targets by miRNA.
lncRNA targets by miRNA
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source
ENSG00000170846hsa-mir-22ENST00000307533chr4:6675475-6675572191.00-88.2096NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6673803-6673894188.00-75.8790NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6674486-6674576182.00-100.4894NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6675048-6675138171.00-72.8680NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6674103-6674191169.00-92.0785NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6674395-6674476165.00-100.1586NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6674312-6674385164.00-89.6683NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6674649-6674735164.00-85.3887NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6674011-6674103163.00-87.0389NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6674196-6674277163.00-91.7485NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6675287-6675375162.00-61.9284NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6673452-6673526160.00-64.0880NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6673601-6673686156.00-58.1085NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6674895-6674992154.00-78.8194NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6673920-6674011152.00-102.6393NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6673684-6673774151.00-81.1589NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6675580-6675661151.00-69.0679NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6674785-6674875146.00-63.0479NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6675203-6675274144.00-68.3480NA
ENSG00000170846hsa-mir-22ENST00000307533chr4:6675399-6675475141.00-64.2884NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6675406-6675503191.00-88.2096NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6673803-6673894188.00-75.8790NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6674486-6674576182.00-100.4894NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6674979-6675069171.00-72.8680NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6674103-6674191169.00-92.0785NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6674598-6674691169.00-87.3790NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6674395-6674476165.00-100.1586NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6674312-6674385164.00-89.6683NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6674011-6674103163.00-87.0389NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6674196-6674277163.00-91.7485NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6675218-6675306162.00-61.9284NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6673452-6673526160.00-64.0880NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6673601-6673686156.00-58.1085NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6674826-6674923154.00-78.8194NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6673920-6674011152.00-102.6393NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6673684-6673774151.00-81.1589NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6675511-6675592151.00-69.0679NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6674716-6674806146.00-63.0479NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6675134-6675205144.00-68.3480NA
ENSG00000170846hsa-mir-22ENST00000444232chr4:6675330-6675406141.00-64.2884NA

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Variants for AC093323.3

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types
ENSG00000170846ENSG00000130254SAFB2ENSG00000167967E4F16ACC,CHOL,HNSC,KIRP,LIHC,PAAD
ENSG00000170846ENSG00000158773USF1ENSG00000167967E4F17CHOL,DLBC,HNSC,KIRP,LGG,LIHC,THCA
ENSG00000170846ENSG00000130254SAFB2ENSG00000154832CXXC15CHOL,HNSC,KIRP,LIHC,PAAD
ENSG00000170846ENSG00000158773USF1ENSG00000154832CXXC16CHOL,HNSC,KIRP,LGG,LIHC,THCA
ENSG00000170846ENSG00000130254SAFB2ENSG00000063244U2AF26ACC,CHOL,HNSC,KIRP,LIHC,PAAD
ENSG00000170846ENSG00000130254SAFB2ENSG00000166526ZNF35ACC,CHOL,HNSC,KIRP,LIHC
ENSG00000170846ENSG00000130254SAFB2ENSG00000176182MYPOP5ACC,HNSC,KIRP,LIHC,PAAD
ENSG00000170846ENSG00000158773USF1ENSG00000134815DHX345CHOL,HNSC,KIRP,LIHC,THCA
ENSG00000170846ENSG00000158773USF1ENSG00000041988THAP38CHOL,DLBC,ESCA,HNSC,KIRP,LGG,LIHC,THCA
ENSG00000170846ENSG00000130254SAFB2ENSG00000172273HINFP5CHOL,HNSC,KIRP,LIHC,PAAD
ENSG00000170846ENSG00000130254SAFB2ENSG00000099622CIRBP5ACC,CHOL,HNSC,KIRP,PAAD

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000170846.14ENST00000307533.97698328
ENSG00000170846.14ENST00000444232.22331072371