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Cancer Type: BRCA |
Summary for BRCA |
 Patient number summary of BRCA. |
| Cancer Type | Male Tumor Patients | Female Tumor Patients | Male Normal Patients | Female Normal Patients |
| BRCA | 12 | 1096 | 1 | 112 |
| Result summary of BRCA. |
| Molecular | Sex-biased moleculars | Female-specific DEmoleculars | Male-specific DEmoleculars |
| ASevents | 69 | 369 | - |
| A-to-I editing | 4 | 326 | - |
| Coding Gene | 924 | 2638 | 2 |
| lncRNA | 46 | 151 | - |
| Methy | 2501 | 6987 | - |
| miRNA | 16 | 166 | - |
| Protein | 34 | - | - |
| ∗Please click the number for more information. ∗For lncRNA and miRNA, Please click the download page for more detail. |
| Functional enrichment analysis of BRCA. |
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| Cancer Type | Term | Genes | Type | ||||
| BRCA | Arrhythmogenic right ventricular cardiomyopathy | GJA1;CACNG1;CACNG4 | Malebaised | ||||
| BRCA | Biosynthesis of unsaturated fatty acids | ELOVL5;SCD | Malebaised | ||||
| BRCA | Hippo signaling pathway | CCND1;BMP8B;WNT3;LLGL2 | Malebaised | ||||
| BRCA | Fructose and mannose metabolism | PFKFB2;SORD | Malebaised | ||||
| BRCA | Pentose and glucuronate interconversions | DCXR;SORD | Malebaised | ||||
| BRCA | Tight junction | TUBA3E;SLC9A3R1;CCND1;LLGL2 | Malebaised | ||||
| BRCA | MAPK signaling pathway | HSPB1;RAC3;CACNG1;RASGRP1;CACNG4 | Malebaised | ||||
| BRCA | AMPK signaling pathway | PFKFB2;CCND1;SCD | Malebaised | ||||
| BRCA | Cell cycle | CCND1;CDC6;ANAPC11 | Malebaised | ||||
| BRCA | VEGF signaling pathway | HSPB1;RAC3 | Malebaised | ||||
| BRCA | Viral myocarditis | CCND1;RAC3 | Malebaised | ||||
| BRCA | Cytokine-cytokine receptor interaction | CXCL9;CSF3R;CXCL8;CXCL17;CXCL1;CXCL13;TNF;CXCL2;CX3CL1;IL27RA;CCR7;CCR5;CCR4;IL6R;CCR2;IL17RE;IL1B;XCL2;LTB;TNFRSF21;CX3CR1;CCL13;EBI3;CSF2RB;TNFRSF11B;CXCR6;IL2RG;CCL8;CCL4;IL21R;TNFRSF17;CCL2;CCL19;CCL18;CCL17;CCR1;IL32;NGFR;IL33;TGFB2;CCL20;IL10RA;IL34;LIF;BMP6;CXCL10;CXCL11;IL6;IL2RA;LEP;IL2RB;CD27;IL7R;CCL28 | Femalebaised | ||||
| BRCA | Viral protein interaction with cytokine and cytokine receptor | CX3CR1;CCL13;CXCL9;CXCL8;CXCL1;CXCL13;IL2RG;TNF;CXCL2;CX3CL1;CCL8;CCL4;CCL2;CCR7;CCL19;CCR5;CCL18;IL6R;CCR4;CCL17;CCR2;CCR1;CCL20;IL10RA;IL34;CXCL10;CXCL11;IL6;IL2RA;IL2RB;XCL2;CCL28 | Femalebaised | ||||
| BRCA | Chemokine signaling pathway | SHC4;CX3CR1;CCL13;CXCL9;CXCL8;PIK3CD;CXCL1;CXCR6;CXCL13;CXCL2;CX3CL1;PIK3CG;ADCY5;CCL8;GNG4;CCL4;PLCG2;CCL2;CCR7;CCL19;CCR5;CCL18;CCR4;JAK3;CCL17;CCR2;CCR1;LYN;PRKCB;CCL20;CXCL10;CXCL11;XCL2;DOCK2;PLCB1;CCL28 | Femalebaised | ||||
| BRCA | IL-17 signaling pathway | CXCL8;CCL20;MMP3;TNFAIP3;CXCL1;FOS;IL17RE;PTGS2;MUC5B;CXCL2;TNF;S100A7A;FOSL1;CXCL10;IL6;IL1B;LCN2;CCL2;S100A9;CCL17;S100A8;S100A7 | Femalebaised | ||||
| BRCA | Hematopoietic cell lineage | CR2;CSF3R;MME;CD1E;CD3G;CD1C;CD3E;TNF;CD3D;CD2;IL6;CD8B;CD5;IL1B;IL2RA;KIT;CD38;CD36;IL7R;HLA-DOB;IL6R;MS4A1 | Femalebaised | ||||
| BRCA | TNF signaling pathway | EDN1;CCL20;MMP3;LIF;PIK3CD;TNFAIP3;CXCL1;FOS;TRAF1;PTGS2;TNF;SELE;CXCL2;CX3CL1;ICAM1;CXCL10;IL6;IL1B;CCL2;MAP3K8;BIRC3 | Femalebaised | ||||
| BRCA | Kaposi sarcoma-associated herpesvirus infection | CXCL8;CALML5;TCF7;PIK3CD;CALML3;CXCL1;PTGS2;CXCL2;PIK3CG;ICAM1;C3;ZFP36;GNG4;PLCG2;CCR5;CCR4;CCR1;LYN;TCF7L1;HLA-B;HLA-A;FOS;HLA-F;HLA-G;RCAN1;IL6;CDK6;TLR3 | Femalebaised | ||||
| BRCA | NF-kappa B signaling pathway | LYN;CCL13;CXCL8;BCL2A1;PRKCB;TNFAIP3;CXCL1;TRAF1;PTGS2;TNF;CXCL2;ICAM1;LCK;IL1B;CCL4;PLCG2;LBP;LTB;CCL19;BIRC3 | Femalebaised | ||||
| BRCA | Malaria | TGFB2;CXCL8;KLRB1;HBB;TNF;SELE;ICAM1;SELP;IL6;IL1B;CCL2;CD36;ACKR1;MET | Femalebaised | ||||
| BRCA | Primary immunodeficiency | CD79A;CIITA;PTPRC;CD8B;LCK;TAP2;TAP1;CD3E;IL2RG;IL7R;CD3D;JAK3 | Femalebaised | ||||
| BRCA | Cell adhesion molecules | CD274;HLA-B;HLA-A;PDCD1LG2;HLA-F;L1CAM;CLDN1;HLA-G;SELE;ICAM1;CLDN6;SELP;CLDN11;CD2;CDH3;PTPRC;CD8B;CD6;CTLA4;PDCD1;LRRC4C;TIGIT;HLA-DOB | Femalebaised | ||||
Top |
Sex-biased mutation in BRCA |
| Sex-biased mutation in BRCA. |
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Top |
TF-Gene regulation in BRCA |
| Top20 sex-biased TF-Gene regulation in BRCA. |
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| Table of top20 male-biased TF-Gene regulation in BRCA. |
| Cancer Type | Sex | Gene ID | TF | Gene Symbol | Score |
| BRCA | Male | ENSG00000176907 | SOX4 | TCIM | 7.9417077947022 |
| BRCA | Male | ENSG00000126010 | FOXL1 | GRPR | 7.93085316970373 |
| BRCA | Male | ENSG00000225556 | FOXI1 | C2CD4D | 7.27531125999221 |
| BRCA | Male | ENSG00000222014 | ZNF418 | RAB6C | 7.27082944460417 |
| BRCA | Male | ENSG00000225556 | MECOM | C2CD4D | 6.95761157328685 |
| BRCA | Male | ENSG00000225556 | SOX2 | C2CD4D | 6.95369632133253 |
| BRCA | Male | ENSG00000253846 | ZNF605 | PCDHGA10 | 6.92590422290981 |
| BRCA | Male | ENSG00000225556 | SOX7 | C2CD4D | 6.90970568375629 |
| BRCA | Male | ENSG00000225556 | ZNF35 | C2CD4D | 6.88644494111129 |
| BRCA | Male | ENSG00000225556 | SOX4 | C2CD4D | 6.79975544031704 |
| BRCA | Male | ENSG00000146281 | MEIS1 | PM20D2 | 6.79158804383777 |
| BRCA | Male | ENSG00000225556 | ZNF25 | C2CD4D | 6.77617224513264 |
| BRCA | Male | ENSG00000222014 | ZNF879 | RAB6C | 6.73886549700191 |
| BRCA | Male | ENSG00000146281 | ZNF250 | PM20D2 | 6.71179075655354 |
| BRCA | Male | ENSG00000146281 | ONECUT3 | PM20D2 | 6.70912621185513 |
| BRCA | Male | ENSG00000225556 | ZNF615 | C2CD4D | 6.62878714635182 |
| BRCA | Male | ENSG00000111371 | FOXA3 | NAT2 | 6.60415146980968 |
| BRCA | Male | ENSG00000111371 | FOXA1 | NAT2 | 6.52975434260684 |
| BRCA | Male | ENSG00000156284 | FOXL1 | CLDN8 | 6.49170460502106 |
| BRCA | Male | ENSG00000081853 | GLI3 | PCDHGA2 | 6.46554985883748 |
| ∗Please click the gene id for more information. |
| Table of top20 female-biased TF-Gene regulation in BRCA. |
| Cancer Type | Sex | Gene ID | TF | Gene Symbol | Score |
| BRCA | Female | ENSG00000112818 | ZNF418 | MEP1A | 7.88872810311419 |
| BRCA | Female | ENSG00000276547 | BARX2 | PCDHGB5 | 7.82472504937995 |
| BRCA | Female | ENSG00000276547 | FOXO6 | PCDHGB5 | 7.81484215702023 |
| BRCA | Female | ENSG00000253846 | SKOR2 | PCDHGA10 | 7.75908161469138 |
| BRCA | Female | ENSG00000143196 | ZBTB42 | DPT | 7.58831825148038 |
| BRCA | Female | ENSG00000176907 | ZNF19 | TCIM | 7.52840476515031 |
| BRCA | Female | ENSG00000176907 | ZNF419 | TCIM | 7.32798651290788 |
| BRCA | Female | ENSG00000143196 | ZNF626 | DPT | 7.31654970850373 |
| BRCA | Female | ENSG00000143196 | XPA | DPT | 7.30956703672454 |
| BRCA | Female | ENSG00000276547 | NKX3-1 | PCDHGB5 | 7.2898407675812 |
| BRCA | Female | ENSG00000239389 | POU6F1 | PCDHA13 | 7.283138694585 |
| BRCA | Female | ENSG00000253846 | NKX3-1 | PCDHGA10 | 7.24468796530727 |
| BRCA | Female | ENSG00000264424 | ZNF418 | MYH4 | 7.21953801282107 |
| BRCA | Female | ENSG00000253846 | NKX2-2 | PCDHGA10 | 7.20199225293737 |
| BRCA | Female | ENSG00000253846 | TBR1 | PCDHGA10 | 7.18657148224669 |
| BRCA | Female | ENSG00000143196 | GLI3 | DPT | 7.09847772151065 |
| BRCA | Female | ENSG00000172318 | HESX1 | B3GALT1 | 7.05809178273522 |
| BRCA | Female | ENSG00000212916 | ZNF573 | MAP10 | 6.92365553122463 |
| BRCA | Female | ENSG00000156284 | ZNF157 | CLDN8 | 6.91369233865548 |
| BRCA | Female | ENSG00000126010 | CTCFL | GRPR | 6.90074460584283 |
| ∗Please click the gene id for more information. |
Top |
RBP-ES regulation in BRCA |
| Top20 sex-biased RBP-ES regulation in BRCA. |
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| Table of top20 male-biased RBP-ES regulation in BRCA. |
| Cancer Type | Sex | Gene ID | RBP | ES | Score |
| BRCA | Male | ENSG00000075884 | MSI1 | exon_skip_330145 | 17.3674494850706 |
| BRCA | Male | ENSG00000131508 | MSI1 | exon_skip_438020 | 17.3674494850705 |
| BRCA | Male | ENSG00000101966 | MSI1 | exon_skip_512277 | 17.3674494850705 |
| BRCA | Male | ENSG00000159267 | RBM3 | exon_skip_361847 | 17.0980845698157 |
| BRCA | Male | ENSG00000156931 | RBM3 | exon_skip_379978 | 17.0980845698157 |
| BRCA | Male | ENSG00000164961 | RBM3 | exon_skip_492343 | 17.0980845698157 |
| BRCA | Male | ENSG00000129925 | ANKHD1 | exon_skip_140214 | 16.9497182383683 |
| BRCA | Male | ENSG00000130175 | ANKHD1 | exon_skip_302531 | 16.9497182383683 |
| BRCA | Male | ENSG00000163214 | ANKHD1 | exon_skip_338471 | 16.9497182383683 |
| BRCA | Male | ENSG00000099889 | ANKHD1 | exon_skip_367542 | 16.9497182383682 |
| BRCA | Male | ENSG00000112562 | ANKHD1 | exon_skip_455517 | 16.9497182383682 |
| BRCA | Male | ENSG00000116001 | MSI1 | exon_skip_339887 | 16.6571494731932 |
| BRCA | Male | ENSG00000196411 | RBM3 | exon_skip_478359 | 16.3321039428516 |
| BRCA | Male | ENSG00000110955 | RBM3 | exon_skip_93804 | 16.3013569204621 |
| BRCA | Male | ENSG00000100650 | STAR-PAP | exon_skip_107749 | 16.0664264615906 |
| BRCA | Male | ENSG00000167978 | STAR-PAP | exon_skip_132613 | 16.0664264615906 |
| BRCA | Male | ENSG00000117593 | STAR-PAP | exon_skip_14235 | 16.0664264615906 |
| BRCA | Male | ENSG00000124228 | STAR-PAP | exon_skip_352920 | 16.0664264615905 |
| BRCA | Male | ENSG00000089006 | STAR-PAP | exon_skip_355279 | 16.0664264615905 |
| BRCA | Male | ENSG00000120705 | STAR-PAP | exon_skip_444574 | 16.0664264615905 |
| ∗Please click the gene id for more information. |
| Table of top20 female-biased RBP-ES regulation in BRCA. |
| Cancer Type | Sex | Gene ID | RBP | ES | Score |
| BRCA | Female | ENSG00000196199 | MSI1 | exon_skip_99234 | 15.2859306985473 |
| BRCA | Female | ENSG00000156976 | DAZAP1 | exon_skip_380274 | 14.9780116789259 |
| BRCA | Female | ENSG00000136243 | RBMS1 | exon_skip_464742 | 14.0393450074557 |
| BRCA | Female | ENSG00000205581 | DAZAP1 | exon_skip_362018 | 13.4056759171667 |
| BRCA | Female | ENSG00000118705 | SFPQ | exon_skip_351524 | 13.2485140795991 |
| BRCA | Female | ENSG00000013288 | RBM8A | exon_skip_422409 | 12.5675898244525 |
| BRCA | Female | ENSG00000169592 | PPRC1 | exon_skip_135631 | 12.4743561885665 |
| BRCA | Female | ENSG00000100938 | RBMS1 | exon_skip_105753 | 12.4150619326246 |
| BRCA | Female | ENSG00000103126 | PPRC1 | exon_skip_140155 | 12.4015468408441 |
| BRCA | Female | ENSG00000116754 | RBMS1 | exon_skip_7240 | 12.2703884335193 |
| BRCA | Female | ENSG00000115415 | RBMS1 | exon_skip_345660 | 12.2444881068982 |
| BRCA | Female | ENSG00000100938 | RBMS1 | exon_skip_105755 | 12.2388452854515 |
| BRCA | Female | ENSG00000090565 | RBM4 | exon_skip_131607 | 12.1748090043707 |
| BRCA | Female | ENSG00000160813 | RBM4 | exon_skip_478176 | 12.1654550947536 |
| BRCA | Female | ENSG00000115459 | RBMS1 | exon_skip_327160 | 12.0549010554288 |
| BRCA | Female | ENSG00000115310 | MSI1 | exon_skip_339045 | 12.0424990116702 |
| BRCA | Female | ENSG00000067829 | RBM4 | exon_skip_517266 | 12.0017460926487 |
| BRCA | Female | ENSG00000083444 | RBM4 | exon_skip_1365 | 11.9722088951904 |
| BRCA | Female | ENSG00000105676 | RBM4 | exon_skip_304174 | 11.9707891564559 |
| BRCA | Female | ENSG00000028116 | DAZAP1 | exon_skip_325772 | 11.9571700944246 |
| ∗Please click the gene id for more information. |
Top |
eQTL regulation in BRCA |
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| Top Male-specific cis-sQTM regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | SNP ID |
| ∗Please click the gene id for more information. |
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| Female-specific cis-eQTL regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | SNP ID |
| ∗Please click the gene id for more information. |
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| Opposite sex-biased cis-eQTL regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | SNP ID |
| ∗Please click the gene id for more information. |
Top |
sQTL regulation in BRCA |
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| Male-specific cis-sQTL regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | ES ID | SNP ID |
| ∗Please click the gene id for more information. |
|
| Female-specific cis-sQTL regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | ES ID | SNP ID |
| ∗Please click the gene id for more information. |
|
| Opposite sex-biased cis-sQTL regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | ES ID | SNP ID |
| ∗Please click the gene id for more information. |
Top |
eQTM regulation in BRCA |
|
| Male-specific cis-eQTM regulation (FDR <1e-5). |
| Cancer Type | Gene ID | CpG ID |
| ∗Please click the gene id for more information. |
|
| Female-specific cis-eQTM regulation (FDR <1e-5). |
| Cancer Type | Gene ID | CpG ID |
| ∗Please click the gene id for more information. |
|
| Opposite sex-biased cis-eQTM regulation (FDR <1e-5). |
| Cancer Type | Gene ID | CpG ID |
| ∗Please click the gene id for more information. |
Top |
sQTM regulation in BRCA |
|
| Male-specific cis-sQTM regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | ES ID | CpG ID |
| ∗Please click the gene id for more information. |
|
| Female-specific cis-sQTM regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | ES ID | CpG ID |
| ∗Please click the gene id for more information. |
|
| Opposite sex-biased cis-sQTM regulation (FDR <1e-5). |
| Cancer Type | Gene ID | Gene Name | ES ID | CpG ID |
| ∗Please click the gene id for more information. |
