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Cancer Type: SARC |
Summary for SARC |
 Patient number summary of SARC. |
| Cancer Type | Male Tumor Patients | Female Tumor Patients | Male Normal Patients | Female Normal Patients |
| SARC | 119 | 144 | 1 | 1 |
| Result summary of SARC. |
| Molecular | Sex-biased moleculars | Female-specific DEmoleculars | Male-specific DEmoleculars |
| ASevents | 5 | - | - |
| A-to-I editing | 141 | - | - |
| Coding Gene | 288 | - | - |
| lncRNA | 21 | - | - |
| Methy | 1597 | - | - |
| miRNA | 21 | - | - |
| Protein | 55 | - | - |
| ∗Please click the number for more information. ∗For lncRNA and miRNA, Please click the download page for more detail. |
| Functional enrichment analysis of SARC. |
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| Cancer Type | Term | Genes | Type | ||||
| SARC | cGMP-PKG signaling pathway | NPPB;KCNMB4;ADRA2C;ADRA1B;ADRA2A;MYH7 | Malebaised | ||||
| SARC | Neuroactive ligand-receptor interaction | CHRNA1;P2RY8;SCT;TAC3;CTSG;ADRA2C;ADRA1B;ADRA2A | Malebaised | ||||
| SARC | Adrenergic signaling in cardiomyocytes | TNNC1;TNNT2;SCN7A;ADRA1B;MYH7 | Malebaised | ||||
| SARC | ABC transporters | ABCA6;ABCA9;ABCA8 | Malebaised | ||||
| SARC | IL-17 signaling pathway | CCL11;LCN2;CXCL1;S100A9 | Malebaised | ||||
| SARC | Renin-angiotensin system | CMA1;CTSG | Malebaised | ||||
| SARC | Retinol metabolism | CYP2W1;ADH1C;ADH1B | Malebaised | ||||
| SARC | Complement and coagulation cascades | SERPINB2;PLAU;SERPINA5 | Malebaised | ||||
| SARC | Cardiac muscle contraction | TNNC1;TNNT2;MYH7 | Malebaised | ||||
| SARC | ECM-receptor interaction | COMP;IBSP;THBS2 | Malebaised | ||||
| SARC | Hypertrophic cardiomyopathy | TNNC1;TNNT2;MYH7 | Malebaised | ||||
| SARC | Neuroactive ligand-receptor interaction | CHRM2;GABBR2;CALCA;EDN3;SSTR1;PRL;PRLR;CCKBR;HRH2;NPY;NMU;PENK;NTSR1 | Femalebaised | ||||
| SARC | cAMP signaling pathway | CHRM2;VAV3;GABBR2;EDN3;HHIP;NPY;SSTR1 | Femalebaised | ||||
| SARC | Calcium signaling pathway | CHRM2;MCOLN3;CCKBR;HRH2;FGF19;NTSR1;CACNA1H | Femalebaised | ||||
| SARC | Protein digestion and absorption | COL26A1;COL2A1;COL22A1;COL11A2 | Femalebaised | ||||
| SARC | Cholinergic synapse | CHRM2;KCNJ4;GNG4;GNG8 | Femalebaised | ||||
| SARC | GnRH secretion | GABBR2;KCNN2;CACNA1H | Femalebaised | ||||
| SARC | Prolactin signaling pathway | PRL;PRLR;ESR1 | Femalebaised | ||||
| SARC | Gastric acid secretion | CCKBR;HRH2;SLC26A7 | Femalebaised | ||||
| SARC | PI3K-Akt signaling pathway | CHRM2;COL2A1;GNG4;FGF19;GNG8;PRL;PRLR | Femalebaised | ||||
| SARC | Estrogen signaling pathway | GABBR2;KRT17;PGR;ESR1 | Femalebaised | ||||
| SARC | Pathways in cancer | GNG4;CDH1;FGF19;HHIP;GSTA1;GNG8;PMAIP1;FZD10;ESR1 | Femalebaised | ||||
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Sex-biased mutation in SARC |
| Sex-biased mutation in SARC. |
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TF-Gene regulation in SARC |
| Top20 sex-biased TF-Gene regulation in SARC. |
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| Table of top20 male-biased TF-Gene regulation in SARC. |
| Cancer Type | Sex | Gene ID | TF | Gene Symbol | Score |
| SARC | Male | ENSG00000119138 | NFATC1 | KLF9 | 8.56275391169628 |
| SARC | Male | ENSG00000183269 | ZNF418 | OR52E8 | 8.38217761392529 |
| SARC | Male | ENSG00000175820 | ZNF235 | CCDC168 | 8.08306800124184 |
| SARC | Male | ENSG00000065491 | HOMEZ | TBC1D22B | 8.04753856459707 |
| SARC | Male | ENSG00000175820 | ZNF418 | CCDC168 | 8.02756698654471 |
| SARC | Male | ENSG00000155886 | NFATC3 | SLC24A2 | 7.81643832540516 |
| SARC | Male | ENSG00000175820 | ZNF287 | CCDC168 | 7.78723826431974 |
| SARC | Male | ENSG00000163736 | GBX1 | PPBP | 7.64832826020466 |
| SARC | Male | ENSG00000126010 | FOXL1 | GRPR | 7.6375843546318 |
| SARC | Male | ENSG00000119138 | ZNF418 | KLF9 | 7.62533520267422 |
| SARC | Male | ENSG00000155886 | ZNF410 | SLC24A2 | 7.47045862365577 |
| SARC | Male | ENSG00000126010 | ZNF225 | GRPR | 7.25611456882783 |
| SARC | Male | ENSG00000253719 | POU3F1 | ATXN7L3B | 7.20486517324484 |
| SARC | Male | ENSG00000143631 | ZNF334 | FLG | 7.18300140374681 |
| SARC | Male | ENSG00000170681 | ZNF418 | CAVIN4 | 7.10794944434719 |
| SARC | Male | ENSG00000155886 | FOXF2 | SLC24A2 | 7.10649505305374 |
| SARC | Male | ENSG00000251258 | IRX3 | RFPL4B | 7.09925066755929 |
| SARC | Male | ENSG00000015153 | HOXD13 | YAF2 | 7.01098687079103 |
| SARC | Male | ENSG00000187026 | ZNF235 | KRTAP21-2 | 6.99436460004597 |
| SARC | Male | ENSG00000155886 | ZKSCAN7 | SLC24A2 | 6.97275950920494 |
| ∗Please click the gene id for more information. |
| Table of top20 female-biased TF-Gene regulation in SARC. |
| Cancer Type | Sex | Gene ID | TF | Gene Symbol | Score |
| SARC | Female | ENSG00000129824 | HOXA11 | RPS4Y1 | 9.7886526744075 |
| SARC | Female | ENSG00000129824 | CDX1 | RPS4Y1 | 9.54894389267821 |
| SARC | Female | ENSG00000129824 | HOXD10 | RPS4Y1 | 9.3396916440602 |
| SARC | Female | ENSG00000129824 | HOXC12 | RPS4Y1 | 9.13117490851236 |
| SARC | Female | ENSG00000129824 | CDX4 | RPS4Y1 | 8.61884508759807 |
| SARC | Female | ENSG00000129824 | HOXC9 | RPS4Y1 | 8.28333977830466 |
| SARC | Female | ENSG00000129824 | HOXD9 | RPS4Y1 | 8.08029501816724 |
| SARC | Female | ENSG00000173597 | HOXD11 | SULT1B1 | 7.37898465232332 |
| SARC | Female | ENSG00000129824 | HOXB9 | RPS4Y1 | 7.21693890484166 |
| SARC | Female | ENSG00000198680 | E2F6 | TUSC1 | 7.17509534351087 |
| SARC | Female | ENSG00000120324 | FOXD2 | PCDHB10 | 7.1303424999163 |
| SARC | Female | ENSG00000185479 | PBX4 | KRT6B | 7.00344282753699 |
| SARC | Female | ENSG00000198680 | ZNF566 | TUSC1 | 6.92937709562974 |
| SARC | Female | ENSG00000120324 | FOXG1 | PCDHB10 | 6.79827538176729 |
| SARC | Female | ENSG00000186810 | ZBTB33 | CXCR3 | 6.78726357403064 |
| SARC | Female | ENSG00000120327 | ZNF418 | PCDHB14 | 6.7088001275935 |
| SARC | Female | ENSG00000185479 | POU4F3 | KRT6B | 6.61698498392229 |
| SARC | Female | ENSG00000121858 | HOXD11 | TNFSF10 | 6.5757238559631 |
| SARC | Female | ENSG00000185479 | POU4F1 | KRT6B | 6.55938198432197 |
| SARC | Female | ENSG00000179144 | ZNF285 | GIMAP7 | 6.51062669794216 |
| ∗Please click the gene id for more information. |
Top |
RBP-ES regulation in SARC |
| Top20 sex-biased RBP-ES regulation in SARC. |
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| Table of top20 male-biased RBP-ES regulation in SARC. |
| Cancer Type | Sex | Gene ID | RBP | ES | Score |
| SARC | Male | ENSG00000104064 | MSI1 | exon_skip_127026 | 15.7538076606453 |
| SARC | Male | ENSG00000120438 | QKI | exon_skip_463216 | 15.7392078802902 |
| SARC | Male | ENSG00000185246 | QKI | exon_skip_106324 | 15.7392078802901 |
| SARC | Male | ENSG00000185627 | MSI1 | exon_skip_55179 | 15.6792671124146 |
| SARC | Male | ENSG00000120137 | QKI | exon_skip_446112 | 15.3861078138113 |
| SARC | Male | ENSG00000100266 | ZNF638 | exon_skip_370171 | 15.1948588113463 |
| SARC | Male | ENSG00000000460 | ZNF638 | exon_skip_13964 | 15.1948588113462 |
| SARC | Male | ENSG00000090273 | ZNF638 | exon_skip_3041 | 15.1948588113462 |
| SARC | Male | ENSG00000185624 | ANKHD1 | exon_skip_294580 | 14.9309233377884 |
| SARC | Male | ENSG00000213923 | ANKHD1 | exon_skip_369450 | 14.884996884841 |
| SARC | Male | ENSG00000025434 | ANKHD1 | exon_skip_59198 | 14.8747029690824 |
| SARC | Male | ENSG00000155097 | MSI1 | exon_skip_485313 | 14.8435565049549 |
| SARC | Male | ENSG00000113838 | MSI1 | exon_skip_390756 | 14.7244914968879 |
| SARC | Male | ENSG00000167522 | RBMS1 | exon_skip_147357 | 14.6833769999874 |
| SARC | Male | ENSG00000068912 | RBMS1 | exon_skip_325573 | 14.6833769999874 |
| SARC | Male | ENSG00000116679 | RBMS1 | exon_skip_35080 | 14.6833769999874 |
| SARC | Male | ENSG00000161016 | PPRC1 | exon_skip_494570 | 14.3881385293256 |
| SARC | Male | ENSG00000177169 | PPRC1 | exon_skip_88673 | 14.3881385293256 |
| SARC | Male | ENSG00000164961 | STAR-PAP | exon_skip_492350 | 14.3229927104899 |
| SARC | Male | ENSG00000158882 | STAR-PAP | exon_skip_13289 | 14.3068360959914 |
| ∗Please click the gene id for more information. |
| Table of top20 female-biased RBP-ES regulation in SARC. |
| Cancer Type | Sex | Gene ID | RBP | ES | Score |
| SARC | Female | ENSG00000164961 | RBM3 | exon_skip_492343 | 17.3705432566685 |
| SARC | Female | ENSG00000103855 | STAR-PAP | exon_skip_123388 | 16.3271451528794 |
| SARC | Female | ENSG00000061794 | QKI | exon_skip_80932 | 15.7384924215857 |
| SARC | Female | ENSG00000026025 | MSI1 | exon_skip_39933 | 15.6753860086551 |
| SARC | Female | ENSG00000104221 | ZNF638 | exon_skip_489144 | 15.20316560731 |
| SARC | Female | ENSG00000038358 | ZNF638 | exon_skip_137869 | 15.2031656073099 |
| SARC | Female | ENSG00000102901 | QKI | exon_skip_145479 | 15.1752731260782 |
| SARC | Female | ENSG00000130520 | ANKHD1 | exon_skip_316424 | 14.8765311654127 |
| SARC | Female | ENSG00000083093 | MSI1 | exon_skip_143172 | 14.6243234534405 |
| SARC | Female | ENSG00000143514 | YBX2 | exon_skip_37320 | 14.3068052306393 |
| SARC | Female | ENSG00000108509 | STAR-PAP | exon_skip_285854 | 14.2561129535395 |
| SARC | Female | ENSG00000172456 | RBMS1 | exon_skip_6809 | 14.1417861748466 |
| SARC | Female | ENSG00000105953 | RBM3 | exon_skip_465772 | 14.0399431154344 |
| SARC | Female | ENSG00000101928 | QKI | exon_skip_516824 | 13.5456006482858 |
| SARC | Female | ENSG00000111725 | ANKHD1 | exon_skip_87560 | 13.3763349574007 |
| SARC | Female | ENSG00000133961 | HNRNPA1L2 | exon_skip_114259 | 13.3141039038304 |
| SARC | Female | ENSG00000102024 | ZCRB1 | exon_skip_512033 | 13.1572984965797 |
| SARC | Female | ENSG00000144535 | QKI | exon_skip_334803 | 13.0697490151053 |
| SARC | Female | ENSG00000071082 | RBMS1 | exon_skip_328145 | 12.786484658095 |
| SARC | Female | ENSG00000196141 | STAR-PAP | exon_skip_332240 | 12.699243903921 |
| ∗Please click the gene id for more information. |
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eQTL regulation in SARC |
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| Top Male-specific cis-sQTM regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | SNP ID |
| ∗Please click the gene id for more information. |
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| Female-specific cis-eQTL regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | SNP ID |
| ∗Please click the gene id for more information. |
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| Opposite sex-biased cis-eQTL regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | SNP ID |
| ∗Please click the gene id for more information. |
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sQTL regulation in SARC |
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| Male-specific cis-sQTL regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | ES ID | SNP ID |
| SARC | ENSG00000186470 | BTN3A2 | exon_skip_448544 | rs62392674,rs72840306,rs62392676,rs150505205,rs17320558,rs62392695,rs72840350,rs62392696,rs62392673,rs62392756 |
| SARC | ENSG00000162882 | HAAO | exon_skip_338631 | rs10208422,rs2165158,rs13024598,rs34694462,rs13013413,rs12989612,rs12996292,rs12997274,rs12997362,rs13006016 |
| ∗Please click the gene id for more information. |
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| Female-specific cis-sQTL regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | ES ID | SNP ID |
| SARC | ENSG00000119977 | TCTN3 | exon_skip_52483 | rs34519673,rs7096164,rs34603628,rs66728103,rs34091243,rs11591374,rs7916068,rs35038457,rs34844027,rs141791178 |
| ∗Please click the gene id for more information. |
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| Opposite sex-biased cis-sQTL regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | ES ID | SNP ID |
| ∗Please click the gene id for more information. |
Top |
eQTM regulation in SARC |
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| Male-specific cis-eQTM regulation (FDR <1e-5). |
| Cancer Type | Gene ID | CpG ID |
| SARC | ENSG00000131323 | cg04846720 |
| SARC | ENSG00000107736 | cg09810750 |
| SARC | ENSG00000152977 | cg21776417,cg27136844 |
| SARC | ENSG00000184828 | cg11837016 |
| SARC | ENSG00000038382 | cg15143268 |
| SARC | ENSG00000133315 | cg23459863 |
| SARC | ENSG00000105997 | cg03331474 |
| SARC | ENSG00000036672 | cg24258886 |
| SARC | ENSG00000135480 | cg25029197 |
| ∗Please click the gene id for more information. |
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| Female-specific cis-eQTM regulation (FDR <1e-5). |
| Cancer Type | Gene ID | CpG ID |
| SARC | ENSG00000197757 | cg16264616,cg22679316,cg21837192 |
| SARC | ENSG00000184384 | cg03371275 |
| SARC | ENSG00000235568 | cg03365751 |
| SARC | ENSG00000005073 | cg12810084,cg25901381 |
| SARC | ENSG00000074621 | cg01704999 |
| SARC | ENSG00000160801 | cg16339096 |
| SARC | ENSG00000116473 | cg01918604 |
| SARC | ENSG00000143537 | cg13069100 |
| SARC | ENSG00000163637 | cg20584157 |
| SARC | ENSG00000122367 | cg22715761,cg19286437 |
| SARC | ENSG00000184937 | cg15446391 |
| SARC | ENSG00000155093 | cg04207084 |
| SARC | ENSG00000170745 | cg25104233 |
| ∗Please click the gene id for more information. |
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| Opposite sex-biased cis-eQTM regulation (FDR <1e-5). |
| Cancer Type | Gene ID | CpG ID |
| ∗Please click the gene id for more information. |
Top |
sQTM regulation in SARC |
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| Male-specific cis-sQTM regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | ES ID | CpG ID |
| SARC | ENSG00000154175 | ABI3BP | exon_skip_385976 | cg10507762 |
| SARC | ENSG00000130023 | ERMARD | exon_skip_455573 | cg11299476 |
| SARC | ENSG00000092931 | MFSD11 | exon_skip_156572 | cg09326547,cg05121093,cg09509528,cg17177017 |
| ∗Please click the gene id for more information. |
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| Female-specific cis-sQTM regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | ES ID | CpG ID |
| SARC | ENSG00000182179 | UBA7 | exon_skip_384378 | cg12577320,cg06660385,cg12479660,cg02490920,cg24342610 |
| SARC | ENSG00000101391 | CDK5RAP1 | exon_skip_355879 | cg22369703 |
| SARC | ENSG00000011132 | APBA3 | exon_skip_313096 | cg25058957 |
| SARC | ENSG00000138231 | DBR1 | exon_skip_388839 | cg08932381 |
| SARC | ENSG00000168393 | DTYMK | exon_skip_348254 | cg21446171,cg22924060 |
| SARC | ENSG00000103197 | TSC2 | exon_skip_132443 | cg01383203 |
| SARC | ENSG00000119403 | PHF19 | exon_skip_506602 | cg00403579 |
| SARC | ENSG00000146828 | SLC12A9 | exon_skip_469348 | cg04305808 |
| SARC | ENSG00000166165 | CKB | exon_skip_116177 | cg23142890 |
| ∗Please click the gene id for more information. |
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| Opposite sex-biased cis-sQTM regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | ES ID | CpG ID |
| ∗Please click the gene id for more information. |
